Signalling pathways of the TNF superfamily: a double-edged sword

Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation.

Lacey, D. L., Timms, E., Tan, H.-L., Kelley, M. J., Dunstan, C. R., Burgess, T., Elliott, R., Colombero, A., Elliott, G., Scully, S., et al. (1998) · Cell · doi:10.1016/s0092-8674(00)81569-x · Cited by 5,439

Osteoprotegerin: a novel secreted protein involved in the regulation of bone density.

Simonet, W. S., Lacey, D. L., Dunstan, C. R., Kelley, M., Chang, M.-S., Lüthy, R., Nguyen, H. Q., Wooden, S., Bennett, L., Boone, T., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)80209-3 · Cited by 5,130

An endotoxin-induced serum factor that causes necrosis of tumors

Carswell, E. A., Old, L. J., Kassel, R. L., Green, S., Fiore, N., & Williamson, B. (1975) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.72.9.3666 · Cited by 4,532

The Fas Death Factor

Nagata, S., & Golstein, P. (1995) · Science · doi:10.1126/science.7533326 · Cited by 3,979

The TNF and TNF Receptor Superfamilies

Locksley, R. M., Killeen, N., & Lenardo, M. J. (2001) · Cell · doi:10.1016/s0092-8674(01)00237-9 · Cited by 3,650

OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph node organogenesis.

Kong, Y.-Y., Yoshida, H., Sarosi, I., Tan, H.-L., Timms, E., Capparelli, C., Morony, S., Oliveira-dos-Santos, A. J., Van, G., Itie, A., et al. (1999) · Nature · doi:10.1038/16852 · Cited by 3,351

A metalloproteinase disintegrin that releases tumour-necrosis factor-α from cells

Black, R. A., Rauch, C. T., Kozlosky, C. J., Peschon, J. J., Slack, J. L., Wolfson, M. F., Castner, B. J., Stocking, K. L., Reddy, P., Srinivasan, S., et al. (1997) · Nature · doi:10.1038/385729a0 · Cited by 3,149

Identification and characterization of a new member of the TNF family that induces apoptosis

Wiley, S. R., Schooley, K., Smolak, P. J., Din, W. S., Huang, C.-P., Nicholl, J. K., Sutherland, G. R., Smith, T. D., Rauch, C., Smith, C. A., et al. (1995) · Immunity · doi:10.1016/1074-7613(95)90057-8 · Cited by 2,900

The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis

Itoh, N., Yonehara, S., Ishii, A., Yonehara, M., Mizushima, S.-I., Sameshima, M., Hase, A., Seto, Y., & Nagata, S. (1991) · Cell · doi:10.1016/0092-8674(91)90614-5 · Cited by 2,736

NF-κB at the crossroads of life and death

Karin, M., & Lin, A. (2002) · Nature Immunology · doi:10.1038/ni0302-221 · Cited by 2,709

Soy isoflavone phyto-pharmaceuticals in interleukin-6 affections

Dijsselbloem, N., Berghe, W. V., Naeyer, A. D., & Haegeman, G. (2004) · Biochemical Pharmacology · doi:10.1016/j.bcp.2004.05.036 · Cited by 138

EDA Signaling and Skin Appendage Development

Cui, C., & Schlessinger, D. (2006) · Cell Cycle · doi:10.4161/cc.5.21.3403 · Cited by 135

Cyanidin-3- O -glucoside inhibits NF-kB signalling in intestinal epithelial cells exposed to TNF-α and exerts protective effects via Nrf2 pathway activation

Ferrari, D., Speciale, A., Cristani, M., Fratantonio, D., Molonia, M. S., Ranaldi, G., Saija, A., & Cimino, F. (2016) · Toxicology Letters · doi:10.1016/j.toxlet.2016.10.014 · Cited by 135

Tumor necrosis factor-α–dependent expression of phosphodiesterase 2: role in endothelial hyperpermeability

Seybold, J., Thomas, D., Witzenrath, M., Boral, Ş., Hocke, A. C., Bürger, A., Hatzelmann, A., Tenor, H., Schudt, C., Krüll, M., et al. (2005) · Blood · doi:10.1182/blood-2004-07-2729 · Cited by 135

The roles of Pellino E3 ubiquitin ligases in immunity

Moynagh, P. N. (2014) · Nature reviews. Immunology · doi:10.1038/nri3599 · Cited by 134

