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Proximal events in Wnt signal transduction

Angers, Stephane, Moon, Randall T.·2009·Nature Reviews Molecular Cell Biology
DOI 10.1038/nrm2717
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  1. Logan, C. Y. & Nusse, R. The Wnt signaling pathway in development and disease. Annu. Rev. Cell Dev. Biol. 20, 781–810 (2004). · DOI · Paper page
  2. Rijsewijk, F. et al. The Drosophila homolog of the mouse mammary oncogene int-1 is identical to the segment polarity gene wingless. Cell 50, 649–657 (1987). · DOI · Paper page
  3. McMahon, A. P. & Moon, R. T. Ectopic expression of the proto-oncogene int-1 in Xenopus embryos leads to duplication of the embryonic axis. Cell 58, 1075–1084 (1989). The initial demonstration that Wnt signalling is functionally important in vertebrate development. · DOI · Paper page
  4. Stoick-Cooper, C. L., Moon, R. T. & Weidinger, G. Advances in signaling in vertebrate regeneration as a prelude to regenerative medicine. Genes Dev. 21, 1292–1315 (2007). · DOI · Paper page
  5. Stoick-Cooper, C. L. et al. Distinct Wnt signaling pathways have opposing roles in appendage regeneration. Development 134, 479–489 (2007). · DOI · Paper page
  6. Bhanot, P. et al. A new member of the frizzled family from Drosophila functions as a Wingless receptor. Nature 382, 225–230 (1996). The first study to directly implicate Frizzled proteins as receptors for Wnt ligands. · DOI · Paper page
  7. Yang-Snyder, J., Miller, J. R., Brown, J. D., Lai, C. J. & Moon, R. T. A Frizzled homolog functions in a vertebrate Wnt signaling pathway. Curr. Biol. 6, 1302–1306 (1996). Implicates vertebrate Frizzled proteins as receptors for Wnt ligands. · DOI · Paper page
  8. Bjarnadottir, T. K. et al. Comprehensive repertoire and phylogenetic analysis of the G protein-coupled receptors in human and mouse. Genomics 88, 263–273 (2006). · DOI · Paper page
  9. Angers, S., Salahpour, A. & Bouvier, M. Dimerization: an emerging concept for G protein-coupled receptor ontogeny and function. Annu. Rev. Pharmacol. Toxicol. 42, 409–435 (2002). · DOI · Paper page
  10. Kaykas, A. et al. Mutant Frizzled 4 associated with vitreoretinopathy traps wild-type Frizzled in the endoplasmic reticulum by oligomerization. Nature Cell Biol. 6, 52–58 (2004). · DOI · Paper page
  11. Hikasa, H., Shibata, M., Hiratani, I. & Taira, M. The Xenopus receptor tyrosine kinase Xror2 modulates morphogenetic movements of the axial mesoderm and neuroectoderm via Wnt signaling. Development 129, 5227–5239 (2002). · DOI
  12. Yoshikawa, S., McKinnon, R. D., Kokel, M. & Thomas, J. B. Wnt-mediated axon guidance via the Drosophila Derailed receptor. Nature 422, 583–588 (2003). Identifies the Tyr kinase receptor Derailed ( D. melanogaster RYK homologue) as a non-Frizzled receptor for Wnt, which is important in commisural axon guidance. · DOI · Paper page
  13. Lu, W., Yamamoto, V., Ortega, B. & Baltimore, D. Mammalian Ryk is a Wnt coreceptor required for stimulation of neurite outgrowth. Cell 119, 97–108 (2004). · DOI · Paper page
  14. Inoue, T. et al. C. elegans LIN-18 is a Ryk ortholog and functions in parallel to LIN-17/Frizzled in Wnt signaling. Cell 118, 795–806 (2004). · DOI · Paper page
  15. Clevers, H. Wnt/β-catenin signaling in development and disease. Cell 127, 469–480 (2006). · DOI · Paper page
