The DOI matches its Crossref record; 153 of the 153 references it cites were found in a registry or an index.
The influence of bio-behavioural factors on tumour biology: pathways and mechanisms
Open accessAbstract
Epidemiological studies indicate that stress, chronic depression and lack of social support might serve as risk factors for cancer development and progression. Recent cellular and molecular studies have identified biological processes that could potentially mediate such effects. This review integrates clinical, cellular and molecular studies to provide a mechanistic understanding of the interface between biological and behavioural influences in cancer, and identifies novel behavioural or pharmacological interventions that might help improve cancer outcomes.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Furthermore, the same cortisol-cytokine negative relationship has been found in response to other psychosocial interventions in oncology [4–5].”
From Singing modulates mood, stress, cortisol, cytokine and neuropeptide activity in cancer patients and carers (2016) · cites this paper as [5]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Inflammation is also a proposed mechanism mediating ELA effects on later depression, age-related diseases [3], neurodevelopmental changes [40], cancers [49], and other systemic effects discussed.”
From Biological embedding of childhood adversity: from physiological mechanisms to clinical implications (2017) · cites this paper as [49]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Glucocorticoid dysregulation may also promote oncogenic tumor cell microenvironments (in part via pro-inflammatory effects, as discussed below), fostering growth, migration, invasiveness, and angiogenesis [49], thus potentially contributing to observed links between ELA and cancers [7].”
From Biological embedding of childhood adversity: from physiological mechanisms to clinical implications (2017) · cites this paper as [49]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“In contrast, negative psychological states and limited social interactions have been linked to lower white blood cell activity, reduced numbers of antibodies and increased stress hormone response [2, 4–5].”
From Singing modulates mood, stress, cortisol, cytokine and neuropeptide activity in cancer patients and carers (2016) · cites this paper as [5]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“These positive states have, in turn, been linked to optimised immune responses including the lowering of inflammation, enhanced cellular function and other longer term health outcomes [4–5].”
From Singing modulates mood, stress, cortisol, cytokine and neuropeptide activity in cancer patients and carers (2016) · cites this paper as [5]
Experimental — accuracy not yet measured
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“and earlier cancer-related mortality [20–22]”
From A randomized controlled trial of a multi-modal palliative care intervention to promote advance care planning and psychological well-being among adults with advanced cancer: study protocol. (2022) · cites this paper as [22]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“These symptoms are thought to further exacerbate inflammation and, in doing so, contribute to the pathogenesis of various diseases of aging (6–8), many of which involve excessive cytokine activity (9, 10).”
From Clustering of depression and inflammation in adolescents previously exposed to childhood adversity (2012) · cites this paper as [7]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Coussens, L. M., & Werb, Z. (2002) · Nature · doi:10.1038/nature01322 · Cited by 15,111
Cancer: Principles and Practice of Oncology.
(1991) · Annals of Internal Medicine · doi:10.7326/0003-4819-114-9-819_4 · Cited by 8,524
Inflammation and cancer: back to Virchow?
