Cited by 2,793NF-κB Signaling PathwaysCytokine Signaling Pathways and InteractionsCell death mechanisms and regulation

The DOI matches its Crossref record; 124 of the 124 references it cites were found in a registry or an index.

Signalling pathways of the TNF superfamily: a double-edged sword

Aggarwal, Bharat B.·2003·Nature Reviews Immunology

Open this paper in CoChat — free account

Abstract

Two different tumour-necrosis factors (TNFs), first isolated in 1984, were found to be cytotoxic to tumour cells and to induce tumour regression in mice. Research during the past two decades has shown the existence of a superfamily of TNF proteins consisting of 19 members that signal through 29 receptors. These ligands, while regulating normal functions such as immune responses, haematopoiesis and morphogenesis, have also been implicated in tumorigenesis, transplant rejection, septic shock, viral replication, bone resorption, rheumatoid arthritis and diabetes; so indicating their role as 'double-edged swords'. These cytokines either induce cellular proliferation, survival, differentiation or apoptosis. Blockers of TNF have been approved for human use in treating TNF-linked autoimmune diseases in the United States and other countries.

Integrity signals

Registry

Crossref · 10.1038/nri1184

Cites

124 of 124 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation.
Lacey, D. L., Timms, E., Tan, H.-L., Kelley, M. J., Dunstan, C. R., Burgess, T., Elliott, R., Colombero, A., Elliott, G., Scully, S., et al. (1998) · Cell · doi:10.1016/s0092-8674(00)81569-x · Cited by 5,439
Osteoprotegerin: a novel secreted protein involved in the regulation of bone density.
Simonet, W. S., Lacey, D. L., Dunstan, C. R., Kelley, M., Chang, M.-S., Lüthy, R., Nguyen, H. Q., Wooden, S., Bennett, L., Boone, T., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)80209-3 · Cited by 5,130
An endotoxin-induced serum factor that causes necrosis of tumors
Carswell, E. A., Old, L. J., Kassel, R. L., Green, S., Fiore, N., & Williamson, B. (1975) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.72.9.3666 · Cited by 4,532
The Fas Death Factor
Nagata, S., & Golstein, P. (1995) · Science · doi:10.1126/science.7533326 · Cited by 3,979
The TNF and TNF Receptor Superfamilies
Locksley, R. M., Killeen, N., & Lenardo, M. J. (2001) · Cell · doi:10.1016/s0092-8674(01)00237-9 · Cited by 3,650
OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph node organogenesis.
Kong, Y.-Y., Yoshida, H., Sarosi, I., Tan, H.-L., Timms, E., Capparelli, C., Morony, S., Oliveira-dos-Santos, A. J., Van, G., Itie, A., et al. (1999) · Nature · doi:10.1038/16852 · Cited by 3,351
A metalloproteinase disintegrin that releases tumour-necrosis factor-α from cells
Black, R. A., Rauch, C. T., Kozlosky, C. J., Peschon, J. J., Slack, J. L., Wolfson, M. F., Castner, B. J., Stocking, K. L., Reddy, P., Srinivasan, S., et al. (1997) · Nature · doi:10.1038/385729a0 · Cited by 3,149
Identification and characterization of a new member of the TNF family that induces apoptosis
Wiley, S. R., Schooley, K., Smolak, P. J., Din, W. S., Huang, C.-P., Nicholl, J. K., Sutherland, G. R., Smith, T. D., Rauch, C., Smith, C. A., et al. (1995) · Immunity · doi:10.1016/1074-7613(95)90057-8 · Cited by 2,900
The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis
Itoh, N., Yonehara, S., Ishii, A., Yonehara, M., Mizushima, S.-I., Sameshima, M., Hase, A., Seto, Y., & Nagata, S. (1991) · Cell · doi:10.1016/0092-8674(91)90614-5 · Cited by 2,736
NF-κB at the crossroads of life and death
Karin, M., & Lin, A. (2002) · Nature Immunology · doi:10.1038/ni0302-221 · Cited by 2,709

Flagged first, then by citations

Show all 124 references

Research works printed but not linked: 2

Bruns, P. Die Heilwirkung des Erysipels auf Geschwulste. Beitr. Klin. Chir. 3, 443–446 (1868).
Gratia, A. & Linz, R. C. R. Seances Soc. Biol. Ses Fil. 108, 421–428 (1931).