  16. Dabdoub, A. et al. Wnt signaling mediates reorientation of outer hair cell stereociliary bundles in the mammalian cochlea. Development 130, 2375–2384 (2003). · DOI
  17. Westfall, T. A. et al. Wnt-5/pipetail functions in vertebrate axis formation as a negative regulator of Wnt/β-catenin activity. J. Cell Biol. 162, 889–898 (2003). · DOI · Paper page
  18. Torres, M. A. et al. Activities of the Wnt-1 class of secreted signaling factors are antagonized by the Wnt-5A class and by a dominant negative cadherin in early Xenopus development. J. Cell Biol. 133, 1123–1137 (1996). · DOI · Paper page
  19. Topol, L. et al. Wnt-5a inhibits the canonical Wnt pathway by promoting GSK-3-independent β-catenin degradation. J. Cell Biol. 162, 899–908 (2003). · DOI · Paper page
  20. Liang, H. et al. Noncanonical Wnt signaling promotes apoptosis in thymocyte development. J. Exp. Med. 204, 3077–3084 (2007). · DOI
  21. Liu, T., Liu, X., Wang, H., Moon, R. T. & Malbon, C. C. Activation of rat frizzled-1 promotes Wnt signaling and differentiation of mouse F9 teratocarcinoma cells via pathways that require Gαq and Gαo function. J. Biol. Chem. 274, 33539–33544 (1999). · DOI
  22. Liu, X., Rubin, J. S. & Kimmel, A. R. Rapid, Wnt-induced changes in GSK3β associations that regulate β-catenin stabilization are mediated by Gα proteins. Curr. Biol. 15, 1989–1997 (2005). · DOI
  23. Katanaev, V. L., Ponzielli, R., Semeriva, M. & Tomlinson, A. Trimeric G protein-dependent frizzled signaling in Drosophila. Cell 120, 111–122 (2005). · DOI · Paper page
  24. Dejmek, J., Safholm, A., Kamp Nielsen, C., Andersson, T. & Leandersson, K. Wnt-5a/Ca2+-induced NFAT activity is counteracted by Wnt-5a/Yes–Cdc42–casein kinase 1α signaling in human mammary epithelial cells. Mol. Cell. Biol. 26, 6024–6036 (2006). · DOI
  25. Kremenevskaja, N. et al. Wnt-5a has tumor suppressor activity in thyroid carcinoma. Oncogene 24, 2144–2154 (2005). · DOI · Paper page
  26. Schleiffarth, J. R. et al. Wnt5a is required for cardiac outflow tract septation in mice. Pediatr. Res. 61, 386–391 (2007). · DOI
  27. Ma, L. & Wang, H. Y. Suppression of cyclic GMP-dependent protein kinase is essential to the Wnt/cGMP/Ca2+ pathway. J. Biol. Chem. 281, 30990–31001 (2006). · DOI
  28. Pereira, C., Schaer, D. J., Bachli, E. B., Kurrer, M. O. & Schoedon, G. Wnt5A/CaMKII signaling contributes to the inflammatory response of macrophages and is a target for the antiinflammatory action of activated protein C and interleukin-10. Arterioscler. Thromb. Vasc. Biol. 28, 504–510 (2008). · DOI · Paper page
  29. Dissanayake, S. K. et al. The Wnt5A/protein kinase C pathway mediates motility in melanoma cells via the inhibition of metastasis suppressors and initiation of an epithelial to mesenchymal transition. J. Biol. Chem. 282, 17259–17271 (2007). · DOI · Paper page
  30. Weeraratna, A. T. et al. Wnt5a signaling directly affects cell motility and invasion of metastatic melanoma. Cancer Cell 1, 279–288 (2002). · DOI · Paper page
  31. Kilian, B. et al. The role of Ppt/Wnt5 in regulating cell shape and movement during zebrafish gastrulation. Mech. Dev. 120, 467–476 (2003). · DOI · Paper page
  32. Tada, M. & Smith, J. C. Xwnt11 is a target of Xenopus Brachyury: regulation of gastrulation movements via Dishevelled, but not through the canonical Wnt pathway. Development 127, 2227–2238 (2000). · DOI · Paper page
