Cited by 371Inflammasome and immune disordersImmune Response and InflammationCell death mechanisms and regulation

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NLRs at the intersection of cell death and immunity

Ting, Jenny P.-Y., Willingham, Stephen B., Bergstralh, Daniel T.·2008·Nature Reviews Immunology

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Abstract

Inflammation is a crucial element of the host response to cellular insult. Pathogen-induced inflammation includes a molecular pathway which proceeds through activation of the protease caspase-1 to the release of the inflammatory cytokines interleukin-1 (IL-1) and IL-18. Importantly, pathogens may also induce forms of cell death that have inherently pro-inflammatory features. Here, we review recent evidence demonstrating that NLR (nucleotide-binding domain, leucine-rich repeat containing) family proteins serve as a common component of both caspase-1-activated apoptotic pathways and caspase-independent necrotic pathways. Parallels are drawn between NLR protein function and the activity of structurally similar proteins involved in cell death: the apoptotic mediator APAF1 (apoptotic-protease-activating factor 1) and the plant disease resistance NBS-LRR (nucleotide-binding site leucine-rich repeats) proteins.

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Authors: Ting, J. P.-Y., Willingham, S. B., & Bergstralh, D. T.
Affiliations: University of North Carolina at Chapel Hill (US)
Corresponding author: Ting, Jenny P.-Y.
ORCID: Ting, Jenny P.-Y.
Venue: Nature Reviews Immunology
Publisher: Springer Science and Business Media LLC
Published: 2008-05
Volume: 8
Issue: 5
Pages: 372-379
ISSN: 1474-1733 (ISSN-L)
1474-1741
DOI: 10.1038/nri2296
OpenAlex: W2050870561
Cited by: 371
References: 145
Citations by year: 2026: 5 · 2025: 9 · 2024: 7 · 2023: 8 · 2022: 10 · 2021: 14 · 2020: 10 · 2019: 19 · 2018: 18 · 2017: 18 · 2016: 17 · 2015: 19 · 2014: 22 · 2013: 27 · 2012: 36
FWCI: 3.40
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature reviews. Immunology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Keywords: NLR proteins, cell death, pyroptosis, caspase-1, apoptosis, necrosis, inflammation, interleukin-1, IL-18, Apaf-1, NBS-LRR proteins, plant disease resistance, host-pathogen interaction
MeSH terms: NLR Proteins, Leucine-Rich Repeat Proteins, Animals, Communicable Diseases, Humans, Interleukin-1, Necrosis, Proteins, Tumor Necrosis Factor-alpha, Apoptosis, Caspase 1, HMGB1 Protein, Intracellular Signaling Peptides and Proteins, Adaptor Proteins, Signal Transducing, Apoptosis Regulatory Proteins, Apoptotic Protease-Activating Factor 1

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NLRs at the intersection of cell death and immunity

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