Adhesion molecule signalling: not always a sticky business

Wnt/β-Catenin Signaling in Development and Disease

Clevers, H. (2006) · Cell · doi:10.1016/j.cell.2006.10.018 · Cited by 5,568

Integrins in cancer: biological implications and therapeutic opportunities

Desgrosellier, J. S., & Cheresh, D. A. (2010) · Nature Reviews Cancer · doi:10.1038/nrc2748 · Cited by 3,736

Molecular regulation of angiogenesis and lymphangiogenesis

Adams, R. H., & Alitalo, K. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2183 · Cited by 2,019

A mechanosensory complex that mediates the endothelial cell response to fluid shear stress

Tzima, E., Irani-Tehrani, M., Kiosses, W. B., Dejana, E., Schultz, D. A., Engelhardt, B., Cao, G., DeLisser, H., & Schwartz, M. A. (2005) · Nature · doi:10.1038/nature03952 · Cited by 1,711

Adherens and tight junctions: Structure, function and connections to the actin cytoskeleton

Hartsock, A., & Nelson, W. J. (2008) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2007.07.012 · Cited by 1,559

Control of vascular morphogenesis and homeostasis through the angiopoietin–Tie system

Augustin, H. G., Young Koh, G., Thurston, G., & Alitalo, K. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2639 · Cited by 1,465

Endothelial Cell-to-Cell Junctions: Molecular Organization and Role in Vascular Homeostasis

Bazzoni, G., & Dejana, E. (2004) · Physiological Reviews · doi:10.1152/physrev.00035.2003 · Cited by 1,389

Proximal events in Wnt signal transduction

Angers, S., & Moon, R. T. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2717 · Cited by 1,112

Adherens junctions: from molecules to morphogenesis

Harris, T. J. C., & Tepass, U. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2927 · Cited by 990

Neural recognition molecules of the immunoglobulin superfamily: signaling transducers of axon guidance and neuronal migration

Maness, P. F., & Schachner, M. (2007) · Nature Neuroscience · doi:10.1038/nn1827 · Cited by 847

Angiogenesis: A Team Effort Coordinated by Notch

Phng, L.-K., & Gerhardt, H. (2009) · Developmental Cell · doi:10.1016/j.devcel.2009.01.015 · Cited by 832

Untitled work

Vestweber (2008) · doi:10.1161/atvbaha.107.158014 · Cited by 806

N-Cadherin Promotes Motility in Human Breast Cancer Cells Regardless of Their E-Cadherin Expression

Nieman, M. T., Prudoff, R. S., Johnson, K. R., & Wheelock, M. J. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.147.3.631 · Cited by 789

Mechanisms of cutaneous toxicities to EGFR inhibitors

Lacouture, M. E. (2006) · Nature Reviews Cancer · doi:10.1038/nrc1970 · Cited by 789

The Control of Vascular Integrity by Endothelial Cell Junctions: Molecular Basis and Pathological Implications

Dejana, E., Tournier-Lasserve, E., & Weinstein, B. M. (2009) · Developmental Cell · doi:10.1016/j.devcel.2009.01.004 · Cited by 788

Endothelial adherens junctions control tight junctions by VE-cadherin-mediated upregulation of claudin-5

Taddei, A., Giampietro, C., Conti, A., Orsenigo, F., Breviario, F., Pirazzoli, V., Potente, M., Daly, C., Dimmeler, S., & Dejana, E. (2008) · Nature Cell Biology · doi:10.1038/ncb1752 · Cited by 653

Regulation of Endothelial Permeability via Paracellular and Transcellular Transport Pathways

Komarova, Y., & Malik, A. B. (2010) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021909-135833 · Cited by 641

Interplay of Cadherin-Mediated Cell Adhesion and Canonical Wnt Signaling

Heuberger, J., & Birchmeier, W. (2010) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a002915 · Cited by 619

Adherens Junction: Molecular Architecture and Regulation

Meng, W., & Takeichi, M. (2009) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a002899 · Cited by 593

