DNA repair mechanisms protect our genome from carcinogenesis

Molecular Structure of Nucleic Acids: A Structure for Deoxyribose Nucleic Acid

WATSON, J. D., & CRICK, F. H. C. (1953) · Nature · doi:10.1038/171737a0 · Cited by 13,584 · see citing works

Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

Farmer, H., McCabe, N., Lord, C. J., Tutt, A. N. J., Johnson, D. A., Richardson, T. B., Santarosa, M., Dillon, K. J., Hickson, I., Knights, C., et al. (2005) · Nature · doi:10.1038/nature03445 · Cited by 6,683 · see citing works

Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase

Bryant, H. E., Schultz, N., Thomas, H. D., Parker, K. M., Flower, D., Lopez, E., Kyle, S., Meuth, M., Curtin, N. J., & Helleday, T. (2005) · Nature · doi:10.1038/nature03443 · Cited by 5,198 · see citing works

Inhibition of Poly(ADP-Ribose) Polymerase in Tumors from <i>BRCA</i> Mutation Carriers

Fong, P. C., Boss, D. S., Yap, T. A., Tutt, A., Wu, P., Mergui-Roelvink, M., Mortimer, P., Swaisland, H., Lau, A., O'Connor, M. J., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0900212 · Cited by 3,634 · see citing works

ATM and ATR Substrate Analysis Reveals Extensive Protein Networks Responsive to DNA Damage

Matsuoka, S., Ballif, B. A., Smogorzewska, A., McDonald, E. R., Hurov, K. E., Luo, J., Bakalarski, C. E., Zhao, Z., Solimini, N., Lerenthal, Y., et al. (2007) · Science · doi:10.1126/science.1140321 · Cited by 3,075 · see citing works

The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer

Fishel, R. A., Lescoe, M. K., Rao, M. R. S., Copeland, N. G., Jenkins, N. A., Garber, J. E., Kane, M., & Kolodner, R. D. (1993) · Cell · doi:10.1016/0092-8674(93)90546-3 · Cited by 2,857 · see citing works

A Single Ataxia Telangiectasia Gene with a Product Similar to PI-3 Kinase

Savitsky, K., Bar-Shira, A., Gilad, S., Rotman, G., Ziv, Y., Vanagaite, L., Tagle, D. A., Smith, S., Uziel, T., Sfez, S., et al. (1995) · Science · doi:10.1126/science.7792600 · Cited by 2,785 · see citing works

Genomic instability — an evolving hallmark of cancer

Negrini, S., Gorgoulis, V. G., & Halazonetis, T. D. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2858 · Cited by 2,397 · see citing works

Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer

Leach, F. S., Nicolaides, N. C., Papadopoulos, N., Liu, B., Jen, J., Parsons, R. E., Peltomäki, P., Sistonen, P., Aaltonen, L. A., Nyström, M., et al. (1993) · Cell · doi:10.1016/0092-8674(93)90330-s · Cited by 2,271 · see citing works

Mutation in the DNA mismatch repair gene homologue hMLH 1 is associated with hereditary non-polyposis colon cancer

Bronner, C. E., Baker, S. M., Morrison, P. T., Warren, G., Smith, L. G., Lescoe, M. K., Kane, M., Earabino, C., Lipford, J. R., Lindblom, A., et al. (1994) · Nature · doi:10.1038/368258a0 · Cited by 2,050 · see citing works

Activation of the ATM Kinase by Ionizing Radiation and Phosphorylation of p53

Canman, C. E., Lim, D.-S., Cimprich, K. A., Taya, Y., Tamai, K., Sakaguchi, K., Appella, E., Kastan, M. B., & Siliciano, J. D. (1998) · Science · doi:10.1126/science.281.5383.1677 · Cited by 2,042 · see citing works

Cell cycle checkpoint signaling through the ATM and ATR kinases

Abraham, R. T. (2001) · Genes &amp; Development · doi:10.1101/gad.914401 · Cited by 1,966 · see citing works

Mutation of a mutL Homolog in Hereditary Colon Cancer

Papadopoulos, N., Nicolaides, N. C., Wei, Y.-F., Ruben, S. M., Carter, K. C., Rosen, C. A., Haseltine, W. A., Fleischmann, R. D., Fraser, C. M., Adams, M. D., et al. (1994) · Science · doi:10.1126/science.8128251 · Cited by 1,822 · see citing works

Enhanced Phosphorylation of p53 by ATM in Response to DNA Damage

Banin, S., Moyal, L., Shieh, S.-Y., Taya, Y., Anderson, C. W., Chessa, L., Smorodinsky, N. I., Prives, C., Reiss, Y., Shiloh, Y., et al. (1998) · Science · doi:10.1126/science.281.5383.1674 · Cited by 1,797 · see citing works

Defective repair replication of DNA in xeroderma pigmentosum

CLEAVER, J. E. (1968) · Nature · doi:10.1038/218652a0 · Cited by 1,729 · see citing works

The DNA Damage Response: Ten Years After

Harper, J. W., & Elledge, S. J. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.11.015 · Cited by 1,705 · see citing works

DNA repair pathways as targets for cancer therapy

Helleday, T., Petermann, E., Lundin, C., Hodgson, B., & Sharma, R. A. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2342 · Cited by 1,666 · see citing works

Mutations of two P/WS homologues in hereditary nonpolyposis colon cancer

Nicolaides, N. C., Papadopoulos, N., Liu, B., Weit, Y.-F., Carter, K. C., Ruben, S. M., Rosen, C. A., Haseltine, W. A., Fleischmann, R. D., Fraser, C. M., et al. (1994) · Nature · doi:10.1038/371075a0 · Cited by 1,543 · see citing works

Inherited variants of MYH associated with somatic G:C→T:A mutations in colorectal tumors

Tassan, N. A. A., Chmiel, N. H., Maynard, J. H., Fleming, N. I., Livingston, A. L., Williams, G. T., Hodges, A., Davies, D. R., David, S. S., Sampson, J. R., et al. (2002) · Nature Genetics · doi:10.1038/ng828 · Cited by 1,392 · see citing works

DNA and its associated processes as targets for cancer therapy

Hurley, L. H. (2002) · Nature reviews. Cancer · doi:10.1038/nrc749 · Cited by 1,350 · see citing works

Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage

Falck, J., Coates, J., & Jackson, S. P. (2005) · Nature · doi:10.1038/nature03442 · Cited by 1,248 · see citing works

Brca1 Controls Homology-Directed DNA Repair

Moynahan, M. E., Chiu, J. W., Koller, B. H., & Jasin, M. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80202-6 · Cited by 1,245 · see citing works

Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM

Hickson, I., Zhao, Y., Richardson, C. J., Green, S. J., Martin, N. M. B., Orr, A. I., Reaper, P. M., Jackson, S. P., Curtin, N. J., & Smith, G. C. M. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-2727 · Cited by 1,220 · see citing works

Biallelic Inactivation of <i>BRCA2</i> in Fanconi Anemia

Howlett, N. G., Taniguchi, T., Olson, S., Cox, B., Waisfisz, Q., de Die-Smulders, C., Persky, N., Grompe, M., Joenje, H., Pals, G., et al. (2002) · Science · doi:10.1126/science.1073834 · Cited by 1,149 · see citing works

ATM Activation by Oxidative Stress

Guo, Z., Kozlov, S., Lavin, M. F., Person, M. D., & Paull, T. T. (2010) · Science · doi:10.1126/science.1192912 · Cited by 1,079 · see citing works

The DNA Double-Strand Break Repair Gene hMRE11 Is Mutated in Individuals with an Ataxia-Telangiectasia-like Disorder

Stewart, G. S., Maser, R. S., Stankovic, T., Bressan, D. A., Kaplan, M. I., Jaspers, N. G. J., Raams, A., Byrd, P. J., Petrini, J. H. J., & Taylor, A. M. R. (1999) · Cell · doi:10.1016/s0092-8674(00)81547-0 · Cited by 1,060 · see citing works

Ataxia telangiectasia: a human mutation with abnormal radiation sensitivity

Taylor, A. M. R., Harnden, D. G., Arlett, C. F., Harcourt, S. A., Lehmann, A. R., Stevens, S., & Bridges, B. A. (1975) · Nature · doi:10.1038/258427a0 · Cited by 991 · see citing works

The BRCT Domain Is a Phospho-Protein Binding Domain

Yu, X., Chini, C. C. S., He, M., Mer, G., & Chen, J. (2003) · Science · doi:10.1126/science.1088753 · Cited by 862 · see citing works

Review of the Lynch syndrome: history, molecular genetics, screening, differential diagnosis, and medicolegal ramifications

Lynch, H. T., Lynch, P. M., Lanspa, S. J., Snyder, C., Lynch, J. F., & Boland, C. R. (2009) · Clinical Genetics · doi:10.1111/j.1399-0004.2009.01230.x · Cited by 842 · see citing works

Cockayne syndrome: Review of 140 cases

Nance, M. A., & Berry, S. A. (1992) · American Journal of Medical Genetics · doi:10.1002/ajmg.1320420115 · Cited by 806 · see citing works

A splicing mutation affecting expression of ataxia–telangiectasia and Rad3–related protein (ATR) results in Seckel syndrome

O'Driscoll, M., Ruiz-Perez, V. L., Woods, C. G., Jeggo, P. A., & Goodship, J. A. (2003) · Nature Genetics · doi:10.1038/ng1129 · Cited by 794 · see citing works

Radiosensitivity in ataxia-telangiectasia: a new explanation.