  33. Penzo-Mendez, A., Umbhauer, M., Djiane, A., Boucaut, J. C. & Riou, J. F. Activation of Gβγ signaling downstream of Wnt-11/Xfz7 regulates Cdc42 activity during Xenopus gastrulation. Dev. Biol. 257, 302–314 (2003). · DOI
  34. Dohlman, H. G. & Thorner, J. W. Regulation of G protein-initiated signal transduction in yeast: paradigms and principles. Annu. Rev. Biochem. 70, 703–754 (2001). · DOI · Paper page
  35. Tu, X. et al. Noncanonical Wnt signaling through G protein-linked PKCδ activation promotes bone formation. Dev. Cell 12, 113–127 (2007). · DOI · Paper page
  36. DeCamp, D. L., Thompson, T. M., de Sauvage, F. J. & Lerner, M. R. Smoothened activates Gαi-mediated signaling in frog melanophores. J. Biol. Chem. 275, 26322–26327 (2000). · DOI
  37. Philipp, M. & Caron, M. G. Hedgehog signaling: is Smo a G protein-coupled receptor? Curr. Biol. 19, R125–R127 (2009). · DOI
  38. Ogden, S. K. et al. G protein Gαi functions immediately downstream of Smoothened in Hedgehog signalling. Nature 456, 967–970 (2008). · DOI
  39. Wehrli, M. et al. Arrow encodes an LDL-receptor-related protein essential for Wingless signalling. Nature 407, 527–530 (2000). · DOI · Paper page
  40. Tamai, K. et al. LDL-receptor-related proteins in Wnt signal transduction. Nature 407, 530–535 (2000). References 48 and 49 describe the identification of Arrow in D. melanogaster and LRP5 in vertebrates as co-receptors for Wnt signal transduction. · DOI · Paper page
  41. Willert, K., Shibamoto, S. & Nusse, R. Wnt-induced dephosphorylation of axin releases β-catenin from the axin complex. Genes Dev. 13, 1768–1773 (1999). · DOI · Paper page
  42. Lee, E., Salic, A., Kruger, R., Heinrich, R. & Kirschner, M. W. The roles of APC and Axin derived from experimental and theoretical analysis of the Wnt pathway. PLoS Biol. 1, E10 (2003). · DOI · Paper page
  43. Tamai, K. et al. A mechanism for Wnt coreceptor activation. Mol. Cell 13, 149–156 (2004). · DOI · Paper page
  44. Wolf, J., Palmby, T. R., Gavard, J., Williams, B. O. & Gutkind, J. S. Multiple PPPS/TP motifs act in a combinatorial fashion to transduce Wnt signaling through LRP6. FEBS Lett. 582, 255–261 (2008). · DOI
  45. Davidson, G. et al. Casein kinase 1γ couples Wnt receptor activation to cytoplasmic signal transduction. Nature 438, 867–872 (2005). · DOI · Paper page
  46. Zeng, X. et al. A dual-kinase mechanism for Wnt co-receptor phosphorylation and activation. Nature 438, 873–877 (2005). References 55 and 56 identify GSK3 and CK1γ as kinases that are important for the phosphorylation of LRP5 or LRP6 in response to Wnt. This phosphorylation creates a signal for Axin to be recruited to the C terminus of LRP5 or LRP6. · DOI · Paper page
  47. Siegfried, E., Wilder, E. L. & Perrimon, N. Components of wingless signalling in Drosophila. Nature 367, 76–80 (1994). · DOI · Paper page
  48. Smalley, M. J. et al. Interaction of axin and Dvl-2 proteins regulates Dvl-2-stimulated TCF-dependent transcription. EMBO J. 18, 2823–2835 (1999). · DOI
  49. Kishida, S. et al. DIX domains of Dvl and axin are necessary for protein interactions and their ability to regulate β-catenin stability. Mol. Cell. Biol. 19, 4414–4422 (1999). · DOI · Paper page
  50. Bilic, J. et al. Wnt induces LRP6 signalosomes and promotes dishevelled-dependent LRP6 phosphorylation. Science 316, 1619–1622 (2007). Introduces the concept of signalosomes to Wnt signalling. · DOI · Paper page