Sorted by citations

Items 201–300 of 1,004

Genetic Deletion of Glycogen Synthase Kinase-3β Abrogates Activation of IκBα Kinase, JNK, Akt, and p44/p42 MAPK but Potentiates Apoptosis Induced by Tumor Necrosis Factor
Takada, Y., Fang, X., Jamaluddin, M. S., Boyd, D. D., & Aggarwal, B. B. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m403449200 · Cited by 180
Self-citation
Zerumbone Enhances TRAIL-Induced Apoptosis through the Induction of Death Receptors in Human Colon Cancer Cells: Evidence for an Essential Role of Reactive Oxygen Species
Yodkeeree, S., Sung, B., Limtrakul, P., & Aggarwal, B. B. (2009) · Cancer Research · doi:10.1158/0008-5472.can-09-1161 · Cited by 181
Self-citation
Erythropoietin, erythropoiesis and beyond
Chateauvieux, S., Grigorakaki, C., Morceau, F., Dicato, M. A., & Diederich, M. F. (2011) · Biochemical Pharmacology · doi:10.1016/j.bcp.2011.06.045 · Cited by 180
Inflammation, Cancer and Chemoresistance: Taking Advantage of the Toll‐Like Receptor Signaling Pathway
Chen, R., Alvero, A. B., Silasi, D., & Mor, G. (2007) · American Journal of Reproductive Immunology · doi:10.1111/j.1600-0897.2006.00441.x · Cited by 182
Diosgenin inhibits osteoclastogenesis, invasion, and proliferation through the downregulation of Akt, IκB kinase activation and NF-κB-regulated gene expression
Shishodia, S., & Aggarwal, B. B. (2005) · Oncogene · doi:10.1038/sj.onc.1209194 · Cited by 179
Self-citation
Systemic use of tumor necrosis factor alpha as an anticancer agent
Roberts, N. J., Zhou, S., Diaz, L. A., & Holdhoff, M. (2011) · Oncotarget · doi:10.18632/oncotarget.344 · Cited by 178
Role of inflammation in the progression of heart failure
Yndestad, A., Damås, J. K., Øie, E., Ueland, T., Gullestad, L. L., & Aukrust, P. (2007) · Current Cardiology Reports · doi:10.1007/bf02938356 · Cited by 177
Targeting the T-Cell Co-stimulatory CD27/CD70 Pathway in Cancer Immunotherapy: Rationale and Potential
van de Ven, K., & Borst, J. G. (2015) · Immunotherapy · doi:10.2217/imt.15.32 · Cited by 184
Molecular docking for virtual screening of natural product databases
Ma, D., Chan, D. S., & Leung, C. (2011) · Chemical Science · doi:10.1039/c1sc00152c · Cited by 182
Tumor necrosis factor induces GSK3 kinase–mediated cross-tolerance to endotoxin in macrophages
Park, S. H., Park‐Min, K., Chen, J., Hu, X., & Ivashkiv, L. B. (2011) · Nature Immunology · doi:10.1038/ni.2043 · Cited by 183
NF-κB transmits Eda A1/EdaR signalling to activate Shh and cyclin D1 expression, and controls post-initiation hair placode down growth
Schmidt-Ullrich, R., Tobin, D. J., Lenhard, D., Schneider, P., Paus, R., & Scheidereit, C. (2006) · Development · doi:10.1242/dev.02278 · Cited by 171
Thymol Inhibits LPS-Stimulated Inflammatory Response via Down-Regulation of NF-κB and MAPK Signaling Pathways in Mouse Mammary Epithelial Cells
Liang, D., Li, F., Fu, Y., Cao, Y., Song, X., Wang, T., Wang, W., Guo, M., Zhou, E., Li, D., et al. (2013) · Inflammation · doi:10.1007/s10753-013-9732-x · Cited by 173
TRAIL and cancer therapy
Kruyt, F. A. E. (2008) · Cancer Letters · doi:10.1016/j.canlet.2008.02.003 · Cited by 172
Ferulic acid protects against carbon tetrachloride-induced liver injury in mice
Kim, H.-Y., Park, J., Lee, K.-H., Lee, D., Kwak, J.-H., Kim, Y. S., & Lee, S. (2011) · Toxicology · doi:10.1016/j.tox.2011.01.017 · Cited by 171
ADAM17 as a Therapeutic Target in Multiple Diseases
Arribas, J., & Esselens, C. W. (2009) · Current Pharmaceutical Design · doi:10.2174/138161209788682398 · Cited by 171
Mitochondria in cell death
Parsons, M. J., & Green, D. R. (2010) · Essays in Biochemistry · doi:10.1042/bse0470099 · Cited by 178
Essential protective role of tumor necrosis factor receptor 2 in neurodegeneration
Dong, Y., Fischer, R., Naudé, P. J. W., Maier, O., Nyakas, C. J., Duffey, M., van der Zee, E. A., Dekens, D. W., Douwenga, W., Herrmann, A., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1605195113 · Cited by 169
Hypothalamic innate immune reaction in obesity
Kälin, S., Heppner, F. L., Bechmann, I., Prinz, M., Tschöp, M. H., & Yi, C.-X. (2015) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2015.48 · Cited by 167
