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Regulating Rho GTPases and their regulators

Hodge, Richard G., Ridley, Anne J.·2016·Nature Reviews Molecular Cell Biology
DOI 10.1038/nrm.2016.67
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Abstract

Rho GTPases regulate cytoskeletal and cell adhesion dynamics and thereby coordinate a wide range of cellular processes, including cell migration, cell polarity and cell cycle progression. Most Rho GTPases cycle between a GTP-bound active conformation and a GDP-bound inactive conformation to regulate their ability to activate effector proteins and to elicit cellular responses. However, it has become apparent that Rho GTPases are regulated by post-translational modifications and the formation of specific protein complexes, in addition to GTP-GDP cycling. The canonical regulators of Rho GTPases - guanine nucleotide exchange factors, GTPase-activating proteins and guanine nucleotide dissociation inhibitors - are regulated similarly, creating a complex network of interactions to determine the precise spatiotemporal activation of Rho GTPases.

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Metadata

Authors
Hodge, R. G., & Ridley, A. J.
Venue
Nature Reviews Molecular Cell Biology
Publisher
Springer Science and Business Media LLC
Published
2016-06-15
Volume
17
Issue
8
Pages
496-510
ISSN
  • 1471-0072
  • 1471-0080
DOI
10.1038/nrm.2016.67
Cited by
872
References
4
Language
en
Licence
www.springer.com/tdm (tdm)

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