Cited by 2,343Chemokine receptors and signalingProtease and Inhibitor MechanismsMechanisms of cancer metastasis

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Cancer and the chemokine network

Balkwill, Fran·2004·Nature Reviews Cancer

DOI 10.1038/nrc1388

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Müller, A., Homey, B., Soto, H., Ge, N., Catron, D., Buchanan, M. E., McClanahan, T., Murphy, E., Yuan, W., Wagner, S. N., et al. (2001) · Nature · doi:10.1038/35065016 · Cited by 5,340
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Zlotnik, A., & Yoshie, O. (2000) · Immunity · doi:10.1016/s1074-7613(00)80165-x · Cited by 3,923
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A multigenic program mediating breast cancer metastasis to bone
Kang, Y., Siegel, P. M., Shu, W., Drobnjak, M., Käkönen, S.-M., Cordon‐Cardo, C., Guise, T. A., & Massagué, J. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00132-6 · Cited by 2,605
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Bingle, L., Brown, N. J., & Lewis, C. E. (2002) · The Journal of Pathology · doi:10.1002/path.1027 · Cited by 2,022
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Murphy, P. M., Baggiolini, M., Charo, I. F., Hébert, C. A., Horuk, R., Matsushima, K., Miller, L. H., Oppenheim, J. J., & Power, C. A. (2000) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01439-x · Cited by 1,817
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Tachibana, K., Hirota, S., Iizasa, H., Yoshida, H., Kawabata, K., Kataoka, Y., Kitamura, Y., Matsushima, K., Yoshida, N., Nishikawa, S.-I., et al. (1998) · Nature · doi:10.1038/31261 · Cited by 1,547
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Petit, I., Szyper‐Kravitz, M., Nagler, A., Lahav, M., Peled, A., Habler, L., Ponomaryov, T., Taichman, R. S., Arenzana‐Seisdedos, F., Fujii, N., et al. (2002) · Nature Immunology · doi:10.1038/ni813 · Cited by 1,331
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Staller, P., Sulitkova, J., Lisztwan, J., Moch, H., Oakeley, E. J., & Krek, W. (2003) · Nature · doi:10.1038/nature01874 · Cited by 870
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Schioppa, T., Uranchimeg, B., Saccani, A., Biswas, S. K., Doni, A., Rapisarda, A., Bernasconi, S., Saccani, S., Nebuloni, M., Vago, L., et al. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20030267 · Cited by 841
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Moore, R. J., Owens, D. M., Stamp, G., Arnott, C., Burke, F., East, N., Holdsworth, H., Turner, L., Rollins, B., Pasparakis, M., et al. (1999) · Nature Medicine · doi:10.1038/10552 · Cited by 839
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Gu, L., Tseng, S., Horner, R. M., Tam‐Amersdorfer, C., Loda, M. F., & Rollins, B. J. (2000) · Nature · doi:10.1038/35006097 · Cited by 832
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Koshiba, T., Hosotani, R., Miyamoto, Y., Ida, J., Tsuji, S., Nakajima, S., Kawaguchi, M., Kobayashi, H., Doi, R., Hori, T., et al. (2000) · PubMed · Cited by 427
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Chemokine Receptors in Human Endothelial Cells
Gupta, S. K., Lysko, P. G., Pillarisetti, K., Ohlstein, E. H., & Stadel, J. M. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.7.4282 · Cited by 408
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Homey, B., Müller, A., & Zlotnik, A. (2002) · Nature Reviews Immunology · doi:10.1038/nri748 · Cited by 398
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Self-citation
Untitled work
(2003) · PubMed · Cited by 355
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Bottazzi, B., Polentarutti, N., Acero, R., Balsari, A., Boraschi, D., Ghezzi, P., Salmona, M., & Mantovani, A. (1983) · Science · doi:10.1126/science.6828888 · Cited by 352
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Murakami, T., Maki, W. C., Cardones, A. R., Fang, H., Tun-Kyi, A., Nestle, F. O., & Hwang, S. T. (2002) · PubMed · Cited by 347
Quantitative assessment of the leukocyte infiltrate in ovarian cancer and its relationship to the expression of C-C chemokines.
Negus, R. P. M., Stamp, G. W. H., Hadley, J., & Balkwill, F. R. (1997) · Europe PMC (PubMed Central) · Cited by 341
Self-citation