ERK-Dependent Bim Modulation Downstream of the 4-1BB-TRAF1 Signaling Axis Is a Critical Mediator of CD8 T Cell Survival In Vivo
Sabbagh, L., Pulle, G., Liu, Y., Tsitsikov, E. N., & Watts, T. H. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.12.8093 · Cited by 167
A Metal‐Based Inhibitor of Tumor Necrosis Factor‐α
Leung, C., Zhong, H., Yang, H., Cheng, Z., Chan, D. S., Ma, V. P., Abagyan, R. A., Wong, C., & Ma, D. (2012) · Angewandte Chemie International Edition · doi:10.1002/anie.201202937 · Cited by 165
Therapeutic Treg expansion in mice by TNFRSF25 prevents allergic lung inflammation
Schreiber, T. H., Wolf, D., Tsai, M. S., Chirinos, J., Deyev, V. V., Gonzalez, L. E., Malek, T. R., Levy, R. B., & Podack, E. R. (2010) · Journal of Clinical Investigation · doi:10.1172/jci42933 · Cited by 163
Response of gut health and microbiota to sulfide exposure in Pacific white shrimp Litopenaeus vannamei
Suo, Y., Li, E., Li, T., Jia, Y., Qin, J. G., Gu, Z., & Chen, L. (2017) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2017.02.008 · Cited by 163
Obesity, Neuroinflammation, and Reproductive Function
Lainez, N. M., & Coss, D. (2019) · Endocrinology · doi:10.1210/en.2019-00487 · Cited by 180
T Cell Proliferation by Direct Cross-Talk between OX40 Ligand on Human Mast Cells and OX40 on Human T Cells: Comparison of Gene Expression Profiles between Human Tonsillar and Lung-Cultured Mast Cells
Kashiwakura, J., Yokoi, H., Saito, H., & Okayama, Y. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.8.5247 · Cited by 165
TNFα-senescence initiates a STAT-dependent positive feedback loop, leading to a sustained interferon signature, DNA damage, and cytokine secretion
Kandhaya-Pillai, R., Miro-Mur, F., Alijotas-Reig, J., Tchkonia, T., Kirkland, J. L., & Schwartz, S. (2017) · Aging · doi:10.18632/aging.101328 · Cited by 165
Bioactive sphingolipids in the modulation of the inflammatory response
El‐Alwani, M., Wu, B. X., Obeid, L. M., & Hannun, Y. A. (2006) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2006.04.004 · Cited by 168
The advent of the cytokine storm
Clark, I. A. (2007) · Immunology and Cell Biology · doi:10.1038/sj.icb.7100062 · Cited by 160
Comparison of the Inhibition Mechanisms of Adalimumab and Infliximab in Treating Tumor Necrosis Factor α-Associated Diseases from a Molecular View
Hu, S., Liang, S., Guo, H., Zhang, D., Li, H., Wang, X., Yang, W., Qian, W., Hou, S., Wang, H., et al. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.491530 · Cited by 161
Aging predisposes to acute inflammatory induced pathology after tumor immunotherapy
Bouchlaka, M. N., Sckisel, G. D., Chen, M., Mirsoian, A., Zamora, A. E., Maverakis, E., Wilkins, D. E. C., Alderson, K. L., Hsiao, H., Weiss, J. M., et al. (2013) · The Journal of Experimental Medicine · doi:10.1084/jem.20131219 · Cited by 162
Tumor-Elicited Inflammation and Colorectal Cancer
Wang, K., & Karin, M. (2015) · Advances in cancer research · doi:10.1016/bs.acr.2015.04.014 · Cited by 167
Recent Advances in Anti-cancer Protein/Peptide Delivery
Liu, X., Wu, F., Ji, Y. I., & Yin, L. (2018) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.8b00750 · Cited by 163
TNF Receptor 2 and Disease: Autoimmunity and Regenerative Medicine
Faustman, D. L., & Davis, M. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00478 · Cited by 160
Proinflammatory Effects of Tweak/Fn14 Interactions in Glomerular Mesangial Cells
Campbell, S., Burkly, L. C., Gao, H.-X., Berman, J. W., Su, L., Browning, B., Zheng, T. S., Schiffer, L. E., Michaelson, J. S., & Putterman, C. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.3.1889 · Cited by 157
Metformin inhibits TNF-α-induced IκB kinase phosphorylation, IκB-α degradation and IL-6 production in endothelial cells through PI3K-dependent AMPK phosphorylation
Huang, N.-L., Chiang, S.-H., Hsueh, C., Liang, Y., Chen, Y.-J., & Lai, L. (2008) · International Journal of Cardiology · doi:10.1016/j.ijcard.2008.04.010 · Cited by 162
Coordinated regulation of synthesis and stability of RNA during the acute TNF-induced proinflammatory response
