Human Fanconi anemia monoubiquitination pathway promotes homologous DNA repair

XRCC3 promotes homology-directed repair of DNA damage in mammalian cellsPreprint

Pierce, A. J., Johnson, R. D., Thompson, L. H., & Jasin, M. (1999) · Genes & Development · doi:10.1101/gad.13.20.2633 · Cited by 1,384 · see citing works

Brca1 Controls Homology-Directed DNA Repair

Moynahan, M. E., Chiu, J. W., Koller, B. H., & Jasin, M. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80202-6 · Cited by 1,245 · see citing works

Interaction of the Fanconi Anemia Proteins and BRCA1 in a Common Pathway

Garcia-Higuera, I., Taniguchi, T., Ganesan, S., Meyn, M. S., Timmers, C., Hejna, J., Grompe, M., & D'Andrea, A. D. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00173-3 · Cited by 1,198 · see citing works

Biallelic Inactivation of <i>BRCA2</i> in Fanconi Anemia

Howlett, N. G., Taniguchi, T., Olson, S., Cox, B., Waisfisz, Q., de Die-Smulders, C., Persky, N., Grompe, M., Joenje, H., Pals, G., et al. (2002) · Science · doi:10.1126/science.1073834 · Cited by 1,149 · see citing works

BRCA2 Is Required for Homology-Directed Repair of Chromosomal Breaks

Moynahan, M. E., Pierce, A. J., & Jasin, M. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00174-5 · Cited by 1,007 · see citing works

Molecular views of recombination proteins and their control

West, S. C. (2003) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1127 · Cited by 947 · see citing works

The Fanconi anaemia/BRCA pathway

D'Andrea, A. D., & Grompe, M. (2003) · Nature Reviews Cancer · doi:10.1038/nrc970 · Cited by 822 · see citing works

Saccharomyces Ku70, Mre11/Rad50, and RPA Proteins Regulate Adaptation to G2/M Arrest after DNA Damage

Lee, S. E., Moore, J. K., Holmes, A. M., Umezu, K., Kolodner, R. D., & Haber, J. E. (1998) · Cell · doi:10.1016/s0092-8674(00)81482-8 · Cited by 775 · see citing works

BRCA2 Function in DNA Binding and Recombination from a BRCA2-DSS1-ssDNA Structure

Yang, H., Jeffrey, P. D., Miller, J. J., Kinnucan, E., Sun, Y., Thomä, N. H., Zheng, N., Chen, P., Lee, W., & Pavletich, N. P. (2002) · Science · doi:10.1126/science.297.5588.1837 · Cited by 705 · see citing works

Homology-directed repair is a major double-strand break repair pathway in mammalian cells

Liang, F., Han, M., Romanienko, P. J., & Jasin, M. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.9.5172 · Cited by 649 · see citing works

In search of the tumour-suppressor functions of BRCA1 and BRCA2

Scully, R., & Livingston, D. M. (2000) · Nature · doi:10.1038/35044000 · Cited by 643 · see citing works

The emerging genetic and molecular basis of Fanconi anaemia

Joenje, H., & Patel, K. J. (2001) · Nature Reviews Genetics · doi:10.1038/35076590 · Cited by 566 · see citing works

Ku DNA end-binding protein modulates homologous repair of double-strand breaks in mammalian cellsPreprint

Pierce, A. J., Hu, P., Han, M., Ellis, N. A., & Jasin, M. (2001) · Genes & Development · doi:10.1101/gad.946401 · Cited by 514 · see citing works

Genetic Steps of Mammalian Homologous Repair with Distinct Mutagenic Consequences

Stark, J. M., Pierce, A. J., Oh, J., Pastink, A., & Jasin, M. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.21.9305-9316.2004 · Cited by 501 · see citing works

Convergence of the Fanconi Anemia and Ataxia Telangiectasia Signaling Pathways

Taniguchi, T., García-Higuera, I., Xu, B., Andreassen, P. R., Gregory, R. C., Kim, S., Lane, W. S., Kastan, M. B., & D’Andrea, A. D. (2002) · Cell · doi:10.1016/s0092-8674(02)00747-x · Cited by 447 · see citing works

Rad51 Recombinase and Recombination Mediators

Sung, P., Krejčí, L., Komen, S. V., & Sehorn, M. G. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.r300027200 · Cited by 446 · see citing works

Double-strand break repair by interchromosomal recombination: suppression of chromosomal translocationsPreprint

Richardson, C. A., Moynahan, M. E., & Jasin, M. (1998) · Genes & Development · doi:10.1101/gad.12.24.3831 · Cited by 442 · see citing works

Mutation in Brca2 stimulates error‐prone homology‐directed repair of DNA double‐strand breaks occurring between repeated sequences

Tutt, A. N. J., Bertwistle, D., Valentine, J., Gabriel, A., Swift, S., Ross, G., Griffin, C. S., Thacker, J., & Ashworth, A. (2001) · The EMBO Journal · doi:10.1093/emboj/20.17.4704 · Cited by 429 · see citing works

Genetic Requirements for the Single-Strand Annealing Pathway of Double-Strand Break Repair in Saccharomyces cerevisiae

Ivanov, E. L., Sugawara, N., Fishman‐Lobell, J., & Haber, J. E. (1996) · Genetics · doi:10.1093/genetics/142.3.693 · Cited by 390 · see citing works

Homology-directed dna repair, mitomycin-c resistance, and chromosome stability is restored with correction of a Brca1 mutation.

