Opportunities in somatostatin research: biological, chemical and therapeutic aspects

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Affinity profiles for human somatostatin receptor subtypes SST1–SST5 of somatostatin radiotracers selected for scintigraphic and radiotherapeutic use

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Somatostatin

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Octreotide

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Receptors for Dopamine and Somatostatin: Formation of Hetero-Oligomers with Enhanced Functional Activity

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The Role of Somatostatin and Its Analogs in the Diagnosis and Treatment of Tumors

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Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney.

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SOM230: a novel somatostatin peptidomimetic with broad somatotropin release inhibiting factor (SRIF) receptor binding and a unique antisecretory profile

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Somatostatin receptor sst1–sst5 expression in normal and neoplastic human tissues using receptor autoradiography with subtype-selective ligands

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Concomitant expression of several peptide receptors in neuroendocrine tumours: molecular basis for in vivo multireceptor tumour targeting

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G-Protein-coupled receptor oligomerization and its potential for drug discovery

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Somatostatin

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Subtypes of the Somatostatin Receptor Assemble as Functional Homo- and Heterodimers

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The Pathophysiological Consequences of Somatostatin Receptor Internalization and Resistance

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Rapid Identification of Subtype-Selective Agonists of the Somatostatin Receptor Through Combinatorial Chemistry

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A potent cyclic hexapeptide analogue of somatostatin

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A cortical neuropeptide with neuronal depressant and sleep-modulating properties

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Molecular pharmacology of somatostatin receptor subtypes

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Somatostatin receptor-targeted radionuclide therapy of tumors: Preclinical and clinical findings

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Peptide receptor imaging and therapy.

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Expression of somatostatin receptor types 1–5 in 81 cases of gastrointestinal and pancreatic endocrine tumors: A correlative immunohistochemical and reverse-transcriptase polymerase chain reaction analysis

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[111In-DTPA-D-Phe1]-octreotide, a potential radiopharmaceutical for imaging of somatostatin receptor-positive tumors: synthesis, radiolabeling and in vitro validation

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Homo- and Heterodimerization of Somatostatin Receptor Subtypes

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Somatostatin receptor subtype specificity in human fetal pituitary cultures. Differential role of SSTR2 and SSTR5 for growth hormone, thyroid-stimulating hormone, and prolactin regulation.

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Somatostatin Analogs in Acromegaly

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Treatment of hepatocellular carcinoma with octreotide: a randomised controlled study

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Cloned somatostatin receptors: identification of subtype-selective peptides and demonstration of high affinity binding of linear peptides.

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Primary Medical Therapy for Acromegaly: An Open, Prospective, Multicenter Study of the Effects of Subcutaneous and Intramuscular Slow-Release Octreotide on Growth Hormone, Insulin-Like Growth Factor-I, and Tumor Size

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Cancer chemotherapy based on targeting of cytotoxic peptide conjugates to their receptors on tumors

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The neurobiology of somatostatin.

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Heterodimerization of Somatostatin and Opioid Receptors Cross-modulates Phosphorylation, Internalization, and Desensitization

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Interrelationship between the Novel Peptide Ghrelin and Somatostatin/Growth Hormone-Releasing Hormone in Regulation of Pulsatile Growth Hormone Secretion

Tannenbaum, G. S., Epelbaum, J., & Bowers, C. Y. (2003) · Endocrinology · doi:10.1210/en.2002-220852 · Cited by 247

Safety and efficacy of long-term octreotide therapy of acromegaly: results of a multicenter trial in 103 patients--a clinical research center study.

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111In- and 90Y-DOTA-Lanreotide: Results and implications of the MAURITIUS trial

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86Y-DOTA0-d-Phe1-Tyr3-octreotide (SMT487)—a phase 1 clinical study: pharmacokinetics, biodistribution and renal protective effect of different regimens of amino acid co-infusion

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Regional Brain Concentrations of Neuropeptides in Huntington's Chorea and Schizophrenia

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Somatostatin analogs in the diagnosis and treatment of cancer

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Ghrelin Secretion in Humans Is Sexually Dimorphic, Suppressed by Somatostatin, and Not Affected by the Ambient Growth Hormone Levels

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Identification of somatostatin receptor subtypes 1, 2A, 3, and 5 in neuroendocrine tumours with subtype specific antibodies

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Receptor-mediated radiotherapy with 90Y-DOTA-D-Phe1-Tyr3-octreotide

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Putative pathophysiological role of growth factors and cytokines in experimental diabetic kidney disease

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Cortistatin: a member of the somatostatin neuropeptide family with distinct physiological functions

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High affinity binding sites for a somatostatin-28 analog in rat brain

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Neurotransmitter-Induced Inhibition of Exocytosis in Insulin-Secreting β Cells by Activation of Calcineurin

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Medical Therapy of Cushing's Disease

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A randomized placebo-controlled study of long-acting octreotide for the treatment of advanced hepatocellular carcinoma

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Insulin-like growth factor-1 (IGF-1) and growth hormone (GH) in immunity and inflammation

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Three Year Follow-Up of Acromegalic Patients Treated with Intramuscular Slow-Release Lanreotide1

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Somatostatin Inhibits Tumor Angiogenesis and Growth via Somatostatin Receptor-3-Mediated Regulation of Endothelial Nitric Oxide Synthase and Mitogen-Activated Protein Kinase Activities

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Somatostatin analogues suppress the inflammatory reaction in vivo.

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Results of a European Multicentre Study with Sandostatin® LAR® in Acromegalic Patients

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Identification and Characterization of a Novel Human Cortistatin-like Peptide

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SOM230: A New Somatostatin Peptidomimetic with Potent Inhibitory Effects on the Growth Hormone/Insulin-Like Growth Factor-I Axis in Rats, Primates, and Dogs

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Treatment of Neuroendocrine GEP Tumours with Somatostatin Analogues

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Identification and characterization of novel somatostatin antagonists.

