Cited by 2,343Chemokine receptors and signalingProtease and Inhibitor MechanismsMechanisms of cancer metastasis

The DOI matches its Crossref record; 101 of the 102 references it cites were found in a registry or an index.

Cancer and the chemokine network

Balkwill, Fran·2004·Nature Reviews Cancer

DOI 10.1038/nrc1388

Open this paper in CoChat — free account

Integrity signals

Registry

Crossref · 10.1038/nrc1388

Cites

101 of 101 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Inflammation and cancer
Coussens, L. M., & Werb, Z. (2002) · Nature · doi:10.1038/nature01322 · Cited by 15,111
Stem cells, cancer, and cancer stem cells
Reya, T., Morrison, S. J., Clarke, M. F., & Weissman, I. L. (2001) · Nature · doi:10.1038/35102167 · Cited by 9,738
Inflammation and cancer: back to Virchow?
Balkwill, F., & Mantovani, A. (2001) · The Lancet · doi:10.1016/s0140-6736(00)04046-0 · Cited by 7,746
Self-citation
International Union of Pharmacology: Approaches to the Nomenclature of Voltage-Gated Ion Channels
Catterall, W. A., Chandy, K. G., Clapham, D. E., Gutman, G. A., Hofmann, F., Harmar, A. J., Abernethy, D. R., & Spedding, M. (2003) · Pharmacological Reviews · doi:10.1124/pr.55.4.5 · Cited by 7,126
Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes
MANTOVANI, A., SOZZANI, S., LOCATI, M., ALLAVENA, P., & SICA, A. (2002) · Trends in Immunology · doi:10.1016/s1471-4906(02)02302-5 · Cited by 5,528
Involvement of chemokine receptors in breast cancer metastasis
Müller, A., Homey, B., Soto, H., Ge, N., Catron, D., Buchanan, M. E., McClanahan, T., Murphy, E., Yuan, W., Wagner, S. N., et al. (2001) · Nature · doi:10.1038/35065016 · Cited by 5,340
Chemokines
Zlotnik, A., & Yoshie, O. (2000) · Immunity · doi:10.1016/s1074-7613(00)80165-x · Cited by 3,923
Tumour-educated macrophages promote tumour progression and metastasis
Pollard, J. W. (2004) · Nature reviews. Cancer · doi:10.1038/nrc1256 · Cited by 3,414
Intratumoral T Cells, Recurrence, and Survival in Epithelial Ovarian Cancer
Zhang, L., Conejo-Garcia, J. R., Katsaros, D., Gimotty, P. A., Massobrio, M., Regnani, G., Makrigiannakis, A., Gray, H., Schlienger, K., Liebman, M. N., et al. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa020177 · Cited by 3,397
A multigenic program mediating breast cancer metastasis to bone
Kang, Y., Siegel, P. M., Shu, W., Drobnjak, M., Käkönen, S.-M., Cordon‐Cardo, C., Guise, T. A., & Massagué, J. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00132-6 · Cited by 2,605

Show all 102 references

Research works printed but not linked: 1

Darash-Yahana, M. et al. Human prostate cancer growth, vascularisation and metastasis is stimulated via high expression levels of the chemokine receptor CXCR4. Proc. Am. Assoc. Cancer Res. 44, 789 (2003).