Balkwill, F., & Mantovani, A. (2001) · The Lancet · doi:10.1016/s0140-6736(00)04046-0 · Cited by 7,746
The Biology of Vascular Endothelial Growth Factor
Ferrara, N., & Davis-Smyth, T. (1997) · Endocrine Reviews · doi:10.1210/edrv.18.1.0287 · Cited by 4,585
The Concepts of Stress and Stress System Disorders: Overview of Physical and Behavioral Homeostasis
Chrousos, G. P. (1992) · JAMA · doi:10.1001/jama.1992.03480090092034 · Cited by 2,689
EFFECT OF PSYCHOSOCIAL TREATMENT ON SURVIVAL OF PATIENTS WITH METASTATIC BREAST CANCER
Spiegel, D., Kraemer, H., Bloom, J., & Gottheil, E. (1989) · The Lancet · doi:10.1016/s0140-6736(89)91551-1 · Cited by 2,353
Stress-induced immune dysfunction: implications for health
Glaser, R., & Kiecolt-Glaser, J. K. (2005) · Nature Reviews Immunology · doi:10.1038/nri1571 · Cited by 2,190
Gabrilovich, D. I., Chen, H. L., Girgis, K. R., Cunningham, H. T., Meny, G. M., Nadaf, S., Kavanaugh, D., & Carbone, D. P. (1996) · Nature Medicine · doi:10.1038/nm1096-1096 · Cited by 1,977
Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP
de Rooij, J., Zwartkruis, F. J. T., Verheijen, M. H. G., Cool, R. H., Nijman, S. M. B., Wittinghofer, A., & Bos, J. L. (1998) · Nature · doi:10.1038/24884 · Cited by 1,970
Allostasis and Allostatic Load Implications for Neuropsychopharmacology
McEwen, B. (2000) · Neuropsychopharmacology · doi:10.1016/s0893-133x(99)00129-3 · Cited by 1,833
Research works printed but not linked: 2
- Stefanek, M. & McDonald, P. G. in Handbook of Behavioral Science and Cancer (eds Miller, S. M., Bowen, D. J., Croyle, R. T. & Rowland, J.) (American Psychological Association, Washington DC) (in the press).
- Antoni, M. H. et al. Randomized clinical trial of cognitive behavioral stress management on HIV viral load in gay men treated with HAART. Psychosom. Med. (in the press).
Cited by
Sorted by citations
Psychological Stress and Disease
Cohen, S., Janicki-Deverts, D., & Miller, G. E. (2007) · JAMA · doi:10.1001/jama.298.14.1685 · Cited by 3,168
Effects of stress on immune function: The good, the bad, and the beautiful
Dhabhar, F. S. (2014) · Immunologic Research · doi:10.1007/s12026-014-8517-0 · Cited by 1,343
Self-citationChronic stress promotes tumor growth and angiogenesis in a mouse model of ovarian carcinoma
Thaker, P. H., Han, L. Y., Kamat, A. A., Arevalo, J. M., Takahashi, R., Lu, C., Jennings, N. B., Armaiz-Pena, G., Bankson, J. A., Ravoori, M., et al. (2006) · Nature Medicine · doi:10.1038/nm1447 · Cited by 1,320
Self-citationDo stress-related psychosocial factors contribute to cancer incidence and survival?
Chida, Y., Hamer, M., Wardle, J., & Steptoe, A. (2008) · Nature Clinical Practice Oncology · doi:10.1038/ncponc1134 · Cited by 1,072
Delivering High-Quality Cancer Care: Charting a New Course for a System in Crisis
Levit, L. A., Balogh, E. P., Nass, S. J., & Ganz, P. A. (2014) · Cited by 956
The sympathetic nervous system induces a metastatic switch in primary breast cancer
Sloan, E. K., Priceman, S. J., Cox, B. F., Yu, S., Pimentel, M. A., Tangkanangnukul, V., Arevalo, J. M. G., Morizono, K., Karanikolas, B. D. W., Wu, L., et al. (2010) · Cancer Research · doi:10.1158/0008-5472.can-10-0522 · Cited by 930
Self-citationSocial regulation of gene expression in human leukocytes
Cole, S. W., Hawkley, L. C., Arevalo, J. M., Sung, C. Y., Rose, R. M., & Cacioppo, J. T. (2007) · Genome Biology · doi:10.1186/gb-2007-8-9-r189 · Cited by 745
“These candidate 'social signal transduction pathways' provide a mechanistic basis for understanding social epidemiology in terms of molecular interactions between the human genome and the external socio-environmental stimuli that regulate cellular gene expression [26,48,49].”
BackgroundSelf-citationMolecular Pathways: Beta-Adrenergic Signaling in Cancer
Cole, S. W., & Sood, A. K. (2011) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-11-0641 · Cited by 713
Self-citationHealth Psychology: Psychological Adjustment to Chronic Disease
Stanton, A. L., Revenson, T. A., & Tennen, H. A. (2006) · Annual Review of Psychology · doi:10.1146/annurev.psych.58.110405.085615 · Cited by 749
Depressive disorders and immunity: 20 years of progress and discovery
Irwin, M. R., & Miller, A. H. (2007) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2007.01.010 · Cited by 676
Biological embedding of childhood adversity: from physiological mechanisms to clinical implications
Berens, A. E., Jensen, S. K. G., & Nelson, C. A. (2017) · BMC Medicine · doi:10.1186/s12916-017-0895-4 · Cited by 657
“microenvironments in conjunction with stress mediators, as discussed above [49].”