  51. Schwarz-Romond, T., Merrifield, C., Nichols, B. J. & Bienz, M. The Wnt signalling effector Dishevelled forms dynamic protein assemblies rather than stable associations with cytoplasmic vesicles. J. Cell Sci. 118, 5269–5277 (2005). · DOI
  52. Wong, H. C. et al. Direct binding of the PDZ domain of Dishevelled to a conserved internal sequence in the C-terminal region of Frizzled. Mol. Cell 12, 1251–1260 (2003). · DOI · Paper page
  53. Xu, Y. K. & Nusse, R. The Frizzled CRD domain is conserved in diverse proteins including several receptor tyrosine kinases. Curr. Biol. 8, R405–R406 (1998). · DOI
  54. Patthy, L. The WIF module. Trends Biochem. Sci. 25, 12–13 (2000). · DOI
  55. Forrester, W. C., Kim, C. & Garriga, G. The Caenorhabditis elegans Ror RTK CAM-1 inhibits EGL-20/Wnt signaling in cell migration. Genetics 168, 1951–1962 (2004). · DOI
  56. Oishi, I. et al. Spatio-temporally regulated expression of receptor tyrosine kinases, mRor1, mRor2, during mouse development: implications in development and function of the nervous system. Genes Cells 4, 41–56 (1999). · DOI
  57. Oishi, I. et al. The receptor tyrosine kinase Ror2 is involved in non-canonical Wnt5a/JNK signalling pathway. Genes Cells 8, 645–654 (2003). Identifies the receptor Tyr kinase ROR2 as a non-Frizzled receptor that is important for signalling through a β-catenin-independent pathway. · DOI · Paper page
  58. Schambony, A. & Wedlich, D. Wnt-5A/Ror2 regulate expression of XPAPC through an alternative noncanonical signaling pathway. Dev. Cell 12, 779–792 (2007). · DOI · Paper page
  59. Unterseher, F. et al. Paraxial protocadherin coordinates cell polarity during convergent extension via Rho A and JNK. EMBO J. 23, 3259–3269 (2004). · DOI
  60. Ishitani, T. et al. The TAK1–NLK mitogen-activated protein kinase cascade functions in the Wnt-5a/Ca2+ pathway to antagonize Wnt/β-catenin signaling. Mol. Cell. Biol. 23, 131–139 (2003). · DOI · Paper page
  61. Mikels, A. J. & Nusse, R. Purified Wnt5a protein activates or inhibits β-catenin–TCF signaling depending on receptor context. PLoS Biol. 4, e115 (2006). Shows that ROR2 is a receptor for WNT5A, which is required to antagonize the β-catenin pathway. · DOI · Paper page
  62. Cselenyi, C. S. & Lee, E. Context-dependent activation or inhibition of Wnt–β-catenin signaling by Kremen. Sci. Signal. 1, pe10 (2008). · DOI
  63. Verkaar, F., van Rosmalen, J. W., Smits, J. F., Blankesteijn, W. M. & Zaman, G. J. Stably overexpressed human Frizzled-2 signals through the β-catenin pathway and does not activate Ca2+-mobilization in human embryonic kidney 293 cells. Cell Signal. 21, 22–33 (2009). · DOI
  64. Hovens, C. M. et al. RYK, a receptor tyrosine kinase-related molecule with unusual kinase domain motifs. Proc. Natl Acad. Sci. USA 89, 11818–11822 (1992). · DOI
  65. Bonkowsky, J. L., Yoshikawa, S., O'Keefe, D. D., Scully, A. L. & Thomas, J. B. Axon routing across the midline controlled by the Drosophila Derailed receptor. Nature 402, 540–544 (1999). · DOI
  66. Wouda, R. R., Bansraj, M. R., de Jong, A. W., Noordermeer, J. N. & Fradkin, L. G. Src family kinases are required for WNT5 signaling through the Derailed/RYK receptor in the Drosophila embryonic central nervous system. Development 135, 2277–2287 (2008). · DOI
  67. Lyu, J., Yamamoto, V. & Lu, W. Cleavage of the Wnt receptor Ryk regulates neuronal differentiation during cortical neurogenesis. Dev. Cell 15, 773–780 (2008). · DOI
  68. Chenn, A. & Walsh, C. A. Regulation of cerebral cortical size by control of cell cycle exit in neural precursors. Science 297, 365–369 (2002). · DOI · Paper page