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Scotton, C. J., Wilson, J. L., Milliken, D., Stamp, G., & Balkwill, F. R. (2001) · PubMed · Cited by 335
Self-citation
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Barbero, S., Bonavia, R., Bajetto, A., Porcile, C., Pirani, P., Ravetti, J. L., Zona, G., Spaziante, R., Florio, T., & Schettini, G. (2003) · PubMed · Cited by 335
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Negus, R. P., Stamp, G. W., Relf, M. G., Burke, F., Malik, S. T., Bernasconi, S., Allavena, P., Sozzani, S., Mantovani, A., & Balkwill, F. R. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117933 · Cited by 315
Self-citation
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Dhawan, P., & Richmond, A. J. (2002) · Journal of Leukocyte Biology · doi:10.1189/jlb.72.1.9 · Cited by 309
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Libura, J., Drukała, J., Majka, M., Tomescu, O. A., Navenot, J. M., Kucia, M., Marquez‐Curtis, L. A., Peiper, S. C., Barr, F. G., Janowska‐Wieczorek, A., et al. (2002) · Blood · doi:10.1182/blood-2002-01-0031 · Cited by 303
Expression of chemokine receptor CCR7 is associated with lymph node metastasis of gastric carcinoma.
Mashino, K., Sadanaga, N., Yamaguchi, H., Tanaka, F., Ohta, M., Shibuta, K., Inoue, H., & Mori, M. (2002) · PubMed · Cited by 300
Elevated expression of the CC chemokine regulated on activation, normal T cell expressed and secreted (RANTES) in advanced breast carcinoma.
Luboshits, G., Shina, S., Kaplan, O., Engelberg, S., Nass, D., Lifshitz-Mercer, B., Chaitchik, S., Keydar, I., & Ben‐Baruch, A. (1999) · PubMed · Cited by 297
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Hall, J. M., & Korach, K. S. (2003) · Molecular Endocrinology · doi:10.1210/me.2002-0438 · Cited by 295
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Kijima, T., Maulik, G., Ma, P. C., Tibaldi, E. V., Turner, R. E., Rollins, B. J., Sattler, M., Johnson, B. E., & Salgia, R. (2002) · PubMed · Cited by 275
Expression pattern of CXC chemokine receptor-4 is correlated with lymph node metastasis in human invasive ductal carcinoma
Kato, M., Kitayama, J., Kazama, S., & Nagawa, H. (2003) · Breast Cancer Research · doi:10.1186/bcr627 · Cited by 267
A chemokine receptor antagonist inhibits experimental breast tumor growth.
Robinson, S. C., Scott, K. A., Wilson, J. L., Thompson, R. G., Proudfoot, A. E. I., & Balkwill, F. R. (2003) · PubMed · Cited by 258
Self-citation
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Till, K. J., Lin, K., Zuzel, M., & Cawley, J. C. (2002) · Blood · doi:10.1182/blood.v99.8.2977 · Cited by 222
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Egawa, T., Kawabata, K., Kawamoto, H., Amada, K., Okamoto, R., Fujii, N., Kishimoto, T., Katsura, Y., & Nagasawa, T. (2001) · Immunity · doi:10.1016/s1074-7613(01)00185-6 · Cited by 220
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Monti, P., Leone, B. E., Marchesi, F., Balzano, G., Zerbi, A., Scaltrini, F., Pasquali, C., Calori, G., Pessi, F., Sperti, C., et al. (2003) · PubMed · Cited by 208
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Bertolini, F., Dell’Agnola, C., Mancuso, P., Rabascio, C., Burlini, A., Monestiroli, S., Gobbi, A., Pruneri, G., & Martinelli, G. (2002) · PubMed · Cited by 204
Association of CC chemokine receptor 7 with lymph node metastasis of esophageal squamous cell carcinoma.
Ding, Y., Shimada, Y., Maeda, M., Kawabe, A., Kaganoi, J., Komoto, I., Hashimoto, Y., Miyake, M., Hashida, H., & Imamura, M. (2003) · PubMed · Cited by 201
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Ara, T., Itoi, M., Kawabata, K., Egawa, T., Tokoyoda, K., Sugiyama, T., Fujii, N., Amagai, T., & Nagasawa, T. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.9.4649 · Cited by 183
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Locati, M., Deuschle, U., Massardi, M. L., Martínez, F. O., Sironi, M., Sozzani, S., Bartfai, T., & Mantovani, A. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.7.3557 · Cited by 181
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Allavena, P., Sica, A., Vecchi, A., Locati, M., Sozzani, S., & Mantovani, A. (2000) · Immunological Reviews · doi:10.1034/j.1600-065x.2000.17714.x · Cited by 172