Moynahan, M. E., Cui, T. Y., & Jasin, M. (2001) · PubMed · Cited by 382 · see citing works

Homologous repair of DNA damage and tumorigenesis:the BRCA connection

Jasin, M. (2002) · Oncogene · doi:10.1038/sj.onc.1206176 · Cited by 356 · see citing works

Mammalian XRCC2 promotes the repair of DNA double-strand breaks by homologous recombination

Johnson, R. D., Liu, N., & Jasin, M. (1999) · Nature · doi:10.1038/43932 · Cited by 323 · see citing works

The Fanconi Anaemia Gene FANCC Promotes Homologous Recombination and Error-Prone DNA Repair

Niedźwiedź, W., Mosedale, G., Johnson, M. A., Ong, C. Y., Pace, P., & Patel, K. J. (2004) · Molecular Cell · doi:10.1016/j.molcel.2004.08.009 · Cited by 306 · see citing works

Structure of the single-strand annealing domain of human RAD52 protein

Singleton, M. R., Wentzell, L. M., Liu, Y., West, S. C., & Wigley, D. B. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.212449899 · Cited by 222 · see citing works

Fanconi anemia and DNA repair

Grompe, M. (2001) · Human Molecular Genetics · doi:10.1093/hmg/10.20.2253 · Cited by 181 · see citing works

Ku80-deficient Cells Exhibit Excess Degradation of Extrachromosomal DNA

Liang, F., & Jasin, M. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.24.14405 · Cited by 174 · see citing works

Mouse RAD54 Affects DNA Double-Strand Break Repair and Sister Chromatid Exchange

Dronkert, M. L. G., Beverloo, H. B., Johnson, R. D., Hoeijmakers, J. H. J., Jasin, M., & Kanaar, R. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.9.3147-3156.2000 · Cited by 174 · see citing works

Roles of BRCA1 in DNA damage repair: a link between development and cancer

Deng, C. (2003) · Human Molecular Genetics · doi:10.1093/hmg/ddg082 · Cited by 167 · see citing works

Fanconi Anemia FANCG Protein in Mitigating Radiation- and Enzyme-Induced DNA Double-Strand Breaks by Homologous Recombination in Vertebrate Cells

Yamamoto, K., Ishiai, M., Matsushita, N., Arakawa, H., Lamerdin, J. E., Buerstedde, J.-M., Tanimoto, M., Harada, M., Thompson, L. H., & Takata, M. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.15.5421-5430.2003 · Cited by 150 · see citing works

ATP Hydrolysis by Mammalian RAD51 Has a Key Role during Homology-directed DNA Repair

Stark, J. M., Hu, P., Pierce, A. J., Moynahan, M. E., Ellis, N. A., & Jasin, M. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m112132200 · Cited by 144 · see citing works

Extensive Loss of Heterozygosity Is Suppressed during Homologous Repair of Chromosomal Breaks

Stark, J. M., & Jasin, M. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.23.2.733-743.2003 · Cited by 122 · see citing works

Hypomutability in Fanconi anemia cells is associated with increased deletion frequency at the HPRT locus.

Papadopoulo, D., Guillouf, C., Mohrenweiser, H. W., & Moustacchi, E. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.21.8383 · Cited by 120 · see citing works

BARD1 Participates with BRCA1 in Homology-Directed Repair of Chromosome Breaks

Westermark, U., Reyngold, M., Olshen, A. B., Baer, R. J., Jasin, M., & Moynahan, M. E. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.21.7926-7936.2003 · Cited by 119 · see citing works

Cancer susceptibility of mice with a homozygous deletion in the COOH-terminal domain of the Brca2 gene.

McAllister, K. A., Bennett, L. M., Houle, C. D., Ward, T., Malphurs, J., Collins, N. K., Cachafeiro, C., Haseman, J., Goulding, E. H., Bunch, D. O., et al. (2002) · PubMed · Cited by 113 · see citing works

Impaired DNA damage-induced nuclear Rad51 foci formation uniquely characterizes Fanconi anemia group D1

Godthelp, B. C., Artwert, F., Joenje, H., & Zdzienicka, M. Z. (2002) · Oncogene · doi:10.1038/sj.onc.1205656 · Cited by 100 · see citing works

Deletion of Brca2 exon 27 causes hypersensitivity to DNA crosslinks, chromosomal instability, and reduced life span in mice

Donoho, G. P., Brenneman, M. A., Cui, T. X., Donoviel, D. B., Vogel, H. S., Goodwin, E. H., Chen, D. J., & Hasty, P. (2003) · Genes Chromosomes and Cancer · doi:10.1002/gcc.10148 · Cited by 97 · see citing works

Attenuation of the formation of DNA-repair foci containing RAD51 in Fanconi anaemia

Digweed, M. (2002) · Carcinogenesis · doi:10.1093/carcin/23.7.1121 · Cited by 87 · see citing works

Fanconi anemia C gene product plays a role in the fidelity of blunt DNA end-joining

Escarceller, M., Buchwald, M., Singleton, B. K., Jeggo, P. A., Jackson, S. P., Moustacchi, E., & Papadopoulo, D. (1998) · Journal of Molecular Biology · doi:10.1006/jmbi.1998.1784 · Cited by 82 · see citing works

Frequencies of HPRT− lymphocytes and glycophorin A variants erythrocytes in Fanconi anemia patients, their parents and control donors

Sala-Trepat, M., Boyse, J., Richard, P., Papadopoulo, D., & Moustacchi, E. (1993) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/0027-5107(93)90137-5 · Cited by 48 · see citing works

A DNA Double Strand Break Repair Defect in Fanconi Anemia Fibroblasts

Donahue, S. L., & Campbell, C. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m207937200 · Cited by 43 · see citing works