BackgroundAnesthetic Technique for Radical Prostatectomy Surgery Affects Cancer Recurrence
Biki, B., Mascha, E. J., Moriarty, D. C., Fitzpatrick, J. M., Sessler, D. I., & Buggy, D. J. (2008) · Anesthesiology · doi:10.1097/aln.0b013e31817f5b73 · Cited by 597
Miller, G., Chen, E., & Cole, S. W. (2009) · Annual Review of Psychology · doi:10.1146/annurev.psych.60.110707.163551 · Cited by 591
Self-citationSympathetic nervous system regulation of the tumour microenvironment
Cole, S. W., Nagaraja, A. S., Lutgendorf, S. K., Green, P. A., & Sood, A. K. (2015) · Nature Reviews Cancer · doi:10.1038/nrc3978 · Cited by 576
Self-citationBeta Blockers and Breast Cancer Mortality: A Population- Based Study
Barron, T. I., Connolly, R. M., Sharp, L., Bennett, K., & Visvanathan, K. (2011) · Journal of Clinical Oncology · doi:10.1200/jco.2010.33.5422 · Cited by 532
Ten Surprising Facts About Stressful Life Events and Disease Risk
Cohen, S., Murphy, M. L. M., & Prather, A. A. (2019) · Annual Review of Psychology · doi:10.1146/annurev-psych-010418-102857 · Cited by 531
Impact of Stress on Cancer Metastasis
Moreno‐Smith, M., Lutgendorf, S. K., & Sood, A. K. (2010) · Future Oncology · doi:10.2217/fon.10.142 · Cited by 522
Self-citationPsychologic intervention improves survival for breast cancer patients
Andersen, B. L., Yang, H., Farrar, W. B., Golden‐Kreutz, D. M., Emery, C. F., Thornton, L. M., Young, D. C., & Carson, W. E. (2008) · Cancer · doi:10.1002/cncr.23969 · Cited by 508
Zahalka, A. H., & Frenette, P. S. (2020) · Nature Reviews Cancer · doi:10.1038/s41568-019-0237-2 · Cited by 470
Melhem‐Bertrandt, A., Chávez‐MacGregor, M., Lei, X. J., Brown, E. N., Lee, R. T., Meric‐Bernstam, F., Sood, A. K., Conzen, S. D., Hortobágyi, G. N., & Gonzalez-Angulo, A. M. (2011) · Journal of Clinical Oncology · doi:10.1200/jco.2010.33.4441 · Cited by 471
Self-citationEarly Events in the Pathogenesis of Epithelial Ovarian Cancer
Landen, C. N., Birrer, M. J., & Sood, A. K. (2008) · Journal of Clinical Oncology · doi:10.1200/jco.2006.07.9970 · Cited by 462
Self-citationA stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1
Hara, M. R., Kovacs, J. J., Whalen, E. J., Rajagopal, S., Strachan, R. T., Grant, W., Towers, A. J., Williams, B., Lam, C. M., Xiao, K., et al. (2011) · Nature · doi:10.1038/nature10368 · Cited by 420
Psychosocial concerns and interventions for cancer survivors
Stanton, A. L. (2006) · Journal of Clinical Oncology · doi:10.1200/jco.2006.06.8775 · Cited by 409
The impact of psychosocial stress and stress management on immune responses in patients with cancer
Antoni, M. H., & Dhabhar, F. S. (2019) · Cancer · doi:10.1002/cncr.31943 · Cited by 419
Self-citationKiecolt‐Glaser, J. K., Bennett, J. M., Andridge, R., Peng, J., Shapiro, C. L., Malarkey, W. B., Emery, C. F., Layman, R. M., Mrózek, E., & Glaser, R. (2014) · Journal of Clinical Oncology · doi:10.1200/jco.2013.51.8860 · Cited by 409
Biological Rhythm and Chronotype: New Perspectives in Health
Montaruli, A., Castelli, L., Mulè, A., Scurati, R., Esposito, F., Galasso, L., & Roveda, E. (2021) · Biomolecules · doi:10.3390/biom11040487 · Cited by 400
Kemeny, M. E., & Schedlowski, M. (2007) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2007.07.010 · Cited by 354
Stress and cancer: mechanisms, significance and future directions
Eckerling, A., Ricon-Becker, I., Sorski, L., Sandbank, E., & Ben-Eliyahu, S. (2021) · Nature Reviews Cancer · doi:10.1038/s41568-021-00395-5 · Cited by 348