Paulsen, M. T., Veloso, A., Prasad, J., Bedi, K., Ljungman, E. A., Tsan, Y.-C., Chang, C., Tarrier, B., Washburn, J. G., Lyons, R., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1219192110 · Cited by 162
An evolutionary perspective on the necroptotic pathway
Dondelinger, Y., Hulpiau, P., Saeys, Y., Bertrand, M. J. M., & Vandenabeele, P. (2016) · Trends in Cell Biology · doi:10.1016/j.tcb.2016.06.004 · Cited by 159
Heparanase and the hallmarks of cancer
Jayatilleke, K. M., & Hulett, M. D. (2020) · Journal of Translational Medicine · doi:10.1186/s12967-020-02624-1 · Cited by 167
Tumor Necrosis Factor-like Weak Inducer of Apoptosis Inhibits Skeletal Myogenesis through Sustained Activation of Nuclear Factor-κB and Degradation of MyoD Protein
Dogra, C., Changotra, H., Mohan, S., & Kumar, A. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m511131200 · Cited by 159
Infectious diseases of marine molluscs and host responses as revealed by genomic tools
Guo, X., & Ford, S. E. (2016) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2015.0206 · Cited by 158
TRAF ‐Mediated TNFR ‐Family Signaling
Arron, J. R., Walsh, M. C., & Choi, Y. (2002) · Current Protocols in Immunology · doi:10.1002/0471142735.im1109ds51 · Cited by 157
Fine-tuning of dendritic cell biology by the TNF superfamily
deLuca, L. S., & Gommerman, J. L. (2012) · Nature reviews. Immunology · doi:10.1038/nri3193 · Cited by 154
Immunomodulation of autoimmune arthritis by pro-inflammatory cytokines
Kim, E. Y., & Moudgil, K. D. (2017) · Cytokine · doi:10.1016/j.cyto.2017.04.012 · Cited by 157
A novel purified Lactobacillus acidophilus 20079 exopolysaccharide, LA-EPS-20079, molecularly regulates both apoptotic and NF-κB inflammatory pathways in human colon cancer
El-Deeb, N., Yassin, A. M., Al-Madboly, L. A., & El-Hawiet, A. M. (2018) · Microbial Cell Factories · doi:10.1186/s12934-018-0877-z · Cited by 144
The Cytokine TNF Promotes Transcription Factor SREBP Activity and Binding to Inflammatory Genes to Activate Macrophages and Limit Tissue Repair
Kusnadi, A., Park, S. H., Yuan, R., Pannellini, T., Giannopoulou, E., Oliver, D., Lu, T., Park-Min, K.-H., & Ivashkiv, L. B. (2019) · Immunity · doi:10.1016/j.immuni.2019.06.005 · Cited by 157
Selective Chemical Functional Probes of Granzymes A and B Reveal Granzyme B Is a Major Effector of Natural Killer Cell-Mediated Lysis of Target Cells
Mahrus, S., & Craik, C. S. (2005) · Chemistry & Biology · doi:10.1016/j.chembiol.2005.03.006 · Cited by 156
Rapid mitochondrial dysfunction mediates TNF ‐alpha‐induced neurotoxicity
Doll, D. N., Rellick, S. L., Barr, T. L., Ren, X. S., & Simpkins, J. W. (2014) · Journal of Neurochemistry · doi:10.1111/jnc.13008 · Cited by 155
The multifaceted roles of TRAFs in the regulation of B-cell function
Bishop, G. A. (2004) · Nature reviews. Immunology · doi:10.1038/nri1462 · Cited by 155
Competitive Control of Independent Programs of Tumor Necrosis Factor Receptor-Induced Cell Death by TRADD and RIP1
Zheng, L., Bidère, N., Staudt, D., Cubre, A., Orenstein, J. M., Chan, F. K.-M., & Lenardo, M. J. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.26.9.3505-3513.2006 · Cited by 155
Sleep and innate immunity
Krueger, J. M. (2010) · Frontiers in Bioscience-Scholar · doi:10.2741/s176 · Cited by 160
Embelin, an Inhibitor of X Chromosome-Linked Inhibitor-of-Apoptosis Protein, Blocks Nuclear Factor-κB (NF-κB) Signaling Pathway Leading to Suppression of NF-κB-Regulated Antiapoptotic and Metastatic Gene Products
Ahn, K. S., Sethi, G., & Aggarwal, B. B. (2006) · Molecular Pharmacology · doi:10.1124/mol.106.028787 · Cited by 154
Self-citation
The TNF–TNFR Family of Co-signal Molecules
So, T., & Ishii, N. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-981-32-9717-3_3 · Cited by 156
TRAF‐Mediated TNFR‐Family Signaling
Ha, H., Han, D., & Choi, Y. (2009) · Current Protocols in Immunology · doi:10.1002/0471142735.im1109ds87 · Cited by 159
TAK1 Is a Master Regulator of Epidermal Homeostasis Involving Skin Inflammation and Apoptosis