Deficient Regulation of DNA Double-strand Break Repair in Fanconi Anemia Fibroblasts

Donahue, S. L., Lundberg, R., Saplis, R., & Campbell, C. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m213251200 · Cited by 32 · see citing works

Immortalization of four new fanconi anemia fibroblast cell lines by an improved procedure

Jakobs, P. M., Sahaayaruban, P., Saito, H., Reifsteck, C. A., Olson, S. B., Joenje, H., Moses, R. E., & Grompe, M. (1996) · Somatic Cell and Molecular Genetics · doi:10.1007/bf02369905 · Cited by 32 · see citing works

53BP1 Inhibits Homologous Recombination in Brca1-Deficient Cells by Blocking Resection of DNA Breaks

Bunting, S. F., Callén, E., Wong, N., Chen, H.-T., Polato, F., Gunn, A., Bothmer, A., Feldhahn, N., Fernandez-Capetillo, O., Cao, L., et al. (2010) · Cell · doi:10.1016/j.cell.2010.03.012 · Cited by 1,671 · see citing works

Double-Strand Break End Resection and Repair Pathway Choice

Symington, L. S., & Gautier, J. (2011) · Annual Review of Genetics · doi:10.1146/annurev-genet-110410-132435 · Cited by 1,481 · see citing works

Deficiency in the Repair of DNA Damage by Homologous Recombination and Sensitivity to Poly(ADP-Ribose) Polymerase Inhibition

McCabe, N., Turner, N. C., Lord, C. J., Kluzek, K., Białkowska, A., Swift, S., Giavara, S., O’Connor, M. J., Tutt, A. N. J., Zdzienicka, M. Z., et al. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-0140 · Cited by 1,311 · see citing works

Mitotic homologous recombination maintains genomic stability and suppresses tumorigenesis

Moynahan, M. E., & Jasin, M. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2851 · Cited by 923 · see citing works

Homologous Recombination and Human Health: The Roles of BRCA1, BRCA2, and Associated Proteins

Prakash, R., Zhang, Y., Feng, W., & Jasin, M. (2015) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a016600 · Cited by 869 · see citing works

Homologous-recombination-deficient tumours are dependent on Polθ-mediated repair

Ceccaldi, R., Liu, J., Amunugama, R., Hajdú, I., Primack, B., Petalcorin, M. I. R., O’Connor, K. W., Konstantinopoulos, P. A., Elledge, S. J., Boulton, S. J., et al. (2015) · Nature · doi:10.1038/nature14184 · Cited by 914 · see citing works

Control of BRCA2 Cellular and Clinical Functions by a Nuclear Partner, PALB2

Xia, B., Sheng, Q., Nakanishi, K., Ohashi, A., Wu, J., Christ, N., Liu, X., Jasin, M., Couch, F. J., & Livingston, D. M. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.05.022 · Cited by 861 · see citing works

Abraxas and RAP80 Form a BRCA1 Protein Complex Required for the DNA Damage Response

Wang, B., Matsuoka, S., Ballif, B. A., Zhang, D., Smogorzewska, A., Gygi, S. P., & Elledge, S. J. (2007) · Science · doi:10.1126/science.1139476 · Cited by 695 · see citing works

Identification of the FANCI Protein, a Monoubiquitinated FANCD2 Paralog Required for DNA Repair

Smogorzewska, A., Matsuoka, S., Vinciguerra, P., McDonald, E. R., Hurov, K. E., Luo, J., Ballif, B. A., Gygi, S. P., Hofmann, K., D’Andrea, A. D., et al. (2007) · Cell · doi:10.1016/j.cell.2007.03.009 · Cited by 695 · see citing works

Emergence of a DNA-damage response network consisting of Fanconi anaemia and BRCA proteins

Wang, W. (2007) · Nature Reviews Genetics · doi:10.1038/nrg2159 · Cited by 663 · see citing works

How the Fanconi Anemia Pathway Guards the Genome

Moldovan, G., & D’Andrea, A. D. (2009) · Annual Review of Genetics · doi:10.1146/annurev-genet-102108-134222 · Cited by 586 · see citing works

2-Hydroxyglutarate produced by neomorphic IDH mutations suppresses homologous recombination and induces PARP inhibitor sensitivity

Sulkowski, P. L., Corso, C. D., Robinson, N. D., Scanlon, S. E., Purshouse, K. R., Bai, H., Liu, Y., Sundaram, R. K., Hegan, D. C., Fons, N. R., et al. (2017) · Science Translational Medicine · doi:10.1126/scitranslmed.aal2463 · Cited by 556 · see citing works

Regulation of DNA cross-link repair by the Fanconi anemia/BRCA pathwayPreprint

Kim, H., & D’Andrea, A. D. (2012) · Genes & Development · doi:10.1101/gad.195248.112 · Cited by 510 · see citing works

The Fanconi Anemia/BRCA pathway: new faces in the crowdPreprint

Kennedy, R. D., & D’Andrea, A. D. (2005) · Genes & Development · doi:10.1101/gad.1370505 · Cited by 464 · see citing works

miR-182-Mediated Downregulation of BRCA1 Impacts DNA Repair and Sensitivity to PARP Inhibitors

Moskwa, P., Buffa, F. M., Pan, Y., Panchakshari, R. A., Gottipati, P., Muschel, R. J., Beech, J. S., Kulshrestha, R., Abdelmohsen, K., Weinstock, D. M., et al. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.12.005 · Cited by 428 · see citing works

Human DNA repair genes, 2005

Wood, R. D., Mitchell, M., & Lindahl, T. L. (2005) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2005.03.007 · Cited by 424 · see citing works