Ballesta, A., Innominato, P. F., Dallmann, R., Rand, D. A. J., & Lévi, F. (2017) · Pharmacological Reviews · doi:10.1124/pr.116.013441 · Cited by 348
Dhabhar, F. S. (2018) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2018.03.004 · Cited by 377
Self-citationClustering of depression and inflammation in adolescents previously exposed to childhood adversity
Miller, G. E., & Cole, S. W. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.02.034 · Cited by 331
Self-citationMyles, P. S., Peyton, P. J., SILBERT, B. S., Hunt, J. O., Rigg, J. R. A., Sessler, D. I., & for the ANZCA Trials Group Investigators (2011) · BMJ · doi:10.1136/bmj.d1491 · Cited by 320
Yang, E. V., Kim, S.-J., Donovan, E. L., Chen, M., Gross, A. C., Marketon, J. I. W., Barsky, S. H., & Glaser, R. (2008) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2008.10.005 · Cited by 325
Diurnal cortisol rhythm as a predictor of lung cancer survival
Sephton, S. E., Cash, E. D., Dedert, E. A., Floyd, A. R., Rebholz, W. N., Dhabhar, F. S., Spiegel, D., & Salmon, P. M. (2012) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2012.07.019 · Cited by 322
Self-citationInterdisciplinarity and Systems Science to Improve Population Health
Mabry, P. L., Olster, D. H., Morgan, G. D., & Abrams, D. B. (2008) · American Journal of Preventive Medicine · doi:10.1016/j.amepre.2008.05.018 · Cited by 295
Adrenergic modulation of focal adhesion kinase protects human ovarian cancer cells from anoikis
Sood, A. K., Armaiz-Pena, G. N., Halder, J., Nick, A. M., Stone, R. L., Hu, W., Carroll, A. R., Spannuth, W. A., Deavers, M. T., Allen, J. K., et al. (2010) · Journal of Clinical Investigation · doi:10.1172/jci40802 · Cited by 283
Self-citationSocial support and cancer progression: A systematic review
Nausheen, B., Gidron, Y., Peveler, R., & Moss-Morris, R. E. (2009) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2008.12.012 · Cited by 283
Psychological distress and cancer mortality
Hamer, M., Chida, Y., & Molloy, G. J. (2009) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2008.11.002 · Cited by 282
Depression and inflammation among children and adolescents: A meta-analysis
Colasanto, M., Madigan, S. L., & Korczak, D. J. (2020) · Journal of Affective Disorders · doi:10.1016/j.jad.2020.09.025 · Cited by 298
New Directions in the Epidemiology of Uterine Fibroids
Laughlin, S., Schroeder, J. C., & Baird, D. D. (2010) · Seminars in Reproductive Medicine · doi:10.1055/s-0030-1251477 · Cited by 274
Aging and the HPA axis: Stress and resilience in older adults
Gaffey, A. E., Bergeman, C. S., Clark, L. A., & Wirth, M. M. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.05.036 · Cited by 273
Aspinwall, L. G., & Tedeschi, R. G. (2010) · Annals of Behavioral Medicine · doi:10.1007/s12160-009-9153-0 · Cited by 271
Tumor Neurobiology and the War of Nerves in Cancer
Faulkner, S., Jobling, P., March, B., Jiang, C. C., & Hondermarck, H. (2019) · Cancer Discovery · doi:10.1158/2159-8290.cd-18-1398 · Cited by 275
Deng, G. E., Frenkel, M. A., Cohen, L. G., Cassileth, B. R., Abrams, D. I., Capodice, J. L., Courneya, K. S., Dryden, T., Hanser, S. B., Kumar, N. B., et al. (2009) · PubMed · Cited by 272
Psychological Prehabilitation Before Cancer Surgery: A Systematic Review
Tsimopoulou, I., Pasquali, S., Howard, R. A., Desai, A., Gourevitch, D., Tolosa, I., & Vohra, R. (2015) · Annals of Surgical Oncology · doi:10.1245/s10434-015-4550-z · Cited by 265