Nectins and nectin-like molecules: roles in contact inhibition of cell movement and proliferation

Takai, Y., Miyoshi, J., Ikeda, W., & Ogita, H. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2457 · Cited by 586

Activation of the FGF receptor underlies neurite outgrowth stimulated by L1, N-CAM, and N-cadherin

Williams, E. J., Furness, J., Walsh, F. S., & Doherty, P. (1994) · Neuron · doi:10.1016/0896-6273(94)90027-2 · Cited by 585

Vascular endothelial cadherin controls VEGFR-2 internalization and signaling from intracellular compartments

Lampugnani, M. G., Orsenigo, F., Gagliani, M. C., Tacchetti, C., & Dejana, E. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200602080 · Cited by 525

A signaling pathway leading to metastasis is controlled by N-cadherin and the FGF receptor

Suyama, K., Shapiro, I., Guttman, M., & Hazan, R. B. (2002) · Cancer Cell · doi:10.1016/s1535-6108(02)00150-2 · Cited by 515

Endothelial adherens and tight junctions in vascular homeostasis, inflammation and angiogenesis

Wallez, Y., & Huber, P. (2008) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2007.09.003 · Cited by 473

Contact inhibition of VEGF-induced proliferation requires vascular endothelial cadherin, β-catenin, and the phosphatase DEP-1/CD148

Lampugnani, M. G., Zanetti, A., Corada, M., Takahashi, T., Balconi, G., Breviario, F., Orsenigo, F., Cattelino, A., Kemler, R., Daniel, T. O., et al. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200209019 · Cited by 410

Molecular Basis of the Core Structure of Tight Junctions

Furuse, M. (2010) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a002907 · Cited by 408

Alternative Wnt Signaling Is Initiated by Distinct Receptors

van Amerongen, R., Mikels, A., & Nusse, R. (2008) · Science Signaling · doi:10.1126/scisignal.135re9 · Cited by 401

The Immunoglobulin-Like Cell Adhesion Molecule Nectin and Its Associated Protein Afadin

Takai, Y., Ikeda, W., Ogita, H., & Rikitake, Y. (2008) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.24.110707.175339 · Cited by 371

L1, a novel target of β-catenin signaling, transforms cells and is expressed at the invasive front of colon cancers

Gavert, N., Conacci-Sorrell, M., Gast, D., Schneider, A., Altevogt, P., Brabletz, T., & Ben-Ze'ev, A. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200408051 · Cited by 359

VEGF receptor 2 and the adherens junction as a mechanical transducer in vascular endothelial cells

Shay-Salit, A., Shushy, M., Wolfovitz, E., Yahav, H., Breviario, F., Dejana, E., & Resnick, N. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.142224299 · Cited by 339

N-CAM modulates tumour-cell adhesion to matrix by inducing FGF-receptor signalling

Cavallaro, U., Niedermeyer, J., Fuxa, M., & Christofori, G. (2001) · Nature Cell Biology · doi:10.1038/35083041 · Cited by 307

Cleavage and Shedding of E-cadherin after Induction of Apoptosis

Steinhusen, U., Weiske, J., Badock, V., Tauber, R., Bommert, K., & Huber, O. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m006102200 · Cited by 278

Structural Basis for a Direct Interaction between FGFR1 and NCAM and Evidence for a Regulatory Role of ATP

Kiselyov, V. V., Skladchikova, G., Hinsby, A. M., Jensen, P. H., Kulahin, N., Soroka, V., Pedersen, N., Tsetlin, V., Poulsen, F. M., Berezin, V., et al. (2003) · Structure · doi:10.1016/s0969-2126(03)00096-0 · Cited by 265

Interactions between growth factor receptors and adhesion molecules: breaking the rules

Comoglio, P. M., Boccaccio, C., & Trusolino, L. (2003) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(03)00096-6 · Cited by 254

N-Cadherin Signaling Potentiates Mammary Tumor Metastasis via Enhanced Extracellular Signal-Regulated Kinase Activation