BRCA1–BARD1 promotes RAD51-mediated homologous DNA pairing

Zhao, W., Steinfeld, J. B., Liang, F., Chen, X., Maranon, D. G., Jian Ma, C., Kwon, Y., Rao, T., Wang, W., Sheng, C., et al. (2017) · Nature · doi:10.1038/nature24060 · Cited by 393 · see citing works

Advances in genome editing through control of DNA repair pathways

Yeh, C. D., Richardson, C. D., & Corn, J. E. (2019) · Nature Cell Biology · doi:10.1038/s41556-019-0425-z · Cited by 405 · see citing works

BACH1 is critical for homologous recombination and appears to be the Fanconi anemia gene product FANCJ

Litman, R., Peng, M., Jin, Z., Zhang, F., Zhang, J., Powell, S., Andreassen, P. R., & Cantor, S. B. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.08.004 · Cited by 396 · see citing works

Molecular pathogenesis of Fanconi anemia: recent progress

Taniguchi, T., & D’Andrea, A. D. (2006) · Blood · doi:10.1182/blood-2005-10-4240 · Cited by 387 · see citing works

I-SceI-Based Assays to Examine Distinct Repair Outcomes of Mammalian Chromosomal Double Strand Breaks

Gunn, A., & Stark, J. M. (2012) · Methods in molecular biology · doi:10.1007/978-1-61779-998-3_27 · Cited by 363 · see citing works

Collaboration and competition between DNA double‐strand break repair pathways

Kass, E. M., & Jasin, M. (2010) · FEBS Letters · doi:10.1016/j.febslet.2010.07.057 · Cited by 326 · see citing works

Homology-Directed Repair and the Role of BRCA1, BRCA2, and Related Proteins in Genome Integrity and Cancer

Chen, C.-C., Feng, W., Lim, P. X., Kass, E. M., & Jasin, M. (2017) · Annual Review of Cancer Biology · doi:10.1146/annurev-cancerbio-030617-050502 · Cited by 313 · see citing works

Identification of KIAA1018/FAN1, a DNA Repair Nuclease Recruited to DNA Damage by Monoubiquitinated FANCD2

MacKay, C., Déclais, A., Lundin, C., Agostinho, A., Deans, A. J., Macartney, T., Hofmann, K., Gartner, A., West, S. C., Helleday, T., et al. (2010) · Cell · doi:10.1016/j.cell.2010.06.021 · Cited by 311 · see citing works

Expanded roles of the Fanconi anemia pathway in preserving genomic stabilityPreprint

Kee, Y., & D’Andrea, A. D. (2010) · Genes & Development · doi:10.1101/gad.1955310 · Cited by 309 · see citing works

PALB2 Functionally Connects the Breast Cancer Susceptibility Proteins BRCA1 and BRCA2

Zhang, F., Fan, Q., Ren, K., & Andreassen, P. R. (2009) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-09-0123 · Cited by 303 · see citing works

DNA Strand Break Repair and Human Genetic Disease

McKinnon, P. J., & Caldecott, K. W. (2007) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev.genom.7.080505.115648 · Cited by 303 · see citing works

Polyubiquitination of proliferating cell nuclear antigen by HLTF and SHPRH prevents genomic instability from stalled replication forks.

Motegi, A., Liaw, H.-J., Lee, K.-Y., Roest, H. P., Maas, A., Wu, X., Moinova, H., Markowitz, S. D., Ding, H., Hoeijmakers, J. H. J., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0805685105 · Cited by 304 · see citing works

Preventing Nonhomologous End Joining Suppresses DNA Repair Defects of Fanconi Anemia

Adamo, A., Collis, S. J., Adelman, C. A., Silva, N., Hořejšı́, Z., Ward, J. D., Martínez-Pérez, E., Boulton, S. J., & Volpe, A. L. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.06.026 · Cited by 297 · see citing works

DNA Damage Induced by Alkylating Agents and Repair Pathways

Kondo, N., Takahashi, A., Ono, K., & Ohnishi, T. (2010) · Journal of Nucleic Acids · doi:10.4061/2010/543531 · Cited by 299 · see citing works

Cellular functions of the BRCA tumour-suppressor proteins

Boulton, S. J. (2006) · Biochemical Society Transactions · doi:10.1042/bst0340633 · Cited by 292 · see citing works

Fanconi Anemia (Cross)linked to DNA Repair

Niedernhofer, L. J., Lalai, A. S., & Hoeijmakers, J. H. J. (2005) · Cell · doi:10.1016/j.cell.2005.12.009 · Cited by 290 · see citing works

FANCI is a second monoubiquitinated member of the Fanconi anemia pathway

Sims, A. E., Spiteri, E., Sims, R. J., Arita, A., Lach, F. P., Landers, T., Wurm, M., Freund, M., Neveling, K., Hanenberg, H., et al. (2007) · Nature Structural & Molecular Biology · doi:10.1038/nsmb1252 · Cited by 275 · see citing works

BMI1 Is Recruited to DNA Breaks and Contributes to DNA Damage-Induced H2A Ubiquitination and Repair

Ginjala, V., Nacerddine, K., Kulkarni, A., Oza, J. H., Hill, S. J., Yao, M., Citterio, E., van Lohuizen, M., & Ganesan, S. (2011) · Molecular and Cellular Biology · doi:10.1128/mcb.00981-10 · Cited by 254 · see citing works

Inactivation of Murine Usp1 Results in Genomic Instability and a Fanconi Anemia Phenotype

Kim, J. M., Parmar, K., Huang, M., Weinstock, D. M., Ruit, C. A., Kutok, J. L., & D’Andrea, A. D. (2009) · Developmental Cell · doi:10.1016/j.devcel.2009.01.001 · Cited by 246 · see citing works