  69. Zechner, D. et al. β-Catenin signals regulate cell growth and the balance between progenitor cell expansion and differentiation in the nervous system. Dev. Biol. 258, 406–418 (2003). · DOI · Paper page
  70. Singla, V. & Reiter, J. F. The primary cilium as the cell's antenna: signaling at a sensory organelle. Science 313, 629–633 (2006). · DOI · Paper page
  71. Eliasson, R., Mossberg, B., Camner, P. & Afzelius, B. A. The immotile-cilia syndrome. A congenital ciliary abnormality as an etiologic factor in chronic airway infections and male sterility. N. Engl. J. Med. 297, 1–6 (1977). · DOI · Paper page
  72. Hou, X. et al. Cystin, a novel cilia-associated protein, is disrupted in the cpk mouse model of polycystic kidney disease. J. Clin. Invest. 109, 533–540 (2002). · DOI · Paper page
  73. Pazour, G. J., San Agustin, J. T., Follit, J. A., Rosenbaum, J. L. & Witman, G. B. Polycystin-2 localizes to kidney cilia and the ciliary level is elevated in orpk mice with polycystic kidney disease. Curr. Biol. 12, R378–R380 (2002). · DOI · Paper page
  74. Ansley, S. J. et al. Basal body dysfunction is a likely cause of pleiotropic Bardet–Biedl syndrome. Nature 425, 628–633 (2003). · DOI · Paper page
  75. Eggenschwiler, J. T. & Anderson, K. V. Cilia and developmental signaling. Annu. Rev. Cell Dev. Biol. 23, 345–373 (2007). · DOI · Paper page
  76. Otto, E. A. et al. Mutations in INVS encoding inversin cause nephronophthisis type 2, linking renal cystic disease to the function of primary cilia and left–right axis determination. Nature Genet. 34, 413–420 (2003). · DOI · Paper page
  77. Ross, A. J. et al. Disruption of Bardet–Biedl syndrome ciliary proteins perturbs planar cell polarity in vertebrates. Nature Genet. 37, 1135–1140 (2005). · DOI · Paper page
  78. Kishimoto, N., Cao, Y., Park, A. & Sun, Z. Cystic kidney gene seahorse regulates cilia-mediated processes and Wnt pathways. Dev. Cell 14, 954–961 (2008). · DOI
  79. Park, T. J., Mitchell, B. J., Abitua, P. B., Kintner, C. & Wallingford, J. B. Dishevelled controls apical docking and planar polarization of basal bodies in ciliated epithelial cells. Nature Genet. 40, 871–879 (2008). · DOI · Paper page
  80. DasGupta, R., Kaykas, A., Moon, R. T. & Perrimon, N. Functional genomic analysis of the Wnt-wingless signaling pathway. Science 308, 826–833 (2005). · DOI · Paper page
  81. Major, M. B. et al. New regulators of Wnt/β-catenin signaling revealed by integrative molecular screening. Sci. Signal. 1, ra12 (2008).
  82. Tang, W. et al. A genome-wide RNAi screen for Wnt/β-catenin pathway components identifies unexpected roles for TCF transcription factors in cancer. Proc. Natl Acad. Sci. USA 105, 9697–9702 (2008). · DOI · Paper page
  83. Major, M. B. et al. Wilms tumor suppressor WTX negatively regulates WNT/β-catenin signaling. Science 316, 1043–1046 (2007). · DOI · Paper page

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Metadata

Authors
Angers, S., & Moon, R. T.
Venue
Nature Reviews Molecular Cell Biology
Publisher
Springer Science and Business Media LLC
Published
2009-06-17
Volume
10
Issue
7
Pages
468-477
ISSN
  • 1471-0072 (ISSN-L)
  • 1471-0080
DOI
10.1038/nrm2717
OpenAlex
W2071497196
Cited by
1,112
References
17
FWCI
4.38
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)

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