Painter, R. B., & Young, B. R. (1980) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.77.12.7315 · Cited by 794 · see citing works

Truncating mutations in the Fanconi anemia J gene BRIP1 are low-penetrance breast cancer susceptibility alleles

The Breast Cancer Susceptibility Collaboration (UK), Seal, S., Thompson, D., Renwick, A., Elliott, A., Kelly, P., Barfoot, R., Chagtai, T., Jayatilake, H., Ahmed, M., et al. (2006) · Nature Genetics · doi:10.1038/ng1902 · Cited by 746 · see citing works

Systematic Discovery of In Vivo Phosphorylation Networks

Linding, R., Jensen, L. J., Ostheimer, G. J., van Vugt, M. A. T. M., Jørgensen, C., Miron, I. M., Diella, F., Colwill, K., Taylor, L., Elder, K., et al. (2007) · Cell · doi:10.1016/j.cell.2007.05.052 · Cited by 735 · see citing works

Germline mutation of MSH6 as the cause of hereditary nonpolyposis colorectal cancer

Miyaki, M., Konishi, M., Tanaka, K., Kikuchi‐Yanoshita, R., Muraoka, M., Yasuno, M., Igari, T., Koike, M., Chiba, M., & Mori, T. (1997) · Nature Genetics · doi:10.1038/ng1197-271 · Cited by 720 · see citing works

Disease-corrected haematopoietic progenitors from Fanconi anaemia induced pluripotent stem cells

Raya, Á., Rodríguez-Pizà, I., Güenechea, G., Vassena, R., Navarro, S., Barrero, M. J., Consiglio, A., Castellà, M., Rı́o, P., Sleep, E., et al. (2009) · Nature · doi:10.1038/nature08129 · Cited by 690 · see citing works

BACH1, a Novel Helicase-like Protein, Interacts Directly with BRCA1 and Contributes to Its DNA Repair Function

Cantor, S. B., Bell, D. W., Ganesan, S., Kass, E. M., Drapkin, R., Grossman, S., Wahrer, D. C. R., Sgroi, D. C., Lane, W. S., Haber, D. A., et al. (2001) · Cell · doi:10.1016/s0092-8674(01)00304-x · Cited by 674 · see citing works

A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axis

Niedernhofer, L. J., Garinis, G. A., Raams, A., Lalai, A. S., Robinson, A. R., Appeldoorn, E., Odijk, H., Oostendorp, R., Ahmad, A., van Leeuwen, W., et al. (2006) · Nature · doi:10.1038/nature05456 · Cited by 669 · see citing works

Xeroderma pigmentosum cells with normal levels of excision repair have a defect in DNA synthesis after UV-irradiation

Lehman, A. R., Kirk-Bell, S., Arlett, C. F., Paterson, M. C., Lohman, P. H., de Weerd-Kastelein, E. A., & Bootsma, D. (1975) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.72.1.219 · Cited by 614 · see citing works

ATM and ATR: networking cellular responses to DNA damage

Shiloh, Y. (2001) · Current Opinion in Genetics &amp; Development · doi:10.1016/s0959-437x(00)00159-3 · Cited by 601 · see citing works

How the Fanconi Anemia Pathway Guards the Genome

Moldovan, G., & D’Andrea, A. D. (2009) · Annual Review of Genetics · doi:10.1146/annurev-genet-102108-134222 · Cited by 586 · see citing works

Nuclear localization of Cdc25 is regulated by DNA damage and a 14-3-3 protein

Lopez‐Girona, A., Furnari, B. A., Mondésert, O., & Russell, P. R. (1999) · Nature · doi:10.1038/16488 · Cited by 574 · see citing works

Disruption of the Fanconi anemia–BRCA pathway in cisplatin-sensitive ovarian tumors

Taniguchi, T., Tischkowitz, M. D., Ameziane, N., Hodgson, S. V., Mathew, C. G., Joenje, H., Mok, S. C., & D’Andrea, A. D. (2003) · Nature Medicine · doi:10.1038/nm852 · Cited by 537 · see citing works

The complete sequence of the coding region of the ATM gene reveals similarity to cell cycle regulators in different species

Savitsky, K., Sfez, S., Tagle, D. A., Ziv, Y., Sartiel, A., Collins, F. S., Shiloh, Y., & Rotman, G. (1995) · Human Molecular Genetics · doi:10.1093/hmg/4.11.2025 · Cited by 535 · see citing works

A high susceptibility of Fanconi's anemia to chromosome breakage by DNA cross-linking agents.

Sasaki, M. S., & Tonomura, A. (1973) · PubMed · Cited by 530 · see citing works

DNA-PK, ATM and ATR as sensors of DNA damage: variations on a theme?

Durocher, D., & Jackson, S. P. (2001) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(00)00201-5 · Cited by 506 · see citing works

Mre11 Dimers Coordinate DNA End Bridging and Nuclease Processing in Double-Strand-Break Repair

Williams, R. S., Moncalián, G., Williams, J. S., Yamada, Y., Limbo, O., Shin, D. S., Groocock, L., Cahill, D., Hitomi, C., Guenther, G., et al. (2008) · Cell · doi:10.1016/j.cell.2008.08.017 · Cited by 496 · see citing works

ATM associates with and phosphorylates p53: mapping the region of interaction

Khanna, K. K., Keating, K. E., Kozlov, S., Scott, S. P., Gatei, M. H., Hobson, K., Taya, Y., Gabrielli, B. G., Chan, D. W., Lees‐Miller, S. P., et al. (1998) · Nature Genetics · doi:10.1038/3882 · Cited by 481 · see citing works

Increased Nuclear DNA Oxidation in the Brain in Alzheimer's Disease

Gabbita, S. P., Lovell, M. A., & Markesbery, W. R. (1998) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1998.71052034.x · Cited by 479 · see citing works

EVIDENCE THAT XERODERMA PIGMENTOSUM CELLS DO NOT PERFORM THE FIRST STEP IN THE REPAIR OF ULTRAVIOLET DAMAGE TO THEIR DNA

Setlow, R. B., Regan, J. D., GERMAN, J. L., & Carrier, W. L. (1969) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.64.3.1035 · Cited by 469 · see citing works

Depletion of mammalian O6-alkylguanine-DNA alkyltransferase activity by O6-benzylguanine provides a means to evaluate the role of this protein in protection against carcinogenic and therapeutic alkylating agents.

Dolan, M. E., Moschel, R. C., & Pegg, A. E. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.14.5368 · Cited by 460 · see citing works

A human ortholog of archaeal DNA repair protein Hef is defective in Fanconi anemia complementation group M

Meetei, A. R., Medhurst, A. L., Ling, C., Xue, Y., Singh, T. R., Bier, P., Steltenpool, J., Stone, S., Dokal, I. S., Mathew, C. G., et al. (2005) · Nature Genetics · doi:10.1038/ng1626 · Cited by 454 · see citing works

Increased oxidative damage in nuclear and mitochondrial DNA in Alzheimer's disease

Wang, J., Xiong, S., Xie, C., Markesbery, W. R., & Lovell, M. A. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03053.x · Cited by 452 · see citing works

Xeroderma pigmentosum, trichothiodystrophy and Cockayne syndrome: A complex genotype–phenotype relationship

Kraemer, K. H., Patronas, N. J., Schiffmann, R., Brooks, B. P., Tamura, D., & DiGiovanna, J. J. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2006.12.020 · Cited by 443 · see citing works

Ataxia-telangiectasia; a familial syndrome of progressive cerebellar ataxia, oculocutaneous telangiectasia and frequent pulmonary infection.

Boder, E., & Sedgwick, R. P. (1958) · PubMed · Cited by 432 · see citing works

ATM Activation and Its Recruitment to Damaged DNA Require Binding to the C Terminus of Nbs1

You, Z., Chahwan, C., Bailis, J. M., Hunter, T. R., & Russell, P. R. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.13.5363-5379.2005 · Cited by 428 · see citing works

Cancer in xeroderma pigmentosum and related disorders of DNA repair

Cleaver, J. E. (2005) · Nature Reviews Cancer · doi:10.1038/nrc1652 · Cited by 427 · see citing works

Failure of RNA synthesis to recover after UV irradiation; An early defect in cells from individuals with Cockayne syndrome and xeroderma pigmentosum

Mayne, L. V., & Lehmann, A. R. (1982) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/0027-5107(82)90047-1 · Cited by 420 · see citing works

γH2AX and MDC1: Anchoring the DNA-damage-response machinery to broken chromosomes

Stucki, M., & Jackson, S. P. (2006) · DNA Repair · doi:10.1016/j.dnarep.2006.01.012 · Cited by 412 · see citing works

XERODERMA PIGMENTOSUM: A HUMAN DISEASE IN WHICH AN INITIAL STAGE OF DNA REPAIR IS DEFECTIVE

Cleaver, J. E. (1969) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.63.2.428 · Cited by 409 · see citing works

Mre11–Rad50–Nbs1 is a keystone complex connecting DNA repair machinery, double-strand break signaling, and the chromatin templateThis paper is one of a selection of papers published in this Special Issue, entitled 28th International West Coast Chromatin and Chromosome Conference, and has undergone the Journal's usual peer review process.

Williams, R. S., Williams, J. S., & Tainer, J. A. (2007) · Biochemistry and Cell Biology · doi:10.1139/o07-069 · Cited by 399 · see citing works

BACH1 is critical for homologous recombination and appears to be the Fanconi anemia gene product FANCJ

Litman, R., Peng, M., Jin, Z., Zhang, F., Zhang, J., Powell, S., Andreassen, P. R., & Cantor, S. B. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.08.004 · Cited by 396 · see citing works

Dwarfism with retinal atrophy and deafness

Cockayne, E. A. (1936) · Archives of Disease in Childhood · doi:10.1136/adc.11.61.1 · Cited by 377 · see citing works

The eukaryotic nucleotide excision repair pathway

Costa, R. (2003) · Biochimie · doi:10.1016/j.biochi.2003.10.017 · Cited by 373 · see citing works

Mutations of the SLX4 gene in Fanconi anemia

Kim, Y., Lach, F. P., Desetty, R. D., Hanenberg, H., Auerbach, A. D., & Smogorzewska, A. (2011) · Nature Genetics · doi:10.1038/ng.750 · Cited by 372 · see citing works

Defective excision repair of γ-ray-damaged DNA in human (ataxia telangiectasia) fibroblasts

Paterson, M. C., Smith, B. P., Lohman, P. H. M., ANDERSON, A. K., & FISHMAN, L. (1976) · Nature · doi:10.1038/260444a0 · Cited by 362 · see citing works

Single-Stranded DNA Orchestrates an ATM-to-ATR Switch at DNA Breaks

Shiotani, B., & Zou, L. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.01.024 · Cited by 353 · see citing works