Sorted by citations

Items 101–200 of 1,000

Inhibition of CXCR2 profoundly suppresses inflammation-driven and spontaneous tumorigenesis
Jamieson, T., Clarke, M., Steele, C. W., Samuel, M. S., Neumann, J., Jung, A., Huels, D., Olson, M. F., Das, S., Nibbs, R. J. B., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci61067 · Cited by 391
Immunology in the clinic review series; focus on cancer: tumour-associated macrophages: undisputed stars of the inflammatory tumour microenvironment
Allavena, P., & Mantovani, A. (2011) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2011.04515.x · Cited by 399
Known and novel roles of the MET oncogene in cancer: a coherent approach to targeted therapy
Comoglio, P. M., Trusolino, L., & Boccaccio, C. (2018) · Nature reviews. Cancer · doi:10.1038/s41568-018-0002-y · Cited by 385
Cellular and molecular processes in ovarian cancer metastasis. A Review in the Theme: Cell and Molecular Processes in Cancer Metastasis
Yeung, T.-L., Leung, C. S., Yip, K., Yeung, C. L. A., Wong, S. T. C., & Mok, S. C. (2015) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00188.2015 · Cited by 384
Tumor Cell-Organ Microenvironment Interactions in the Pathogenesis of Cancer Metastasis
Langley, R. R., & Fidler, I. J. (2007) · Endocrine Reviews · doi:10.1210/er.2006-0027 · Cited by 377
Interleukin-8 in cancer pathogenesis, treatment and follow-up
Alfaro, C., Sanmamed, M. F., Rodriguez-Ruiz, M. E., Teijeira, Á., Oñate, C., González, Á., Ponz‐Sarvisé, M., Schalper, K. A., Perez‐Gracia, J. L., & Melero, I. (2017) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2017.08.004 · Cited by 380
Targeting the PI3K/AKT Pathway for the Treatment of Prostate Cancer
Sarker, D., Reid, A. H. M., Yap, T. A., & de Bono, J. S. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-08-0125 · Cited by 366
Grapefruit-Derived Nanovectors Use an Activated Leukocyte Trafficking Pathway to Deliver Therapeutic Agents to Inflammatory Tumor Sites
Wang, Q., Ren, Y., Mu, J., Egilmez, N. K., Zhuang, X., Deng, Z., Zhang, L., Yan, J., Miller, D. M., & Zhang, H. (2015) · Cancer Research · doi:10.1158/0008-5472.can-14-3095 · Cited by 371
Tumor-associated macrophages: function, phenotype, and link to prognosis in human lung cancer.
Quatromoni, J. G., & Eruslanov, E. B. (2012) · Europe PMC (PubMed Central) · Cited by 361
Molecular networks that regulate cancer metastasis
Spano, D., Heck, C., Antonellis, P. D., Christofori, G., & Zollo, M. (2012) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2012.03.006 · Cited by 367
CXCL13 and Its Receptor CXCR5 in Cancer: Inflammation, Immune Response, and Beyond
Kazanietz, M. G., Durando, M., & Cooke, M. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00471 · Cited by 360
Overexpression of CXCL5 mediates neutrophil infiltration and indicates poor prognosis for hepatocellular carcinoma
Zhou, S., Dai, Z., Zhou, Z., Wang, X., Yang, G., Wang, Z., Huang, X., Fan, J., & Zhou, J. (2012) · Hepatology · doi:10.1002/hep.25907 · Cited by 358
Cancer-associated fibroblasts enhance tumor-associated macrophages enrichment and suppress NK cells function in colorectal cancer
Zhang, R., Qi, F., Zhao, F., Li, G., Shao, S., Zhang, X., Yuan, L., & Feng, Y. (2019) · Cell Death & Disease · doi:10.1038/s41419-019-1435-2 · Cited by 343
Tumor-associated macrophages: Effectors of angiogenesis and tumor progression
Coffelt, S. B., Hughes, R., & Lewis, C. E. (2009) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2009.02.004 · Cited by 358
Crosstalk between cancer and immune cells: Role of tumor‐associated macrophages in the tumor microenvironment
Wang, J., Li, D., Cang, H., & Guo, B. (2019) · Cancer Medicine · doi:10.1002/cam4.2327 · Cited by 363
Chemokines in tumor progression and metastasis
Sarvaiya, P. J., Guo, D., Ulasov, I. V., Gabikian, P., & Lesniak, M. S. (2013) · Oncotarget · doi:10.18632/oncotarget.1426 · Cited by 363
HMGB1: guiding immunity from within