CRISPR–Cas9 genome editing in human cells occurs via the Fanconi anemia pathway

Richardson, C. D., Kazane, K. R., Feng, S. J., Zelin, E., Bray, N. L., Schäfer, A. J., Floor, S. N., & Corn, J. E. (2018) · Nature Genetics · doi:10.1038/s41588-018-0174-0 · Cited by 249 · see citing works

Mechanism of RAD51-Dependent DNA Interstrand Cross-Link Repair

Long, D. T., Räschle, M., Joukov, V., & Walter, J. C. (2011) · Science · doi:10.1126/science.1204258 · Cited by 238 · see citing works

RAP80-directed tuning of BRCA1 homologous recombination function at ionizing radiation-induced nuclear fociPreprint

Hu, Y., Scully, R., Sobhian, B., Xie, A., Shestakova, E. A., & Livingston, D. M. (2011) · Genes & Development · doi:10.1101/gad.2011011 · Cited by 232 · see citing works

Inhibition of Homologous Recombination by the PCNA-Interacting Protein PARI

Moldovan, G., Dejsuphong, D., Petalcorin, M. I. R., Hofmann, K., Takeda, S., Boulton, S. J., & D’Andrea, A. D. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.11.010 · Cited by 232 · see citing works

53BP1 fosters fidelity of homology-directed DNA repair

Ochs, F., Somyajit, K., Altmeyer, M., Rask, M., Lukas, J., & Lukas, C. (2016) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.3251 · Cited by 219 · see citing works

Local generation of fumarate promotes DNA repair through inhibition of histone H3 demethylation

Jiang, Y., Qian, X., Shen, J., Wang, Y., Li, X., Liu, R., Xia, Y., Chen, Q., Peng, G., Lin, S.-Y., et al. (2015) · Nature Cell Biology · doi:10.1038/ncb3209 · Cited by 208 · see citing works

Interplay between Fanconi anemia and homologous recombination pathways in genome integrity

Michl, J., Zimmer, J., & Tarsounas, M. (2016) · The EMBO Journal · doi:10.15252/embj.201693860 · Cited by 204 · see citing works

FANCD2 Maintains Fork Stability in BRCA1/2-Deficient Tumors and Promotes Alternative End-Joining DNA Repair

Kais, Z., Rondinelli, B., Holmes, A. L., O’Leary, C., Kozono, D., D’Andrea, A. D., & Ceccaldi, R. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.05.031 · Cited by 198 · see citing works

The vertebrate Hef ortholog is a component of the Fanconi anemia tumor-suppressor pathway

Mosedale, G., Niedźwiedź, W., Alpi, A. F., Perrina, F., Pereira‐Leal, J. B., Johnson, M. A., Langevin, F., Pace, P., & Patel, K. J. (2005) · Nature Structural & Molecular Biology · doi:10.1038/nsmb981 · Cited by 191 · see citing works

Roles of ATP binding and ATP hydrolysis in human Rad51 recombinase function

Chi, P., Komen, S. V., Sehorn, M. G., Sigurðsson, S., & Sung, P. (2006) · DNA repair · doi:10.1016/j.dnarep.2005.11.005 · Cited by 187 · see citing works

DNA damage response – A double-edged sword in cancer prevention and cancer therapy

Tian, H., Gao, Z., Li, H., Zhang, B., Wang, G., Zhang, Q., Pei, D., & Zheng, J. (2014) · Cancer Letters · doi:10.1016/j.canlet.2014.12.038 · Cited by 186 · see citing works

BRIT1/MCPH1 links chromatin remodelling to DNA damage response

Peng, G., Yim, E.-K., Dai, H., Jackson, A. P., van der Burgt, I., Pan, M., Hu, R., Li, K., & Lin, S. (2009) · Nature Cell Biology · doi:10.1038/ncb1895 · Cited by 186 · see citing works

Myelodysplasia and leukemia of Fanconi anemia are associated with a specific pattern of genomic abnormalities that includes cryptic RUNX1/AML1 lesions

Quentin, S., Cuccuini, W., Ceccaldi, R., Nibourel, O., Pondarré, C., Pagès, M., Vasquez, N., d’Enghien, C. D., Larghero, J., de Latour, R. P., et al. (2011) · Blood · doi:10.1182/blood-2010-09-308726 · Cited by 185 · see citing works

Promotion of BRCA2-Dependent Homologous Recombination by DSS1 via RPA Targeting and DNA Mimicry

Zhao, W., Vaithiyalingam, S., San Filippo, J., Maranon, D. G., Jimenez-Sainz, J., Fontenay, G. V., Kwon, Y., Leung, S. G., Lu, L., Jensen, R. B., et al. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.05.032 · Cited by 177 · see citing works

Small Interfering RNA Screens Reveal Enhanced Cisplatin Cytotoxicity in Tumor Cells Having both BRCA Network and TP53 Disruptions

Bartz, S. R., Zhang, Z., Burchard, J., Imakura, M., Martin, M. M., Palmieri, A., Needham, R. H. V., Guo, J., Gordon, M. L., Chung, N., et al. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.01229-06 · Cited by 177 · see citing works

The Ubiquitin-Interacting Motif–Containing Protein RAP80 Interacts with BRCA1 and Functions in DNA Damage Repair Response

Yan, J., Kim, Y. S., Yang, X.-P., Li, L., Liao, G., Xia, F., & Jetten, A. M. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-0924 · Cited by 170 · see citing works