Modulation of mismatch repair and genomic stability by miR-155

Valeri, N., Gasparini, P., Fabbri, M., Braconi, C., Veronese, A., Lovat, F., Adair, B., Vannini, I., Fanini, F., Bottoni, A., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1002472107 · Cited by 347 · see citing works

Susceptibility of Fanconi's anaemia fibroblasts to chromosome damage by carcinogens

Auerbach, A. D., & Wolman, S. R. (1976) · Nature · doi:10.1038/261494a0 · Cited by 339 · see citing works

International Fanconi Anemia Registry: relation of clinical symptoms to diepoxybutane sensitivity

Auerbach, A., Rogatko, A., & Schroeder-Kurth, T. (1989) · Blood · doi:10.1182/blood.v73.2.391.391 · Cited by 338 · see citing works

The FANC pathway and BLM collaborate during mitosis to prevent micro-nucleation and chromosome abnormalities

Naim, V., & Rosselli, F. (2009) · Nature Cell Biology · doi:10.1038/ncb1883 · Cited by 335 · see citing works

A new, tenth subunit of TFIIH is responsible for the DNA repair syndrome trichothiodystrophy group A

Giglia‐Mari, G., Coin, F., Ranish, J. A., Hoogstraten, D., Theil, A. F., Wijgers, N., Jaspers, N. G. J., Raams, A., Argentini, M., van der Spek, P. J., et al. (2004) · Nature Genetics · doi:10.1038/ng1387 · Cited by 334 · see citing works

Frequency of ultraviolet light-induced mutations is higher in xeroderma pigmentosum variant cells than in normal human cells

MAHER, V. M., OUELLETTE, L. M., CURREN, R. D., & MCCORMICK, J. J. (1976) · Nature · doi:10.1038/261593a0 · Cited by 333 · see citing works

A Genetic Screen Identifies FAN1, a Fanconi Anemia-Associated Nuclease Necessary for DNA Interstrand Crosslink Repair

Smogorzewska, A., Desetty, R. D., Saito, T. T., Schlabach, M. R., Lach, F. P., Sowa, M. E., Clark, A. B., Kunkel, T. A., Harper, J. W., Colaiácovo, M. P., et al. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.06.023 · Cited by 332 · see citing works

X-linked inheritance of Fanconi anemia complementation group B

Meetei, A. R., Levitus, M., Xue, Y., Medhurst, A. L., Zwaan, M. C., Chen, L., Rooimans, M. A., Bier, P., Hoatlin, M. E., Pals, G., et al. (2004) · Nature Genetics · doi:10.1038/ng1458 · Cited by 322 · see citing works

Phase II Trial of Temozolomide Plus O6-Benzylguanine in Adults With Recurrent, Temozolomide-Resistant Malignant Glioma

Quinn, J. A., Jiang, X. “., Reardon, D. A., Desjardins, A., Vredenburgh, J. J., Rich, J. N., Gururangan, S., Friedman, A. H., Bigner, D. D., Sampson, J. H., et al. (2009) · Journal of Clinical Oncology · doi:10.1200/jco.2008.18.8417 · Cited by 314 · see citing works

Mechanism of Radiosensitization by the Chk1/2 Inhibitor AZD7762 Involves Abrogation of the G2 Checkpoint and Inhibition of Homologous Recombinational DNA Repair

Morgan, M. A., Parsels, L. A., Zhao, L., Parsels, J. D., Davis, M. A., Hassan, M. C., Arumugarajah, S., Hylander-Gans, L., Morosini, D., Simeone, D. M., et al. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-3573 · Cited by 299 · see citing works

Human exonuclease 1 and BLM helicase interact to resect DNA and initiate DNA repair

Nimonkar, A. V., Özsoy, A. Z., Genschel, J., Modrich, P. L., & Kowalczykowski, S. C. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0809380105 · Cited by 295 · see citing works

The structure‐specific endonuclease Mus81–Eme1 promotes conversion of interstrand DNA crosslinks into double‐strands breaks

Hanada, K., Budzowska, M., Modesti, M., Maas, A., Wyman, C., Essers, J., & Kanaar, R. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601344 · Cited by 290 · see citing works

Rothmund-Thomson syndrome

Larizza, L., Roversi, G., & Volpi, L. (2010) · Orphanet Journal of Rare Diseases · doi:10.1186/1750-1172-5-2 · Cited by 290 · see citing works

Nuclear Retention of ATM at Sites of DNA Double Strand Breaks

Andegeko, Y., Moyal, L., Rotman, G., Shiloh, Y., Mittelman, L., & Tsarfaty, I. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m102986200 · Cited by 276 · see citing works

ATM, ATR and DNA-PK: initiators of the cellular genotoxic stress responses

Yang, H. J. (2003) · Carcinogenesis · doi:10.1093/carcin/bgg137 · Cited by 275 · see citing works

Effect of ionizing radiation on DNA synthesis in ataxia telangiectasia cells

Houldsworth, J., & Lavin, M. F. (1980) · Nucleic Acids Research · doi:10.1093/nar/8.16.3709 · Cited by 265 · see citing works

Trichothiodystrophy: a systematic review of 112 published cases characterises a wide spectrum of clinical manifestations

Faghri, S., Tamura, D., Kraemer, K. H., & DiGiovanna, J. J. (2008) · Journal of Medical Genetics · doi:10.1136/jmg.2008.058743 · Cited by 264 · see citing works

Rising from the RecQ-age: the role of human RecQ helicases in genome maintenance

Bohr, V. A. (2008) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2008.09.003 · Cited by 257 · see citing works

Xeroderma Pigmentosum: Variants with Normal Dna Repair and Normal Sensitivity to Ultraviolet Light

Cleaver, J. E. (1972) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12538913 · Cited by 245 · see citing works

FANCM Connects the Genome Instability Disorders Bloom's Syndrome and Fanconi Anemia

Deans, A. J., & West, S. C. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.12.006 · Cited by 245 · see citing works

DNA mismatch repair deficiency in sporadic colorectal cancer and Lynch syndrome

Poulogiannis, G., Frayling, I. M., & Arends, M. J. (2009) · Histopathology · doi:10.1111/j.1365-2559.2009.03392.x · Cited by 242 · see citing works

DNA Damage Links Mitochondrial Dysfunction to Atherosclerosis and the Metabolic Syndrome

Mercer, J. R., Cheng, K., Figg, N. L., Gorenne, I., Mahmoudi, M., Griffin, J. L., Vidal‐Puig, A., Logan, A., Murphy, M. P., & Bennett, M. R. (2010) · Circulation Research · doi:10.1161/circresaha.110.218966 · Cited by 240 · see citing works

Isolation of a small molecule inhibitor of DNA base excision repair

Madhusudan, S., Smart, F., Shrimpton, P. J., Parsons, J. L., Gardiner, L., Houlbrook, S., Talbot, D. C., Hammonds, T. R., Freemont, P. S., Sternberg, M. J. E., et al. (2005) · Nucleic Acids Research · doi:10.1093/nar/gki781 · Cited by 239 · see citing works

PARP inhibitors for cancer therapy

Curtin, N. J. (2005) · Expert Reviews in Molecular Medicine · doi:10.1017/s146239940500904x · Cited by 238 · see citing works

ATM-dependent suppression of stress signaling reduces vascular disease in metabolic syndrome

Schneider, J. G., Finck, B. N., Ren, J., Standley, K. N., Takagi, M., Maclean, K. H., Bernal‐Mizrachi, C., Muslin, A. J., Kastan, M. B., & Semenkovich, C. F. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.10.002 · Cited by 235 · see citing works

On diseases of the skin, including the exanthemata

Hebra, F., Kaposi, M., Fagge, C. H., Pye-Smith, P. H., & Tay, W. K. (1866) · Medical Entomology and Zoology · Cited by 228 · see citing works

The DNA crosslink‐induced S‐phase checkpoint depends on ATR–CHK1 and ATR–NBS1–FANCD2 pathways

Pichierri, P., & Rosselli, F. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600113 · Cited by 222 · see citing works

The emerging role of DNA repair proteins as predictive, prognostic and therapeutic targets in cancer

Madhusudan, S., & Middleton, M. R. (2005) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2005.09.006 · Cited by 219 · see citing works

Cancer risks in Fanconi anemia: findings from the German Fanconi Anemia Registry

Rosenberg, P. S., Alter, B. P., & Ebell, W. (2008) · Haematologica · doi:10.3324/haematol.12234 · Cited by 214 · see citing works

First Reported Patient with Human ERCC1 Deficiency Has Cerebro-Oculo-Facio-Skeletal Syndrome with a Mild Defect in Nucleotide Excision Repair and Severe Developmental Failure

Jaspers, N. G. J., Raams, A., Silengo, M., Wijgers, N., Niedernhofer, L. J., Robinson, A. R., Giglia‐Mari, G., Hoogstraten, D., Kleijer, W. J., Hoeijmakers, J. H. J., et al. (2007) · The American Journal of Human Genetics · doi:10.1086/512486 · Cited by 213 · see citing works

Polymorphisms in base-excision repair and nucleotide-excision repair genes in relation to lung cancer risk

Ruyck, K. D., Szaumkessel, M., Rudder, I. D., Dehoorne, A., Vral, A., Claes, K., Velghe, A., van Meerbeeck, J. P., & Thierens, H. M. (2007) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2007.03.010 · Cited by 212 · see citing works

FANCM and FAAP24 Function in ATR-Mediated Checkpoint Signaling Independently of the Fanconi Anemia Core Complex

Collis, S. J., Ciccia, A., Deans, A. J., Hořejšı́, Z., Martin, J. S., Maslen, S., Skehel, M. J., Elledge, S. J., West, S. C., & Boulton, S. J. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.10.014 · Cited by 210 · see citing works

A genetic screen identifies the Triple T complex required for DNA damage signaling and ATM and ATR stability

Hurov, K. E., Cotta-Ramusino, C., & Elledge, S. J. (2010) · Genes &amp; Development · doi:10.1101/gad.1934210 · Cited by 210 · see citing works

Trichothiodystrophy: sulfur-deficient brittle hair as a marker for a neuroectodermal symptom complex