Dumitriu, I. E., Baruah, P., Manfredi, A. A., Bianchi, M. E., & Rovere, P. Q. (2005) · Trends in Immunology · doi:10.1016/j.it.2005.04.009 · Cited by 340
Increased Survival, Proliferation, and Migration in Metastatic Human Pancreatic Tumor Cells Expressing Functional CXCR4
Marchesi, F., Monti, P., Leone, B. E., Zerbi, A., Vecchi, A., Piemonti, L., Mantovani, A., & Allavena, P. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-1343 · Cited by 342
CXCL1 induced by prostaglandin E2 promotes angiogenesis in colorectal cancer
Wang, D., Wang, H., Brown, J. R., Daikoku, T., Wei, N., Shi, Q., Richmond, A. J., Strieter, R. M., Dey, S. K., & DuBois, R. N. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20052124 · Cited by 337
Chemokines, chemokine receptors, and cancer metastasis
Kakinuma, T., & Hwang, S. T. (2006) · Journal of Leukocyte Biology · doi:10.1189/jlb.1105633 · Cited by 340
Induction of a proinflammatory program in normal human thyrocytes by the RET/PTC1 oncogene
Borrello, M. G., Alberti, L., Fischer, A. H., Degl’Innocenti, D., Ferrario, C., Gariboldi, M., Marchesi, F., Allavena, P., Greco, A., Collini, P., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0503039102 · Cited by 331
Cytokines as a key component of cancer-related inflammation
Germano, G., Allavena, P., & Mantovani, A. (2008) · Cytokine · doi:10.1016/j.cyto.2008.07.014 · Cited by 334
Stem Cell Trafficking in Tissue Development, Growth, and Disease
Laird, D. J., von Andrian, U. H., & Wagers, A. J. (2008) · Cell · doi:10.1016/j.cell.2008.01.041 · Cited by 331
Tissue-resident stem cells promote breast cancer growth and metastasis
Muehlberg, F. L., Song, Y.-H., Krohn, A., Pinilla, S. P., Droll, L. H., Leng, X., Seidensticker, M., Ricke, J., Altman, A. M., Devarajan, E., et al. (2009) · Carcinogenesis · doi:10.1093/carcin/bgp036 · Cited by 330
Elevated neutrophil and monocyte counts in peripheral blood are associated with poor survival in patients with metastatic melanoma: a prognostic model
Schmidt, H., Bastholt, L., Geertsen, P. F., Christensen, I. J., Larsen, S., Gehl, J., & von der Maase, H. (2005) · British Journal of Cancer · doi:10.1038/sj.bjc.6602702 · Cited by 327
Tumor-associated Macrophages (TAM) and Inflammation in Colorectal Cancer
Erreni, M., Mantovani, A., & Allavena, P. (2010) · Cancer Microenvironment · doi:10.1007/s12307-010-0052-5 · Cited by 336
Epithelial-mesenchymal Transition and Cell Invasion
Son, H., & Moon, A. (2010) · Toxicological Research · doi:10.5487/tr.2010.26.4.245 · Cited by 330
Role of the tumor microenvironment in tumor progression and the clinical applications (Review)
YUAN, Y., JIANG, Y.-C., SUN, C.-K., & CHEN, Q.-M. (2016) · Oncology Reports · doi:10.3892/or.2016.4660 · Cited by 320
CCL2/CCR2 signaling in cancer pathogenesis
Hao, Q., Vadgama, J. V., & Wang, P. (2020) · Cell Communication and Signaling · doi:10.1186/s12964-020-00589-8 · Cited by 324
Clinical applications of mesenchymal stem cells
Kim, N., & Cho, S. (2013) · The Korean Journal of Internal Medicine · doi:10.3904/kjim.2013.28.4.387 · Cited by 334
The Role of Tumor-Associated Neutrophils in Colorectal Cancer
Mizuno, R., Kawada, K., Itatani, Y., Ogawa, R., Kiyasu, Y., & Sakai, Y. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20030529 · Cited by 316
Breast Cancer Lung Metastasis Requires Expression of Chemokine Receptor CCR4 and Regulatory T Cells
Olkhanud, P. B., Baatar, D., Bodogai, M., Hakim, F. T., Gress, R. E., Anderson, R. L., Deng, J., Xu, M., Briest, S., & Biragyn, A. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-4619 · Cited by 316
Inflammatory cell infiltration of tumors: Jekyll or Hyde
Talmadge, J. E., Donkor, M. K., & Scholar, E. M. (2007) · Cancer and Metastasis Reviews · doi:10.1007/s10555-007-9072-0 · Cited by 312
Tumor necrosis factor, cancer and anticancer therapy
D, S. M. M., Rossi, C. R., Pilati, P., & Nitti, D. (2004) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2004.11.001 · Cited by 316
