The blockade of immune checkpoints in cancer immunotherapy
Pardoll, Drew M.·2012·Nature Reviews Cancer
DOI 10.1038/nrc3239
Cited by (1,122)
Items 101–200 of 1,122
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- Combination cancer immunotherapies tailored to the tumour microenvironmentSmyth, Mark J., Ngiow, Shin Foong, Ribas, Antoni, Teng, Michele W. L. · 2016 · Nature Reviews Clinical Oncology
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- Current Challenges in Cancer TreatmentJon Zugazagoitia, Cristiano Guedes, Santiago Ponce, Irene Ferrer, Sonia Molina‐Pinelo, Luis G Paz-Ares · 2016 · Clinical Therapeutics
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- Lactic acid promotes PD-1 expression in regulatory T cells in highly glycolytic tumor microenvironmentsKumagai, Shogo, Koyama, Shohei, Itahashi, Kota, Tanegashima, Tokiyoshi, Lin, Yi-tzu, Togashi, Yosuke, Kamada, Takahiro, Irie, Takuma, Okumura, Genki, Kono, Hidetoshi et al. · 2022 · Cancer Cell
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- IL-12 and IL-23 cytokines: from discovery to targeted therapies for immune-mediated inflammatory diseasesMichele W.L. Teng, Edward P. Bowman, Joshua J. McElwee, Mark John Smyth, Jean‐Laurent Casanova, Andrea May Cooper, Daniel J Cua · 2015 · Nature Medicine
- Breast Cancer Immunotherapy: Facts and HopesLeisha A. Emens · 2017 · Clinical Cancer Research
- Dendritic-Cell-Based Therapeutic Cancer VaccinesPalucka, Karolina, Banchereau, Jacques · 2013 · Immunity
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- Autosomal dominant immune dysregulation syndrome in humans with CTLA4 mutationsDesirée Schubert, Claudia Bode, Rupert Kenefeck, Tie Zheng Hou, James B. Wing, Alan Kennedy, Alla Bulashevska, Britt‐Sabina Petersen, Alejandro A. Schäffer, Björn Andreas Grüning et al. · 2014 · Nature Medicine
- Quantitative Assessment of the Heterogeneity of PD-L1 Expression in Non–Small-Cell Lung CancerJoseph Francis McLaughlin, Gang Han, Kurt Alex Schalper, Daniel Carvajal‐Hausdorf, Vasiliki Pelekanou, Jamaal Rehman, Vamsidhar Velcheti, Roy S. Herbst, Patricia Mucci LoRusso, David L. Rimm · 2015 · JAMA Oncology
- The Interplay of Immunotherapy and Chemotherapy: Harnessing Potential SynergiesLeisha A. Emens, Gary Middleton · 2015 · Cancer Immunology Research
- Treatment of renal cell carcinoma: Current status and future directionsPedro Coelho Barata, Brian I. Rini · 2017 · CA A Cancer Journal for Clinicians
- Pembrolizumab monotherapy for previously treated metastatic triple-negative breast cancer: cohort A of the phase II KEYNOTE-086 studyAdams, S., Schmid, P., Rugo, H.S., Winer, E.P., Loirat, D., Awada, A., Cescon, D.W., Iwata, H., Campone, M., Nanda, R. et al. · 2019 · Annals of Oncology
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- mRNA-based therapeutics: powerful and versatile tools to combat diseasesShugang Qin, Xiaoshan Tang, Yuting Chen, Kepan Chen, Na Fan, Wen Xiao, Qian Zheng, Guohong Li, Yuqin Teng, Min Wu et al. · 2022 · Signal Transduction and Targeted Therapy
- The burgeoning family of unconventional T cellsDale Ian Godfrey, Adam P. Uldrich, James McCluskey, Jamie Rossjohn, David Branch Moody · 2015 · Nature Immunology
- Neuroblastoma: developmental biology, cancer genomics and immunotherapyNai‐Kong V. Cheung, Michael A. Dyer · 2013 · Nature reviews. Cancer