Price, V. H. (1980) · Archives of Dermatology · doi:10.1001/archderm.116.12.1375 · Cited by 199 · see citing works

A Genome-Scale DNA Repair RNAi Screen Identifies SPG48 as a Novel Gene Associated with Hereditary Spastic Paraplegia

Slabicki, M. M., Theis, M., Krastev, D. B., Samsonov, S. A., Mundwiller, E., Junqueira, M., Paszkowski‐Rogacz, M., Teyra, J., Heninger, A., Poser, I., et al. (2010) · PLoS Biology · doi:10.1371/journal.pbio.1000408 · Cited by 198 · see citing works

The vertebrate Hef ortholog is a component of the Fanconi anemia tumor-suppressor pathway

Mosedale, G., Niedźwiedź, W., Alpi, A. F., Perrina, F., Pereira‐Leal, J. B., Johnson, M. A., Langevin, F., Pace, P., & Patel, K. J. (2005) · Nature Structural & Molecular Biology · doi:10.1038/nsmb981 · Cited by 191 · see citing works

Radiation Reaction in Ataxia Telangiectasia

Morgan, J. L. (1968) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/archpedi.1968.02100020561022 · Cited by 181 · see citing works

Promyelocytic leukemia nuclear bodies behave as DNA damage sensors whose response to DNA double-strand breaks is regulated by NBS1 and the kinases ATM, Chk2, and ATR

Dellaire, G., Ching, R. W., Ahmed, K., Jalali, F., Tse, K. C. K., Bristow, R. G., & Bazett‐Jones, D. P. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200604009 · Cited by 179 · see citing works

Complete absence of Cockayne syndrome group B gene product gives rise to UV-sensitive syndrome but not Cockayne syndrome

Horibata, K., Iwamoto, Y., Kuraoka, I., Jaspers, N. G. J., Kurimasa, A., Oshimura, M., Ichihashi, M., & Tanaka, K. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0404587101 · Cited by 178 · see citing works

Genetic complementation analysis of ataxia telangiectasia and Nijmegen breakage syndrome: a survey of 50 patients

Jaspers, N. G. J., Gatti, R. A., Baan, C. C., Linssen, P. C. M., & Bootsma, D. (2008) · Cytogenetics and Cell Genetics · doi:10.1159/000132673 · Cited by 178 · see citing works

Seckel syndrome exhibits cellular features demonstrating defects in the ATR-signalling pathway

Alderton, G. K., Joenje, H., Varon, R., Børglum, A. D., Jeggo, P. A., & O’Driscoll, M. (2004) · Human Molecular Genetics · doi:10.1093/hmg/ddh335 · Cited by 177 · see citing works

Unusual levels of (ADP-ribose)n and DNA synthesis in ataxia telangiectasia cells following γ-ray irradiation

Edwards, M. J., & Taylor, A. M. R. (1980) · Nature · doi:10.1038/287745a0 · Cited by 175 · see citing works

Decreased base excision repair and increased helicase activity in Alzheimer's disease brain

Lovell, M. A., Xie, C., & Markesbery, W. R. (2000) · Brain Research · doi:10.1016/s0006-8993(99)02335-5 · Cited by 174 · see citing works

ATR and ATM differently regulate WRN to prevent DSBs at stalled replication forks and promote replication fork recovery

Ammazzalorso, F., Pirzio, L. M., Bignami, M., Franchitto, A., & Pichierri, P. (2010) · The EMBO Journal · doi:10.1038/emboj.2010.205 · Cited by 171 · see citing works

Pharmacologic disruption of base excision repair sensitizes mismatch repair-deficient and -proficient colon cancer cells to methylating agents.

Liu, L., Taverna, P., Whitacre, C. M., Chatterjee, S., & Gerson, S. L. (1999) · PubMed · Cited by 162 · see citing works

Roles of the Bloom's syndrome helicase in the maintenance of genome stability

Cheok, C. F., Bachrati, C. Z., Chan, K., Ralf, C., Wu, L., & Hickson, I. D. (2005) · Biochemical Society Transactions · doi:10.1042/bst20051456 · Cited by 158 · see citing works

ATR activation and replication fork restart are defective in FANCM‐deficient cells

Schwab, R. A., Blackford, A. N., & Niedźwiedź, W. (2010) · The EMBO Journal · doi:10.1038/emboj.2009.385 · Cited by 155 · see citing works

Cancer in Ataxia-telangiectasia patients

Hecht, F. M., & Hecht, B. K. (1990) · Cancer Genetics and Cytogenetics · doi:10.1016/0165-4608(90)90003-s · Cited by 151 · see citing works

Targeted cancer therapies based on the inhibition of DNA strand break repair

O’Connor, M. J., Martin, N. M. B., & Smith, G. C. M. (2007) · Oncogene · doi:10.1038/sj.onc.1210879 · Cited by 144 · see citing works

A UV-sensitive syndrome patient with a specific CSA mutation reveals separable roles for CSA in response to UV and oxidative DNA damage

Nardò, T., Oneda, R., Spivak, G., Vaz, B., Mortier, L., Thomas, P., Orioli, D., Laugel, V., Stary, A., Hanawalt, P. C., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0902113106 · Cited by 140 · see citing works

Manipulation of Base Excision Repair to Sensitize Ovarian Cancer Cells to Alkylating Agent Temozolomide

Fishel, M. L., He, Y., Smith, M. L., & Kelley, M. R. (2007) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-06-1920 · Cited by 140 · see citing works

Statins Use a Novel Nijmegen Breakage Syndrome-1–Dependent Pathway to Accelerate DNA Repair in Vascular Smooth Muscle Cells

Mahmoudi, M., Gorenne, I., Mercer, J. R., Figg, N., Littlewood, T. D., & Bennett, M. R. (2008) · Circulation Research · doi:10.1161/circresaha.108.182899 · Cited by 139 · see citing works

Reduced expression levels of nucleotide excision repair genes in lung cancer: a case-control analysis

Cheng, L., Spitz, M. R., Hong, W. K., & Wei, Q. (2000) · Carcinogenesis · doi:10.1093/carcin/21.5.527 · Cited by 139 · see citing works

XPF-ERCC1 Participates in the Fanconi Anemia Pathway of Cross-Link Repair

Bhagwat, N. R., Olsen, A. L., Wang, A. T., Hanada, K., Stuckert, P., Kanaar, R., D’Andrea, A. D., Niedernhofer, L. J., & McHugh, P. J. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.00086-09 · Cited by 138 · see citing works

Cerebro-Oculo-Facio-Skeletal Syndrome with a Nucleotide Excision–Repair Defect and a Mutated XPD Gene, with Prenatal Diagnosis in a Triplet Pregnancy

Graham, J. M., Anyane‐Yeboa, K., Raams, A., Appeldoorn, E., Kleijer, W. J., Garritsen, V. H., Busch, D. B., Edersheim, T. G., & Jaspers, N. G. J. (2001) · The American Journal of Human Genetics · doi:10.1086/321295 · Cited by 133 · see citing works

Genome instability, cancer and aging

Maslov, A. Y., & Vijg, J. (2009) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2009.03.020 · Cited by 128 · see citing works

Inhibition of the human apurinic/apyrimidinic endonuclease (APE1) repair activity and sensitization of breast cancer cells to DNA alkylating agents with lucanthone.

Luo, M., & Kelley, M. R. (2004) · PubMed · Cited by 128 · see citing works

The human Rothmund-Thomson syndrome gene product, RECQL4, localizes to distinct nuclear foci that coincide with proteins involved in the maintenance of genome stability

Petkovic, M., Dietschy, T., Freire, R., Jiao, R., & Štagljar, I. (2005) · Journal of Cell Science · doi:10.1242/jcs.02556 · Cited by 126 · see citing works

Identification and characterization of OGG1 mutations in patients with Alzheimer's disease

Mao, G., Pan, X., Zhu, B., Zhang, Y., Yuan, F., Huang, J. V., Lovell, M. A., Lee, M. P., Markesbery, W. R., Li, G., et al. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm189 · Cited by 124 · see citing works

Trichothiodystrophy: From basic mechanisms to clinical implications

Stefanini, M., Botta, E., Lanzafame, M., & Orioli, D. (2009) · DNA repair · doi:10.1016/j.dnarep.2009.10.005 · Cited by 119 · see citing works

Radioresistant DNA synthesis: an intrinsic feature of ataxia telangiectasia

Painter, R. B. (1981) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/0027-5107(81)90061-0 · Cited by 115 · see citing works

Fanconi Anemia Proteins Localize to Chromatin and the Nuclear Matrix in a DNA Damage- and Cell Cycle-regulated Manner

Qiao, F., Moss, A., & Kupfer, G. M. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m101855200 · Cited by 111 · see citing works

Age-related motor neuron degeneration in DNA repair-deficient Ercc1 mice

de Waard, M. C., van der Pluijm, I., Borgesius, N. Z., Comley, L. H., Haasdijk, E. D., Rijksen, Y., Ridwan, Y. R., Zondag, G. C. M., Hoeijmakers, J. H. J., Elgersma, Y., et al. (2010) · Acta Neuropathologica · doi:10.1007/s00401-010-0715-9 · Cited by 110 · see citing works

The Role of DNA Polymerase η in Translesion Synthesis Past Platinum–DNA Adducts in Human Fibroblasts

Bassett, E., King, N. M., Bryant, M. F., Hector, S., Pendyala, L., Chaney, S. G., & Cordeiro‐Stone, M. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-1328 · Cited by 107 · see citing works

Structural features of substituted purine derivatives compatible with depletion of human O6-alkylguanine-DNA alkyltransferase

Moschel, R. C., McDougall, M. G., Dolan, M. E., Stine, L., & Pegg, A. E. (1992) · Journal of Medicinal Chemistry · doi:10.1021/jm00101a028 · Cited by 106 · see citing works

Novel Small-Molecule Inhibitor of Apurinic/Apyrimidinic Endonuclease 1 Blocks Proliferation and Reduces Viability of Glioblastoma Cells

Bapat, A., Glass, L. S., Luo, M., Fishel, M. L., Long, E. C., Georgiadis, M. M., & Kelley, M. R. (2010) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.110.169128 · Cited by 106 · see citing works