Macrophage Markers in Serum and Tumor Have Prognostic Impact in American Joint Committee on Cancer Stage I/II Melanoma
Jensen, T. Ø., Schmidt, H., Møller, H. J., Høyer, M., Maniecki, M. B., Sjoegren, P., Christensen, I. J., & Steiniche, T. (2009) · Journal of Clinical Oncology · doi:10.1200/jco.2008.19.9919 · Cited by 296
Periprostatic adipocytes act as a driving force for prostate cancer progression in obesity
Laurent, V., Guérard, A., Mazerolles, C., Gonidec, S. L., Toulet, A., Nieto, L., Zaidi, F., Majed, B., Garandeau, D., Socrier, Y., et al. (2016) · Nature Communications · doi:10.1038/ncomms10230 · Cited by 298
Breast cancer lung metastasis: Molecular biology and therapeutic implications
Jin, L., Han, B., Siegel, E. L., Cui, Y., Giuliano, A. E., & Cui, X. (2018) · Cancer Biology & Therapy · doi:10.1080/15384047.2018.1456599 · Cited by 308
Chemokines and cancer: migration, intracellular signalling and intercellular communication in the microenvironment
O’Hayre, M., Salanga, C. L., Handel, T. M., & Allen, S. J. (2008) · Biochemical Journal · doi:10.1042/bj20071493 · Cited by 303
Novel insights into G protein and G protein-coupled receptor signaling in cancer
O’Hayre, M., Degese, M. S., & Gutkind, J. S. (2014) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2014.01.005 · Cited by 307
Macrophages: The Road Less Traveled, Changing Anticancer Therapy
Guerriero, J. L. (2018) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2018.03.006 · Cited by 300
Fusobacterium nucleatum promotes colorectal cancer metastasis through miR-1322/CCL20 axis and M2 polarization
Xu, C., Fan, L., Lin, Y., Shen, W., Qi, Y., Zhang, Y., Chen, Z., Wang, L., Long, Y., Hou, T., et al. (2021) · Gut Microbes · doi:10.1080/19490976.2021.1980347 · Cited by 294
Molecular Pathways: Targeting the CXCR4–CXCL12 Axis—Untapped Potential in the Tumor Microenvironment
Scala, S. (2015) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-14-0914 · Cited by 293
Blockade of EGFR improves responsiveness to PD-1 blockade in EGFR -mutated non–small cell lung cancer
Sugiyama, E., Togashi, Y., Takeuchi, Y., Shinya, S., Tada, Y., Kataoka, K., Tane, K., Sato, E., Ishii, G., Goto, K., et al. (2020) · Science Immunology · doi:10.1126/sciimmunol.aav3937 · Cited by 295
Fibroblast activation in cancer: when seed fertilizes soil
Kužet, S.-E., & Gaggioli, C. (2016) · Cell and Tissue Research · doi:10.1007/s00441-016-2467-x · Cited by 301
Regulation of IKKβ by miR-199a affects NF-κB activity in ovarian cancer cells
Chen, R. J., Alvero, A. B., Silasi, D., Kelly, M. G., Fest, S., Visintin, I., Leiser, A., Schwartz, P. E., Rutherford, T., & Mor, G. (2008) · Oncogene · doi:10.1038/onc.2008.112 · Cited by 291
Macrophages, Inflammation, and Lung Cancer
Conway, E. M., Pikor, L. A., Kung, S. H. Y., Hamilton, M. J., Lam, S. C., Lam, W. L., & Bennewith, K. L. (2015) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201508-1545ci · Cited by 295
Anti-inflammatory Properties of the Novel Antitumor Agent Yondelis (Trabectedin): Inhibition of Macrophage Differentiation and Cytokine Production
Allavena, P., Signorelli, M., Chieppa, M., Erba, E., Bianchi, G., Marchesi, F., Olimpio, C. O., Bonardi, C., Garbi, A., Lissoni, A. A., et al. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-4037 · Cited by 287
SMAD4-deficient intestinal tumors recruit CCR1+ myeloid cells that promote invasion
Kitamura, T., Kometani, K., Hashida, H., Matsunaga, A., Miyoshi, H., Hosogi, H., Aoki, M., Oshima, M., Hattori, M., Takabayashi, A., et al. (2007) · Nature Genetics · doi:10.1038/ng1997 · Cited by 288
CXCR3 Ligands in Cancer and Autoimmunity, Chemoattraction of Effector T Cells, and Beyond
Karin, N. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00976 · Cited by 285
Expression of CXCR4 Predicts Poor Prognosis in Patients with Malignant Melanoma
Scala, S., Ottaiano, A., Ascierto, P. A., Cavalli, M., Simeone, E., Giuliano, P., Napolitano, M., Franco, R., Botti, G., & Castello, G. (2005) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-04-1887 · Cited by 279