- Therapeutic target database 2020: enriched resource for facilitating research and early development of targeted therapeuticsYunxia Wang, Song Zhang, Fengcheng Li, Ying Zhou, Ying Zhang, Zhengwen Wang, Runyuan Zhang, Jiang Zhu, Yuxiang Ren, Ying Ching Tan et al. · 2019 · Nucleic Acids Research
- Deubiquitination and Stabilization of PD-L1 by CSN5Lim, Seung-Oe, Li, Chia-Wei, Xia, Weiya, Cha, Jong-Ho, Chan, Li-Chuan, Wu, Yun, Chang, Shih-Shin, Lin, Wan-Chi, Hsu, Jung-Mao, Hsu, Yi-Hsin et al. · 2016 · Cancer Cell
- Enhanced Cancer Immunotherapy by Microneedle Patch-Assisted Delivery of Anti-PD1 AntibodyChao Wang, Yanqi Ye, Gabrielle M. Hochu, Hasan Sadeghifar, Zhen Gu · 2016 · Nano Letters
- The role of myeloid cells in cancer therapiesEngblom, Camilla, Pfirschke, Christina, Pittet, Mikael J. · 2016 · Nature Reviews Cancer
- PD-L1 expression in human cancers and its association with clinical outcomesYu, Jinming, Wang, Xin, Teng, Feifei, Kong, Li · 2016 · OncoTargets and Therapy
- Opportunities and challenges of radiotherapy for treating cancerSchaue, Dörthe, McBride, William H. · 2015 · Nature Reviews Clinical Oncology
- Single-cell analyses reveal key immune cell subsets associated with response to PD-L1 blockade in triple-negative breast cancerZhang, Yuanyuan, Chen, Hongyan, Mo, Hongnan, Hu, Xueda, Gao, Ranran, Zhao, Yahui, Liu, Baolin, Niu, Lijuan, Sun, Xiaoying, Yu, Xiao et al. · 2021 · Cancer Cell
- Therapeutic vaccines for cancer: an overview of clinical trialsIgnacio Melero, Gustav Gaudernack, Winald R. Gerritsen, Christoph Huber, Giorgio Parmiani, Suzy Scholl, Nicholas J. Thatcher, John Wagstaff, Christoph Carl Zielinski, Ian Faulkner et al. · 2014 · Nature Reviews Clinical Oncology
- Metformin Promotes Antitumor Immunity via Endoplasmic-Reticulum-Associated Degradation of PD-L1Jong‐Ho Cha, Wenhao Yang, Weiya Xia, Yongkun Wei, Li-Chuan Chan, Seung‐Oe Lim, Chia-Wei Li, Tae‐Wan Kim, Shih-Shin Chang, Heng‐Huan Lee et al. · 2018 · Molecular Cell
- CDK4/6 Inhibition Augments Antitumor Immunity by Enhancing T-cell ActivationDeng, Jiehui, Wang, Eric S., Jenkins, Russell W., Li, Shuai, Dries, Ruben, Yates, Kathleen, Chhabra, Sandeep, Huang, Wei, Liu, Hongye, Aref, Amir R. et al. · 2018 · Cancer Discovery
- Cell death-based treatment of lung adenocarcinomaDenisenko, Tatiana V., Budkevich, Inna N., Zhivotovsky, Boris · 2018 · Cell Death & Disease
- Disruption of CXCR2-Mediated MDSC Tumor Trafficking Enhances Anti-PD1 EfficacyHighfill, Steven L., Cui, Yongzhi, Giles, Amber J., Smith, Jillian P., Zhang, Hua, Morse, Elizabeth, Kaplan, Rosandra N., Mackall, Crystal L. · 2014 · Science Translational Medicine
- Durvalumab With or Without Tremelimumab for Patients With Metastatic Pancreatic Ductal Adenocarcinoma: A Phase 2 Randomized Clinical TrialO’Reilly, Eileen M., Oh, Do-Youn, Dhani, Neesha, Renouf, Daniel J., Lee, Myung Ah, Sun, Weijing, Fisher, George, Hezel, Aram, Chang, Shao-Chun, Vlahovic, Gordana et al. · 2019 · JAMA Oncology
- Regulation of PD-L1: a novel role of pro-survival signalling in cancer.Chen, J., Jiang, C.C., Jin, L., Zhang, X.D. · 2016 · Annals of Oncology
- Tumor-Derived Exosomes and Their Role in Cancer ProgressionTheresa L. Whiteside · 2016 · Advances in clinical chemistry
- Next generation antibody drugs: pursuit of the 'high-hanging fruit'Paul J. Carter, Greg A. Lazar · 2017 · Nature Reviews Drug Discovery