Genetic Deletion of NAD(P)H:Quinone Oxidoreductase 1 Abrogates Activation of Nuclear Factor-κB, IκBα Kinase, c-Jun N-terminal Kinase, Akt, p38, and p44/42 Mitogen-activated Protein Kinases and Potentiates Apoptosis

Ahn, K. S., Sethi, G., Jain, A. K., Jaiswal, A. K., & Aggarwal, B. B. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m601162200 · Cited by 134

Targeting TNF-α for COVID-19: Recent Advanced and Controversies

Guo, Y., Hu, K., Li, Y., Lu, C., Ling, K., Cai, C., Wang, W., & Ye, D. (2022) · Frontiers in Public Health · doi:10.3389/fpubh.2022.833967 · Cited by 143

Birc2 (cIap1) regulates endothelial cell integrity and blood vessel homeostasis

Santoro, M. M., Samuel, T., Mitchell, T. S., Reed, J. C., & Stainier, D. Y. R. (2007) · Nature Genetics · doi:10.1038/ng.2007.8 · Cited by 137

Role of endocrine-immune dysregulation in osteoporosis, sarcopenia, frailty and fracture risk

Joseph, C., Kenny, R. A., Taxel, P., Lorenzo, J., Duque, G., & Kuchel, G. A. (2005) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2005.01.004 · Cited by 137

Microglia dynamics and function in the CNS

Parkhurst, C. N., & Gan, W.-B. (2010) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2010.07.002 · Cited by 132

Inhibition of Glucocorticoid Receptor-mediated Transcriptional Activation by p38 Mitogen-activated Protein (MAP) Kinase

Szatmáry, Z., Garabedian, M. J., & Vilček, J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m406568200 · Cited by 132

Mitochondrial Thioredoxin-2 Has a Key Role in Determining Tumor Necrosis Factor-α–Induced Reactive Oxygen Species Generation, NF-κB Activation, and Apoptosis

Hansen, J. M., Zhang, H., & Jones, D. P. (2006) · Toxicological Sciences · doi:10.1093/toxsci/kfj175 · Cited by 131

Innate but not adaptive immune responses contribute to behavioral seizures following viral infection

Kirkman, N. J., Libbey, J. E., Wilcox, K. S., White, H. S., & Fujinami, R. S. (2009) · Epilepsia · doi:10.1111/j.1528-1167.2009.02390.x · Cited by 131

SPATA2 links CYLD to the TNF‐α receptor signaling complex and modulates the receptor signaling outcomes

Wagner, S., Satpathy, S., Beli, P., & Choudhary, C. (2016) · The EMBO Journal · doi:10.15252/embj.201694300 · Cited by 133

M2‐like macrophages induce colon cancer cell invasion via matrix metalloproteinases

Vinnakota, K., Zhang, Y., Selvanesan, B. C., Topi, G., Salim, T., Sand‐Dejmek, J., Jönsson, G., & Sjölander, A. (2017) · Journal of Cellular Physiology · doi:10.1002/jcp.25808 · Cited by 131

Signaling via the type I IL-1 and TNF receptors is necessary for bacterially induced preterm labor in a murine model

Hirsch, E., Filipovich, Y., & Mahendroo, M. (2006) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2005.11.004 · Cited by 131

Fos and Jun Proteins Are Specifically Expressed During Differentiation of Human Keratinocytes

Mehic, D., Bakiri, L., Ghannadan, M., Wagner, E. F., & Tschachler, E. (2005) · Journal of Investigative Dermatology · doi:10.1111/j.0022-202x.2004.23558.x · Cited by 131

Tumor Necrosis Factor-Like Weak Inducer of Apoptosis-Induced Neurodegeneration

Potrovita, I., Zhang, W., Burkly, L. C., Hahm, K., Lincecum, J. M., Wang, M. Z., Maurer, M. H., Rossner, M. J., Schneider, A., & Schwaninger, M. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.1089-04.2004 · Cited by 132

Honokiol Potentiates Apoptosis, Suppresses Osteoclastogenesis, and Inhibits Invasion through Modulation of Nuclear Factor-κB Activation Pathway

Ahn, K. S., Sethi, G., Shishodia, S., Sung, B., Arbiser, J. L., & Aggarwal, B. B. (2006) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-06-0076 · Cited by 131