The double helix: a personal view

Crick, F. H. C. (1974) · Nature · doi:10.1038/248766a0 · Cited by 100 · see citing works

Guido Fanconi (1892–1979): a jack of all trades

Lobitz, S., & Velleuer, E. (2006) · Nature reviews. Cancer · doi:10.1038/nrc2009 · Cited by 98 · see citing works

P53 plays a protective role against UV- and cisplatin-induced apoptosis in transcription-coupled repair proficient fibroblasts

McKay, B. C., Becerril, C., & Ljungman, M. E. (2001) · Oncogene · doi:10.1038/sj.onc.1204901 · Cited by 98 · see citing works

Genetic determinants at the interface of cancer and neurodegenerative disease

Morris, L. G. T., Veeriah, S., & Chan, T. A.-T. (2010) · Oncogene · doi:10.1038/onc.2010.127 · Cited by 97 · see citing works

Roles of RECQ helicases in recombination based DNA repair, genomic stability and aging

Singh, D. K., Ahn, B., & Bohr, V. A. (2008) · Biogerontology · doi:10.1007/s10522-008-9205-z · Cited by 95 · see citing works

DNA cross-link-dependent RAD50/MRE11/NBS1 subnuclear assembly requires the Fanconi anemia C protein

Pichierri, P. (2002) · Human Molecular Genetics · doi:10.1093/hmg/11.21.2531 · Cited by 90 · see citing works

Knockdown of Fanconi anemia genes in human embryonic stem cells reveals early developmental defects in the hematopoietic lineage.

Tulpule, A., Lensch, M., Miller, J. D., Austin, K. M., D'Andrea, A., Schlaeger, T., Shimamura, A., & Daley, G. Q. (2010) · Blood · doi:10.1182/blood-2009-10-246694 · Cited by 89 · see citing works

PARP inhibitors in cancer therapy: Two modes of attack on the cancer cell widening the clinical applications

Drew, Y., & Plummer, R. (2009) · Drug Resistance Updates · doi:10.1016/j.drup.2009.10.001 · Cited by 87 · see citing works

Double-strand breaks induce homologous recombinational repair of interstrand cross-links via cooperation of MSH2, ERCC1-XPF, REV3, and the Fanconi anemia pathway

Zhang, N., Liu, X., Li, L., & Legerski, R. J. (2007) · DNA repair · doi:10.1016/j.dnarep.2007.06.002 · Cited by 87 · see citing works

Direct and indirect roles of RECQL4 in modulating base excision repair capacity

Schurman, S. H., Hedayati, M. A., Wang, Z., Singh, D. K., Speina, E., Zhang, Y., Becker, K. G., Macris, M. A., Sung, P., Wilson, D. M., et al. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddp291 · Cited by 85 · see citing works

Familial Colorectal Cancer Type X: The Other Half of Hereditary Nonpolyposis Colon Cancer Syndrome

Lindor, N. M. (2009) · Surgical Oncology Clinics of North America · doi:10.1016/j.soc.2009.07.003 · Cited by 83 · see citing works

Molecular genetics of xeroderma pigmentosum variant

Gratchev, A., Strein, P., Utikal, J., & Goerdt, S. (2003) · Experimental Dermatology · doi:10.1034/j.1600-0625.2003.00124.x · Cited by 83 · see citing works

Genetic susceptibility to esophageal cancer: the role of the nucleotide excision repair pathway

Pan, J. Y.-J., Lin, J. M., Izzo, J. G., Liu, Y., Xing, J., Huang, M., Ajani, J. A., & Wu, X. (2009) · Carcinogenesis · doi:10.1093/carcin/bgp058 · Cited by 83 · see citing works

Genomic instability and the selection of treatments for cancer

Martin, S. A., Hewish, M., Lord, C. J., & Ashworth, A. (2009) · The Journal of Pathology · doi:10.1002/path.2631 · Cited by 80 · see citing works

Ataxia-telangiectasia and the ATM gene: Linking neurodegeneration, immunodeficiency, and cancer to cell cycle checkpoints

Shiloh, Y., & Rotman, G. (1996) · Journal of Clinical Immunology · doi:10.1007/bf01541389 · Cited by 79 · see citing works

The pyridinylfuranopyrimidine inhibitor, PI-103, chemosensitizes glioblastoma cells for apoptosis by inhibiting DNA repair

Westhoff, M., Kandenwein, J. A., Karl, S., Vellanki, S. H., Braun, V., Eramo, A., Antoniadis, G., Debatin, K., & Fulda, S. (2009) · Oncogene · doi:10.1038/onc.2009.215 · Cited by 78 · see citing works

Radioresistant DNA synthesis and human genetic disease

Young, B. R., & Painter, R. B. (1989) · Human Genetics · doi:10.1007/bf00284040 · Cited by 78 · see citing works

Inhibition of base excision repair potentiates iododeoxyuridine-induced cytotoxicity and radiosensitization.

Taverna, P., Hwang, H. S., Schupp, J. E., Radivoyevitch, T., Session, N. N., Reddy, G., Zarling, D. A., & Kinsella, T. J. (2003) · PubMed · Cited by 73 · see citing works

RecQ4 Facilitates UV Light-induced DNA Damage Repair through Interaction with Nucleotide Excision Repair Factor Xeroderma Pigmentosum Group A (XPA)

Fan, W., & Luo, J. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m801928200 · Cited by 72 · see citing works

Transcription-coupled repair and premature ageing

Andressoo, J., & Hoeijmakers, J. H. J. (2005) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2005.04.004 · Cited by 70 · see citing works

New tricks for old drugs: the anticarcinogenic potential of DNA repair inhibitors

Srougi, M. C., Bey, E. A., Dong, Y., Reinicke, K. E., & Boothman, D. A. (2006) · Journal of Molecular Histology · doi:10.1007/s10735-006-9043-8 · Cited by 68 · see citing works

Biological and Molecular Mechanisms of Sulfur Mustard Analogue-Induced Toxicity in JB6 and HaCaT Cells: Possible Role of Ataxia Telangiectasia-Mutated/Ataxia Telangiectasia-Rad3-Related Cell Cycle Checkpoint Pathway

Tewari‐Singh, N., Gu, M., Agarwal, C., White, C. W., & Agarwal, R. (2010) · Chemical Research in Toxicology · doi:10.1021/tx100038b · Cited by 67 · see citing works

The protein shuffle

Park, C., & Choi, B. (2006) · FEBS Journal · doi:10.1111/j.1742-4658.2006.05189.x · Cited by 65 · see citing works

XPC polymorphisms play a role in tissue-specific carcinogenesis: a meta-analysis

Francisco, G., Menezes, P. R., Eluf‐Neto, J., & Chammas, R. J. (2008) · European Journal of Human Genetics · doi:10.1038/ejhg.2008.6 · Cited by 65 · see citing works

Fanconi anemia proteins stabilize replication forks

Wang, L. C., Stone, S., Hoatlin, M. E., & Gautier, J. (2008) · DNA repair · doi:10.1016/j.dnarep.2008.08.005 · Cited by 64 · see citing works

Identical mutations in the CSB gene associated with either Cockayne syndrome or the DeSanctis-Cacchione variant of xeroderma pigmentosum

Colella, S. (2000) · Human Molecular Genetics · doi:10.1093/hmg/9.8.1171 · Cited by 63 · see citing works

Blockage of abasic site repair enhances antitumor efficacy of 1,3-bis-(2-chloroethyl)-1-nitrosourea in colon tumor xenografts.

Liu, L., Yan, L., Donze, J. R., & Gerson, S. L. (2003) · PubMed · Cited by 62 · see citing works

Fanconi anaemia cells are not uniformly deficient in unhooking of DNA interstrand crosslinks, induced by mitomycin C or 8-methoxypsoralen plus UVA

Poll, E. H. A., Arwert, F., Kortbeek, H. T., & Eriksson, A. W. (1984) · Human Genetics · doi:10.1007/bf00418393 · Cited by 61 · see citing works

Single Nucleotide Polymorphisms in Nucleotide Excision Repair Genes XPA, XPD, XPG and ERCC1 in Advanced Colorectal Cancer Patients Treated with First-Line Oxaliplatin/Fluoropyrimidine

Monzó, M., Moreno, I., Navarro, A., Ibeas, R., Artells, R., Gel, B., Martínez-Ródenas, F., Moreno, J., Hernandez, R., & Navarro-Vigo, M. (2007) · Oncology · doi:10.1159/000113534 · Cited by 61 · see citing works

MRE11–RAD50–NBS1 is a critical regulator of FANCD2 stability and function during DNA double‐strand break repair

Lopez‐Roques, C., Coulombe, Y., Delannoy, M., Vignard, J., Grossi, S., Brodeur, I., Rodrigue, A., Gautier, J., Stasiak, A. Z., Stasiak, A., et al. (2009) · The EMBO Journal · doi:10.1038/emboj.2009.193 · Cited by 59 · see citing works

Xeroderma pigmentosum: From Symptoms and Genetics to Gene-Based Skin Therapy

Magnaldo, T., & Sarasin, A. R. (2004) · Cells Tissues Organs · doi:10.1159/000079993 · Cited by 58 · see citing works

Ultraviolet-induced mutations in Cockayne syndrome cells are primarily caused by cyclobutane dimer photoproducts while repair of other photoproducts is normal.

