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Mast cell secretory granules: armed for battle

Wernersson, Sara, Pejler, Gunnar·2014·Nature Reviews Immunology
DOI 10.1038/nri3690
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Abstract

Mast cells are important effector cells of the immune system and recent studies show that they have immunomodulatory roles in diverse processes in both health and disease. Mast cells are distinguished by their high content of electron-dense secretory granules, which are filled with large amounts of preformed and pre-activated immunomodulatory compounds. When appropriately activated, mast cells undergo degranulation, a process by which these preformed granule compounds are rapidly released into the surroundings. In many cases, the effects that mast cells have on an immune response are closely associated with the biological actions of the granule compounds that they release, as exemplified by the recent studies showing that mast cell granule proteases account for many of the protective and detrimental effects of mast cells in various inflammatory settings. In this Review, we discuss the current knowledge of mast cell secretory granules.

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Metadata

Authors
Wernersson, S., & Pejler, G.
Venue
Nature Reviews Immunology
Publisher
Springer Science and Business Media LLC
Published
2014-06-06
Volume
14
Issue
7
Pages
478-494
ISSN
  • 1474-1733
  • 1474-1741
DOI
10.1038/nri3690
Cited by
906
References
1
Language
en
Licence
www.springer.com/tdm (tdm)

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