Differential roles of TNFα-TNFR1 and TNFα-TNFR2 in the differentiation and function of CD4+Foxp3+ induced Treg cells in vitro and in vivo periphery in autoimmune diseases

Yang, S., Xie, C., Chen, Y., Wang, J., Chen, X., Lu, Z., June, R. R., & Zheng, S. G. (2019) · Cell Death and Disease · doi:10.1038/s41419-018-1266-6 · Cited by 130

Cytokine Release Syndrome in COVID-19 Patients, A New Scenario for an Old Concern: The Fragile Balance between Infections and Autoimmunity

Diamanti, A. P., Rosado, M. M., Pioli, C., Sesti, G., & Laganà, B. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21093330 · Cited by 129

Caspases: evolutionary aspects of their functions in vertebrates

Sakamaki, K., & Satou, Y. (2009) · Journal of Fish Biology · doi:10.1111/j.1095-8649.2009.02184.x · Cited by 134

Oxidative Stress in Fanconi Anemia Hematopoiesis and Disease Progression

Du, W., Ádám, Z., Rani, R., Zhang, X., & Pang, Q. (2008) · Antioxidants and Redox Signaling · doi:10.1089/ars.2008.2129 · Cited by 133

Tumor necrosis factor α blockade exacerbates murine psoriasis‐like disease by enhancing Th17 function and decreasing expansion of Treg cells

Ma, H., Napierata, L., Stedman, N., Benoit, S., Collins, M. A., Nickerson‐Nutter, C. L., & Young, D. A. (2010) · Arthritis & Rheumatism · doi:10.1002/art.27203 · Cited by 130

Effect of Paeonol on Antioxidant and Immune Regulatory Activity in Hepatocellular Carcinoma Rats

Chen, B., Ning, M., & Yang, G. (2012) · Molecules · doi:10.3390/molecules17044672 · Cited by 128

Functional characterization of TNF-α in grass carp head kidney leukocytes: Induction and involvement in the regulation of NF-κB signaling

Zhang, A., Chen, D., He, W., Du, L., Zhao, T., Wang, X., & Zhou, H. Y. (2012) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2012.08.029 · Cited by 128

Selective death of autoreactive T cells in human diabetes by TNF or TNF receptor 2 agonism

Ban, L., Zhang, J. Y., Wang, L., Kühtreiber, W. M., Burger, D., & Faustman, D. L. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0803429105 · Cited by 130

TNF-α as a promising therapeutic target in chronic asthma: a lesson from rheumatoid arthritis

Russo, C., & Polosa, R. (2005) · Clinical Science · doi:10.1042/cs20050038 · Cited by 127

The RIG-I-like Receptor LGP2 Controls CD8+ T Cell Survival and Fitness

Suthar, M. S., Ramos, H. J., Brassil, M. M., Netland, J., Chappell, C. P., Blahnik, G., McMillan, A., Diamond, M., Clark, E. A., Bevan, M. J., et al. (2012) · Immunity · doi:10.1016/j.immuni.2012.07.004 · Cited by 127

TNF Blockade: An Inflammatory Issue

Aggarwal, B. B., Shishodia, S., Takada, Y., Jackson-Bernitsas, D., Ahn, K. S., Sethi, G., & Ichikawa, H. (2006) · Springer eBooks · doi:10.1007/3-540-37673-9_10 · Cited by 125

Preclinical Antilymphoma Activity of a Humanized Anti-CD40 Monoclonal Antibody, SGN-40

Law, C., Gordon, K. A., Collier, J., Klussman, K., McEarchern, J. A., Cerveny, C. G., Mixan, B. J., Lee, W. P., Lin, Z., Valdez, P. A., et al. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-0095 · Cited by 125

Polymorphisms in immune function genes and risk of non-Hodgkin lymphoma: findings from the New South Wales non-Hodgkin Lymphoma Study

Purdue, M. P., Lan, Q., Kricker, A., Grulich, A. E., Vajdic, C. M., Turner, J., Whitby, D., Chanock, S. J., Rothman, N., & Armstrong, B. K. (2006) · Carcinogenesis · doi:10.1093/carcin/bgl200 · Cited by 126

All About (NK Cell-Mediated) Death in Two Acts and an Unexpected Encore: Initiation, Execution and Activation of Adaptive Immunity