Omori, E., Matsumoto, K., Sanjo, H., Sato, S., Akira, S., Smart, R. C., & Ninomiya‐Tsuji, J. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m603384200 · Cited by 154
Role of Redox Status in Development of Glioblastoma
Salazar, A., Ortega, D. R., de la Cruz, V. P., Hernández‐Pedro, N., González‐Esquivel, D. F., Sotelo, J., & Pineda, B. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00156 · Cited by 158
TNF-Receptor-1 inhibition reduces liver steatosis, hepatocellular injury and fibrosis in NAFLD mice
Wandrer, F., Liebig, S., Marhenke, S., Vogel, A., John, K., Manns, M. P., Teufel, A., Itzel, T., Longerich, T., Maier, O., et al. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-2411-6 · Cited by 156
The spike protein of SARS-CoV-2 induces endothelial inflammation through integrin α5β1 and NF-κB signaling
Robles, J. P., Zamora, M., Adán‐Castro, E., Siqueiros‐Márquez, L., de la Escalera, G. M., & Clapp, C. (2022) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2022.101695 · Cited by 156
Novel therapeutic applications of nitric oxide donors in cancer: Roles in chemo- and immunosensitization to apoptosis and inhibition of metastases
Bonavida, B., Baritaki, S., Huerta‐Yépez, S., Vega, M. I., Chatterjee, D., & Yeung, K. C. (2008) · Nitric Oxide · doi:10.1016/j.niox.2008.04.018 · Cited by 152
Mesothelin confers pancreatic cancer cell resistance to TNF-α-induced apoptosis through Akt/PI3K/NF-κB activation and IL-6/Mcl-1 overexpression
Bharadwaj, U., Marin-Muller, C., Li, M., Chen, C., & Yao, Q. (2011) · Molecular Cancer · doi:10.1186/1476-4598-10-106 · Cited by 151
“TNF-a induces NF- B activation in most cells [17,18] but this is not always sufficient to avoid the pro-apoptotic effects of TNF-a; rather, a constitutive activation of NF- B seems to be necessary [20].”
Background
New perspectives of Lactobacillus plantarum as a probiotic: The gut-heart-brain axis
Liu, Y.-W., Liong, M., & Tsai, Y.-C. (2018) · The Journal of Microbiology · doi:10.1007/s12275-018-8079-2 · Cited by 158
Signals and ReceptorsPreprint
Heldin, C., Lu, B. C., Evans, R. M., & Gutkind, J. S. (2016) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a005900 · Cited by 163
A Synthetic Triterpenoid, CDDO-Me, Inhibits IκBα Kinase and Enhances Apoptosis Induced by TNF and Chemotherapeutic Agents through Down-Regulation of Expression of Nuclear Factor κB–Regulated Gene Products in Human Leukemic Cells
Shishodia, S., Sethi, G., Konopleva, M. Y., Andreeff, M., & Aggarwal, B. B. (2006) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-05-2044 · Cited by 147
Self-citation
Metformin Down-regulates TNF-α Secretion via Suppression of Scavenger Receptors in Macrophages
Hyun, B., Shin, S., Lee, A., Lee, S., Song, Y., Ha, N., Cho, K., & Kim, K. (2013) · Immune Network · doi:10.4110/in.2013.13.4.123 · Cited by 151
Signaling pathways in macrophages: molecular mechanisms and therapeutic targets
Li, M., Wang, M., Wen, Y., Zhang, H., Zhao, G., & Gao, Q. (2023) · MedComm · doi:10.1002/mco2.349 · Cited by 165
Negative Regulation of JNK Signaling by the Tumor Suppressor CYLD
Reiley, W. W., Zhang, M., & Sun, S. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m411049200 · Cited by 148
Beyond RNAi: Antiviral defense strategies in Drosophila and mosquito
Merkling, S. H., & van Rij, R. P. (2012) · Journal of Insect Physiology · doi:10.1016/j.jinsphys.2012.07.004 · Cited by 157
Enterocyte-Derived TAK1 Signaling Prevents Epithelium Apoptosis and the Development of Ileitis and Colitis
Kajino‐Sakamoto, R., Inagaki, M., Lippert, E., Akira, S., Robine, S., Matsumoto, K., Jobin, C., & Ninomiya‐Tsuji, J. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.2.1143 · Cited by 147
Functional Diversity of Flavonoids in the Inhibition of the Proinflammatory NF-κB, IRF, and Akt Signaling Pathways in Murine Intestinal Epithelial Cells
Ruiz, P. A., & Haller, D. (2006) · Journal of Nutrition · doi:10.1093/jn/136.3.664 · Cited by 147
A Critical Role of Luteolin-Induced Reactive Oxygen Species in Blockage of Tumor Necrosis Factor-Activated Nuclear Factor-κB Pathway and Sensitization of Apoptosis in Lung Cancer Cells