Parris, C. N., & Kraemer, K. H. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.15.7260 · Cited by 58 · see citing works

Reduced efficiency and increased mutagenicity of translesion DNA synthesis across a TT cyclobutane pyrimidine dimer, but not a TT 6-4 photoproduct, in human cells lacking DNA polymerase η

Hendel, A., Ziv, O., Guéranger, Q., Geacintov, N. E., & Livneh, Z. (2008) · DNA repair · doi:10.1016/j.dnarep.2008.06.008 · Cited by 57 · see citing works

Correcting the blueprint of life: an historical account of the discovery of DNA repair mechanisms

(1997) · Choice Reviews Online · doi:10.5860/choice.35-2086 · Cited by 56 · see citing works

Fanconi anemia, complementation group A, cells are defective in ability to produce incisions at sites of psoralen interstrand cross-links

Kumaresan, K. R., & Lambert, M. W. (2000) · Carcinogenesis · doi:10.1093/carcin/21.4.741 · Cited by 56 · see citing works

A SINGLE ATAXIA TELANGIECTASIA GENE WITH A PRODUCT SIMILAR TO PI-3 KINASE

Gern, J. E. (1996) · PEDIATRICS · doi:10.1542/peds.98.2.350a · Cited by 54 · see citing works

DNA damage, neuronal and glial cell death and neurodegeneration

Barzilai, A. (2010) · APOPTOSIS · doi:10.1007/s10495-010-0501-0 · Cited by 53 · see citing works

Phenylbutyrate interferes with the Fanconi anemia and BRCA pathway and sensitizes head and neck cancer cells to cisplatin

Burkitt, K., & Ljungman, M. E. (2008) · Molecular Cancer · doi:10.1186/1476-4598-7-24 · Cited by 53 · see citing works

Repair of 4,5',8-trimethylpsoralen plus light-induced DNA damage in normal and Fanconi's anemia cell lines.

Averbeck, D., Papadopoulo, D., & Moustacchi, E. (1988) · PubMed · Cited by 52 · see citing works

Poly(ADP-ribose) polymerase inhibitors as potential chemotherapeutic agents

Bryant, H. E., & Helleday, T. (2004) · Biochemical Society Transactions · doi:10.1042/bst0320959 · Cited by 51 · see citing works

Mechanisms of Action of Cancer Chemotherapeutic Agents: DNA ‐Interactive Alkylating Agents and Antitumour Platinum‐Based Drugs

Siddik, Z. H. (2005) · The Cancer Handbook · doi:10.1002/0470025077.chap84b · Cited by 47 · see citing works

FANCM–FAAP24 and FANCJ: FA proteins that metabolize DNA

Ali, A. M., Singh, T. R., & Meetei, A. R. (2009) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2009.04.002 · Cited by 47 · see citing works

Mechanisms of ATR-mediated checkpoint signalling

Smits, V. A. J. (2010) · Frontiers in bioscience · doi:10.2741/3649 · Cited by 45 · see citing works

The molecular basis for different disease states caused by mutations in TFIIH and XPG

Schärer, O. D. (2008) · DNA repair · doi:10.1016/j.dnarep.2007.10.007 · Cited by 45 · see citing works

Implication of MYH in Colorectal Polyposis

Lefèvre, J. H., Rodrigue, C. M., Mourra, N., Bennis, M., Fléjou, J., Parc, R., Tiret, E., Gespach, C. P., & Parc, Y. R. (2006) · Annals of Surgery · doi:10.1097/01.sla.0000246937.54435.50 · Cited by 45 · see citing works

New Form of Molecular Defect in Xeroderma Pigmentosum

Jung, E. G. (1970) · Nature · doi:10.1038/228361a0 · Cited by 45 · see citing works

Fanconi Anemia Proteins and the S Phase Checkpoint

Pichierri, P., & Rosselli, F. (2004) · Cell Cycle · doi:10.4161/cc.3.6.911 · Cited by 44 · see citing works

Hereditary Colon Cancer: Lynch Syndrome

Jang, E. J., & Chung, D. C. (2010) · Gut and Liver · doi:10.5009/gnl.2010.4.2.151 · Cited by 43 · see citing works

Phase I trial of temozolomide plus O6-benzylguanine 5-day regimen with recurrent malignant glioma

Quinn, J. A., Jiang, X. “., Reardon, D. A., Desjardins, A., Vredenburgh, J. J., Rich, J. N., Gururangan, S., Friedman, A. H., Bigner, D. D., Sampson, J. H., et al. (2009) · Neuro-Oncology · doi:10.1215/15228517-2009-007 · Cited by 42 · see citing works

DNA excision repair in cell extracts from human cell lines exhibiting hypersensitivity to DNA-damaging agents.

Hansson, J., Keyse, S. M., Lindahl, T., & Wood, R. D. (1991) · PubMed · Cited by 40 · see citing works

Possible involvement of RecQL4 in the repair of double-strand DNA breaks in Xenopus egg extracts

Kumata, Y., Tada, S., Yamanada, Y., Tsuyama, T., Kobayashi, T., Dong, Y., Ikegami, K., Murofushi, H., Seki, M., & Enomoto, T. (2007) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2007.01.005 · Cited by 40 · see citing works

Treatment of human brain tumor xenografts with O6-benzyl-2'-deoxyguanosine and BCNU.

Schold, S. C., Kokkinakis, D. M., Rudy, J. L., Moschel, R. C., & Pegg, A. E. (1996) · PubMed · Cited by 38 · see citing works

The DNA Damage-Binding Protein XPC Is a Frequent Target for Inactivation in Squamous Cell Carcinomas

de Feraudy, S. M., Ridd, K., Richards, L. M., Kwok, P., Revet, I. M., Oh, D. H., Feeney, L., & Cleaver, J. E. (2010) · American Journal Of Pathology · doi:10.2353/ajpath.2010.090925 · Cited by 38 · see citing works

International Fanconi Anemia Registry: relation of clinical symptoms to diepoxybutane sensitivity

Auerbach, A., Rogatko, A., & Schroeder-Kurth, T. (1989) · Blood · doi:10.1182/blood.v73.2.391.bloodjournal732391 · Cited by 36 · see citing works

Xeroderma pigmentosum

Khatri, M. L., Shafi, M., & Mashina, A. (1992) · Journal of the American Academy of Dermatology · doi:10.1016/0190-9622(92)70010-d · Cited by 34 · see citing works

Blockade of MGMT Expression by O6 Benzyl Guanine Leads to Inhibition of Pancreatic Cancer Growth and Induction of Apoptosis

Konduri, S. D., Ticku, J., Bobustuc, G. C., Sutphin, R. M., Colon, J. F., Isley, B. A., Bhakat, K. K., Kalkunte, S. S., & Baker, C. H. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-09-0887 · Cited by 34 · see citing works

TTDN1 is a Plk1-interacting protein involved in maintenance of cell cycle integrity

Zhang, Y., Tian, Y., Chen, Q., Chen, D., Zhai, Z., & Shu, H. (2007) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-007-6501-8 · Cited by 33 · see citing works

Chemosensitizing tumor cells by targeting the Fanconi anemia pathway with an adenovirus overexpressing dominant-negative FANCA

Ferrer, M., de Winter, J. P., Mastenbroek, D. C. J., Curiel, D. T., Gerritsen, W. R., Giaccone, G., & Kruyt, F. A. E. (2004) · Cancer Gene Therapy · doi:10.1038/sj.cgt.7700734 · Cited by 32 · see citing works

WRN participates in translesion synthesis pathway through interaction with NBS1

Kobayashi, J., Okui, M., Asaithamby, A., Burma, S., Chen, B. P. C., Tanimoto, K., Matsuura, S., Komatsu, K., & Chen, D. J. (2010) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2010.06.005 · Cited by 31 · see citing works

XPA A23G polymorphism is associated with the elevated response to platinum-based chemotherapy in advanced non-small cell lung cancer

Feng, J., Sun, X., Sun, N., Qin, S., Li, F., Cheng, H., Chen, B., Cao, Y., Ma, J., Cheng, L., et al. (2009) · Acta Biochimica et Biophysica Sinica · doi:10.1093/abbs/gmp027 · Cited by 31 · see citing works

Mutagenic processing of ethylation damage in mammalian cells: the use of methoxyamine to study apurinic/apyrimidinic site-induced mutagenesis.

Fortini, P., Calcagnile, A. S., Vrieling, H., van Zeeland, A. A., Bignami, M., & Eugenia Dogliotti, Y. (1993) · PubMed · Cited by 28 · see citing works

Phase 1 trial of temozolomide plus irinotecan plus O6‐benzylguanine in adults with recurrent malignant glioma

Quinn, J. A., Jiang, X. “., Reardon, D. A., Desjardins, A., Vredenburgh, J. J., Gururangan, S., Sampson, J. H., McLendon, R. E., Herndon, J. E., & Friedman, H. S. (2009) · Cancer · doi:10.1002/cncr.24336 · Cited by 28 · see citing works

XPC genetic polymorphisms correlate with the response to imatinib treatment in patients with chronic phase chronic myeloid leukemia

Guillem, V. M., Cervantes, F., Martı́nez, J., Álvarez‐Larrán, A., Collado, M., Camós, M., Sureda, A. M., Maffioli, M., Marugán, I., & Hernández‐Boluda, J. C. (2010) · American Journal of Hematology · doi:10.1002/ajh.21726 · Cited by 28 · see citing works

DNA repair enzyme deficiency and in vitro complementation of the enzyme activity in cell-free extracts from ataxia telangiectasia fibroblasts

Inoue, T., Yokoiyama, A., & Kada, T. (1981) · Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis · doi:10.1016/0005-2787(81)90065-4 · Cited by 26 · see citing works

An enzyme activity in normal and ataxia telangiectasia cell lines which is involved in the repair of γ-irradiation-induced DNA damage

Edwards, M. J., Taylor, A. M., & Duckworth, G. (1980) · Biochemical Journal · doi:10.1042/bj1880677 · Cited by 24 · see citing works

Compromised Fanconi anemia response due to BRCA1 deficiency in cisplatin-sensitive head and neck cancer cell lines

Burkitt, K., & Ljungman, M. E. (2007) · Cancer Letters · doi:10.1016/j.canlet.2007.01.017 · Cited by 24 · see citing works

Pharmacokinetics of temozolomide administered in combination with O6-benzylguanine in children and adolescents with refractory solid tumors

Meany, H. J., Warren, K. E., Fox, E., Cole, D. E., Aikin, A. A., & Balis, F. M. (2009) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-009-1015-8 · Cited by 22 · see citing works

Sunlight damage to cellular DNA: focus on oxidatively generated lesions

Schuch, A. P., Moreno, N. C., Schuch, N. J., Menck, C. F. M., & Garcia, C. C. M. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.01.029 · Cited by 436 · see citing works

DNA damage and repair in age-related inflammation

Zhao, Y., Simon, M. A., Seluanov, A., & Gorbunova, V. A. (2022) · Nature reviews. Immunology · doi:10.1038/s41577-022-00751-y · Cited by 393 · see citing works

DNA damage tolerance: a double-edged sword guarding the genome.