Targeting the DNA repair defect of BRCA tumours

Turner, N. C., Tutt, A. N. J., & Ashworth, A. (2005) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2005.03.006 · Cited by 162 · see citing works

Assaying Double‐Strand Break Repair Pathway Choice in Mammalian Cells Using a Targeted Endonuclease or the RAG Recombinase

Weinstock, D. M., Nakanishi, K., Helgadottir, H. R., & Jasin, M. (2006) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(05)09031-2 · Cited by 163 · see citing works

Bortezomib-induced “BRCAness” sensitizes multiple myeloma cells to PARP inhibitors

Neri, P. E., Ren, L., Gratton, K., Stebner, E., Johnson, J., Klimowicz, A. C., Duggan, P. R., Tassone, P., Mansoor, A., Stewart, D. A., et al. (2011) · Blood · doi:10.1182/blood-2011-06-363911 · Cited by 157 · see citing works

BRCA2 suppresses replication stress-induced mitotic and G1 abnormalities through homologous recombination

Feng, W., & Jasin, M. (2017) · Nature Communications · doi:10.1038/s41467-017-00634-0 · Cited by 155 · see citing works

Cellular and molecular consequences of defective Fanconi anemia proteins in replication-coupled DNA repair: Mechanistic insights

Thompson, L. H., & Hinz, J. M. (2009) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2009.02.003 · Cited by 154 · see citing works

Histone H4 deacetylation facilitates 53BP1 DNA damage signaling and double-strand break repair

Hsiao, K., & Mizzen, C. A. (2013) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjs066 · Cited by 152 · see citing works

Genotype–phenotype correlations in Fanconi anemia

Neveling, K., Endt, D., Hoehn, H., & Schindler, D. (2009) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2009.05.006 · Cited by 144 · see citing works

DNA Damage Response Factors from Diverse Pathways, Including DNA Crosslink Repair, Mediate Alternative End Joining

Howard, S. M., Yanez, D. A., & Stark, J. M. (2015) · PLoS Genetics · doi:10.1371/journal.pgen.1004943 · Cited by 145 · see citing works

Ovarian carcinoma CDK12 mutations misregulate expression of DNA repair genes via deficient formation and function of the Cdk12/CycK complex

Ekumi, K. M., Paculová, H., Lenasi, T., Pospíchalová, V., Bösken, C. A., Rybaříková, J., Bryja, V., Geyer, M., Blažek, D., & Barborič, M. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv101 · Cited by 145 · see citing works

A FancD2-Monoubiquitin Fusion Reveals Hidden Functions of Fanconi Anemia Core Complex in DNA Repair

Matsushita, N., Kitao, H., Ishiai, M., Nagashima, N., Hirano, S., Okawa, K., Ohta, T., Yu, D. S., McHugh, P. J., Hickson, I. D., et al. (2005) · Molecular Cell · doi:10.1016/j.molcel.2005.08.018 · Cited by 138 · see citing works

Hypomorphic Mutations in the Gene Encoding a Key Fanconi Anemia Protein, FANCD2, Sustain a Significant Group of FA-D2 Patients with Severe Phenotype

Kalb, R., Neveling, K., Hoehn, H., Schneider, H., Linka, Y., Batish, S. D., Hunt, C., Berwick, M., Callén, E., Surrallés, J., et al. (2007) · The American Journal of Human Genetics · doi:10.1086/517616 · Cited by 139 · see citing works

Breast cancer-associated missense mutants of the PALB2 WD40 domain, which directly binds RAD51C, RAD51 and BRCA2, disrupt DNA repair

Park, J.-Y., Singh, T. R., Nassar, N., Zhang, F., Freund, M., Hanenberg, H., Meetei, A. R., & Andreassen, P. R. (2014) · Oncogene · doi:10.1038/onc.2013.421 · Cited by 130 · see citing works

BRCA1 and HSP90 cooperate in homologous and non-homologous DNA double-strand-break repair and G2/M checkpoint activation

Stecklein, S. R., Kumaraswamy, E., Behbod, F., Wang, W., Chaguturu, V., Harlan-Williams, L. M., & Jensen, R. A. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1203326109 · Cited by 135 · see citing works

Skp2 E3 Ligase Integrates ATM Activation and Homologous Recombination Repair by Ubiquitinating NBS1

Wu, J., Zhang, X., Zhang, L., Wu, C., Rezaeian, A. H., Chan, C., Li, J.-M., Wang, J., Gao, Y., Han, F., et al. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.02.018 · Cited by 130 · see citing works

Histone H2AX and Fanconi anemia FANCD2 function in the same pathway to maintain chromosome stability

Bogliolo, M., Lyakhovich, A., Callén, E., Castellà, M., Cappelli, E., Ramı́rez, M. J., Creus, A., Marcos, R., Kalb, R., Neveling, K., et al. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601574 · Cited by 128 · see citing works

Phosphorylation of FANCD2 on Two Novel Sites Is Required for Mitomycin C Resistance

Ho, G. P. H., Margossian, S. P., Taniguchi, T., & D’Andrea, A. D. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.02018-05 · Cited by 118 · see citing works

Fanconi anemia and DNA replication repair

PATEL, K., & Joenje, H. (2007) · DNA repair · doi:10.1016/j.dnarep.2007.02.002 · Cited by 114 · see citing works

Regulation of the Fanconi anemia pathway by a SUMO-like delivery networkPreprint

Yang, K., Moldovan, G., Vinciguerra, P., Murai, J., Takeda, S., & D’Andrea, A. D. (2011) · Genes & Development · doi:10.1101/gad.17020911 · Cited by 114 · see citing works

Akt-mediated phosphorylation of Bmi1 modulates its oncogenic potential, E3 ligase activity, and DNA damage repair activity in mouse prostate cancer

Nacerddine, K., Beaudry, J., Ginjala, V., Westerman, B. A., Mattiroli, F., Song, J., van der Poel, H. G., Balagué, O., Pritchard, C. E. J., Cornelissen‐Steijger, P., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci57477 · Cited by 113 · see citing works

Hsp90: A New Player in DNA Repair?