Ju, W., Wang, X., Shi, H., Chen, W., Belinsky, S. A., & Lin, Y. (2007) · Molecular Pharmacology · doi:10.1124/mol.106.032185 · Cited by 146
Chalcones with electron-withdrawing and electron-donating substituents: Anticancer activity against TRAIL resistant cancer cells, structure–activity relationship analysis and regulation of apoptotic proteins
Mai, C., Yaeghoobi, M., Abd-Rahman, N., Kang, Y. B., & Pichika, M. R. (2014) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2014.03.002 · Cited by 147
Toll-like receptors (TLR) 2 and 4 on human sperm recognize bacterial endotoxins and mediate apoptosis
Fujita, Y., Mihara, T., Okazaki, T., Shitanaka, M., Kushino, R., Ikeda, C., Negishi, H., Liu, Z., Richards, J. S., & Shimada, M. (2011) · Human Reproduction · doi:10.1093/humrep/der234 · Cited by 159
Pathological Neovascularization Is Reduced by Inactivation of ADAM17 in Endothelial Cells but Not in Pericytes
Weskamp, G., Mendelson, K., Swendeman, S. L., Gall, S. M. L., Ma, Y., Lyman, S. L., Hinoki, A., Eguchi, S., Guaiquil, V. H., Horiuchi, K., et al. (2010) · Circulation Research · doi:10.1161/circresaha.109.207415 · Cited by 147
Apoptosis in liver disease
Schattenberg, J. M., Galle, P. R., & Schuchmann, M. (2006) · Liver International · doi:10.1111/j.1478-3231.2006.01324.x · Cited by 144
Molecular Mechanisms of Cancer-Induced Sleep Disruption
Walker, W. H., II, & Borniger, J. C. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20112780 · Cited by 149
Cancer chemoprevention by phytochemicals: potential molecular targets, biomarkers and animal models
Ki Han, K. W. O. N., Barve, A., Yu, S., Huang, M., & Kong, A. T. (2007) · Acta Pharmacologica Sinica · doi:10.1111/j.1745-7254.2007.00694.x · Cited by 146
Ursolic acid induces apoptosis by activating p53 and caspase-3 gene expressions and suppressing NF-κB mediated activation of bcl-2 in B16F-10 melanoma cells
Manu, K. A., & Kuttan, G. (2008) · International Immunopharmacology · doi:10.1016/j.intimp.2008.02.013 · Cited by 147
Cytotoxicity of TNFα is regulated by integrin‐mediated matrix signaling
Chen, C., Young, J. L., Monzon, R. I., Chen, N., Todorović, V., & Lau, L. F. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601596 · Cited by 143
Signal Transducer and Activator of Transcription 1 Regulates Both Cytotoxic and Prosurvival Functions in Tumor Cells
Khodarev, N. N., Minn, A. J., Efimova, E. V., Darga, T. E., Labay, E., Beckett, M., Mauceri, H. J., Roizman, B., & Weichselbaum, R. R. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-1019 · Cited by 147
Mechanisms Linking Excess Adiposity and Carcinogenesis Promotion
Pérez-Hernández, A. I., Catalán, V., Gómez‐Ambrosi, J., RodrÃguez, A., & FrÃ¼hbeck, G. (2014) · Frontiers in Endocrinology · doi:10.3389/fendo.2014.00065 · Cited by 148
Tumor-specific cytotoxic T lymphocyte activity determines colorectal cancer patient prognosis
Reißfelder, C., Stamova, S., Gossmann, C., Braun, M., Bonertz, A., Walliczek, U., Grimm, M., Rahbari, N. N., Koch, M., Saadati, M., et al. (2014) · Journal of Clinical Investigation · doi:10.1172/jci74894 · Cited by 140
TNFR2: A Novel Target for Cancer Immunotherapy
Vanamee, É. S., & Faustman, D. L. (2017) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2017.09.007 · Cited by 142
Regulation of a distinct activated RIPK1 intermediate bridging complex I and complex II in TNFα-mediated apoptosis
Amin, P. P., Florez, M. A., Najafov, A., Pan, H., Geng, J., Ofengeim, D., Dziedzic, S. A., Wang, H., Barrett, V. J., Ito, Y., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1806973115 · Cited by 143
A Novel TNF-α-Targeting Aptamer for TNF-α-Mediated Acute Lung Injury and Acute Liver Failure
Lai, W., Wang, J.-W., Huang, B.-T., Lin, E. P.-Y., & Yang, P. (2019) · Theranostics · doi:10.7150/thno.30972 · Cited by 145
A Metal‐Based Inhibitor of Tumor Necrosis Factor‐α
Leung, C., Zhong, H., Yang, H., Cheng, Z., Chan, D. S., Ma, V. P., Abagyan, R. A., Wong, C., & Ma, D. (2012) · Angewandte Chemie · doi:10.1002/ange.201202937 · Cited by 142
A New Class of Reverse Signaling Costimulators Belongs to the TNF Family
Sun, M., & Fink, P. J. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.7.4307 · Cited by 141