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A Single-Dose Comparison of the Acute Effects between the New Somatostatin Analog SOM230 and Octreotide in Acromegalic Patients

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Brain somatostatin: a candidate inhibitory role in seizures and epileptogenesis

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Somatostatin Receptor-mediated Signaling in Smooth Muscle

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Somatostatin Receptor Subtype 5 Regulates Insulin Secretion and Glucose Homeostasis

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Synthesis and biological activities of potent peptidomimetics selective for somatostatin receptor subtype 2

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Binding properties of somatostatin receptor subtypes

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The clinical role of somatostatin analogues as antineoplastic agents: much ado about nothing?

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Induction of wild-type p53, Bax, and acidic endonuclease during somatostatin-signaled apoptosis in MCF-7 human breast cancer cells

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Carcinoid tumors: molecular genetics, tumor biology, and update of diagnosis and treatment

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SSTR2A is the dominant somatostatin receptor subtype expressed by inflammatory cells, is widely expressed and directly regulates T cell IFN-γ release

Elliott, D. E., Li, J., Blum, A. M., Metwali, A., Patel, Y., & Weinstock, J. V. (1999) · European Journal of Immunology · doi:10.1002/(sici)1521-4141(199908)29:08<2454::aid-immu2454>3.0.co;2-h · Cited by 121

Somatostatin inhibits exocytosis in rat pancreatic α‐cells by G i2 ‐dependent activation of calcineurin and depriming of secretory granules

Gromada, J., Høy, M., Buschard, K., Salehi, A., & Rorsman, P. (2001) · The Journal of Physiology · doi:10.1111/j.1469-7793.2001.00519.x · Cited by 120

Drug Design at Peptide Receptors

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Radiolabeled peptides in the diagnosis and therapy of oncological diseases

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Peptides as regulators of the immune system: emphasis on somatostatin

Krantic, S. M. (2000) · Peptides · doi:10.1016/s0196-9781(00)00347-8 · Cited by 118

Caspase-8-mediated Intracellular Acidification Precedes Mitochondrial Dysfunction in Somatostatin-induced Apoptosis

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The elucidation of somatostatin receptor functions: A current view

Meyerhof, W. (1998) · Reviews of physiology, biochemistry and pharmacology · doi:10.1007/bfb0000613 · Cited by 117

Somatostatin controls Kaposi's sarcoma tumor growth through inhibition of angiogenesis

Albini, A., Florio, T., Giunciuglio, D., Masiello, L., Carlone, S., Corsaro, A., Thellung, S., Cai, T., Noonan, D. M., & Schettini, G. (1999) · The FASEB Journal · doi:10.1096/fasebj.13.6.647 · Cited by 115

Intra-Islet Somatostatin Regulates Glucagon Release via Type 2 Somatostatin Receptors in Rats

Cejvan, K., Coy, D. H., & Efendic, S. (2003) · Diabetes · doi:10.2337/diabetes.52.5.1176 · Cited by 110

Vitreous levels of IGF-I, IGF binding protein 1, and IGF binding protein 3 in proliferative diabetic retinopathy: a case-control study.

Burgos, R., Mateo, C., Cantón, A., Hernández, C., Mesa, J., & Simó, R. (2000) · Diabetes Care · doi:10.2337/diacare.23.1.80 · Cited by 109

Modulation of Receptor and Receptor Subtype Affinities Using Diastereomeric and Enantiomeric Monosaccharide Scaffolds as a Means to Structural and Biological Diversity. A New Route to Ether Synthesis

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Inhibition of IGF-I and b-FGF stimulated growth of human retinal endothelial cells by the somatostatin analogue, octreotide: a potential treatment for ocular neovascularization

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Inhibition of Angiogenesis by Somatostatin and Somatostatin-like Compounds Is Structurally Dependent

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In Vivo and in Vitro Plasma Disappearance and Metabolism of Somatostatin-28 and Somatostatin-14 in the Rat*

Patel, Y., & Wheatley, T. A. (1983) · Endocrinology · doi:10.1210/endo-112-1-220 · Cited by 104

SST3-selective potent peptidic somatostatin receptor antagonists

Reubi, J. C., Schaer, J., Wenger, S., Hoeger, C. A., Érchegyi, J., Waser, B., & Rivier, J. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.250483897 · Cited by 100

New somatostatin analogs: will they fulfil old promises?

Lamberts, S., van der Lely, A., & Hofland, L. J. (2002) · European Journal of Endocrinology · doi:10.1530/eje.0.1460701 · Cited by 100

sst2 somatostatin receptor expression reverses tumorigenicity of human pancreatic cancer cells.

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Activation of Human Somatostatin Receptor 2 Promotes Apoptosis Through a Mechanism that is Independent from Induction of p53

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Growth Hormone and Diabetes mellitus

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Advances in understanding neuronal somatostatin receptors

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Experience with Indium-111 and Yttrium-90-Labeled Somatostatin Analogs

Virgolini, I. J., Traub‐Weidinger, T., Novotny, C., Leimer, M., Fueger, B. J., Li, S., Patri, P., Pangerl, T., Angelberger, P., Raderer, M., et al. (2002) · Current Pharmaceutical Design · doi:10.2174/1381612023393756 · Cited by 97

Somatostatin-28 regulates GLP-1 secretion via somatostatin receptor subtype 5 in rat intestinal cultures

Chisholm, C., & Greenberg, G. R. (2002) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00434.2001 · Cited by 96

Somatostatin: the neuroendocrine story

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A new peptidic somatostatin agonist with high affinity to all five somatostatin receptors

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