Ramírez-Labrada, A., Pesini, C., Santiago, L., Hidalgo, S., Calvo-Pérez, A., Oñate, C., Andrés-Tovar, A., Garzón-Tituaña, M., Uranga-Murillo, I., Arias, M. A., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.896228 · Cited by 146

CD137 ligand mediates opposite effects in human and mouse NK cells and impairs NK-cell reactivity against human acute myeloid leukemia cells

Baessler, T., Charton, J. E., Schmiedel, B. J., Grünebach, F., Krusch, M., Wacker, A., Rammensee, H., & Salih, H. R. (2009) · Blood · doi:10.1182/blood-2009-06-227934 · Cited by 128

Structure‐Based Discovery of Natural‐Product‐like TNF‐α Inhibitors

Chan, D. S., Lee, H., Yang, F., Che, C., Wong, C. C. L., Abagyan, R. A., Leung, C., & Ma, D. (2010) · Angewandte Chemie International Edition · doi:10.1002/anie.200907360 · Cited by 127

Elevated serum soluble CD40 ligand in cancer patients may play an immunosuppressive role

Huang, J., Jochéms, C., Talaie, T., Anderson, A., Jales, A., Tsang, K. Y., Madan, R. A., Gulley, J. L., & Schlom, J. (2012) · Blood · doi:10.1182/blood-2012-05-427799 · Cited by 124

Apoptosis of tumor-infiltrating T lymphocytes: a new immune checkpoint mechanism

Zhu, J., Petit, P.-F., & den Eynde, B. J. V. (2018) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-018-2269-y · Cited by 127

Activation of retinal glial cells contributes to the degeneration of ganglion cells in experimental glaucoma

Miao, Y., Zhao, G., Cheng, S., Wang, Z., & Yang, X.-L. (2023) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2023.101169 · Cited by 126

NSAID Sulindac and Its Analog Bind RXRα and Inhibit RXRα-Dependent AKT Signaling

Zhou, H., Liu, W., Su, Y., Wei, Z., Liu, J., Kolluri, S. K., Wu, H., Cao, Y. J., Chen, J., Wu, Y., et al. (2010) · Cancer Cell · doi:10.1016/j.ccr.2010.04.023 · Cited by 124

Tumor Cells and Tumor-Associated Macrophages: Secreted Proteins as Potential Targets for Therapy

Baay, M. F. D., Brouwer, A., Pauwels, P., Peeters, M., & Lardon, F. (2011) · Clinical and Developmental Immunology · doi:10.1155/2011/565187 · Cited by 130

Endothelial dysfunction and low grade chronic inflammation in subclinical hypothyroidism due to autoimmune thyroiditis

Türemen, E. E., Çetinarslan, B., Şahı̇n, T., Cantürk, Z., & Tarkun, İ. (2011) · Endocrine Journal · doi:10.1507/endocrj.k10e-333 · Cited by 122

Salinosporamide A (NPI-0052) potentiates apoptosis, suppresses osteoclastogenesis, and inhibits invasion through down-modulation of NF-κB–regulated gene products

Ahn, K. S., Sethi, G., Chao, T., Neuteboom, S., Chaturvedi, M. M., Palladino, M. A., Younes, A., & Aggarwal, B. B. (2007) · Blood · doi:10.1182/blood-2007-04-084996 · Cited by 123

A20 deletion is associated with copy number gain at the TNFA/B/C locus and occurs preferentially in translocation‐negative MALT lymphoma of the ocular adnexa and salivary glands

Chanudet, E., Ye, H., Ferry, J. A., Bacon, C. M., Adam, P., Müller-Hermelink, H. K., Radford, J. A., Pileri, S., Ichimura, K., Collins, V. P., et al. (2008) · The Journal of Pathology · doi:10.1002/path.2466 · Cited by 122

Curcumin and lung cancer—a review

Mehta, H. J., Patel, V. J., & Sadikot, R. T. (2014) · Targeted Oncology · doi:10.1007/s11523-014-0321-1 · Cited by 121

The roles of TNFAIP 2 in cancers and infectious diseases

Jia, L., Shi, Y., Wen, Y., Li, W., Feng, J. C., & Chen, C. (2018) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.13822 · Cited by 121