Hulit, J., Suyama, K., Chung, S., Keren, R., Agiostratidou, G., Shan, W., Dong, X., Williams, T. M., Lisanti, M. P., Knudsen, K., et al. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-3401 · Cited by 218

Antagonistic roles of full-length N-cadherin and its soluble BMP cleavage product in neural crest delamination

Shoval, I., Ludwig, A., & Kalcheim, C. (2007) · Development · doi:10.1242/dev.02742 · Cited by 212

Desmoglein 1–dependent suppression of EGFR signaling promotes epidermal differentiation and morphogenesis

Getsios, S., Simpson, C. L., Kojima, S.-I., Harmon, R., Sheu, L. J., Dusek, R. L., Cornwell, M., & Green, K. J. (2009) · Journal of Cell Biology · doi:10.1083/jcb.200809044 · Cited by 209

Regulation of desmosome assembly and adhesion

Yin, T., & Green, K. J. (2004) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2004.09.005 · Cited by 199

De-regulated FGF receptors as therapeutic targets in cancer

Knights, V., & Cook, S. J. (2010) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2009.10.001 · Cited by 196

p120-ctn: A nexus for contextual signaling via Rho GTPases

Anastasiadis, P. Z. (2007) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2006.08.040 · Cited by 192

Differential Mechanisms of LEF/TCF Family-Dependent Transcriptional Activation by β-Catenin and Plakoglobin

Zhurinsky, J., Shtutman, M., & Ben-Ze'ev, A. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.12.4238-4252.2000 · Cited by 185

Structure and Interactions of NCAM Ig1-2-3 Suggest a Novel Zipper Mechanism for Homophilic Adhesion

Soroka, V., Kolkova, K., Kastrup, J. S., Diederichs, K., Breed, J., Kiselyov, V. V., Poulsen, F. M., Larsen, I. K., Welte, W., Berezin, V., et al. (2003) · Structure · doi:10.1016/j.str.2003.09.006 · Cited by 180

CCM1 regulates vascular-lumen organization by inducing endothelial polarity

Lampugnani, M. G., Orsenigo, F., Rudini, N., Maddaluno, L., Boulday, G., Chapon, F., & Dejana, E. (2010) · Journal of Cell Science · doi:10.1242/jcs.059329 · Cited by 174

Adhesive and Signaling Functions of Cadherins and Catenins in Vertebrate Development

Stepniak, E., Radice, G. L., & Vasioukhin, V. (2009) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a002949 · Cited by 167

Identification of an N-cadherin Motif That Can Interact with the Fibroblast Growth Factor Receptor and Is Required for Axonal Growth

Williams, E., Williams, G. H., Howell, F. V., Skaper, S. D., Walsh, F. S., & Doherty, P. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m105876200 · Cited by 149

Immunoglobulin superfamily cell adhesion molecules: zippers and signals

Aricescu, A. R., & Jones, E. Y. (2007) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2007.09.010 · Cited by 146

Dancing in and out of the nucleus: p120ctn and the transcription factor Kaiso

Daniel, J. M. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2006.08.052 · Cited by 135

The binding of NCAM to FGFR1 induces a specific cellular response mediated by receptor trafficking

Francavilla, C., Cattaneo, P., Berezin, V., Bock, E., Ami, D., de Marco, A., Christofori, G., & Cavallaro, U. (2009) · The Journal of Cell Biology · doi:10.1083/jcb.200903030 · Cited by 133

Activity of the β-catenin phosphodestruction complex at cell–cell contacts is enhanced by cadherin-based adhesion

Maher, M. T., Flozak, A. S., Stocker, A. M., Chenn, A., & Gottardi, C. J. (2009) · The Journal of Cell Biology · doi:10.1083/jcb.200811108 · Cited by 131

Polarity and Differential Inheritance—Universal Attributes of Life?