Chronic stress promotes gastric cancer progression and metastasis: an essential role for ADRB2
Zhang, X., Zhang, Y., He, Z., Yin, K., Li, B., Zhang, L., & Xu, Z. (2019) · Cell Death & Disease · doi:10.1038/s41419-019-2030-2 · Cited by 261
Engaging in rather than disengaging from stress: Effective coping and perceived control
Dijkstra, M. T. M., & Homan, A. C. (2016) · Frontiers in Psychology · doi:10.3389/fpsyg.2016.01415 · Cited by 253
Mathur, M. B., Epel, E., Kind, S., Desai, M., Parks, C. G., Sandler, D. P., & Khazeni, N. (2016) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2016.02.002 · Cited by 252
Cognitive-Behavioral Stress Management Reverses Anxiety-Related Leukocyte Transcriptional Dynamics
Antoni, M. H., Lutgendorf, S. K., Blomberg, B., Carver, C. S., Lechner, S., Diaz, A., Stagl, J., Arevalo, J. M. G., & Cole, S. W. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.10.007 · Cited by 251
Self-citationRandomized, controlled trial of yoga in women with breast cancer undergoing radiotherapy.
Chandwani, K., Perkins, G., Nagendra, H., Raghuram, N., Spelman, A., Nagarathna, R., Johnson, K., Fortier, A., Arun, B., Wei, Q., et al. (2014) · Journal of Clinical Oncology · doi:10.1200/jco.2012.48.2752 · Cited by 243
Antoni, M. H., Lechner, S. C., Diaz, A., Vargas, S. E., Holley, H., Phillips, K. K., McGregor, B., Carver, C. S., & Blomberg, B. B. (2008) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2008.09.005 · Cited by 262
Self-citationNeeman, E., & Ben‐Eliyahu, S. (2012) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2012.03.006 · Cited by 249
Wu, F., Fang, T., Yu, L., Lv, G., Lv, H., Dong, L., Li, T., Wang, C., Tan, Y., Ding, J., et al. (2016) · Journal of Hepatology · doi:10.1016/j.jhep.2016.04.019 · Cited by 248
Glasner, A., Avraham, R., Rosenne, E., Benish, M., Zmora, O., Shemer, S., Meiboom, H., & Ben‐Eliyahu, S. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0903301 · Cited by 239
McGregor, B. A., & Antoni, M. H. (2008) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2008.08.002 · Cited by 234
Self-citationSurgical stress and cancer progression: the twisted tango
Chen, Z., Zhang, P., Xu, Y., Yan, J., Liu, Z., Lau, W. B., Lau, B., Li, Y., Zhao, X., Wei, Y., et al. (2019) · Molecular Cancer · doi:10.1186/s12943-019-1058-3 · Cited by 235
Stanton, A. L., Rowland, J. H., & Ganz, P. A. (2015) · American Psychologist · doi:10.1037/a0037875 · Cited by 249
Depression, social support, and beta-adrenergic transcription control in human ovarian cancer
Lutgendorf, S. K., DeGeest, K., Sung, C. Y., Arevalo, J. M., Penedo, F., Lucci, J., Goodheart, M., Lubaroff, D., Farley, D. M., Sood, A. K., et al. (2009) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2008.04.155 · Cited by 215
Self-citationBiobehavioral Factors and Cancer Progression
Lutgendorf, S. K., & Sood, A. K. (2011) · Psychosomatic Medicine · doi:10.1097/psy.0b013e318235be76 · Cited by 213
Self-citationSrc activation by β-adrenoreceptors is a key switch for tumour metastasis
Armaiz-Pena, G. N., Allen, J. K., Cruz, A., Stone, R. L., Nick, A. M., Lin, Y. G., Han, L. Y., Mangala, L. S., Villares, G. J., Vivas-Mejia, P., et al. (2013) · Nature Communications · doi:10.1038/ncomms2413 · Cited by 212
Self-citationSocial stress, immune functions and disease in rodents
Bartolomucci, A. (2007) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2007.02.001 · Cited by 215