Expression of functional CXCR4 chemokine receptors on human colonic epithelial cells
Jordan, N., Kolios, G. C., Abbot, S. E., Sinai, M. A., Thompson, D. A., Petraki, K., & Westwick, J. K. (1999) · Journal of Clinical Investigation · doi:10.1172/jci6685 · Cited by 171
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Sozzani, S., Luini, W., Bianchi, G., Allavena, P., Wells, T. N. C., Napolitano, M., Bernardini, G., Vecchi, A., D’Ambrosio, D., Mazzeo, D., et al. (1998) · Blood · doi:10.1182/blood.v92.11.4036 · Cited by 167
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Proudfoot, A. E. I., Buser, R., Borlat, F., Alouani, S., Soler, D. F., Offord, R. E., Schröder, J.-M., Power, C., & Wells, T. N. C. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.45.32478 · Cited by 153
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Self-citation
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Hwang, J. H., Hwang, J. H., Chung, H. K., Kim, D. W., Hwang, E. S., Suh, J. M., Kim, H., You, K., Kwon, O., Ro, H. K., et al. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-021381 · Cited by 125
CTLA-4 regulates cell cycle progression during a primary immune response
Greenwald, R. J., Oosterwegel, M. A., van der Woude, D., Kubal, A., Mandelbrot, D. A., Boussiotis, V. A., & Sharpe, A. H. (2002) · European Journal of Immunology · doi:10.1002/1521-4141(200202)32:2 · Cited by 120
Self-citation
RANTES expression is a predictor of survival in stage I lung adenocarcinoma.
Moran, C. J., Arenberg, D. A., Huang, C. C., Giordano, T. J., Thomas, D. G., Misek, D. E., Chen, G., Iannettoni, M. D., Orringer, M. B., Hanash, S., et al. (2002) · PubMed · Cited by 111
Stromal Cell-Derived Factor-1 as a Chemoattractant for Follicular Center Lymphoma B Cells
Corcione, A., Ottonello, L. C., Tortolina, G., Facchetti, P., Airoldi, I., Guglielmino, R., Dadati, P., Truini, M., Sozzani, S., Dallegri, F., et al. (2000) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/92.8.628 · Cited by 99
Analysis of CC chemokine and chemokine receptor expression in solid ovarian tumours
Scotton, C. J., Milliken, D., Wilson, J. L., Raju, S., & Balkwill, F. R. (2001) · British Journal of Cancer · doi:10.1054/bjoc.2001.2020 · Cited by 89
Self-citation
Distinct p53-independent apoptotic cell death signalling pathways in testicular germ cell tumour cell lines
Burger, H., Nooter, K., Boersma, A. W. M., van Wingerden, K. E., Looijenga, L. H. J., Jochemsen, A. G., & Stoter, G. (1999) · International Journal of Cancer · doi:10.1002/(sici)1097-0215(19990517)81:4 · Cited by 89
Functional expression of the eotaxin receptor CCR3 in CD30+ cutaneous T-cell lymphoma
Kleinhans, M., Tun-Kyi, A., Gilliet, M. F., Kadin, M. E., Dummer, R., Burg, G., & Nestle, F. O. (2003) · Blood · doi:10.1182/blood-2002-02-0475 · Cited by 89
PARC/CCL18 Is a Plasma CC Chemokine with Increased Levels in Childhood Acute Lymphoblastic Leukemia
Struyf, S., Schutyser, E., Gouwy, M., Gijsbers, K., Proost, P., Benoît, Y., Opdenakker, G., Damme, J. V., & Laureys, G. (2003) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63564-x · Cited by 78
Retention of CXCR4 in the endoplasmic reticulum blocks dissemination of a T cell hybridoma
Zeelenberg, I. S., Stalle, L. R.-V., & Roos, E. (2001) · Journal of Clinical Investigation · doi:10.1172/jci11330 · Cited by 62
Production of IL-1 receptor antagonist by hepatocytes is regulated as an acute-phase proteinin vivo
Gabay, C., Gigley, J. P., Sipe, J. D., Arend, W. P., & Fantuzzi, G. (2001) · European Journal of Immunology · doi:10.1002/1521-4141(200102)31:2 · Cited by 61
Self-citation
Radiolabelled lymphokines and growth factors for in vivo imaging of inflammation, infection and cancer
Signore, A., Capriotti, G., Scopinaro, F., Bonanno, E., & Modesti, A. (2003) · Trends in Immunology · doi:10.1016/s1471-4906(03)00174-1 · Cited by 16
The use of trimodality therapy for the treatment of operable esophageal carcinoma in the veteran population
Billingsley, K. G., Maynard, C. C., Schwartz, D. L., & Dominitz, J. A. (2001) · Cancer · doi:10.1002/1097-0142(20010901)92:5 · Cited by 11
Stem cells take a shortcut to the bone marrow
Dick, J. E., & Lapidot, T. (2003) · Blood · doi:10.1182/blood-2003-02-0392 · Cited by 6