Ghosal, G., & Chen, J. (2013) · PubMed · doi:10.3978/j.issn.2218-676x.2013.04.01 · Cited by 204 · see citing works

DNA repair diseases: what do they tell us about Cancer and aging?

Menck, C. F., & Munford, V. (2014) · Genetics and Molecular Biology · doi:10.1590/s1415-47572014000200008 · Cited by 162 · see citing works

Ageing as an Important Risk Factor for Cancer

Smetana, K., Lacina, L., Szabó, P., Dvořánková, B., Brož, P., & Šedo, A. (2016) · Anticancer Research · doi:10.21873/anticanres.11069 · Cited by 140 · see citing works

Inflammation Response, Oxidative Stress and DNA Damage Caused by Urban Air Pollution Exposure Increase in the Lack of DNA Repair XPC Protein

de Oliveira Alves, N., Martins Pereira, G., Di Domenico, M., Costanzo, G., Benevenuto, S., de Oliveira Fonoff, A. M., de Souza Xavier Costa, N., Ribeiro Júnior, G., Satoru Kajitani, G., Cestari Moreno, N., et al. (2020) · Environment International · doi:10.1016/j.envint.2020.106150 · Cited by 94 · see citing works

The role of DNA repair in the pluripotency and differentiation of human stem cells

Rocha, C. R. R., Lerner, L. K., Okamoto, O. K., Marchetto, M. C., & Menck, C. F. M. (2012) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2012.09.001 · Cited by 93 · see citing works

NER initiation factors, DDB2 and XPC, regulate UV radiation response by recruiting ATR and ATM kinases to DNA damage sites

Ray, A., Milum, K., Battu, A., Wani, G., & Wani, A. A. (2013) · DNA Repair · doi:10.1016/j.dnarep.2013.01.003 · Cited by 85 · see citing works

Interleukin-6: Molecule in the Intersection of Cancer, Ageing and COVID-19

Brábek, J., Jakubek, M., Vellieux, F. M. D., Novotný, J., Kolář, M., Lacina, L., Szabó, P., Strnadová, K., Rösel, D., Dvořánková, B., et al. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21217937 · Cited by 73 · see citing works

Primary Immunodeficiency and Cancer Predisposition Revisited: Embedding Two Closely Related Concepts Into an Integrative Conceptual Framework

Haas, O. A. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2018.03136 · Cited by 70 · see citing works

The emerging role of substance P/neurokinin-1 receptor signaling pathways in growth and development of tumor cells

Javid, H., Mohammadi, F., Zahiri, E., & Hashemy, S. I. (2019) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-019-00697-1 · Cited by 63 · see citing works

RECQ helicase RECQL4 participates in non-homologous end joining and interacts with the Ku complex

Shamanna, R. A., Singh, D. K., Lu, H., Mirey, G., Keijzers, G., Salles, B., Croteau, D. L., & Bohr, V. A. (2014) · Carcinogenesis · doi:10.1093/carcin/bgu137 · Cited by 58 · see citing works

Evaluation of the Gamma-H2AX Assay for Radiation Biodosimetry in a Swine Model

Moroni, M., Maeda, D., Whitnall, M. H., Bonner, W. M., & Redon, C. E. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms140714119 · Cited by 55 · see citing works

ATR- and ATM-Mediated DNA Damage Response Is Dependent on Excision Repair Assembly during G1 but Not in S Phase of Cell Cycle

Ray, A., Blevins, C., Wani, G., & Wani, A. A. (2016) · PLOS ONE · doi:10.1371/journal.pone.0159344 · Cited by 44 · see citing works

Targeting DNA repair: the genome as a potential biomarker

Nesic, K., Wakefield, M. J., Kondrashova, O., Scott, C. L., & McNeish, I. A. (2017) · The Journal of Pathology · doi:10.1002/path.5025 · Cited by 45 · see citing works

Generation of Guanine–Thymine Cross-Links in Human Cells by One-Electron Oxidation Mechanisms

Madugundu, G. S., Wagner, J. R., Cadet, J., Kropachev, K. Y., Yun, B. H., Geacintov, N. E., & Shafirovich, V. (2013) · Chemical Research in Toxicology · doi:10.1021/tx400158g · Cited by 41 · see citing works

DNA Damage and Its Cellular Response in Mother and Fetus Exposed to Hyperglycemic Environment

Moreli, J. B., Santos, J. H., Rocha, C. R. R., Damasceno, D. C., Morceli, G., Rudge, M. V. C., Bevilacqua, E. M. A. F., & Calderon, I. D. M. P. (2014) · BioMed Research International · doi:10.1155/2014/676758 · Cited by 42 · see citing works

Thermodynamic Profiles and Nuclear Magnetic Resonance Studies of Oligonucleotide Duplexes Containing Single Diastereomeric Spiroiminodihydantoin Lesions

Khutsishvili, I., Zhang, N., Marky, L. A., Crean, C. W., Patel, D. J., Geacintov, N. E., & Shafirovich, V. (2013) · Biochemistry · doi:10.1021/bi301566v · Cited by 30 · see citing works

The DNA2 nuclease/helicase is an estrogen-dependent gene mutated in breast and ovarian cancers

Strauss, C., Kornowski, M., Benvenisty, A., Shahar, A., Masury, H., Ben‐Porath, I., Ravid, T., Arbel‐Eden, A., & Goldberg, M. (2014) · Oncotarget · doi:10.18632/oncotarget.2414 · Cited by 30 · see citing works

RAP80 Is Critical in Maintaining Genomic Stability and Suppressing Tumor Development

Yin, Z., Menéndez, D., Resnick, M. A., French, J. E., Janardhan, K. S., & Jetten, A. M. (2012) · Cancer Research · doi:10.1158/0008-5472.can-12-1484 · Cited by 27 · see citing works

High Expression of the Mismatch Repair Protein MSH6 Is Associated With Poor Patient Survival in Melanoma

Alvino, E., Passarelli, F., Cannavò, E., Fortes, C., Mastroeni, S., Caporali, S., Jiricny, J., Cappellini, G. C. A., Scoppola, A., Marchetti, P., et al. (2014) · American Journal of Clinical Pathology · doi:10.1309/ajcpcx2d9yulbblg · Cited by 26 · see citing works

NEK1 deficiency affects mitochondrial functions and the transcriptome of key DNA repair pathways

Martins, M. B., Perez, A. M., Bohr, V. A., Wilson, D. M., & Kobarg, J. (2021) · Mutagenesis · doi:10.1093/mutage/geab011 · Cited by 23 · see citing works

Antitumoral effects of [6]-gingerol [(S)-5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-3-decanone] in sarcoma 180 cells through cytogenetic mechanisms

de Lima, R. M. T., dos Reis, A. C., Santos, J. V. D. O., Ferreira, J. R. D. O., Filho, J. W. G. D. O., Dias, A. C. S., de Menezes, A. P. M., da Mata, A. M. O. F., de Alencar, M. V. O. B., Andrade, T. D. J. A. D. S., et al. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110004 · Cited by 24 · see citing works

The contribution of XRCC3 genotypes to childhood acute lymphoblastic leukemia

PEI, J.-S., CHANG, W.-S., Hsu, P., Chen, C., Cheng, S.-P., WANG, Y.-C., Tsai, C.-W., Shen, T., & Bau, D. (2018) · Cancer Management and Research · doi:10.2147/cmar.s178411 · Cited by 21 · see citing works

Singlet molecular oxygen: Düsseldorf – São Paulo, the Brazilian connection

Mascio, P. D., Martinez, G. R., Miyamoto, S., Ronsein, G. E., de Medeiros, M. H. G., & Cadet, J. (2016) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2015.11.016 · Cited by 21 · see citing works

Differential cell-specific cytotoxic responses of oral cavity cells to tobacco preparations

Gao, H., Prasad, G. L., & Zacharias, W. (2012) · Toxicology in Vitro · doi:10.1016/j.tiv.2012.07.015 · Cited by 19 · see citing works

Protective effect of antioxidants on DNA damage in leukocytes from X‐linked adrenoleukodystrophy patients

Marchetti, D. P., Donida, B., da Rosa, H. T., Manini, P. R., Moura, D. J., Saffi, J., Deon, M., Mescka, C. P., Coelho, D. D. M., Jardim, L. B., et al. (2015) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2015.03.004 · Cited by 19 · see citing works

Genetic predisposition and hematopoietic malignancies in children: Primary immunodeficiency

ten Bosch, J. V. D. W., & van den Akker, M. (2016) · European Journal of Medical Genetics · doi:10.1016/j.ejmg.2016.03.001 · Cited by 18 · see citing works

The Potential of PARP Inhibitors in Neuro-Oncology

Carruthers, R., & Chalmers, A. J. (2012) · CNS Oncology · doi:10.2217/cns.12.13 · Cited by 17 · see citing works

Oxidative Imbalance, Nitrative Stress, and Inflammation in C6 Glial Cells Exposed to Hexacosanoic Acid: Protective Effect of N-acetyl-l-cysteine, Trolox, and Rosuvastatin

Marchetti, D. P., Reinhardt, L. S., Jacques, C. E. D., Guerreiro, G., Mescka, C. P., Deon, M., Coelho, D. D. M., Moura, D. J., Viario, A. G., Poletto, F. S., et al. (2018) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-018-0626-1 · Cited by 17 · see citing works

Antioxidant Activities of Phenolic Metabolites from Flemingia philippinensis Merr. et Rolfe and Their Application to DNA Damage Protection

Kim, J. Y., Wang, Y., Song, Y. W., Uddin, Z., Li, Z., Ban, Y. J., & Park, K. H. (2018) · Molecules · doi:10.3390/molecules23040816 · Cited by 16 · see citing works

Interplay of immune modulation, adaptive response and hormesis: Suggestive of threshold for clinical manifestation of effects of ionizing radiation at low doses?

