The molecular basis of the memory T cell response: differential gene expression and its epigenetic regulation
Open accessAbstract
How the immune system remembers a previous encounter with a pathogen and responds more efficiently to a subsequent encounter has been one of the central enigmas for immunologists for over a century. The identification of pathogen-specific memory lymphocytes that arise after an infection provided a cellular basis for immunological memory. But the molecular mechanisms of immunological memory remain only partially understood. The emerging evidence suggests that epigenetic changes have a key role in controlling the distinct transcriptional profiles of memory lymphocytes and thus in shaping their function. In this Review, we summarize the recent progress that has been made in assessing the differential gene expression and chromatin modifications in memory CD4(+) and CD8(+) T cells, and we present our current understanding of the molecular basis of memory T cell function.
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TEM subset expressed higher levels of memory-associated genes Itgb7, Itgb1, and Il18r1 in both comparisons.
“the TEM subset expressed higher levels of memory-associated genes [e.g., Itgb7, Itgb1, and Il18r1; (27)] in both comparisons.”
From Aging promotes reorganization of the CD4 T cell landscape toward extreme regulatory and effector phenotypes (2019) · cites this paper as [27]
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- Authors
- Weng, N.-P., Araki, Y., & Subedi, K.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- Weng, Nan-ping
- Venue
- Nature Reviews Immunology
- Published
- 2012-03-16
- Volume
- 12
- Issue
- 4
- Pages
- 306-315
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- PMC
- PMC4686144
- OpenAlex
- W2084317828
- Cited by
- 290
- References
- 68
- Citations by year
- 2026: 11 · 2025: 13 · 2024: 22 · 2023: 20 · 2022: 25 · 2021: 20 · 2020: 11 · 2019: 26 · 2018: 22 · 2017: 27 · 2016: 18 · 2015: 24 · 2014: 21 · 2013: 20 · 2012: 10
- FWCI
- 2.21
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Immunology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- Japan Society for the Promotion of Science (23790544)
- National Institute on Aging (ZIAAG000112)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Keywords
- memory T cells, immunological memory, epigenetic regulation, chromatin modification, differential gene expression, naive T cells, CD4+ T cells, CD8+ T cells, gene expression profiling
- MeSH terms
- Animals, Gene Expression Regulation, Humans, Immunologic Memory, T-Lymphocyte Subsets, Epigenesis, Genetic
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