Targeting CXCL12/CXCR4 Axis in Tumor Immunotherapy
Zhou, W., Guo, S., Liu, M., Burow, M. E., & Wang, G. (2017) · Current Medicinal Chemistry · doi:10.2174/0929867324666170830111531 · Cited by 286
Dual prognostic significance of tumour-associated macrophages in human pancreatic adenocarcinoma treated or untreated with chemotherapy
Caro, G. D., Cortese, N., Castino, G. F., Grizzi, F., Gavazzi, F., Ridolfi, C., Capretti, G. L., Mineri, R., Todoric, J., Zerbi, A., et al. (2015) · Gut · doi:10.1136/gutjnl-2015-309193 · Cited by 280
Tumour-infiltrating macrophages and clinical outcome in breast cancer
Mahmoud, S., Lee, A. H. S., Paish, E. C., Macmillan, R. D., Ellis, I. O., & Green, A. R. (2011) · Journal of Clinical Pathology · doi:10.1136/jclinpath-2011-200355 · Cited by 277
Antitumor and Anti-inflammatory Effects of Trabectedin on Human Myxoid Liposarcoma Cells
Germano, G., Frapolli, R., Simone, M., Tavecchio, M., Erba, E., Pesce, S., Pasqualini, F., Grosso, F., Sanfilippo, R. G., Casali, P. G., et al. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-2335 · Cited by 268
Targeting the mechanisms of tumoral immune tolerance with small-molecule inhibitors
Muller, A. J., & Scherle, P. (2006) · Nature reviews. Cancer · doi:10.1038/nrc1929 · Cited by 266
Organ selectivity in metastasis: regulation by chemokines and their receptors
Ben‐Baruch, A. (2007) · Clinical & Experimental Metastasis · doi:10.1007/s10585-007-9097-3 · Cited by 264
Microenvironment and tumor cell plasticity: An easy way out
Taddei, M. L., Giannoni, E., Comito, G., & Chiarugi, P. (2013) · Cancer Letters · doi:10.1016/j.canlet.2013.01.042 · Cited by 272
Emerging avenues linking inflammation and cancer
Kundu, J. K., & Surh, Y. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.02.035 · Cited by 272
Stepping out of the flow: capillary extravasation in cancer metastasis
Miles, F. L., Pruitt, F. L., van Golen, K. L., & Cooper, C. R. (2007) · Clinical & Experimental Metastasis · doi:10.1007/s10585-007-9098-2 · Cited by 259
Neutrophil extracellular traps mediate the crosstalk between glioma progression and the tumor microenvironment via the HMGB1/RAGE/IL-8 axis
Zha, C., Meng, X., Li, L., Mi, S., Qian, D., Li, Z., Wu, P., Hu, S., Zhao, S., Cai, J., et al. (2020) · Cancer Biology and Medicine · doi:10.20892/j.issn.2095-3941.2019.0353 · Cited by 274
Molecular mechanisms of perineural invasion, a forgotten pathway of dissemination and metastasis
Marchesi, F., Piemonti, L., Mantovani, A., & Allavena, P. (2010) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2009.11.001 · Cited by 270
CC chemokine ligand 2 (CCL2) promotes prostate cancer tumorigenesis and metastasis
Zhang, J., Patel, L. R., & Pienta, K. J. (2009) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2009.11.009 · Cited by 261
Chemokine (C-C Motif) Ligand 2 Engages CCR2+ Stromal Cells of Monocytic Origin to Promote Breast Cancer Metastasis to Lung and Bone
Lü, X., & Kang, Y. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.035899 · Cited by 261
Gut Microbiome Directs Hepatocytes to Recruit MDSCs and Promote Cholangiocarcinoma
Zhang, Q., Ma, C., Duan, Y., Heinrich, B., Rosato, U., Diggs, L. P., Ma, L., Roy, S., Fu, Q., Brown, Z. J., et al. (2020) · Cancer Discovery · doi:10.1158/2159-8290.cd-20-0304 · Cited by 266
Anti–Tumor Necrosis Factor Therapy Inhibits Pancreatic Tumor Growth and Metastasis
Egberts, J. D., Cloosters, V., Noack, A., Schniewind, B., Thon, L., Klose, S., Kettler, B., von Forstner, C., Kneitz, C., Tepel, J., et al. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-5704 · Cited by 259
Tumor-Induced Expansion of Regulatory T Cells by Conversion of CD4+CD25− Lymphocytes Is Thymus and Proliferation Independent
Valzasina, B., Piconese, S., Guiducci, C., & Colombo, M. P. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-4217 · Cited by 266
Modulation of the tumor microenvironment and mechanism of immunotherapy-based drug resistance in breast cancer