Chaurasia, R. K., Sapra, B. K., & Aswal, D. K. (2024) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2024.170178 · Cited by 15 · see citing works

UVB-Induced Cell Death Signaling Is Associated with G1-S Progression and Transcription Inhibition in Primary Human Fibroblasts

Ortolan, T. G., & Menck, C. F. M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0076936 · Cited by 15 · see citing works

Radiation and microgravity – Associated stress factors and carcinogensis

Moreno‐Villanueva, M., & Wu, H. (2019) · REACH · doi:10.1016/j.reach.2019.100027 · Cited by 16 · see citing works

Influence of genetic polymorphisms on biomarkers of exposure and effects in children living in Upper Silesia

Mielżyńska‐Švach, D., Błaszczyk, E., Butkiewicz, D., Durzyńska, J., & Rydzanicz, M. (2013) · Mutagenesis · doi:10.1093/mutage/get037 · Cited by 13 · see citing works

Papel das proteínas XPD e DNA polimerase eta nas respostas de células humanas a danos no genoma

Lerner, L. K. (2014) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.5.2014.tde-20102014-103732 · Cited by 13 · see citing works

Busca de variantes em sequência de DNA proveniente de pacientes com deficiência em processos de reparo do genoma

Moura, L. M. S. (2015) · doi:10.11606/d.95.2015.tde-10112015-173956 · Cited by 13 · see citing works

Radiation risks associated with serial imaging in colorectal cancer patients: Should we worry?

Oh, J. S. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i1.100 · Cited by 12 · see citing works

Comparative analysis of clastogen-induced chromosome aberrations observed with light microscopy and by means of atomic force microscopy

Koleva, V. P., Dragoeva, A. P., Andreeva, A., Burova, M., Georgiev, S., & Enchev, D. D. (2013) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2012.12.014 · Cited by 10 · see citing works

DNA damage after chronic oxytocin administration in rats: a safety yellow light?

Leffa, D. D., Daumann, F., Damiani, A. P., Afonso, A. D. C., dos Santos, M. A. B., Pedro, T. H., de Souza, R. P., & de Andrade, V. M. (2016) · Metabolic Brain Disease · doi:10.1007/s11011-016-9885-z · Cited by 9 · see citing works

Information: a missing component in understanding and mitigating social epidemics

Magarey, R. D., & Trexler, C. M. (2020) · Humanities and Social Sciences Communications · doi:10.1057/s41599-020-00620-w · Cited by 9 · see citing works

The Contribution of DNA Ligase 4 Polymorphisms to Colorectal Cancer

Deng, Y., Ke, T., YUEH, T.-C., CHIN, Y.-T., WANG, Y.-C., Hung, Y.-C., Mong, M., Yang, Y., Wu, W., CHANG, W.-S., et al. (2023) · In Vivo · doi:10.21873/invivo.13419 · Cited by 7 · see citing works

Immunoexpression of DNA base excision repair and nucleotide excision repair proteins in ameloblastomas, syndromic and non-syndromic odontogenic keratocysts and dentigerous cysts

Santos, H. B. D. P., de Morais, É. F., Cavalcante, R. B., Nogueira, R. L. M., Nonaka, C. F. W., de Souza, L. B., & Freitas, R. D. A. (2019) · Archives of Oral Biology · doi:10.1016/j.archoralbio.2019.104627 · Cited by 7 · see citing works

Reproductive Health in Xeroderma Pigmentosum

Merideth, M. A., Tamura, D., Angra, D., Khan, S. G., Ferrell, J., Goldstein, A. M., DiGiovanna, J. J., & Kraemer, K. H. (2019) · Obstetrics and Gynecology · doi:10.1097/aog.0000000000003490 · Cited by 7 · see citing works

DR-GAS: A database of functional genetic variants and their phosphorylation states in human DNA repair systems

Sehgal, M., & Singh, T. R. (2014) · DNA repair · doi:10.1016/j.dnarep.2014.01.004 · Cited by 6 · see citing works

[ 18 O]‐Peroxides: Synthesis and Biological Applications

Mascio, P. D., Miyamoto, S., de Medeiros, M. H. G., Martinez, G. R., & Cadet, J. (2014) · Patai's chemistry of functional groups · doi:10.1002/9780470682531.pat0868 · Cited by 5 · see citing works

Effects of Low Dose Ionizing Radiation on Human Health: Evidence for Revisiting Radiation Protection Policies

Chaurasia, R. K., & Sapra, B. K. (2024) · Springer eBooks · doi:10.1007/978-981-97-2795-7_14 · Cited by 4 · see citing works

Role of Quercetin in DNA Repair and Dysregulated Metabolism. Possible Target to Combat Drug Resistance in Cancer

Alam, W., Ali, A., Khan, F., Martins, A. M. C., Hussain, Y., & Khan, H. Z. (2022) · Phytonutrients · doi:10.62368/pn.v1i01.11 · Cited by 3 · see citing works

X-ray repair cross-complementing gene 1 Arg399Gln polymorphism and glioma risk among Asians: A meta-analysis based on 2 326 cases and 3 610 controls.

Zhang, L., Qiu, Z., Luo, J., & Shu, W. (2012) · Europe PMC (PubMed Central) · doi:10.3969/j.issn.1673-5374.2012.29.011 · Cited by 3 · see citing works

Principles of Molecular Biology

Howe, J. G. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-816061-9.00001-1 · Cited by 2 · see citing works

Recombinant Viral Vectors for Investigating DNA Damage Responses and Gene Therapy of Xeroderma Pigmentosum

Quayle, C., Menck, C. F. M., & Moreno, K. (2011) · InTech eBooks · doi:10.5772/22946 · Cited by 1 · see citing works

Deciphering carcinogenic regulatory signatures through network motif–driven pathway analysis for computational prioritization of candidate regulatory proteins

Sehgal, M., Yadav, A. K., Shukla, R., Gupta, R., Dakal, T. C., & Singh, T. R. (2026) · In Silico Research in Biomedicine · doi:10.1016/j.insi.2026.100262 · Cited by 1 · see citing works

DNA repair genes BRCA1 and DNA-PKcs have great potential in radiation therapy

Jiao, Y., Xu, X., & Hao, Y. (2012) · The Chinese-German Journal of Clinical Oncology · doi:10.1007/s10330-012-1088-4 · Cited by 1 · see citing works

Predicting efficacies of anticancer drugs using single cell HaloChip assay

Ma, L., Xun, X., Qiao, Y., An, J., & Su, M. (2016) · The Analyst · doi:10.1039/c5an02564h · Cited by 1 · see citing works

DNA Repair Defects

Porras, Ó. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-405546-9.00007-8 · Cited by 1 · see citing works

DNA stability defects

Shcherbina, A. Y., & Porras, Ó. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-816768-7.00010-7 · Cited by 1 · see citing works

"Dano oxidativo, reparação do DNA e a influência de polimorfismos genéticos na fisiopatogenia da doença pulmonar obstrutiva crônica"

da Silva, A. L. G. (2013)

Reasons of carcinogenesis indicate a big-bang inside: A hypothesis for the aberration of DNA methylation

Roy, A., & Chattopadhyay, N. R. (2013) · Medical Hypotheses · doi:10.1016/j.mehy.2013.04.004

DNA Repair Kinetic of Hydrogen Peroxide and UVA/B Induced Lesions in Peripheral Blood Leucocytes from Xeroderma Pigmentosum Patients and Healthy Subjects

González, E. A. P., Mudry, M. D., & Palermo, A. M. (2014) · Journal of Environmental Pathology Toxicology and Oncology · doi:10.1615/jenvironpatholtoxicoloncol.2014008234

Componentes derivados de venenos de serpentes com ação antitumoral em células de melanoma Murino

Queiroz, R. G. D. P. (2012) · doi:10.11606/t.85.2012.tde-24082012-133252

Prêmio Nobel de Química 2015: Os Mecanismos de Reparo de DNA

Menck, C. F. M., & Meneghini, R. (2015) · Química Nova na Escola · doi:10.5935/0104-8899.20150048

UNIVERSIDADE FEDERAL DO RIO GRANDE DO SUL CENTRO DE BIOTECNOLOGIA PROGRAMA DE PÓS-GRADUAÇÃO EM BIOLOGIA CELULAR E MOLECULAR ESTUDO DAS INTERAÇÕES DO GENE PSO2 DE SACCHAROMYCES CEREVISIAE COM GENES DA RESPOSTA A DANOS NO DNA APÓS TRATAMENTO COM AGENTES INDUTORES DE PONTES INTERCADEIA

Alegre, P. (2013)

Study of the destructive effects of shear stress and ROS-generating drugs on circulating tumor cells

Regmi, S. (2018) · doi:10.32657/10220/47595

Dual-functional Bacillus cereus X1 drives hydrocarbon biodegradation and carbon sequestration via glnQ-mediated metabolic rewiring

Song, J., Lin, H., Qinghong, W., Zhang, L., Xu, A., Peng, Z., Chen, Y., Bai, Y., Li, X., 唐文忠, et al. (2026) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2026.143924

Human DNA repair diseases: From genome instability to cancer

Machado, C. R., & Menck, C. F. M. (1997) · Brazilian Journal of Genetics · doi:10.1590/s0100-84551997000400032 · Cited by 14 · see citing works

Human diseases with genetically altered DNA repair processes.

Cleaver, J. E., Bootsma, D., & Friedberg, E. C. (1975) · PubMed · Cited by 29 · see citing works

Lessons learned from DNA repair defective syndromes

Thoms, K., Kuschal, C., & Emmert, S. (2007) · Experimental Dermatology · doi:10.1111/j.1600-0625.2007.00559.x · Cited by 70 · see citing works

Age-associated changes in DNA repair and mutation rates

Grossman, L. I., Moriwaki, S.-I., Ray, S., Tarone, R. E., Wei, Q., & Kraemer, K. H. (2001) · Advances in cell aging and gerontology · doi:10.1016/s1566-3124(01)04025-1 · Cited by 3 · see citing works

Cancer-Prone Human Disorders with Defects in DNA Repair

Lehmann, A. R., & Dean, S. W. (1990) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-74778-6_4 · Cited by 8 · see citing works