Cited by 655Neurogenesis and neuroplasticity mechanismsDevelopmental Biology and Gene RegulationCongenital heart defects research

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Cell-cycle control and cortical development

Dehay, Colette, Kennedy, Henry·2007·Nature Reviews Neuroscience

DOI 10.1038/nrn2097

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Abstract

The spatio-temporal timing of the last round of mitosis, followed by the migration of neuroblasts to the cortical plate leads to the formation of the six-layered cortex that is subdivided into functionally defined cortical areas. Whereas many of the cellular and molecular mechanisms have been established in rodents, there are a number of unique features that require further elucidation in primates. Recent findings both in rodents and in primates indicate that regulation of the cell cycle, specifically of the G1 phase has a crucial role in controlling area-specific rates of neuron production and the generation of cytoarchitectonic maps.

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Background

Authors: Dehay, C., & Kennedy, H.
Affiliations: Lyon 1 Université (FR)
Corresponding author: Dehay, Colette
ORCID: Dehay, Colette
Kennedy, Henry
Venue: Nature Reviews Neuroscience
Publisher: Springer Science and Business Media LLC
Published: 2007-06
Volume: 8
Issue: 6
Pages: 438-450
ISSN: 1471-003X (ISSN-L)
1471-0048
DOI: 10.1038/nrn2097
OpenAlex: W2010852678
Cited by: 655
References: 170
Citations by year: 2026: 9 · 2025: 15 · 2024: 17 · 2023: 28 · 2022: 18 · 2021: 30 · 2020: 39 · 2019: 30 · 2018: 47 · 2017: 36 · 2016: 39 · 2015: 34 · 2014: 61 · 2013: 52 · 2012: 47
FWCI: 3.18
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature reviews. Neuroscience (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
Keywords: cortical development, cell cycle regulation, G1 phase, neuronal proliferation, neuronal differentiation, neuroblast migration, cortical plate, cortical lamination, cortical regions, cytoarchitecture, primate cortex, rodent cortex
MeSH terms: Animals, Cell Communication, Cell Cycle, Cell Differentiation, Cerebral Cortex, Humans, Neurons, Stem Cells, Signal Transduction, G1 Phase, Cell Cycle Proteins, Cell Proliferation

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Cell-cycle control and cortical development

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