Role of Epigenetics in Inflammation-Associated diseases
Shanmugam, M. K., & Sethi, G. (2013) · Subcellular Biochemistry · doi:10.1007/978-94-007-4525-4_27 · Cited by 141
The Era of Radiogenomics in Precision Medicine: An Emerging Approach to Support Diagnosis, Treatment Decisions, and Prognostication in Oncology
Shui, L., Ren, H., Yang, X., Li, J., Chen, Z., Cheng, Y., Zhu, H., & Shui, P. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2020.570465 · Cited by 150
Paradoxical Anti-Inflammatory Actions of TNF-α: Inhibition of IL-12 and IL-23 via TNF Receptor 1 in Macrophages and Dendritic Cells
Bettini, M., & Ziegler, H. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.8.5024 · Cited by 146
Nitric oxide-mediated sensitization of resistant tumor cells to apoptosis by chemo-immunotherapeutics
Bonavida, B., & Garbán, H. (2015) · Redox Biology · doi:10.1016/j.redox.2015.08.013 · Cited by 143
BCR ligation induced by IgM stimulation results in gene expression and functional changes only in IgVH unmutated chronic lymphocytic leukemia (CLL) cells
Guarini, A. R., Chiaretti, S., Tavolaro, S., Maggio, R., Peragine, N., Citarella, F., Ricciardi, M. R., Santangelo, S., Marinelli, M., Propris, M. S. D., et al. (2008) · Blood · doi:10.1182/blood-2007-12-127688 · Cited by 140
Importance of TNFα and neutral lipases in human adipose tissue lipolysis
Langin, D., & Arner, P. (2006) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2006.08.003 · Cited by 140
Ubiquitin enzymes in the regulation of immune responses
Ebner, P., Versteeg, G. A., & Ikeda, F. (2017) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409238.2017.1325829 · Cited by 143
Crosstalk between Keratinocytes and Adaptive Immune Cells in an IκBα Protein-Mediated Inflammatory Disease of the Skin
Rebholz, B., Haase, I., Eckelt, B., Paxian, S. A., Flaig, M. J., Ghoreschi, K., Nedospasov, S. A., Mailhammer, R., Debey‐Pascher, S., Schultze, J. L., et al. (2007) · Immunity · doi:10.1016/j.immuni.2007.05.024 · Cited by 138
A New Venue of TNF Targeting
Steeland, S., Libert, C., & Vandenbroucke, R. E. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19051442 · Cited by 145
Dual-mechanism based CTLs infiltration enhancement initiated by Nano-sapper potentiates immunotherapy against immune-excluded tumors
Huang, Y., Chen, Y., Zhou, S., Liang, C., Wang, J., Pei, Y., Xu, M., Feng, J., Jiang, T., Liang, K., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-14425-7 · Cited by 137
Distinct Signaling Pathways in TRAIL- versus Tumor Necrosis Factor-Induced Apoptosis
Jin, Z., & El‐Deiry, W. S. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.00257-06 · Cited by 137
Expression of Costimulatory TNFR2 Induces Resistance of CD4+FoxP3− Conventional T Cells to Suppression by CD4+FoxP3+ Regulatory T Cells
Chen, X., Hamano, R., Subleski, J. J., Hurwitz, A. A., Howard, O. M. Z., & Oppenheim, J. J. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0903548 · Cited by 143
Maslinic acid potentiates the anti-tumor activity of tumor necrosis factor α by inhibiting NF-κB signaling pathway
Li, C., Yang, Z., Zhai, C., Qiu, W., Li, D., Yi, Z., Wang, L., Tang, J., Qian, M., Luo, J., et al. (2010) · Molecular Cancer · doi:10.1186/1476-4598-9-73 · Cited by 136
Inhibition of Myogenic MicroRNAs 1, 133, and 206 by Inflammatory Cytokines Links Inflammation and Muscle Degeneration in Adult Inflammatory Myopathies
Georgantas, R. W., Streicher, K. L., Greenberg, S. A., Greenlees, L. M., Zhu, W. P., Brohawn, P. Z., Higgs, B. W., Czapiga, M., Morehouse, C. A., Amato, A. A., et al. (2013) · Arthritis & Rheumatology · doi:10.1002/art.38292 · Cited by 136
Inhibition of soluble tumor necrosis factor is therapeutic in Huntington's disease
Hsiao, H., Chiu, F., Chen, C., Wu, Y., Chen, H., Chen, Y., Kuo, H., & Chern, Y. (2014) · Human Molecular Genetics · doi:10.1093/hmg/ddu151 · Cited by 135
The redox biology network in cancer pathophysiology and therapeutics
Manda, G., Isvoranu, G., Comanescu, M. V., Manea, A., BÜTÜNER, B. D., & Korkmaz, K. (2015) · Redox Biology · doi:10.1016/j.redox.2015.06.014 · Cited by 139