Pennisi, R., Ascenzi, P., & Di Masi, A. (2015) · Biomolecules · doi:10.3390/biom5042589 · Cited by 112 · see citing works

The FANCM family of DNA helicases/translocases

Whitby, M. C. (2010) · DNA repair · doi:10.1016/j.dnarep.2009.12.012 · Cited by 109 · see citing works

Timed inhibition of CDC7 increases CRISPR-Cas9 mediated templated repair

Wienert, B., Nguyen, D. N., Guenther, A., Feng, S. J., Locke, M. N., Wyman, S. K., Shin, J. J., Kazane, K. R., Gregory, G. L., Carter, M., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-15845-1 · Cited by 101 · see citing works

The Fanconi Anemia Pathway of Genomic Maintenance

Levitus, M., Joenje, H., & de Winter, J. P. (2006) · Analytical Cellular Pathology · doi:10.1155/2006/974975 · Cited by 106 · see citing works

Functional and mutational landscapes of BRCA1 for homology-directed repair and therapy resistance

Anantha, R. W., Simhadri, S. R., Foo, T. K., Miao, S. Y., Liu, J., Shen, Z., Ganesan, S., & Xia, B. (2017) · eLife · doi:10.7554/elife.21350 · Cited by 104 · see citing works

DNA Polymerase POLN Participates in Cross-Link Repair and Homologous Recombination

Moldovan, G., Madhavan, M. V., Mirchandani, K. D., McCaffrey, R. M., Vinciguerra, P., & D’Andrea, A. D. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.01124-09 · Cited by 103 · see citing works

The Tumor Suppressor PALB2: Inside Out

Ducy, M., Sesma-Sanz, L., Guitton-Sert, L., Lashgari, A., Gao, Y., Brahiti, N., Rodrigue, A., Margaillan, G., Caron, M., Côté, J., et al. (2019) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2018.10.008 · Cited by 101 · see citing works

Chemistry and Biology of Acylfulvenes: Sesquiterpene-Derived Antitumor Agents

Tanasova, M., & Sturla, S. J. (2012) · Chemical Reviews · doi:10.1021/cr2001367 · Cited by 101 · see citing works

DNA2 and EXO1 in replication-coupled, homology-directed repair and in the interplay between HDR and the FA/BRCA network

Karanja, K. K., Cox, S. W., Duxin, J. P., Stewart, S. A., & Campbell, J. L. (2012) · Cell Cycle · doi:10.4161/cc.22215 · Cited by 98 · see citing works

DNA double-strand breaks: Their production, recognition, and repair in eukaryotes

Ohnishi, T., Mori, E., & Takahashi, A. (2009) · Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis · doi:10.1016/j.mrfmmm.2009.06.010 · Cited by 98 · see citing works

Differential Usage of Alternative Pathways of Double-Strand Break Repair in Drosophila

Preston, C. R., Flores, C. C., & Engels, W. R. (2005) · Genetics · doi:10.1534/genetics.105.050138 · Cited by 96 · see citing works

Reduced Proficiency in Homologous Recombination Underlies the High Sensitivity of Embryonal Carcinoma Testicular Germ Cell Tumors to Cisplatin and Poly (ADP-Ribose) Polymerase Inhibition

Cavallo, F., Graziani, G., Antinozzi, C., Feldman, D. R., Houldsworth, J., Bosl, G. J., Chaganti, R. S. K., Moynahan, M. E., Jasin, M., & Barchi, M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0051563 · Cited by 98 · see citing works

Disruption of Runx1 and Runx3 Leads to Bone Marrow Failure and Leukemia Predisposition due to Transcriptional and DNA Repair Defects

Wang, C. Q., Krishnan, V., Tay, L. S., Chin, D. W. L., Koh, C. P., Chooi, J.-Y., Nah, G. S. S., Du, L., Jacob, B., Yamashita, N., et al. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.06.046 · Cited by 95 · see citing works

Suppression of the DNA repair defects of BRCA2-deficient cells with heterologous protein fusions

Saeki, H., Siaud, N., Christ, N., Wiegant, W. W., van Buul, P. P. W., Han, M., Zdzienicka, M. Z., Stark, J. M., & Jasin, M. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0600298103 · Cited by 95 · see citing works

Fanconi Anemia Proteins Are Required To Prevent Accumulation of Replication-Associated DNA Double-Strand Breaks

Sobeck, A., Stone, S., Costanzo, V., de Graaf, B., Reuter, T., de Winter, J. P., Wallisch, M., Akkari, Y. M. N., Olson, S. B., Wang, W., et al. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.26.2.425-437.2006 · Cited by 92 · see citing works

The Human Papillomavirus Type 16 E7 Oncoprotein Activates the Fanconi Anemia (FA) Pathway and Causes Accelerated Chromosomal Instability in FA Cells

Spardy, N. A., Duensing, A. U., Charles, D., Haines, N., Nakahara, T., Lambert, P. F., & Duensing, S. M. (2007) · Journal of Virology · doi:10.1128/jvi.01121-07 · Cited by 93 · see citing works

FANCG promotes formation of a newly identified protein complex containing BRCA2, FANCD2 and XRCC3