Social Relations, Health Behaviors, and Health Outcomes: A Survey and Synthesis
Tay, L., Tan, K., Diener, E., & Gonzalez, E. (2012) · Applied Psychology Health and Well-Being · doi:10.1111/aphw.12000 · Cited by 228
Hermes, G. L., Delgado, B., Tretiakova, M., Cavigelli, S. A., Krausz, T., Conzen, S. D., & McClintock, M. K. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0910753106 · Cited by 207
Wang, H. M., Liao, Z. X., Komaki, R. U., Welsh, J. W., OʼReilly, M., Chang, J. Y., Zhuang, Y., Levy, L. B., Lu, C., & Gomez, D. R. (2013) · Annals of Oncology · doi:10.1093/annonc/mds616 · Cited by 202
Fancourt, D., Williamon, A., Carvalho, L. A., Steptoe, A., Dow, R., & Lewis, I. (2016) · ecancermedicalscience · doi:10.3332/ecancer.2016.631 · Cited by 201
“response to other psychosocial interventions in oncology [4], [5].”
BackgroundCohen, L., Cole, S. W., Sood, A. K., Prinsloo, S., Kirschbaum, C., Arevalo, J. M. G., Jennings, N. B., Scott, S., Vence, L., Wei, Q., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0042324 · Cited by 197
Self-citationSocial Regulation of Human Gene Expression
Cole, S. W. (2009) · Current Directions in Psychological Science · doi:10.1111/j.1467-8721.2009.01623.x · Cited by 187
Self-citationCircadian Rhythms and Hormonal Homeostasis: Pathophysiological Implications
Gnocchi, D., & Bruscalupi, G. (2017) · Biology · doi:10.3390/biology6010010 · Cited by 193
The Effect of Emotional Stress and Depression on the Prevalence of Digestive Diseases
Lee, S. P., Sung, I., Kim, J. H., Lee, S., Park, H. S., & Shim, C. S. (2015) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm14116 · Cited by 180
Qiao, G., Chen, M., Mohammadpour, H., MacDonald, C. R., Bucsek, M. J., Hylander, B. L., Barbi, J. J., & Repasky, E. A. (2021) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-20-0445 · Cited by 181
Antoni, M. H. (2012) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2012.05.009 · Cited by 188
Self-citationModulation of anti-tumor immunity by the brain’s reward system
Ben-Shaanan, T. L., Schiller, M., Azulay‐Debby, H., Korin, B., Boshnak, N., Koren, T., Krot, M., Shakya, J., Rahat, M. A., Hakim, F., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-05283-5 · Cited by 175
Deegan, C. A., Murray, D. J., Doran, P., Moriarty, D. C., Sessler, D. I., Mascha, E., Kavanagh, B. P., & Buggy, D. J. (2010) · Regional Anesthesia & Pain Medicine · doi:10.1097/aap.0b013e3181ef4d05 · Cited by 172
Depression, cortisol, and suppressed cell-mediated immunity in metastatic breast cancer
Sephton, S. E., Dhabhar, F. S., Keuroghlian, A. S., Giese-Davis, J., McEwen, B. S., Ionan, A. C., & Spiegel, D. (2009) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2009.07.007 · Cited by 170
Self-citationThe Impact of Everyday Stressors on the Immune System and Health
Seiler, A., Fagundes, C. P., & Christian, L. M. (2019) · Springer eBooks · doi:10.1007/978-3-030-16996-1_6 · Cited by 169
Adrenergic Signaling: A Targetable Checkpoint Limiting Development of the Antitumor Immune Response
Qiao, G., Chen, M., Bucsek, M. J., Repasky, E. A., & Hylander, B. L. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00164 · Cited by 172
Chronotherapy and the molecular clock: Clinical implications in oncology☆
Innominato, P. F., Lévi, F., & Bjarnason, G. A. (2010) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2010.06.002 · Cited by 168
Qigong improves quality of life in women undergoing radiotherapy for breast cancer