Kundu, M., Butti, R., Panda, V. K., Malhotra, D., Das, S., Mitra, T., Kapse, P., Gosavi, S., & Kundu, G. C. (2024) · Molecular Cancer · doi:10.1186/s12943-024-01990-4 · Cited by 284
Epithelial-Mesenchymal Transition Induced by Senescent Fibroblasts
Laberge, R.-M., Awad, P., Campisi, J., & Desprez, P.-Y. (2012) · Cancer Microenvironment · doi:10.1007/s12307-011-0069-4 · Cited by 255
CCL2 is a Potent Regulator of Prostate Cancer Cell Migration and Proliferation
Loberg, R. D., Day, L. L., Harwood, J., Chi, Y., John, L. N. S., Giles, R., Neeley, C. K., & Pienta, K. J. (2006) · Neoplasia · doi:10.1593/neo.06280 · Cited by 257
Bone Metastases: An Overview
Macedo, F. (2017) · Cancer therapy & Oncology International Journal · doi:10.19080/ctoij.2017.04.555637 · Cited by 257
The pivotal role of CXCL12 (SDF-1)/CXCR4 axis in bone metastasis
Wang, J., Loberg, R. D., & Taichman, R. S. (2006) · Cancer and Metastasis Reviews · doi:10.1007/s10555-006-9019-x · Cited by 256
Chemokines and chemokine receptors: an overview
Bonecchi, R. (2009) · Frontiers in bioscience · doi:10.2741/3261 · Cited by 255
Emerging targets in cancer management: role of the CXCL12/CXCR4 axis
Dubrovska, A., Cojoc, M., Peitzsch, C., Trautmann, F., Polishchuk, & Telegeev (2013) · OncoTargets and Therapy · doi:10.2147/ott.s36109 · Cited by 274
Differentiation and gene expression profile of tumor-associated macrophages
Schmieder, A., Michel, J., Schönhaar, K., Goerdt, S., & Schledzewski, K. (2012) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2012.02.002 · Cited by 263
Inhibition of the CXCR4/CXCL12 chemokine pathway reduces the development of murine pulmonary metastases
Kim, S. Y., Lee, C. H., Midura, B., Yeung, C. L., Mendoza, A., Hong, S. H., Ren, L., Wong, D., Korz, W., Merzouk, A., et al. (2007) · Clinical & Experimental Metastasis · doi:10.1007/s10585-007-9133-3 · Cited by 253
Profiling circulating tumour cells and other biomarkers of invasive cancers
Poudineh, M., Sargent, E. H., Pantel, K., & Kelley, S. O. (2018) · Nature Biomedical Engineering · doi:10.1038/s41551-018-0190-5 · Cited by 255
Aging and cancer: The role of macrophages and neutrophils
Jackaman, C., Tomay, F., Duong, L., Abdol Razak, N. B., Pixley, F. J., Metharom, P., & Nelson, D. J. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2017.03.008 · Cited by 251
Tumor Necrosis Factor α As a New Target for Renal Cell Carcinoma: Two Sequential Phase II Trials of Infliximab at Standard and High Dose
Harrison, M., Obermueller, E., Maisey, N. R., Hoare, S., Edmonds, K., Li, N. F., Chao, D., Hall, K., Lee, C., Timotheadou, E. T., et al. (2007) · Journal of Clinical Oncology · doi:10.1200/jco.2007.11.2136 · Cited by 251
Self-citation
Pharmacological modulation of chemokine receptor function
Scholten, D. J., Canals, M., Maussang, D., Roumen, L., Smit, M. J., Wijtmans, M., de Graaf, C., Vischer, H. F., & Leurs, R. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01551.x · Cited by 250
Cellular and molecular pathways linking inflammation and cancer
Porta, C., Larghi, P., Rimoldi, M., Totaro, M. G., Allavena, P., Mantovani, A., & Sica, A. (2009) · Immunobiology · doi:10.1016/j.imbio.2009.06.014 · Cited by 262
Regulation of macrophage function in tumors: the multifaceted role of NF-κB
Hagemann, T., Biswas, S. K., Lawrence, T., Sica, A., & Lewis, C. E. (2009) · Blood · doi:10.1182/blood-2008-12-172825 · Cited by 249
Cytokine patterns in cancer patients: a review of the correlation between interleukin 6 and prognosis
Lippitz, B. E., & Harris, R. A. (2016) · OncoImmunology · doi:10.1080/2162402x.2015.1093722 · Cited by 248
The Inflammatory Tumor Microenvironment and Its Impact on Cancer Development
de Visser, K. E., & Coussens, L. M. (2006) · KARGER eBooks · doi:10.1159/000092969 · Cited by 250
Macrophages
Guerriero, J. L. (2018) · International review of cytology · doi:10.1016/bs.ircmb.2018.07.001 · Cited by 256