Wilson, J. B., Yamamoto, K., Marriott, A. S., Hussain, S., Sung, P., Hoatlin, M. E., Mathew, C. G., Takata, M., Thompson, L., Kupfer, G. M., et al. (2008) · Oncogene · doi:10.1038/sj.onc.1211034 · Cited by 91 · see citing works

Cooperation of the ATM and Fanconi Anemia/BRCA Pathways in Double-Strand Break End Resection

Cai, M., Dunn, C. E., Chen, W., Kochupurakkal, B. S., Nguyen, H. Q., Moreau, L. A., Shapiro, G. I., Parmar, K., Kozono, D., & D’Andrea, A. D. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.01.052 · Cited by 87 · see citing works

The Fanconi anemia core complex is required for efficient point mutagenesis and Rev1 foci assembly

Mirchandani, K. D., McCaffrey, R. M., & D’Andrea, A. D. (2008) · DNA repair · doi:10.1016/j.dnarep.2008.03.001 · Cited by 88 · see citing works

Histone Deacetylases 9 and 10 Are Required for Homologous Recombination

Kotian, S., Liyanarachchi, S., Zelent, A., & Parvin, J. D. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.c110.194233 · Cited by 88 · see citing works

The Fanconi anemia (FA) pathway confers glioma resistance to DNA alkylating agents

Chen, C. C., Taniguchi, T., & D’Andrea, A. D. (2007) · Journal of Molecular Medicine · doi:10.1007/s00109-006-0153-2 · Cited by 87 · see citing works

FANCA Promotes DNA Double-Strand Break Repair by Catalyzing Single-Strand Annealing and Strand Exchange

Benitez, A., Liu, W., Palovcak, A., Wang, G., Moon, J., An, K., Kim, A., Zheng, K., Zhang, Y., Bai, F., et al. (2018) · Molecular Cell · doi:10.1016/j.molcel.2018.06.030 · Cited by 83 · see citing works

Epstein-Barr Virus BPLF1 Deubiquitinates PCNA and Attenuates Polymerase η Recruitment to DNA Damage Sites

Whitehurst, C. B., Vaziri, C., Shackelford, J., & Pagano, J. S. (2012) · Journal of Virology · doi:10.1128/jvi.00588-12 · Cited by 86 · see citing works

CtIP mediates replication fork recovery in a FANCD2-regulated manner

Yeo, J. E., Lee, E. H., Hendrickson, E. A., & Sobeck, A. (2014) · Human Molecular Genetics · doi:10.1093/hmg/ddu078 · Cited by 84 · see citing works

A role for monoubiquitinated FANCD2 at telomeres in ALT cells

Fan, Q., Zhang, F., Barrett, B., Ren, K., & Andreassen, P. R. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkn995 · Cited by 84 · see citing works

Conditional deletion of Nbs1 in murine cells reveals its role in branching repair pathways of DNA double‐strand breaks

Yang, Y.-G., Saidi, A., Frappart, P., Min, W., Barrucand, C., Dumon-Jones, V., Michelon, J., Herceg, Z., & Wang, Z. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601411 · Cited by 83 · see citing works

Homologous Recombination DNA Repair Genes Play a Critical Role in Reprogramming to a Pluripotent State

Gonzãlez, F., Georgieva, D., Vanoli, F., Shi, Z., Stadtfeld, M., Ludwig, T., Jasin, M., & Huangfu, D. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.02.005 · Cited by 82 · see citing works

ATR-dependent phosphorylation of FANCA on serine 1449 after DNA damage is important for FA pathway function

Collins, N. B., Wilson, J. B., Bush, T., Tomashevski, A., Roberts, K. J., Jones, N. J., & Kupfer, G. M. (2008) · Blood · doi:10.1182/blood-2008-05-154294 · Cited by 81 · see citing works

The Fanconi anemia/BRCA pathway: A coordinator of cross-link repair

Mirchandani, K. D., & D’Andrea, A. D. (2006) · Experimental Cell Research · doi:10.1016/j.yexcr.2006.06.014 · Cited by 81 · see citing works

Homology-directed Fanconi anemia pathway cross-link repair is dependent on DNA replication

Nakanishi, K., Cavallo, F., Perrouault, L., Giovannangeli, C., Moynahan, M. E., Barchi, M., Brunet, E., & Jasin, M. (2011) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2029 · Cited by 79 · see citing works

A requirement of FancL and FancD2 monoubiquitination in DNA repair

Seki, S., Ohzeki, M., Uchida, A., Hirano, S., Matsushita, N., Kitao, H., Oda, T., Yamashita, T., Kashihara, N., Tsubahara, A., et al. (2007) · Genes to Cells · doi:10.1111/j.1365-2443.2007.01054.x · Cited by 34 · see citing works

In vitro FANCD2 monoubiquitination by HHR6 and hRad18

Pickering, A., Panneerselvam, J., Zhang, J., Zheng, J., Zhang, Y., & Fei, P. (2013) · Cell Cycle · doi:10.4161/cc.26387 · Cited by 12 · see citing works

Functional Interaction of Monoubiquitinated FANCD2 and BRCA2/FANCD1 in Chromatin

Wang, X., Andreassen, P. R., & D’Andrea, A. D. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.13.5850-5862.2004 · Cited by 332 · see citing works

Regulation of the Fanconi anemia pathway by monoubiquitination

Gregory, R. C., Taniguchi, T., & D’Andrea, A. D. (2002) · Seminars in Cancer Biology · doi:10.1016/s1044-579x(02)00102-5 · Cited by 71 · see citing works

Fanconi anemia: The role of FANCD2 protein

Altmannová, V., & Krejčí, L. (2007)