Macara, I. G., & Mili, S. (2008) · Cell · doi:10.1016/j.cell.2008.11.006 · Cited by 128

Soluble N‐cadherin stimulates fibroblast growth factor receptor dependent neurite outgrowth and N‐cadherin and the fibroblast growth factor receptor co‐cluster in cells

Utton, M. A., Eickholt, B. J., Howell, F. V., Wallis, J., & Doherty, P. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00140.x · Cited by 126

Signaling mechanisms of neurite outgrowth induced by the cell adhesion molecules NCAM and N-Cadherin

Hansen, S. M., Berezin, V., & Bock, E. (2008) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-008-8290-0 · Cited by 126

Desmoglein-2: A Novel Regulator of Apoptosis in the Intestinal Epithelium

Nava, P., Laukoetter, M. G., Hopkins, A. M., Laur, O., Gerner-Smidt, K., Green, K. J., Parkos, C. A., & Nusrat, A. (2007) · Molecular Biology of the Cell · doi:10.1091/mbc.e07-05-0426 · Cited by 117

Nuclear translocation and signalling of L1-CAM in human carcinoma cells requires ADAM10 and presenilin/γ-secretase activity

Riedle, S., Kiefel, H., Gast, D., Bondong, S., Wolterink, S., Gutwein, P., & Altevogt, P. (2009) · Biochemical Journal · doi:10.1042/bj20081625 · Cited by 109

The Differentiation-dependent Desmosomal Cadherin Desmoglein 1 Is a Novel Caspase-3 Target That Regulates Apoptosis in Keratinocytes

Dusek, R. L., Getsios, S., Chen, F., Park, J. K., Amargo, E. V., Cryns, V. L., & Green, K. J. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m508258200 · Cited by 106

Truncation of the β-Catenin Binding Domain of E-cadherin Precedes Epithelial Apoptosis during Prostate and Mammary Involution

Vallorosi, C. J., Day, K. C., Zhao, X., Rashid, M. G., Rubin, M. A., Johnson, K. R., Wheelock, M. J., & Day, M. L. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.5.3328 · Cited by 101

Nuclear factor-κB signaling and ezrin are essential for L1-mediated metastasis of colon cancer cells

Gavert, N. S., Ben‐Shmuel, A., Lemmon, V., Brabletz, T., & Ben‐Ze'ev, A. (2010) · Journal of Cell Science · doi:10.1242/jcs.069542 · Cited by 99

Up-regulation of L1CAM in Pancreatic Duct Cells Is Transforming Growth Factor β1– and Slug-Dependent: Role in Malignant Transformation of Pancreatic Cancer

Geismann, C., Morscheck, M., Koch, D., Bergmann, F., Ungefroren, H., Arlt, A., Tsao, M., Bachem, M. G., Altevogt, P., Sipos, B., et al. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-3493 · Cited by 96

Recognition molecules and neural repair

Loers, G., & Schachner, M. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.04409.x · Cited by 89

Junctional Music that the Nucleus Hears: Cell-Cell Contact Signaling and the Modulation of Gene ActivityPreprint

McCrea, P. D., Gu, D., & Balda, B. (2009) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a002923 · Cited by 89

Neural cell adhesion molecule regulates the cellular response to fibroblast growth factor

Francavilla, C., Loeffler, S., Piccini, D., Kren, A., Christofori, G., & Cavallaro, U. (2007) · Journal of Cell Science · doi:10.1242/jcs.010744 · Cited by 86

CD146 Short Isoform Increases the Proangiogenic Potential of Endothelial Progenitor Cells In Vitro and In Vivo

Kebir, A., Harhouri, K., Guillet, B. A., Liu, J. W., Foucault‐Bertaud, A., Lamy, E., Kaspi, É., Elganfoud, N., Vely, F., Sabatier, F., et al. (2010) · Circulation Research · doi:10.1161/circresaha.109.213827 · Cited by 85

The cytoplasmic part of L1-CAM controls growth and gene expression in human tumors that is reversed by therapeutic antibodies