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1 of the 102 references couldn’t be matched to a known paper.

Research works printed but not linked: 1

Darash-Yahana, M. et al. Human prostate cancer growth, vascularisation and metastasis is stimulated via high expression levels of the chemokine receptor CXCR4. Proc. Am. Assoc. Cancer Res. 44, 789 (2003).

Sorted by citations

Cancer-related inflammation
Mantovani, A., Allavena, P., Sica, A., & Balkwill, F. (2008) · Nature · doi:10.1038/nature07205 · Cited by 11,399
Self-citation
The senescence-associated secretory phenotype: the dark side of tumor suppression
Coppé, J.-P., Desprez, P.-Y., Krtolica, A., & Campisi, J. (2010) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-121808-102144 · Cited by 5,206
Stromal Fibroblasts Present in Invasive Human Breast Carcinomas Promote Tumor Growth and Angiogenesis through Elevated SDF-1/CXCL12 Secretion
Orimo, A., Gupta, P. B., Sgroi, D. C., Arenzana-Seisdedos, F., Delaunay, T., Naeem, R., Carey, V. J., Richardson, A. L., & Weinberg, R. A. (2005) · Cell · doi:10.1016/j.cell.2005.02.034 · Cited by 3,759
Mesenchymal stem cells within tumour stroma promote breast cancer metastasis
Karnoub, A. E., Dash, A. B., Vo, A. P., Sullivan, A., Brooks, M. W., Bell, G. W., Richardson, A. L., Polyak, K., Tubo, R., & Weinberg, R. A. (2007) · Nature · doi:10.1038/nature06188 · Cited by 3,206
Genes that mediate breast cancer metastasis to lung
Minn, A. J., Gupta, G. P., Siegel, P. M., Bos, P. D., Shu, W., Giri, D. D., Viale, A., Olshen, A. B., Gerald, W. L., & Massagué, J. (2005) · Nature · doi:10.1038/nature03799 · Cited by 2,922

See all 2,343

Authors: Balkwill, F.
Venue: Nature Reviews Cancer
Publisher: Springer Science and Business Media LLC
Published: 2004-07
Volume: 4
Issue: 7
Pages: 540-550
ISSN: 1474-175X (ISSN-L)
1474-1768
DOI: 10.1038/nrc1388
OpenAlex: W1986986419
Cited by: 2,343
References: 102
Citations by year: 2026: 31 · 2025: 45 · 2024: 57 · 2023: 82 · 2022: 112 · 2021: 132 · 2020: 122 · 2019: 84 · 2018: 131 · 2017: 127 · 2016: 134 · 2015: 133 · 2014: 152 · 2013: 119 · 2012: 135
FWCI: 9.35
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature reviews. Cancer (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Oncology › Chemokine receptors and signaling
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Protease and Inhibitor Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mechanisms of cancer metastasis
Keywords: chemokines, chemokine receptors, carcinogenesis, metastasis, tumor-host interaction, metastatic potential, site-specific metastasis, chemokine receptor antagonists, inflammation, autoimmune disease, cancer therapy
MeSH terms: Animals, Antineoplastic Agents, Autoimmune Diseases, Chemotaxis, Leukocyte, Humans, Inflammation, Macrophage Activation, Mice, Nude, Models, Biological, Neoplasm Invasiveness, Neoplasm Metastasis, Neoplasm Proteins, Neoplasms, Lymphocytes, Tumor-Infiltrating, Chemokines, Receptors, Chemokine, Xenograft Model Antitumor Assays, Mice

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