- Mechanisms of immunotherapy resistance: lessons from glioblastomaChristopher Mitchell Jackson, John Hyunkuk Choi, Michael K. Lim · 2019 · Nature Immunology
- Nivolumab with or without ipilimumab treatment for metastatic sarcoma (Alliance A091401): two open-label, non-comparative, randomised, phase 2 trialsD'Angelo, Sandra P, Mahoney, Michelle R, Van Tine, Brian A, Atkins, James, Milhem, Mohammed M, Jahagirdar, Balkrishna N, Antonescu, Cristina R, Horvath, Elise, Tap, William D, Schwartz, Gary K et al. · 2018 · The Lancet Oncology
- Core-shell nanoscale coordination polymers combine chemotherapy and photodynamic therapy to potentiate checkpoint blockade cancer immunotherapyChunbai He, Xiaopin Duan, Nining Guo, Christina Chan, Christopher J. Poon, Ralph R. Weichselbaum, Wenbin Lin · 2016 · Nature Communications
- In Vitro Tumor Models: Advantages, Disadvantages, Variables, and Selecting the Right PlatformKatt, Moriah E., Placone, Amanda L., Wong, Andrew D., Xu, Zinnia S., Searson, Peter C. · 2016 · Frontiers in Bioengineering and Biotechnology
- T cell anergy, exhaustion, senescence, and stemness in the tumor microenvironmentCrespo, Joel, Sun, Haoyu, Welling, Theodore H, Tian, Zhigang, Zou, Weiping · 2013 · Current Opinion in Immunology
- Adverse cardiac effects of cancer therapies: cardiotoxicity and arrhythmiaHerrmann, Joerg · 2020 · Nature Reviews Cardiology
- PD-1– and CTLA-4–Based Inhibitory Chimeric Antigen Receptors (iCARs) Divert Off-Target Immunotherapy ResponsesVictor D. Fedorov, Maria Themeli, Michel Sadelain · 2013 · Science Translational Medicine
- Precision Diagnosis and Treatment for Advanced Non–Small-Cell Lung CancerMartin Reck, Klaus Friedrich Rabe · 2017 · New England Journal of Medicine
- Building better monoclonal antibody-based therapeuticsGeorge J. Weiner · 2015 · Nature reviews. Cancer
- A microfluidic device for label-free, physical capture of circulating tumor cell clustersAli Fatih Sarioglu, Nicola Aceto, Nikola Kojić, Maria Donaldson Collier, Mahnaz Zeinali, Bashar M. Hamza, Amanda Engstrom, Huili Zhu, Tilak Kumar Sundaresan, David Tomoaki Miyamoto et al. · 2015 · Nature Methods
- MAP Kinase Inhibition Promotes T Cell and Anti-tumor Activity in Combination with PD-L1 Checkpoint Blockade.Ebert, Peter J.R., Cheung, Jeanne, Yang, Yagai, McNamara, Erin, Hong, Rebecca, Moskalenko, Marina, Gould, Stephen E., Maecker, Heather, Irving, Bryan A., Kim, Jeong M. et al. · 2016 · Immunity
- Wnt/beta-catenin pathway: modulating anticancer immune responseSachin Gopalkrishna Pai, Benedito A. Carneiro, José Maurício Mota, Ricardo Borges da Costa, Caio A. Leite, Romualdo Barroso‐Sousa, Jason Benjamin Kaplan, Young Kwang Chae, Francis Joseph Giles · 2017 · Journal of Hematology & Oncology
- Assessing Tumor-infiltrating Lymphocytes in Solid Tumors: A Practical Review for Pathologists and Proposal for a Standardized Method From the International Immunooncology Biomarkers Working Group: Part 1: Assessing the Host Immune Response, TILs in Invasive Breast Carcinoma and Ductal Carcinoma In Situ, Metastatic Tumor Deposits and Areas for Further ResearchShona A. Hendry, Roberto Salgado, Thomas Gevaert, Prudence Anne Russell, Tom John, Bibhusal Thapa, Michael Christie, Koen K Van de Vijver, Monica Valeria Estrada, Paula I. González Ericsson et al. · 2017 · Advances in Anatomic Pathology