Autophagy in metazoans: cell survival in the land of plenty

LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing.

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The role of autophagy during the early neonatal starvation period

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Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

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Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene

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Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor

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Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

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Chemistry and Biology of the Immunophilins and Their Immunosuppressive Ligands

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Growth factor regulation of autophagy and cell survival in the absence of apoptosis

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Akt Stimulates Aerobic Glycolysis in Cancer Cells

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Role of Bcl-2 family proteins in a non-apoptotic programmed cell death dependent on autophagy genes

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Autophagy fights disease through cellular self-digestion

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TOR signaling in growth and metabolism

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Bcl-2 Antiapoptotic Proteins Inhibit Beclin 1-Dependent Autophagy

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FoxO3 Controls Autophagy in Skeletal Muscle In Vivo

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Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum

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Hypoxia signalling in cancer and approaches to enforce tumour regression

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Distinct Roles of Autophagy in the Heart During Ischemia and Reperfusion: Roles of AMP-Activated Protein Kinase and Beclin 1 in Mediating Autophagy

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Defective Hepatic Autophagy in Obesity Promotes ER Stress and Causes Insulin Resistance

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Homeostasis of Naive and Memory T Cells

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The eIF2α/ATF4 pathway is essential for stress-induced autophagy gene expression

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Regulation of autophagy by cytoplasmic p53

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The role of PI3K/AKT/mTOR pathway in the modulation of autophagy and the clearance of protein aggregates in neurodegeneration

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Tumor suppressors and cell metabolism: a recipe for cancer growth

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Mechanisms of Life Span Extension by Rapamycin in the Fruit Fly Drosophila Melanogaster

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p53 and metabolism

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Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG

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The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5

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The two TORCs and Akt

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Autophagy-dependent cell death

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Toll‐like receptors control autophagy

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Linking of autophagy to ubiquitin-proteasome system is important for the regulation of endoplasmic reticulum stress and cell viability.

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A critical role for the autophagy gene Atg5 in T cell survival and proliferation

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Divorcing ARF and p53: an unsettled case

Sherr, C. J. (2006) · Nature reviews. Cancer · doi:10.1038/nrc1954 · Cited by 595

Improvement of Cardiac Functions by Chronic Metformin Treatment Is Associated With Enhanced Cardiac Autophagy in Diabetic OVE26 Mice

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Hepatocyte Death: A Clear and Present Danger

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Targeting ER stress–induced autophagy overcomes BRAF inhibitor resistance in melanoma

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Unconventional secretion of Acb1 is mediated by autophagosomes

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TAK1 activates AMPK‐dependent cytoprotective autophagy in TRAIL‐treated epithelial cells

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BNIP3 Is an RB/E2F Target Gene Required for Hypoxia-Induced Autophagy

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GSK3-TIP60-ULK1 Signaling Pathway Links Growth Factor Deprivation to Autophagy

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Role of mTOR in physiology and pathology of the nervous system

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Dissecting the dynamic turnover of GFP-LC3 in the autolysosome

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Sustained Activation of mTORC1 in Skeletal Muscle Inhibits Constitutive and Starvation-Induced Autophagy and Causes a Severe, Late-Onset Myopathy

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Metabolism in T cell activation and differentiation

Pearce, E. L. (2010) · Current Opinion in Immunology · doi:10.1016/j.coi.2010.01.018 · Cited by 314

Stress and mTORture signaling

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Dual roles of autophagy in the survival of Caenorhabditis elegans during starvation

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Aup1p, a yeast mitochondrial protein phosphatase homolog, is required for efficient stationary phase mitophagy and cell survival

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The Regulation of Skeletal Muscle Protein Turnover during the Progression of Cancer Cachexia in the ApcMin/+ Mouse

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Regulation of autophagy by phosphatidylinositol 3‐phosphate

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Cholesterol trafficking is required for mTOR activation in endothelial cells

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Autophagic Stress in Neuronal Injury and Disease

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Autophagy in disease: a double-edged sword with therapeutic potential

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Autophagy Regulation of Metabolism Is Required for CD8+ T Cell Anti-tumor Immunity

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C. elegansfeeding defective mutants have shorter body lengths and increased autophagy

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CD63 is regulated by iron via the IRE-IRP system and is important for ferritin secretion by extracellular vesicles

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Ageing and the regulation of protein synthesis: a balancing act?

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DRAM1 regulates apoptosis through increasing protein levels and lysosomal localization of BAX

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A GDI (AGS3) and a GEF (GIV) regulate autophagy by balancing G protein activity and growth factor signals

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Glucocorticoid elevation of dexamethasone-induced gene 2 (Dig2/RTP801/REDD1) protein mediates autophagy in lymphocytes

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Novel AKT1-GLI3-VMP1 Pathway Mediates KRAS Oncogene-induced Autophagy in Cancer Cells

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mTOR-Dependent Cell Proliferation in the Brain

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Branched-Chain Amino Acids Reduce Hindlimb Suspension-Induced Muscle Atrophy and Protein Levels of Atrogin-1 and MuRF1 in Rats

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Induction of Autophagy and Inhibition of Melanoma Growth In Vitro and In Vivo by Hyperactivation of Oncogenic BRAF

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Dual Src and MEK Inhibition Decreases Ovarian Cancer Growth and Targets Tumor Initiating Stem-Like Cells

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Repositioning chloroquine and metformin to eliminate cancer stem cell traits in pre-malignant lesions

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Transcriptomic profiles of aging in purified human immune cells

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Lanatoside C sensitizes glioblastoma cells to tumor necrosis factor–related apoptosis-inducing ligand and induces an alternative cell death pathway

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Phosphorylation of p62 by AMP-activated protein kinase mediates autophagic cell death in adult hippocampal neural stem cells

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“Get the Balance Right”: Pathological Significance of Autophagy Perturbation in Neuromuscular Disorders

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(2012) · PubMed