Pathophysiology of acute graft-versus-host disease: recent advances

Sun, Y., Tawara, I., Toubai, T., & Reddy, P. R. (2007) · Translational research · doi:10.1016/j.trsl.2007.06.003 · Cited by 124

Subcellular Localization and Functional Domain Studies of DEFECTIVE KERNEL1 in Maize and Arabidopsis Suggest a Model for Aleurone Cell Fate Specification Involving CRINKLY4 and SUPERNUMERARY ALEURONE LAYER1

Tian, Q., Olsen, L., Sun, B., Lid, S. E., Brown, R. C., Lemmon, B. E., Fosnes, K., Gruis, D., Opsahl-Sorteberg, H.-G., Otegui, M. S., et al. (2007) · The Plant Cell · doi:10.1105/tpc.106.048868 · Cited by 121

T‐cell intrinsic effects of GITR and 4‐1BB during viral infection and cancer immunotherapy

Snell, L. M., Lin, G. H. Y., McPherson, A. J., Moraes, T. J., & Watts, T. H. (2011) · Immunological Reviews · doi:10.1111/j.1600-065x.2011.01063.x · Cited by 120

Ubiquitin chain cleavage: CYLD at work

Massoumi, R. (2010) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2010.02.007 · Cited by 122

The role of TNF-α signaling pathway on COX-2 upregulation and cognitive decline induced by β-amyloid peptide

Medeiros, R., Figueiredo, C. P., Pandolfo, P., Duarte, F. S., Prediger, R. D. S., Passos, G. F., & Calixto, J. B. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.01.040 · Cited by 121

IL-1β Augments TNF-α–Mediated Inflammatory Responses from Lung Epithelial Cells

Saperstein, S., Chen, L., Oakes, D., Pryhuber, G., & Finkelstein, J. N. (2009) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2008.0076 · Cited by 118

Dysbiosis of intestinal microbiota and decrease in paneth cell antimicrobial peptide level during acute necrotizing pancreatitis in rats

Chen, J., Huang, C., Wang, J., Zhou, H. J., Lu, Y., Lou, L., Zheng, J., Tian, L., Wang, X., Cao, Z., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0176583 · Cited by 117

The TNF-α/ROS/HIF-1-induced Upregulation of FoxMI Expression Promotes HCC Proliferation and Resistance to Apoptosis

Xia, L., Ping, M., Huang, W., Zhang, L., Wang, Y., Zhu, H., Tian, D., Liu, J., Chen, Z., Zhang, Y., et al. (2012) · Carcinogenesis · doi:10.1093/carcin/bgs249 · Cited by 119

Targeting TNF for Treatment of Cancer and Autoimmunity

Sethi, G., Sung, B., Kunnumakkara, A. B., & Aggarwal, B. B. (2009) · Advances in experimental medicine and biology · doi:10.1007/978-0-387-89520-8_3 · Cited by 118

Suberoylanilide Hydroxamic Acid Potentiates Apoptosis, Inhibits Invasion, and Abolishes Osteoclastogenesis by Suppressing Nuclear Factor-κB Activation

Takada, Y., Gillenwater, A. M., Ichikawa, H., & Aggarwal, B. B. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m507213200 · Cited by 118

Tumor Necrosis Factor-α Promotes Malignant Pleural Effusion

Stathopoulos, G. T., Kollintza, A., Moschos, C., Psallidas, I., Sherrill, T. P., Pitsinos, E. N., Vassiliou, S., Karatza, M., Papiris, S. A., Graf, D., et al. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-1064 · Cited by 117

Fighting Cancer with Red Wine? Molecular Mechanisms of Resveratrol

Kraft, T. E., Parisotto, D. A., Schempp, C. M., & Efferth, T. (2009) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408390802248627 · Cited by 116

Beyond tumor necrosis factor receptor: TRADD signaling in toll-like receptors

Chen, N., Chio, I. I. C., Lin, W., Duncan, G. S., Chau, H., Katz, D., Huang, H.-L., Pike, K. A., Hao, Z., Su, Y.-W., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0806585105 · Cited by 116

Modeling of tumor necrosis factor receptor superfamily 1A mutants associated with tumor necrosis factor receptor–associated periodic syndrome indicates misfolding consistent with abnormal function

