The DOI matches its Crossref record; 124 of the 124 references it cites were found in a registry or an index.
Signalling pathways of the TNF superfamily: a double-edged sword
Abstract
Two different tumour-necrosis factors (TNFs), first isolated in 1984, were found to be cytotoxic to tumour cells and to induce tumour regression in mice. Research during the past two decades has shown the existence of a superfamily of TNF proteins consisting of 19 members that signal through 29 receptors. These ligands, while regulating normal functions such as immune responses, haematopoiesis and morphogenesis, have also been implicated in tumorigenesis, transplant rejection, septic shock, viral replication, bone resorption, rheumatoid arthritis and diabetes; so indicating their role as 'double-edged swords'. These cytokines either induce cellular proliferation, survival, differentiation or apoptosis. Blockers of TNF have been approved for human use in treating TNF-linked autoimmune diseases in the United States and other countries.
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In the citing paper
“TNF-α is a pro-inflammatory cytokine and a potent activator of the transcription factor NF-κB, which induces the expression of a multitude of pro-mitogenic, pro-inflammatory, and anti-apoptotic proteins, thus promoting cell proliferation and survival [102].”
From CCN1/CYR61: the very model of a modern matricellular protein (2011) · cites this paper as [102]
In the citing paper
“However, TNF-α is also a powerful apoptotic inducer in vitro when NF-κB signaling is blocked, typically by the addition of cycloheximide.”
From CCN1/CYR61: the very model of a modern matricellular protein (2011) · cites this paper as [102]
In the citing paper
“Tumor necrosis factor alpha (TNFα) is a pleiotropic cytokine that acts on its receptors (TNFRs) to promote either cell survival or cell death 54.”
From Mitochondrial reactive oxygen species regulate cellular signaling and dictate biological outcomes (2010) · cites this paper as [54]
Citations
Cites
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NF-κB at the crossroads of life and death
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Flagged first, then by citations
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TNF-α-mediated suppression of Leydig cell steroidogenesis involves DAX-1
Sadasivam, M., Ramatchandirin, B., Balakrishnan, S., & Prahalathan, C. (2015) · Inflammation Research · doi:10.1007/s00011-015-0835-8 · Cited by 33
Mortality from cirrhosis: lack of progress over the last 35 years
Gluud, C. (2005) · Gut · doi:10.1136/gut.2005.072876 · Cited by 17
The Extracellular Matrix Protein CCN1 Dictates TNFα and FasL Cytotoxicity In Vivo
Chen, C.-C., Juric, V., & Lau, L. F. (2011) · Advances in Experimental Medicine and Biology · doi:10.1007/978-1-4419-6612-4_63 · Cited by 8
Akiba, H., Ise, T., Satoh, R., Abe, Y., Tsumoto, K., Ohno, H., Kamada, H., & Nagata, S. (2025) · Antibody Therapeutics · doi:10.1093/abt/tbaf002 · Cited by 3
Metadata
- Authors
- Aggarwal, B. B.
- Affiliations
- The University of Texas MD Anderson Cancer Center (US)
- Corresponding author
- Aggarwal, Bharat B.
- ORCID
- Aggarwal, Bharat B.
- Venue
- Nature Reviews Immunology
- Published
- 2003-09
- Volume
- 3
- Issue
- 9
- Pages
- 745-756
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- OpenAlex
- W2095013915
- Cited by
- 2,793
- References
- 124
- Citations by year
- 2026: 74 · 2025: 107 · 2024: 82 · 2023: 121 · 2022: 125 · 2021: 114 · 2020: 132 · 2019: 113 · 2018: 114 · 2017: 130 · 2016: 108 · 2015: 142 · 2014: 128 · 2013: 116 · 2012: 159
- FWCI
- 9.77
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Immunology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
- Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Keywords
- TNF superfamily, TNF-α, TNF receptor, signaling pathways, carcinogenesis, graft rejection, septic shock, viral replication, bone resorption, rheumatoid arthritis, diabetes mellitus, apoptosis, TNF-alpha inhibitors, autoimmune disease, cytokines
- MeSH terms
- Animals, Autoimmune Diseases, Carrier Proteins, Humans, Ligands, Lymphotoxin-alpha, Membrane Proteins, Tumor Necrosis Factor-alpha, Signal Transduction, NF-kappa B, Receptors, Tumor Necrosis Factor, Mice
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