Gast, D., Riedle, S., Issa, Y., Pfeifer, M., Beckhove, P., Sanderson, M. P., Arlt, M., Moldenhauer, G., Fogel, M., Krüger, A., et al. (2007) · Oncogene · doi:10.1038/sj.onc.1210747 · Cited by 81

Junctional Adhesion Molecule-C Is a Soluble Mediator of Angiogenesis

Rabquer, B. J., Amin, M. A., Teegala, N., et al. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1000556 · Cited by 78

The neural cell adhesion molecule binds to fibroblast growth factor receptor 2

Christensen, C., Lauridsen, J. B., Berezin, V., Bock, E., & Kiselyov, V. V. (2006) · FEBS Letters · doi:10.1016/j.febslet.2006.05.008 · Cited by 66

Soluble adhesion molecules in human cancers: Sources and fates

van Kilsdonk, J. W. J., van Kempen, L. C. L. T., van Muijen, G. N. P., Ruiter, D. J., & Swart, G. W. M. (2010) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2009.11.026 · Cited by 53

Neuroplastin‐55 binds to and signals through the fibroblast growth factor receptor

Owczarek, S., Kiryushko, D. V., Larsen, M. H., Kastrup, J. S., Gajhede, M., Sandi, C., Berezin, V., Bock, E., & Soroka, V. (2009) · The FASEB Journal · doi:10.1096/fj.09-140509 · Cited by 51

NCAM induces CaMKIIα-mediated RPTPα phosphorylation to enhance its catalytic activity and neurite outgrowth

Bodrikov, V., Sytnyk, V., Leshchyns’ka, I., den Hertog, J., & Schachner, M. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200803045 · Cited by 47

Interactions between the L1 cell adhesion molecule and ezrin support traction‐force generation and can be regulated by tyrosine phosphorylation

Sakurai, T., Gil, O. D., Whittard, J. D., Gazdoiu, M., Joseph, T., Wu, J. M., Waksman, A., Benson, D. L., Salton, S. R., & Felsenfeld, D. P. (2008) · Journal of Neuroscience Research · doi:10.1002/jnr.21705 · Cited by 35

Signaling Pathways Involved in NCAM-Induced Neurite Outgrowth

Ditlevsen, D. K., & Kolkova, K. (2009) · Advances in experimental medicine and biology · doi:10.1007/978-1-4419-1170-4_10 · Cited by 27

Direct demonstration of NCAMcis-dimerization and inhibitory effect of palmitoylation using the BRET2technique

Kulahin, N., Grunnet, L. G., Lundh, M., Christensen, D. P., Jørgensen, R., Heding, A., Billestrup, N., Berezin, V., Bock, E., & Mandrup-Poulsen, T. R. (2010) · FEBS Letters · doi:10.1016/j.febslet.2010.11.043 · Cited by 10

Basic and Therapeutic Aspects of Angiogenesis

Potente, M., Gerhardt, H., & Carmeliet, P. (2011) · Cell · doi:10.1016/j.cell.2011.08.039 · Cited by 2,771

FGF/FGFR signaling in health and disease

Xie, Y., Su, N., Yang, J., Tan, Q., Huang, S., Jin, M., Ni, Z., Zhang, B., Zhang, D., Luo, F., et al. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00222-7 · Cited by 904

Permeability of the Endothelial Barrier: Identifying and Reconciling Controversies

Claesson-Welsh, L., Dejana, E., & McDonald, D. M. (2021) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2020.11.006 · Cited by 631

ZO-1 controls endothelial adherens junctions, cell–cell tension, angiogenesis, and barrier formation

Tornavaca, O., Chia, M., Dufton, N., Almagro, L. O., Conway, D. E., Randi, A. M., Schwartz, M. A., Matter, K., & Balda, M. S. (2015) · Journal of Cell Biology · doi:10.1083/jcb.201404140 · Cited by 585

Deconstructing the skin: cytoarchitectural determinants of epidermal morphogenesis

Simpson, C. L., Patel, D. M., & Green, K. J. (2011) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3175 · Cited by 517