Rebelo, S. L., Bainbridge, S. E., Kashipaz, M. R. A., Radford, P. M., Powell, R. J., Todd, I., & Tighe, P. J. (2006) · Arthritis & Rheumatism · doi:10.1002/art.21964 · Cited by 116

The islet-resident macrophage is in an inflammatory state and senses microbial products in blood

Ferris, S. T., Zakharov, P. N., Wan, X., Calderón, B., Artyomov, M. N., Unanue, E. R., & Carrero, J. A. (2017) · The Journal of Experimental Medicine · doi:10.1084/jem.20170074 · Cited by 118

The Effects of Adipocytes on the Regulation of Breast Cancer in the Tumor Microenvironment: An Update

Chu, D., Nguyen, T. T. P., Tien, N. L. B., Khoa, T. D., Nguyen, T.-T., Thanh, V. V., Quang, T. L., Bui, L. M., Pham, V.-H., Ngọc, V. T. N., et al. (2019) · Cells · doi:10.3390/cells8080857 · Cited by 124

Distinct molecular and immune hallmarks of inflammatory arthritis induced by immune checkpoint inhibitors for cancer therapy

Kim, S. T., Chu, Y., Misoi, M., Suarez-Almazor, M. E., Tayar, J. H., Lu, H., Buni, M., Kramer, J., Rodriguez, E., Hussain, Z., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-29539-3 · Cited by 117

TNF-α: An Activator of CD4+FoxP3+TNFR2+ Regulatory T Cells

Chen, X., & Oppenheim, J. J. (2010) · Current directions in autoimmunity · doi:10.1159/000289201 · Cited by 115

Cloning and expression analysis of three striped trumpeter (Latris lineata) pro-inflammatory cytokines, TNF-α, IL-1β and IL-8, in response to infection by the ectoparasitic, Chondracanthus goldsmidi

Covello, J. M., Bird, S., Morrison, R. N., Battaglene, S., Secombes, C. J., & Nowak, B. F. (2009) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2009.03.012 · Cited by 115

Induction of cancer cell death by apoptosis and slow release of 5-fluoracil from metal-organic frameworks Cu-BTC

Lucena, F. R. S., de Araújo, L. C. C., Rodrigues, M. D. D., da Silva, T. G., Pereira, V. R. A., Militão, G. C. G., Fontes, D. A. F., Neto, P. J. R., da Silva, F. F., & do Nascimento, S. C. (2013) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2013.06.003 · Cited by 115

TNF Receptor-Associated Factor 6 Is an Essential Mediator of CD40-Activated Proinflammatory Pathways in Monocytes and Macrophages

Mukundan, L., Bishop, G. A., Head, K. Z., Zhang, L., Wahl, L. M., & Suttles, J. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.2.1081 · Cited by 114

The unexpected role of lymphotoxin β receptor signaling in carcinogenesis: from lymphoid tissue formation to liver and prostate cancer development

Wolf, M. J., Seleznik, G. M., Zeller, N., & Heikenwälder, M. F. (2010) · Oncogene · doi:10.1038/onc.2010.260 · Cited by 114

Circulating levels of TNF-like cytokine 1A (TL1A) and its decoy receptor 3 (DcR3) in rheumatoid arthritis

Bamias, G., Siakavellas, S. I., Stamatelopoulos, K., Chryssochoou, E., Papamichael, C. M., & Sfikakis, P. P. (2008) · Clinical Immunology · doi:10.1016/j.clim.2008.07.014 · Cited by 114

Prevention of LPS-Induced Acute Lung Injury in Mice by Progranulin

Guo, Z., Li, Q., Yang, H., Liang, Y., Xu, Z., & Ren, T. (2012) · Mediators of Inflammation · doi:10.1155/2012/540794 · Cited by 113

A multi-targeted approach to suppress tumor-promoting inflammation

Samadi, A. K., Bilsland, A. E., Georgakilas, A. G., Amedei, A., Amin, A., Bishayee, A., Azmi, A. S., Lokeshwar, B. L., Grue, B., Panis, C., et al. (2015) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2015.03.006 · Cited by 118

A review of the role of immune cells in acute kidney injury

Bonavia, A. S., & Singbartl, K. (2017) · Pediatric Nephrology · doi:10.1007/s00467-017-3774-5 · Cited by 116

Ubiquitin-conjugating enzyme Ubc13 is a critical component of TNF receptor-associated factor (TRAF)-mediated inflammatory responses

Fukushima, T., Matsuzawa, S., Kress, C. L., Bruey, J. M., Krajewska, M., Lefebvre, S., Zapata, J. M., Ronai, Z. A., & Reed, J. C. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0700548104 · Cited by 114

Structural Basis for Treating Tumor Necrosis Factor α (TNFα)-associated Diseases with the Therapeutic Antibody Infliximab

Liang, S., Dai, J., Hou, S., Su, L., Zhang, D., Guo, H., Hu, S., Wang, H., Rao, Z., Guo, Y., et al. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.433961 · Cited by 112

Progranulin: A key player in autoimmune diseases

Jian, J., Li, G., Hettinghouse, A., & Liu, C.-J. (2016) · Cytokine · doi:10.1016/j.cyto.2016.08.007 · Cited by 113

Role for Tumor Necrosis Factor Alpha in Murine Cytomegalovirus Transcriptional Reactivation in Latently Infected Lungs

Simon, C. O., Seckert, C. K., Dreis, D., Reddehase, M. J., & Grzimek, N. K. A. (2004) · Journal of Virology · doi:10.1128/jvi.79.1.326-340.2005 · Cited by 112

NEMO/IKKγ regulates an early NF-κB-independent cell-death checkpoint during TNF signaling

Legarda, D., Hase, H., O’Donnell, M. A., & Ting, A. T. (2009) · Cell Death and Differentiation · doi:10.1038/cdd.2009.41 · Cited by 111

The Role of Cytokines in the Pathogenesis and Treatment of Systemic Lupus Erythematosus

Davis, L. S., Hutcheson, J., & Mohan, C. (2011) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2011.0047 · Cited by 112

Infliximab-related hepatitis: discussion of a case and review of the literature

Mancini, S., Amorotti, E., Vecchio, S., de Leòn, M. P., & Roncucci, L. (2010) · Internal and Emergency Medicine · doi:10.1007/s11739-009-0342-4 · Cited by 111

TRAF1 Signaling in Human Health and Disease

Edilova, M. I., Sater, A. A. A., & Watts, T. H. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02969 · Cited by 113

Understanding Autoimmunity: Mechanisms, Predisposing Factors, and Cytokine Therapies

Yasmeen, F., Pirzada, R. H., Ahmad, B., Choi, B., & Choi, S. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25147666 · Cited by 131

Timosaponin AIII, a saponin isolated from Anemarrhena asphodeloides, ameliorates learning and memory deficits in mice

Lee, B., Jung, K., & Kim, D. (2009) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2009.04.021 · Cited by 111

Rapid Production of TNF-α following TCR Engagement of Naive CD8 T Cells

Brehm, M. A., Daniels, K. A., & Welsh, R. M. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.8.5043 · Cited by 110

Novel Therapies for Diabetic Kidney Disease

Alicic, R. Z., & Tuttle, K. R. (2014) · Advances in Chronic Kidney Disease · doi:10.1053/j.ackd.2014.01.007 · Cited by 110

Staphylococcus aureus protein A activates TACE through EGFR‐dependent signaling

Gómez, M. I., Seaghdha, M. O., & Prince, A. S. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601554 · Cited by 108

Cell death and hepatocarcinogenesis: Dysregulation of apoptosis signaling pathways

Schattenberg, J. M., Schuchmann, M., & Galle, P. R. (2011) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2010.06582.x · Cited by 108

CCN1 induces hepatic ductular reaction through integrin αvβ5–mediated activation of NF-κB

Kim, K.-H., Chen, C.-C., Alpini, G., & Lau, L. F. (2015) · Journal of Clinical Investigation · doi:10.1172/jci79327 · Cited by 109

Roles of the Hedgehog Signaling Pathway in Epidermal and Hair Follicle Development, Homeostasis, and Cancer

Abe, Y., & Tanaka, N. (2017) · Journal of Developmental Biology · doi:10.3390/jdb5040012 · Cited by 111

Keeping up NF-κB appearances: Epigenetic control of immunity or inflammation-triggered epigenetics

Berghe, W. V., Ndlovu, ’. N., Hoya-Arias, R., Dijsselbloem, N., Gerlo, S., & Haegeman, G. (2006) · Biochemical Pharmacology · doi:10.1016/j.bcp.2006.07.012 · Cited by 108