Authors: Aggarwal, B. B.
Affiliations: The University of Texas MD Anderson Cancer Center (US)
Corresponding author: Aggarwal, Bharat B.
ORCID: Aggarwal, Bharat B.
Venue: Nature Reviews Immunology
Publisher: Springer Science and Business Media LLC
Published: 2003-09
Volume: 3
Issue: 9
Pages: 745-756
ISSN: 1474-1733 (ISSN-L)
1474-1741
DOI: 10.1038/nri1184
OpenAlex: W2095013915
Cited by: 2,793
References: 124
Citations by year: 2026: 74 · 2025: 107 · 2024: 82 · 2023: 121 · 2022: 125 · 2021: 114 · 2020: 132 · 2019: 113 · 2018: 114 · 2017: 130 · 2016: 108 · 2015: 142 · 2014: 128 · 2013: 116 · 2012: 159
FWCI: 9.77
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature reviews. Immunology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Keywords: TNF superfamily, TNF-α, TNF receptor, signaling pathways, carcinogenesis, graft rejection, septic shock, viral replication, bone resorption, rheumatoid arthritis, diabetes mellitus, apoptosis, TNF-alpha inhibitors, autoimmune disease, cytokines
MeSH terms: Animals, Autoimmune Diseases, Carrier Proteins, Humans, Ligands, Lymphotoxin-alpha, Membrane Proteins, Tumor Necrosis Factor-alpha, Signal Transduction, NF-kappa B, Receptors, Tumor Necrosis Factor, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Signalling pathways of the TNF superfamily: a double-edged sword

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks