Cited by 571Cancer Genomics and DiagnosticsCancer Cells and MetastasisLung Cancer Treatments and Mutations

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Precision medicine for cancer with next-generation functional diagnostics

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Friedman, Adam A., Letai, Anthony, Fisher, David E., Flaherty, Keith T.·2015·Nature Reviews Cancer

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Abstract

Precision medicine is about matching the right drugs to the right patients. Although this approach is technology agnostic, in cancer there is a tendency to make precision medicine synonymous with genomics. However, genome-based cancer therapeutic matching is limited by incomplete biological understanding of the relationship between phenotype and cancer genotype. This limitation can be addressed by functional testing of live patient tumour cells exposed to potential therapies. Recently, several 'next-generation' functional diagnostic technologies have been reported, including novel methods for tumour manipulation, molecularly precise assays of tumour responses and device-based in situ approaches; these address the limitations of the older generation of chemosensitivity tests. The promise of these new technologies suggests a future diagnostic strategy that integrates functional testing with next-generation sequencing and immunoprofiling to precisely match combination therapies to individual cancer patients.

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Authors: Friedman, A. A., Letai, A., Fisher, D. E., & Flaherty, K. T.
Affiliations: Harvard University (US)
Corresponding author: Friedman, Adam A.
ORCID: Friedman, Adam A.
Letai, Anthony
Fisher, David E.
Flaherty, Keith T.
Venue: Nature Reviews Cancer
Publisher: Springer Science and Business Media LLC
Published: 2015-11-05
Volume: 15
Issue: 12
Pages: 747-756
ISSN: 1474-175X (ISSN-L)
1474-1768
DOI: 10.1038/nrc4015
PMC: PMC4970460
OpenAlex: W2176372762
Cited by: 570
References: 108
Citations by year: 2026: 19 · 2025: 43 · 2024: 26 · 2023: 42 · 2022: 41 · 2021: 67 · 2020: 93 · 2019: 63 · 2018: 59 · 2017: 73 · 2016: 43
FWCI: 5.69
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Nature reviews. Cancer (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Cancer Institute (UM1CA186709, P01CA066996)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer Genomics and Diagnostics
Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Lung Cancer Treatments and Mutations
Keywords: precision oncology, functional diagnosis, chemosensitivity testing, genotype-phenotype correlation, next-generation sequencing, immune profiling, drug repurposing
MeSH terms: Humans, Neoplasms, Genomics, Molecular Diagnostic Techniques, Precision Medicine, High-Throughput Nucleotide Sequencing

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Precision medicine for cancer with next-generation functional diagnostics

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