Artemisinin inhibits inflammatory response via regulating NF-κB and MAPK signaling pathways

Wang, K. S., Li, J., Wang, Z., Mi, C., Ma, J., Piao, L. X., Xu, G. H., Li, X., & Jin, X. (2016) · Immunopharmacology and Immunotoxicology · doi:10.1080/08923973.2016.1267744 · Cited by 109

Inhibition of the inflammatory cytokine tumor necrosis factor-alpha with etanercept provides protection against lethal H1N1 influenza infection in mice

Shi, X., Zhou, W. M., Huang, H., Zhu, H., Zhou, P., Zhu, H., & Ju, D. (2013) · Critical Care · doi:10.1186/cc13171 · Cited by 107

The effects of tumour necrosis factor‐α on bone cells involved in periodontal alveolar bone loss; osteoclasts, osteoblasts and osteocytes

Algate, K., Haynes, D. R., Bartold, P. M., Crotti, T. N., & Cantley, M. D. (2015) · Journal of Periodontal Research · doi:10.1111/jre.12339 · Cited by 108

The Key Role of TNF-TNFR2 Interactions in the Modulation of Allergic Inflammation: A Review

Ahmad, S., Azid, N. A., Boer, J. C., Lim, J., Chen, X., Plebanski, M., & Mohamud, R. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02572 · Cited by 108

Clustering of Death Receptor for Apoptosis Using Nanoscale Patterns of Peptides

Wang, Y., Baars, I., Fördős, F., & Högberg, B. (2021) · ACS Nano · doi:10.1021/acsnano.0c10104 · Cited by 107

Molecular targets of [6]‐gingerol: Its potential roles in cancer chemoprevention

Oyagbemi, A. A., Saba, A. B., & Azeez, O. I. (2010) · BioFactors · doi:10.1002/biof.78 · Cited by 108

Role for Neutral Sphingomyelinase-2 in Tumor Necrosis Factor α-Stimulated Expression of Vascular Cell Adhesion Molecule-1 (VCAM) and Intercellular Adhesion Molecule-1 (ICAM) in Lung Epithelial Cells

Clarke, C. J., Truong, T., & Hannun, Y. A. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m609216200 · Cited by 108

Effects of Panax ginseng on Tumor Necrosis Factor-α-Mediated Inflammation: A Mini-Review

Lee, D. C., & Lau, A. S. (2011) · Molecules · doi:10.3390/molecules16042802 · Cited by 108

Targeting TNF receptors in rheumatoid arthritis

Blüml, S., Scheinecker, C., Smolen, J. S., & Redlich, K. (2012) · International Immunology · doi:10.1093/intimm/dxs047 · Cited by 108

Akt Promotes Increased Cardiomyocyte Cycling and Expansion of the Cardiac Progenitor Cell Population

Gude, N. A., Muraski, J. A., Rubio, M., Kajstura, J., Schaefer, E., Anversa, P., & Sussman, M. A. (2006) · Circulation Research · doi:10.1161/01.res.0000236754.21499.1c · Cited by 107

Regulation of proliferation, survival and apoptosis by members of the TNF superfamily

Gaur, U., & Aggarwal, B. B. (2003) · Biochemical Pharmacology · doi:10.1016/s0006-2952(03)00490-8 · Cited by 556

Overview of TNF Superfamily: A Chest Full of Potential Therapeutic Targets

Grewal, I. S. (2009) · Advances in experimental medicine and biology · doi:10.1007/978-0-387-89520-8_1 · Cited by 53

Review article Historical perspectives on tumor necrosis factor and its superfamily: 25 years later, a golden journey

Aggarwal, B. B., Gupta, S. C., & Kim, J. H. (2016)

Historical perspectives on tumor necrosis factor and its superfamily: 25 years later, a golden journey

Aggarwal, B. B., Gupta, S. C., & Kim, J. H. (2012) · Blood · doi:10.1182/blood-2011-04-325225 · Cited by 877

The Role of TNF and Its Family Members in Inflammation and Cancer: Lessons from Gene Deletion

Aggarwal, B. B., Shishodia, S., Ashikawa, K., & Bharti, A. C. (2002) · Current Drug Targets - Inflammation & Allergy · doi:10.2174/1568010023344571 · Cited by 131