Chen, Z., Meng, Z., Milbury, K., Bei, W., Zhang, Y., Thornton, B., Liao, Z. X., Wei, Q., Chen, J., Guo, X., et al. (2013) · Cancer · doi:10.1002/cncr.27904 · Cited by 166
Tang, J., Li, Z., Lu, L., & Cho, C. H. (2013) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2013.08.009 · Cited by 164
de Vries, E., Trakatelli, M. G., Kalabalikis, D., Ferrándiz, L., Ruiz-de-Casas, A., Moreno-Ramírez, D., Sotiriadis, D., Ioannides, D., Aquilina, S., Apap, C., et al. (2012) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2012.11081.x · Cited by 160
Mind‐body interventions for fear of cancer recurrence: A systematic review and meta‐analysis
Hall, D. L., Luberto, C. M., Philpotts, L. L., Song, R., Park, E. R., & Yeh, G. Y. (2018) · Psycho-Oncology · doi:10.1002/pon.4757 · Cited by 159
The neuronal influence on tumor progression
Mancino, M., Ametller, E., Gascón, P., & Almendro, V. (2011) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2011.04.005 · Cited by 159
Nilsson, M. B., Armaiz-Peña, G. N., Takahashi, R., Lin, Y. G., Trevino, J. G., Li, Y., Jennings, N., Arevalo, J. M. G., Lutgendorf, S. K., Gallick, G. E., et al. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m611539200 · Cited by 158
Self-citationCan regional analgesia reduce the risk of recurrence after breast cancer?
Sessler, D. I., Ben‐Eliyahu, S., Mascha, E. J., Parat, M., & Buggy, D. J. (2008) · Contemporary Clinical Trials · doi:10.1016/j.cct.2008.01.002 · Cited by 155
Social Stress Mobilizes Hematopoietic Stem Cells to Establish Persistent Splenic Myelopoiesis
McKim, D. B., Yin, W., Wang, Y., Cole, S. W., Godbout, J. P., & Sheridan, J. F. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.10.102 · Cited by 153
Self-citationPoverty, Near-Poverty, and Hardship Around the Time of Pregnancy
Braveman, P., Marchi, K. S., Egerter, S. A., Kim, S.-W., Metzler, M. M., Stancil, T., & Libet, M. (2008) · Maternal and Child Health Journal · doi:10.1007/s10995-008-0427-0 · Cited by 157
Impact of beta blockers on epithelial ovarian cancer survival
Diaz, E. S., Karlan, B. Y., & Li, A. J. (2012) · Gynecologic Oncology · doi:10.1016/j.ygyno.2012.07.102 · Cited by 151
Bernabé, D. G., Tamae, A. C., Biasoli, É. R., & Oliveira, S. H. P. (2010) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2010.12.012 · Cited by 149
The Social Determinants of Cancer
Hiatt, R. A., & Breen, N. (2008) · American Journal of Preventive Medicine · doi:10.1016/j.amepre.2008.05.006 · Cited by 154
The Neuroendocrine Impact of Chronic Stress on Cancer
Thaker, P. H., Lutgendorf, S. K., & Sood, A. K. (2007) · Cell Cycle · doi:10.4161/cc.6.4.3829 · Cited by 152
Self-citationMolecular Mechanisms of Cancer-Induced Sleep Disruption
Walker, W. H., II, & Borniger, J. C. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20112780 · Cited by 149
Work Stress and the Risk of Cancer: A Meta-Analysis of Observational Studies
Yang, T., Qiao, Y., Xiang, S., Li, W., Gan, Y., & Chen, Y. (2019) · International Journal of Cancer · doi:10.1002/ijc.31955 · Cited by 145
Neuroendocrine influences on cancer progression
Armaiz-Pena, G. N., Cole, S. W., Lutgendorf, S. K., & Sood, A. K. (2013) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2012.06.005 · Cited by 145
“Several studies have shown that the effect of stress hormones on cancer cell proliferation varies according to the specific hormone influences and the tumor type studied (as reviewed in Antoni et al., 2006).”