Chemokine receptor CXCR3 promotes colon cancer metastasis to lymph nodes
Kawada, K., Hosogi, H., Sonoshita, M., Sakashita, H., Manabe, T., Shimahara, Y., Sakai, Y., Takabayashi, A., Oshima, M., & Taketo, M. M. (2007) · Oncogene · doi:10.1038/sj.onc.1210267 · Cited by 243
CXCL14 is an autocrine growth factor for fibroblasts and acts as a multi-modal stimulator of prostate tumor growth
Augsten, M., Hägglöf, C., Olsson, E., Stolz, C., Tsagozis, P., Levchenko, T., Frederick, M. J., Borg, Å., Micke, P., Egevad, L., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0813144106 · Cited by 242
Combinations of Immunotherapy and Radiation in Cancer Therapy
Vatner, R. E., Cooper, B. T., Vanpouille‐Box, C., Demaria, S., & Formenti, S. C. (2014) · Frontiers in Oncology · doi:10.3389/fonc.2014.00325 · Cited by 249
Chemokines at the crossroads of tumor-fibroblast interactions that promote malignancy
Mishra, P. J., Banerjee, D., & Ben‐Baruch, A. (2010) · Journal of Leukocyte Biology · doi:10.1189/jlb.0310182 · Cited by 251
Dual Targeted Immunotherapy via In Vivo Delivery of Biohybrid RNAi‐Peptide Nanoparticles to Tumor‐Associated Macrophages and Cancer Cells
Conde, J., Bao, C., Tan, Y., Cui, D., Edelman, E. R., Azevedo, H. S., Byrne, H. J., Artzi, N., & Tian, F. (2015) · Advanced Functional Materials · doi:10.1002/adfm.201501283 · Cited by 242
Deciphering the performance of macrophages in tumour microenvironment: a call for precision immunotherapy
Toledo, B., Chen, L. Z., Paniagua-Sancho, M., Marchal, J. A., Perán, M., & Giovannetti, E. (2024) · Journal of Hematology & Oncology · doi:10.1186/s13045-024-01559-0 · Cited by 255
Chemokines and their Receptors: Multifaceted Roles in Cancer Progression and Potential Value as Cancer Prognostic Markers
Do, H. T. T., Lee, C. H., & Cho, J. (2020) · Cancers · doi:10.3390/cancers12020287 · Cited by 241
Human cytomegalovirus-encoded chemokine receptor US28 promotes tumorigenesis
Maussang, D., Verzijl, D., van Walsum, M., Leurs, R., Holl, J. M., Pleskoff, O., Michel, D., van Dongen, G. A. M. S., & Smit, M. J. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0604433103 · Cited by 233
Metastasis: cell-autonomous mechanisms versus contributions by the tumor microenvironment
Kopfstein, L., & Christofori, G. (2006) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-005-5296-8 · Cited by 236
Inflammatory chemokines and metastasis—tracing the accessory
Borsig, L., Wolf, M. J., Roblek, M., Lorentzen, A., & Heikenwälder, M. F. (2013) · Oncogene · doi:10.1038/onc.2013.272 · Cited by 231
Extravasation of leukocytes in comparison to tumor cells
Strell, C., & Entschladen, F. (2008) · Cell Communication and Signaling · doi:10.1186/1478-811x-6-10 · Cited by 239
Inhibition of histone lysine-specific demethylase 1 elicits breast tumor immunity and enhances antitumor efficacy of immune checkpoint blockade
Ye, Q., Vasilatos, S. N., Chen, L., Wu, H., Cao, Z., Fu, Y., Huang, M., Vlad, A., Lu, B., Oesterreich, S., et al. (2018) · Oncogene · doi:10.1038/s41388-018-0451-5 · Cited by 227
HCMV-Encoded Chemokine Receptor US28 Mediates Proliferative Signaling Through the IL-6–STAT3 Axis
Slinger, E., Maussang, D., Schreiber, A., Siderius, M. H., Rahbar, A., Fraile‐Ramos, A., Lira, S. A., Söderberg‐Nauclér, C., & Smit, M. J. (2010) · Science Signaling · doi:10.1126/scisignal.2001180 · Cited by 226
Constitutive and chemokine-dependent internalization and recycling of CXCR7 in breast cancer cells to degrade chemokine ligands
Luker, G. D., Steele, J. M., Mihalko, L. A., Ray, P., & Luker, G. D. (2010) · Oncogene · doi:10.1038/onc.2010.212 · Cited by 222
Macrophage targeting in cancer
Lopez‐Yrigoyen, M., Cassetta, L., & Pollard, J. W. (2020) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.14377 · Cited by 225
Chemokines and their receptors promoting the recruitment of myeloid-derived suppressor cells into the tumor
Li, B., Garstka, M. A., & Li, Z. (2019) · Molecular Immunology · doi:10.1016/j.molimm.2019.11.014 · Cited by 223

