Cited by 1,810Pain Mechanisms and TreatmentsNeural and Behavioral Psychology StudiesPain Management and Placebo Effect

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Pain and emotion interactions in subregions of the cingulate gyrus

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Vogt, Brent A.·2005·Nature Reviews Neuroscience

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Abstract

Acute pain and emotion are processed in two forebrain networks, and the cingulate cortex is involved in both. Although Brodmann's cingulate gyrus had two divisions and was not based on any functional criteria, functional imaging studies still use this model. However, recent cytoarchitectural studies of the cingulate gyrus support a four-region model, with subregions, that is based on connections and qualitatively unique functions. Although the activity evoked by pain and emotion has been widely reported, some view them as emergent products of the brain rather than of small aggregates of neurons. Here, we assess pain and emotion in each cingulate subregion, and assess whether pain is co-localized with negative affect. Amazingly, these activation patterns do not simply overlap.

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Authors: Vogt, B. A.
Affiliations: SUNY Upstate Medical University (US)
Corresponding author: Vogt, Brent A.
ORCID: Vogt, Brent A.
Venue: Nature Reviews Neuroscience
Publisher: Springer Science and Business Media LLC
Published: 2005-07
Volume: 6
Issue: 7
Pages: 533-544
ISSN: 1471-003X (ISSN-L)
1471-0048
DOI: 10.1038/nrn1704
PMC: PMC2659949
OpenAlex: W2028850601
Cited by: 1,810
References: 118
Citations by year: 2026: 69 · 2025: 77 · 2024: 60 · 2023: 83 · 2022: 78 · 2021: 101 · 2020: 87 · 2019: 88 · 2018: 75 · 2017: 108 · 2016: 100 · 2015: 93 · 2014: 98 · 2013: 109 · 2012: 108
FWCI: 7.91
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Nature reviews. Neuroscience (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Neurological Disorders and Stroke (R01NS044222)
Topics: Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Life Sciences › Neuroscience › Cognitive Neuroscience › Pain Management and Placebo Effect
Keywords: cingulate gyrus, pain, emotions, negative affect, Brodmann areas, brain networks, cytoarchitecture
MeSH terms: Animals, Brain Mapping, Emotions, Gyrus Cinguli, Humans, Models, Biological, Neurons, Afferent, Nociceptors, Pain

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Pain and emotion interactions in subregions of the cingulate gyrus

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