BackgroundInfluentialSelf-citationWitek Janusek, L., Tell, D., & Mathews, H. L. (2019) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2019.04.012 · Cited by 143
Phillips, K. M., Antoni, M. H., Lechner, S. C., Blomberg, B. B., Llabre, M. M., Avisar, E., Glück, S., Derhagopian, R. P., & Carver, C. S. (2008) · Psychosomatic Medicine · doi:10.1097/psy.0b013e318186fb27 · Cited by 143
Self-citationChildhood adversity as a risk for cancer: findings from the 1958 British birth cohort study
Kelly‐Irving, M., Lepage, B., Dedieu, D., Lacey, R. E., Cable, N., Bartley, M., Blane, D., Grosclaude, P., Lang, T., & Delpierre, C. (2013) · BMC Public Health · doi:10.1186/1471-2458-13-767 · Cited by 159
Minireview: Nuclear Receptors and Breast Cancer
Conzen, S. D. (2008) · Molecular Endocrinology · doi:10.1210/me.2007-0421 · Cited by 142
Neuroendocrine modulation of cancer progression
Armaiz-Peña, G. N., Lutgendorf, S. K., Cole, S. W., & Sood, A. K. (2008) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2008.06.007 · Cited by 140
Self-citationCytokine-induced depression during IFN-α treatment: The role of IL-6 and sleep quality
Prather, A. A., Rabinovitz, M., Pollock, B. G., & Lotrich, F. E. (2009) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2009.07.001 · Cited by 139
Anesthetic technique and cancer recurrence in oncologic surgery: unraveling the puzzle
Kim, R. (2016) · Cancer and Metastasis Reviews · doi:10.1007/s10555-016-9647-8 · Cited by 138
Metadata
- Authors
- Antoni, M. H., Lutgendorf, S. K., Cole, S. W., Dhabhar, F. S., Sephton, S. E., McDonald, P. G., Stefanek, M., & Sood, A. K.
- Affiliations
- University of Miami (US)
- University of Iowa (US)
- Stanford Medicine (US)
- University of Louisville (US)
- National Institutes of Health (US)
- The University of Texas MD Anderson Cancer Center (US)
- Venue
- Nature Reviews Cancer
- Published
- 2006-03
- Volume
- 6
- Issue
- 3
- Pages
- 240-248
- ISSN
- 1474-175X (ISSN-L)
- 1474-1768
- PMC
- PMC3146042
- OpenAlex
- W2025845020
- Cited by
- 981
- References
- 153
- Citations by year
- 2026: 43 · 2025: 42 · 2024: 48 · 2023: 51 · 2022: 47 · 2021: 58 · 2020: 57 · 2019: 53 · 2018: 52 · 2017: 46 · 2016: 53 · 2015: 42 · 2014: 40 · 2013: 64 · 2012: 69
- FWCI
- 5.32
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Cancer (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (UH3TR000943)
- National Cancer Institute (R01CA110793, R01CA109298, P50CA083639)
- National Center for Advancing Translational Sciences
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Stress, Anesthesia, and Immune Response
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- psychological stress, depression, social support, tumor progression, tumor biology, behavioral factors, cancer risk factors, molecular mechanisms, pharmacological interventions, oncological outcomes
- MeSH terms
- Animals, Depression, Humans, Neoplasms, Risk Factors, Social Support, Socioeconomic Factors, Stress, Psychological, Signal Transduction
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