Authors: Balkwill, F.
Venue: Nature Reviews Cancer
Publisher: Springer Science and Business Media LLC
Published: 2004-07
Volume: 4
Issue: 7
Pages: 540-550
ISSN: 1474-175X (ISSN-L)
1474-1768
DOI: 10.1038/nrc1388
OpenAlex: W1986986419
Cited by: 2,343
References: 102
Citations by year: 2026: 31 · 2025: 45 · 2024: 57 · 2023: 82 · 2022: 112 · 2021: 132 · 2020: 122 · 2019: 84 · 2018: 131 · 2017: 127 · 2016: 134 · 2015: 133 · 2014: 152 · 2013: 119 · 2012: 135
FWCI: 9.35
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature reviews. Cancer (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Oncology › Chemokine receptors and signaling
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Protease and Inhibitor Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mechanisms of cancer metastasis
Keywords: chemokines, chemokine receptors, carcinogenesis, metastasis, tumor-host interaction, metastatic potential, site-specific metastasis, chemokine receptor antagonists, inflammation, autoimmune disease, cancer therapy
MeSH terms: Animals, Antineoplastic Agents, Autoimmune Diseases, Chemotaxis, Leukocyte, Humans, Inflammation, Macrophage Activation, Mice, Nude, Models, Biological, Neoplasm Invasiveness, Neoplasm Metastasis, Neoplasm Proteins, Neoplasms, Lymphocytes, Tumor-Infiltrating, Chemokines, Receptors, Chemokine, Xenograft Model Antitumor Assays, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Cancer and the chemokine network

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks