The DOI matches its Crossref record; 170 of the 170 references it cites were found in a registry or an index.
Cell-cycle control and cortical development
Abstract
The spatio-temporal timing of the last round of mitosis, followed by the migration of neuroblasts to the cortical plate leads to the formation of the six-layered cortex that is subdivided into functionally defined cortical areas. Whereas many of the cellular and molecular mechanisms have been established in rodents, there are a number of unique features that require further elucidation in primates. Recent findings both in rodents and in primates indicate that regulation of the cell cycle, specifically of the G1 phase has a crucial role in controlling area-specific rates of neuron production and the generation of cytoarchitectonic maps.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“oRGs are present in large numbers in gyrencephalic primates22,23,40–44 and are considered pivotal to the evolutionary increase in human cortex size and complexity45,46.”
From The use of brain organoids to investigate neural development and disease (2017) · cites this paper as [43]
In the citing paper
“Interestingly, G1/S transition rates might be associated with these cell decisions as symmetric divisions can have shorter G1/S transition times than asymmetric divisions [93, 101].”
From The ASD Living Biology: from cell proliferation to clinical phenotype (2019) · cites this paper as [93]
Citations
Cites
Inhibitors of mammalian G1 cyclin-dependent kinases.Preprint
Sherr, C. J., & Roberts, J. M. (1995) · Genes & Development · doi:10.1101/gad.9.10.1149 · Cited by 3,242
Specification of Cerebral Cortical Areas
Rakic, P. (1988) · Science · doi:10.1126/science.3291116 · Cited by 3,127 · cited 1×
“Because these distinct proliferative programmes generate areal differences prior to the arrival of thalamic fibres, they imply the presence of an intrinsic, defined developmental programme and are compatible with the concept of the protomap theor”
ResultKing, M.-C., & Wilson, A. C. (1975) · Science · doi:10.1126/science.1090005 · Cited by 2,815
Noctor, S. C., Martínez-Cerdeño, V., Ivic, L., & Kriegstein, A. R. (2004) · Nature Neuroscience · doi:10.1038/nn1172 · Cited by 2,229
The cell biology of neurogenesis
Götz, M., & Huttner, W. B. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1739 · Cited by 2,130
Neurons derived from radial glial cells establish radial units in neocortex
Noctor, S. C., Flint, A. C., Weissman, T. A., Dammerman, R. S., & Kriegstein, A. R. (2001) · Nature · doi:10.1038/35055553 · Cited by 2,016
Nakayama, K., Ishida, N., Shirane, M., Inomata, A., Inoue, T., SHISHIDO, N., Horii, I., Loh, D. Y., & Nakayama, K. (1996) · Cell · doi:10.1016/s0092-8674(00)81237-4 · Cited by 1,548
Autoradiographic Study of Cell Migration during Histogenesis of Cerebral Cortex in the Mouse
ANGEVINE, J. B., & SIDMAN, R. L. (1961) · Nature · doi:10.1038/192766b0 · Cited by 1,530
Regulation of Cerebral Cortical Size by Control of Cell Cycle Exit in Neural Precursors
Chenn, A., & Walsh, C. A. (2002) · Science · doi:10.1126/science.1074192 · Cited by 1,431
Rakic, P. (1974) · Science · doi:10.1126/science.183.4123.425 · Cited by 1,161
Flagged first, then by citations
Research works printed but not linked: 2
- Polleux, F., Dehay, C. & Kennedy, H. Gradients and timing of the arrival of thalamic axons in the mouse neocortex. Soc. Neurosci. Abstr. 22, 1012 (1996).
- Kennedy, H., Douglas, R. J., Knoblauch, K. & Dehay, C. Self-organization and pattern formation in cortical networks in the primate. Novartis Found. Symp. in the press.
Cited by
Sorted by citations
Items 201–300 of 654
Haijima, A., Endo, T., Zhang, Y., Miyazaki, W., Kakeyama, M., & Tohyama, C. (2010) · NeuroToxicology · doi:10.1016/j.neuro.2010.04.004 · Cited by 56
Building brains in a dish: Prospects for growing cerebral organoids from stem cells
Mason, J. O., & Price, D. J. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.07.048 · Cited by 55
“…O. Mason, D. J. Price /Neuroscience xxx (2016) xxx–xxx 3 because the length of the cell cycle appears to influence their laminar phenotypes (Dehay and Kennedy, 2007; Pilaz et al., 2009).”
Lubanska, D., Market-Velker, B. A., deCarvalho, A. C., Mikkelsen, T., da Silva, E. F., & Porter, L. A. (2014) · Cancer Cell · doi:10.1016/j.ccr.2013.12.006 · Cited by 55
“Cell-cycle regulation appears to underlie the transition between expansion of progenitor pools and differentiation decisions (Dehay and Kennedy, 2007).”
BackgroundGDE2 Regulates Subtype-Specific Motor Neuron Generation through Inhibition of Notch Signaling
Sabharwal, P., Lee, C., Park, S., Rao, M., & Sockanathan, S. (2011) · Neuron · doi:10.1016/j.neuron.2011.07.028 · Cited by 54
“The mechanisms that control neuronal diversity are complex and involve a constant interplay between extrinsic signaling pathways and intrinsic cell-autonomous molecular networks (reviewed in Dasen and Jessell, 2009; Dehay and Kennedy, 2007).”
Aoyama, Y., Toriumi, K., Mouri, A., Hattori, T., Ueda, E., Shimato, A., Sakakibara, N., Soh, Y., Mamiya, T., Nagai, T., et al. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.186 · Cited by 52
Identity of neocortical layer 4 neurons is specified through correct positioning into the cortex
Oishi, K., Nakagawa, N., Tachikawa, K., Sasaki, S., Aramaki, M., Hirano, S., Yamamoto, N., Yoshimura, Y., & Nakajima, K. (2016) · eLife · doi:10.7554/elife.10907 · Cited by 56
“Although it has long been supposed that cell fate decision of cortical neurons takes place mainly in the progenitor cells (Dehay and Kennedy, 2007; Molyneaux et al., 2007), our data now suggest that L4 specification may also occur in postmitotic neurons, which is supported by several lines of…”
BackgroundResultInfluentialLet-7 regulates cell cycle dynamics in the developing cerebral cortex and retina
Fairchild, C. L. A., Cheema, S. K., Wong, J., Hino, K., Simó, S., & Torre, A. L. (2019) · Scientific Reports · doi:10.1038/s41598-019-51703-x · Cited by 52
Braun, S. M. G., Petrova, R., Tang, J., Krokhotin, A., Miller, E. L., Tang, Y., Panagiotakos, G., & Crabtree, G. R. (2021) · Genes & Development · doi:10.1101/gad.342345.120 · Cited by 51
“…channels, neurotransmitter receptors, mitotic spindle orientation, growth factor signaling pathways, cellular metabolism, and transcriptional mechanisms, contribute to cell cycle exit in NSPCs (Chenn and Walsh 2002; Dehay and Kennedy 2007; Kriegstein and Alvarez-Buylla 2009; Knobloch et al. 2013).”
mTOR signaling in neural stem cells: from basic biology to disease
Magri, L., & Galli, R. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-1196-x · Cited by 52
Mouse models of DNA double-strand break repair and neurological disease
Frappart, P., & McKinnon, P. J. (2008) · DNA repair · doi:10.1016/j.dnarep.2008.03.007 · Cited by 53
“Detailed reviews are available that summarize many aspects of neural development [10–14].”
BackgroundLibé‐Philippot, B., Michel, V., de Monvel, J. B., Gal, S. L., Dupont, T., Avan, P., Métin, C., Michalski, N., & Petit, C. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1703408114 · Cited by 58
“In E63 macaque embryos [equivalent to E13– E14 mice (38)], the three proteins were immunodetected in the MGE (Fig.”
BackgroundTocco, C., Bertacchi, M., & Studer, M. (2021) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2021.767965 · Cited by 53
“One of the mechanisms underlying the balance between NP proliferation and neurogenesis is the tight control of cell cycle progression, either in terms of checkpoint regulation or duration of the distinct phases (Dehay and Kennedy, 2007; Borrell and Calegari, 2014).”
BackgroundGeminin Regulates Cortical Progenitor Proliferation and Differentiation
Σπέλλα, Μ., Kyrousi, C., Kritikou, E., Σταθοπούλου, Α., Guillemot, F., Kioussis, D., Pachnis, V., Lygerou, Z., & Taraviras, S. L. (2011) · Stem Cells · doi:10.1002/stem.678 · Cited by 51
Hayashi‐Takagi, A., & Sawa, A. (2010) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2010.04.007 · Cited by 50
MiR-34a Represses Numbl in Murine Neural Progenitor Cells and Antagonizes Neuronal Differentiation
Fineberg, S. K., Datta, P., Stein, C. S., & Davidson, B. L. (2012) · PLoS ONE · doi:10.1371/journal.pone.0038562 · Cited by 49
“The length of the G1 phase of the cell cycle increases during neurogenesis and is thought to facilitate protein synthesis and integration of signals needed for neuronal specification and differentiation [33,34].”
BackgroundZucco, A. J., Pozzo, V. D., Afinogenova, A., Hart, R. P., Devinsky, O., & D’Arcangelo, G. (2018) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2018.08.004 · Cited by 48
“The formation of cortical layers and functional circuitries depend on the appropriate spatial and temporal regulation of neural progenitor proliferation, migration and differentiation (Dehay and Kennedy, 2007; Kwan et al., 2012; Noctor et al., 2004).”
The Carboxyl-terminal Domain of Connexin43 Is a Negative Modulator of Neuronal Differentiation
Santiago, M. F., Alcamí, P., Striedinger, K., Spray, D. C., & Scemes, E. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.058750 · Cited by 49
Stepien, B. K., Naumann, R., Holtz, A. N., Helppi, J., Huttner, W. Β., & Vaid, S. (2020) · Current Biology · doi:10.1016/j.cub.2020.08.046 · Cited by 47
Neuronal fate acquisition and specification: time for a change
Bonnefont, J., & Vanderhaeghen, P. (2021) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2020.12.006 · Cited by 49
“Earlier studies suggest that the decision to become a neuron is largely taken before mitosis, in particular during the G1 phase of the mother cell, the length of which can influence the outcome of the next division [38,39].”
BackgroundScientific Validation of Human Neurosphere Assays for Developmental Neurotoxicity Evaluation
Koch, K., Bartmann, K., Hartmann, J., Kapr, J., Klose, J., Kuchovská, E., Pahl, M., Schlüppmann, K., Zühr, E., & Fritsche, E. (2022) · Frontiers in Toxicology · doi:10.3389/ftox.2022.816370 · Cited by 48
Toriumi, K., Mouri, A., Narusawa, S., Aoyama, Y., Ikawa, N., Lu, L., Nagai, T., Mamiya, T., Kim, H., & Nabeshima, T. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2011.324 · Cited by 48
Role of miRNAs and epigenetics in neural stem cell fate determination
Lopez‐Ramirez, M. A., & Nicoli, S. (2013) · Epigenetics · doi:10.4161/epi.27536 · Cited by 48
“Mathematical modeling suggests that a 50% increase in the rate of cell cycle progression in neural progenitors doubles the neuron number during neurogenesis.(46,47) In agreement with this observation, neocortical areas show differential regulation of cell cycle kinetics of progenitors that give rise to a different num…”
BackgroundLee, C.-M. J., Zhou, L., Liu, J., Shi, J., Geng, Y., Liu, M., Wang, J., Su, X., Barad, N., Wang, J., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1918883117 · Cited by 48
“Ensuring precise coordination between cell division, cell cycle exit, and differentiation is essential to generate diverse functional neurons and glial cells (41).”
BackgroundMitotic WNT signalling orchestrates neurogenesis in the developing neocortex
Silva, F. D., Zhang, K., Pinson, A., Fatti, E., Wilsch‐Bräuninger, M., Herbst, J., Vidal, V., Schedl, A., Huttner, W. Β., & Niehrs, C. (2021) · The EMBO Journal · doi:10.15252/embj.2021108041 · Cited by 47
“The process of neurogenesis is intricately connected to the cell cycle length of NPCs (Go¨tz & Huttner, 2005; Dehay & Kennedy, 2007; Borrell & Calegari, 2014).”
Glycine receptors control the generation of projection neurons in the developing cerebral cortex
Ávila, A., Vidal, P. M., Tielens, S., Morelli, G., Laguesse, S., Harvey, R. J., Rigo, J., & Nguyen, L. (2014) · Cell Death and Differentiation · doi:10.1038/cdd.2014.75 · Cited by 47
Ghosh, T., Aprea, J., Nardelli, J., Engel, H., Selinger, C., Mombereau, C., Lemonnier, T., Moutkine, I., Schwendimann, L., Dori, M., et al. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.05.029 · Cited by 50
Huang, C.-Y., Chang, C.-W., Chen, C.-R., Chuang, C., Chiang, C., Shu, W., Fan, T. C., & Hsu, I. C. (2014) · PLoS ONE · doi:10.1371/journal.pone.0104732 · Cited by 46
“During cell cycle progression, to ensure that all cell cycle phases PLOS ONE | www.plosone.org 4 August 2014 | Volume 9 | Issue 8 | e104732 are executed in the correct order, the transition from one cell cycle phase to the next is controlled by the association of cyclin/CDK complexes (such as Cyclin A/CDK1 and Cyclin…”
BackgroundEpigenetic regulation of fetal brain development and neurocognitive outcome
Petanjek, Z., & Kostović, I. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1208085109 · Cited by 46
“The massive developmental elimination of synapses continues on spines of layer IIIC pyramidal neurons even beyond the adolescence (C and D) (11), although the number of neurons and basic pathways in corticocortical network is determined prenatally by specific interactions in the transient fetal zones that are particul…”
BackgroundWeick, J. P., Johnson, M., & Zhang, S. (2009) · Stem Cells · doi:10.1002/stem.212 · Cited by 47
“Our hNE cells may represent an earlier developmental time point, before the formation of the SVZ, when VZ progenitors predominate [54,55].”
BackgroundEsch, H. V., Colnaghi, R., Freson, K., Starokadomskyy, P., Zankl, A., Backx, L., Abramowicz, I., Outwin, E. A., Rohena, L. O., Faulkner, C., et al. (2019) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2019.03.006 · Cited by 46
Human Brain Evolution: Harnessing the Genomics (R)evolution to Link Genes, Cognition, and Behavior
Konopka, G., & Geschwind, D. H. (2010) · Neuron · doi:10.1016/j.neuron.2010.10.012 · Cited by 44
Hirai, S., Miwa, A., Ohtaka‐Maruyama, C., Kasai, M., Okabe, S., Hata, Y., & Okado, H. (2012) · The EMBO Journal · doi:10.1038/emboj.2011.486 · Cited by 47
“Two primary parameters define the output of NSCs: (1) how fast progenitor cells divide and (2) the balance between cell cycle re-entry and the exit of progenitors (Dehay and Kennedy, 2007).”
Young, F. I., Keruzoré, M., Nan, X., Gennet, N., Bellefroid, E., & Li, M. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1705186114 · Cited by 44
“During normal corticogenesis, the duration of the G1 phase is linked to neuronal differentiation and is always longer in cells committed to undergoing differentiative rather than proliferative division (33, 34).”
BackgroundWnt Signaling and Its Impact on Mitochondrial and Cell Cycle Dynamics in Pluripotent Stem Cells
Rasmussen, M. L., Ortolano, N. A., Romero-Morales, A. I., & Gama, V. (2018) · Genes · doi:10.3390/genes9020109 · Cited by 44
“Strict regulation of cortical progenitor asymmetric division is essential for normal cortical development [157,179,180].”
Ohtsuka, T., & Kageyama, R. (2019) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2019.01.007 · Cited by 45
A Complex Code of Extrinsic Influences on Cortical Progenitor Cells of Higher Mammals
Reillo, I., Romero, C. D. J., Cárdenas, A., Clascá, F., Martínez‐Martínez, M. Á., & Borrell, V. (2017) · Cerebral Cortex · doi:10.1093/cercor/bhx171 · Cited by 44
“and some interesting candidate molecules and signaling pathways were identified, including FGF2 (Dehay et al. 2001; Dehay and Kennedy 2007; Reillo et al. 2011).”
BackgroundInfluentialPeco, E., Escudé, T., Agius, E., Sabado, V., Médevielle, F., Ducommun, B., & Pituello, F. (2012) · Development · doi:10.1242/dev.068569 · Cited by 44
“In the cortex, neuronal differentiation is associated with an increase in the cell cycle mainly due to a lengthening of the G1 phase (Dehay and Kennedy, 2007; Lange and Calegari, 2010) that accompanies the transition from apical to basal progenitors (Arai et al.”
Background(2008) · doi:10.1159/000184744 · Cited by 48
Anticancer effects of crocetin in human esophageal squamous cell carcinoma KYSE-150 cells
Li, S., Jiang, S., Jiang, W., Zhou, Y., Shen, X., Luo, T., Ling-ping, K., & WANG, H.-Q. (2015) · Oncology Letters · doi:10.3892/ol.2015.2869 · Cited by 43
The F-box protein Fbw7 is required for cerebellar development
Jandke, A., Costa, C. D., Sancho, R., Nye, E. L., Spencer‐Dene, B., & Behrens, A. (2011) · Developmental Biology · doi:10.1016/j.ydbio.2011.07.030 · Cited by 43
Marzinke, M. A., & Clagett-Dame, M. (2012) · Experimental Cell Research · doi:10.1016/j.yexcr.2011.10.002 · Cited by 42
Effects of low level of methylmercury on proliferation of cortical progenitor cells
Xu, M., Yan, C., Tian, Y., Yuan, X., & Shen, X. (2010) · Brain Research · doi:10.1016/j.brainres.2010.08.069 · Cited by 42
“In mid/late G1 stage, cyclin E is induced and forms complexes with CDK2, whose activity appears to be essential for entrance of the S phase (Dehay and Kennedy, 2007).”
BackgroundHOXA7 stimulates human hepatocellular carcinoma proliferation through cyclin E1/CDK2
LI, Y., YANG, X. H., FANG, S. J., QIN, C. F., Sun, R., LIU, Z. Y., JIANG, B. Y., Wu, X., & Li, G. (2014) · Oncology Reports · doi:10.3892/or.2014.3668 · Cited by 42
Wagenführ, L., Meyer, A. K., Braunschweig, L., Marrone, L., & Storch, A. (2015) · Development · doi:10.1242/dev.121939 · Cited by 46
Curto, G. G., Nieto‐Estévez, V., Hurtado‐Chong, A., Valero, J., Gómez, C., Alonso, J. R., Weruaga, E., & Vicario‐Abejón, C. (2014) · Stem Cells and Development · doi:10.1089/scd.2014.0058 · Cited by 42
“Several authors have proposed a relationship between the regulation of the cell cycle and the dynamics of stem cell populations, including features such as self-renewal, cell fate choice, differentiation, and cell survival [70,71].”
Álvarez‐Satta, M., Moreno‐Cugnon, L., & Matheu, A. (2019) · Ageing Research Reviews · doi:10.1016/j.arr.2019.04.004 · Cited by 42
Principles of Regulation of Self-Renewing Cell Lineages
Komarova, N. L. (2013) · PLoS ONE · doi:10.1371/journal.pone.0072847 · Cited by 42
“In [26], a ‘‘crowd-control’’ model is described in the context of a local feedback mechanism in the early ventricular zone.”
BackgroundXie, Z., Chen, Y., Li, Z., Bai, G., Zhu, Y., Yan, R., Tan, F., Chen, Y., Guillemot, F., Li, L., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1100160108 · Cited by 44
“In early neural development, neural progenitor cells are seemingly homogeneous (3, 4); as neurogenesis proceeds, cells acquire different developmental potentials and become located in different tissue compartments or zones (5).”
BackgroundWatanabe, N., Kageyama, R., & Ohtsuka, T. (2015) · Development · doi:10.1242/dev.120477 · Cited by 41
Silver, D. L. (2015) · BioEssays · doi:10.1002/bies.201500108 · Cited by 41
The nuclear receptors COUP-TF: a long-lasting experience in forebrain assembly
Alfano, C., Magrinelli, E., Harb, K., & Studer, M. (2013) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-013-1320-6 · Cited by 44
“Accordingly, maintaining a correct balance between neurogenesis and progenitor self-renewal, a process likely regulated by COUP-TF genes, becomes crucial for cell-type specification, neocortical partitioning, and cytoarchitecture of neocortical areas [80, 152, 153, 164, 170, 200, 201].”
SDF-1/CXCR4 Signaling Maintains Stemness Signature in Mouse Neural Stem/Progenitor Cells
Ho, S., Ling, T., Lin, H.-Y., Liou, J. T.-J., Liu, F., Chen, I., Lee, S.-W., Hsu, Y., Lai, D., & Liou, H. (2017) · Stem Cells International · doi:10.1155/2017/2493752 · Cited by 43
Masjosthusmann, S., Becker, D., Petzuch, B., Klose, J., Siebert, C., Deenen, R., Barenys, M., Baumann, J., Dach, K., Tigges, J., et al. (2018) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2018.05.009 · Cited by 42
DNA damage response in neurodevelopment and neuromaintenance
Qing, X., Zhang, G., & Wang, Z. (2022) · FEBS Journal · doi:10.1111/febs.16535 · Cited by 42
Neurogenesis in primates versus rodents and the value of non-human primate models
Zhang, R., Quan, H., Wang, Y., & Luo, F. (2023) · National Science Review · doi:10.1093/nsr/nwad248 · Cited by 47
“Second, primate cortical neural precursors undergo an extended cell-div ision c ycle compared to rodents [ 21 , 40 , 74 ].”
BackgroundDréau, G. L., Saade, M., Gutiérrez-Vallejo, I., & Martı́, E. (2014) · The Journal of Cell Biology · doi:10.1083/jcb.201307031 · Cited by 39
“Variations in cell cycle kinetics are correlated with distinct stem cell fates in the developing cerebral cortex (Dehay and Kennedy, 2007; Salomoni and Calegari, 2010).”
Teissier, A., Waclaw, R. R., Griveau, A., Campbell, K., & Pierani, A. (2011) · Cerebral Cortex · doi:10.1093/cercor/bhr122 · Cited by 42
“…of growth factors and morphogens by postmitotic neurons, some of which reach the developing cortex by tangential migration, or by ingrowing thalamic axons provide an extrinsic control for cortical development (Dehay and Kennedy 2007; Komada et al. 2008; Seuntjens et al. 2009; Griveau et al. 2010).”
BackgroundInfluentialCerebral cortex development: From progenitors patterning to neocortical size during evolution
Pierani, A., & Wassef, M. (2009) · Development Growth & Differentiation · doi:10.1111/j.1440-169x.2009.01095.x · Cited by 44
“Thus, the integration of multiple signaling pathways on common intermediaries might provide a way to coordinate growth and patterning during development mostly by influencing G1 phase duration (see for reviews Dehay & Kennedy 2007; Caviness et al. 2008).”
BackgroundCelf4 controls mRNA translation underlying synaptic development in the prenatal mammalian neocortex
Salamon, I., Park, Y., Miškić, T., Kopić, J., Matteson, P. G., Page, N. F., Roque, A., McAuliffe, G., Favate, J. S., García-Forn, M., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-41730-8 · Cited by 40
TRPM2 mediates the lysophosphatidic acid-induced neurite retraction in the developing brain
Jang, Y., Lee, M. H., Lee, J., Jung, J., Lee, S. H., Yang, D. J., Kim, B. W., Son, H., Lee, B., Chang, S., et al. (2014) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-013-1436-4 · Cited by 38
Narayan, S., Nakajima, K., & Sawa, A. (2013) · The Neuroscientist · doi:10.1177/1073858412470168 · Cited by 37
Fischer, T. J., Walker, T. L., Overall, R. W., Brandt, M., & Kempermann, G. (2014) · Frontiers in Neuroscience · doi:10.3389/fnins.2014.00314 · Cited by 38
“Cell cycle kinetics have been studied extensively in the developing brain (Takahashi et al., 1995; Calegari and Huttner, 2003; Dehay and Kennedy, 2007; Lange et al., 2009).”
BackgroundGenetic maps and patterns of cerebral cortex folding
Romero, C. D. J., & Borrell, V. (2017) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2017.11.009 · Cited by 37
Evolution of genetic mechanisms regulating cortical neurogenesis
Espinós, A., Ortuño, E. F., Negri, E., & Borrell, V. (2022) · Developmental Neurobiology · doi:10.1002/dneu.22891 · Cited by 38
“…of NPCs and complexity of cortical germinal zones, as compared to the small mouse, which exerted key roles in the expansion and complexification of the cerebral cortex during evolution (Dehay & Kennedy, 2007; Llinares-Benadero & Borrell, 2019; Polioudakis et al., 2019; Taverna et al., 2014).”
BackgroundLee, C., Jia, C., Worden, L. T., & Freed, W. J. (2010) · Synapse · doi:10.1002/syn.20814 · Cited by 38
“Longer G1 phases promote differentiation, possibly by increasing the window of time during which cells are sensitive to differentiation signals (Dehay and Kennedy, 2007).”
BackgroundDispersion of the neurons expressing layer specific markers in the reeler brain
Dekimoto, H., Terashima, T., & Katsuyama, Y. (2010) · Development Growth & Differentiation · doi:10.1111/j.1440-169x.2009.01153.x · Cited by 38
“As a consequence of this neuronal migration, the lamination of the cerebral cortex is generated, exhibiting an ‘‘inside-out’’ pattern of neuronal positioning relative to their birth date (recent reviews for Cremisi et al. 2003; Guillemot 2005; Dehay & Kennedy 2007).”
BackgroundColor synesthesia. Insight into perception, emotion, and consciousness
Safran, A. B., & Sanda, N. (2014) · Current Opinion in Neurology · doi:10.1097/wco.0000000000000169 · Cited by 40
Nonstructural Protein σ1s Mediates Reovirus-Induced Cell Cycle Arrest and Apoptosis
Boehme, K. W., Hammer, K., Tollefson, W. C., Konopka‐Anstadt, J. L., Kobayashi, T., & Dermody, T. S. (2013) · Journal of Virology · doi:10.1128/jvi.02080-13 · Cited by 37
“Unlike most cells in culture, neurons do not divide in vivo following completion of a neural developmental program (57).”
BackgroundMethodExpression of the mouse PR domain protein Prdm8 in the developing central nervous system
Komai, T., Iwanari, H., Mochizuki, Y., Hamakubo, T., & Shinkai, Y. (2009) · Gene Expression Patterns · doi:10.1016/j.gep.2009.07.005 · Cited by 38
Extracellular vesicles from neurons promote neural induction of stem cells through cyclin D1
Song, L., Tian, X., & Schekman, R. W. (2021) · The Journal of Cell Biology · doi:10.1083/jcb.202101075 · Cited by 34
“Cyclin D is synthesized at the beginning of G1, and it binds and activates CDK4/6 when the cell leaves the quiescent state (van den Heuvel, 2005; Dehay and Kennedy, 2007).”
Roles of the ubiquitin-proteosome system in neurogenesis
Tuoc, T., & Stoykova, A. (2010) · Cell Cycle · doi:10.4161/cc.9.16.12551 · Cited by 37
Selective gene expression in regions of primate neocortex: Implications for cortical specialization
Yamamori, T. (2011) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2011.04.008 · Cited by 37
“One controls neuron number (Dehay and Kennedy, 2007; Hansen et al., 2010) and the other controls postnatal neuronal development of dendritic arborization and spine formation (Elston and Rosa, 1998; Elston et al., 1999, 2009).”
InfluentialEarly immature neuronal death initiates cerebral ischemia-induced neurogenesis in the dentate gyrus
Kim, D. H., Lee, H., Kwon, K. J., Park, S. J., Heo, H., Lee, Y., Choi, J. W., Shin, C. Y., & Ryu, J. H. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.09.074 · Cited by 36
“Shortening of the cell cycle has been implicated in reductions in the responsiveness to differentiation signals (Dehay and Kennedy, 2007).”
BackgroundFame, R. M., MacDonald, J. L., Dunwoodie, S. L., Takahashi, E., & Macklis, J. D. (2016) · The Journal of Neuroscience · doi:10.1523/jneurosci.4067-15.2016 · Cited by 40
“Laminar composition and circuit organization is distinct within the primary somatosensory neocortex compared with other neocortical areas (Polleux et al., 2001; Rash and Grove, 2006; Dehay and Kennedy, 2007; O’Leary et al., 2007).”
BackgroundUlk4 Regulates Neural Stem Cell Pool
Liu, M., Guan, Z., Shen, Q., Flinter, F. A., Domínguez, L., Ahn, J. W., Collier, D. A., O’Brien, T., & Shen, S. (2016) · Stem Cells · doi:10.1002/stem.2423 · Cited by 34
Metabolic regulation and glucose sensitivity of cortical radial glial cells
Rash, B. G., Micali, N., Huttner, A. J., Morozov, Y. M., Horváth, T. L., & RAKIC, P. T. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1808066115 · Cited by 37
Fujimura, M., & Usuki, F. (2015) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2015.07.006 · Cited by 36
The underside of the cerebral cortex: layer V/VI spiny inverted neurons
Mendizabal‐Zubiaga, J., Reblet, C., & Bueno‐López, J. (2007) · Journal of Anatomy · doi:10.1111/j.1469-7580.2007.00779.x · Cited by 36
“For recent reviews on the neuronal subtype specification of projection neurons in the cerebral cortex, and the cell-cycle control and cortical development, see Molyneaux et al. (2007) and Dehay & Kennedy (2007), respectively.”
BackgroundNeddylation is critical to cortical development by regulating Wnt/β-catenin signaling
Zhang, L., Jing, H., Bailin, P. L., Chen, W., Luo, B., Zhang, H., Dong, Z., Li, L., Su, H., Xiong, W., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2005395117 · Cited by 35
“4M) (42), PH3 cell counts were quantitated based on cell location (VZ surface and non-VZ surface).”
MethodPolycomb‐mediated gene regulation in human brain development and neurodevelopmental disorders
Bölicke, N., & Albert, M. (2022) · Developmental Neurobiology · doi:10.1002/dneu.22876 · Cited by 39
“Other differences include increased human cell cycle length (Kornack & Rakic, 1998) and a longer neurogenic period as well as higher neuronal output and surface area of the human brain (Dehay & Kennedy, 2007; Libe-Philippot & Vanderhaeghen, 2021; Rakic, 2009).”
BackgroundPfeuty, B. (2015) · Development · doi:10.1242/dev.112649 · Cited by 34
“…progenitors, including the tight coordination between cell cycle events (progression, lengthening and exit) and commitment to differentiation (Dehay and Kennedy, 2007; Lange and Calegari, 2010; Hardwick and Philpott, 2014) and the implication of oscillatory Notch-Hes1 signaling in cell fate…”
BackgroundSato, T., Shimazaki, T., Naka-Kaneda, H., Fukami, S., Satoh, Y., Okano, H., Lax, I., Schlessinger, J., & Gotoh, N. (2010) · Stem Cells · doi:10.1002/stem.488 · Cited by 34
Molecular control of brain size: Regulators of neural stem cell life, death and beyond
Joseph, B., & Hermanson, O. (2010) · Experimental Cell Research · doi:10.1016/j.yexcr.2010.03.012 · Cited by 34
Evolution of new miRNAs and cerebro-cortical development
Kosik, K. S., & Nowakowski, T. (2018) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-080317-061822 · Cited by 34
Magrou, L., Barone, P., Markov, N. T., Killackey, H. P., Giroud, P., Berland, M., Knoblauch, K., Dehay, C., & Kennedy, H. (2018) · Cerebral Cortex · doi:10.1093/cercor/bhy125 · Cited by 41
“The lateral geniculate fibers that can influence the kinetics of the cell-cycle of cortical precursors by release of a mitogenic substance (Dehay et al. 2001; Dehay and Kennedy 2007), which would have a profound influence on the cell lineages of cortical precursors generating upper layers of the cortex (Betizeau et al.”
BackgroundSelf-citationDistinct Neocortical Progenitor Lineages Fine-tune Neuronal Diversity in a Layer-specific Manner.
Guillamon-Vivancos, T., Tyler, W. A., Medalla, M., Chang, W. W.-E., Okamoto, M., Haydar, T. F., & Luebke, J. I. (2019) · Cerebral Cortex · doi:10.1093/cercor/bhy019 · Cited by 34
FGF-MAPK signaling regulates human deep-layer corticogenesis
Gantner, C. W., Hunt, C. J., Niclis, J. C., Penna, V., McDougall, S. J., Thompson, L. H., & Parish, C. L. (2021) · Stem Cell Reports · doi:10.1016/j.stemcr.2021.03.014 · Cited by 37
“Instead, eFGF2 shortens cell-cycle length and blocks laminar progression, supporting cell-cycle length as a critical mediator in facilitating maturation (Calegari et al., 2005; Dehay and Kennedy, 2007; Ohtsuka and Kageyama, 2019; Pilaz et al., 2009; Watanabe et al., 2015).”
Comparative landscape of genetic dependencies in human and chimpanzee stem cells
She, R., Fair, T., Schaefer, N. K., Saunders, R. A., Pavlovic, B. J., Weissman, J. S., & Pollen, A. A. (2023) · Cell · doi:10.1016/j.cell.2023.05.043 · Cited by 34
“NPCs were evaluated for purity at days 7-11 of differentiation with antibody staining against NPC markers Pax6 and Nestin.”
InfluentialDoes cell lineage in the developing cerebral cortex contribute to its columnar organization?
Costa, M. R. (2010) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2010.00026 · Cited by 33
“These fundamental blocks could also be influenced by earlier factors, such as incoming afferent systems to cerebral cortex that have been shown to regulate the cell cycle length in the germinal zone and contribute to generate areal differences in the germinal zones (Dehay and Kennedy, 2007).”
Mérot, Y., Rétaux, S., & Heng, J. I. (2009) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2009.04.003 · Cited by 35
Cross-species analyses of the cortical GABAergic and subplate neural populations
Clancy, B. (2009) · Frontiers in Neuroanatomy · doi:10.3389/neuro.05.020.2009 · Cited by 32
“…that analysis of our database does not yet permit us to address such as the possibility of an effect on differences in cell cycle mechanisms (Dehay and Kennedy, 2007), or the effect of variability in the location of GABAergic proliferation when comparing rodents to humans (Letinic et al.,…”
BackgroundAberrant fetal macrophage/microglial reactions to cytomegalovirus infection
Sakao‐Suzuki, M., Kawasaki, H., Akamatsu, T., Meguro, S., Miyajima, H., Iwashita, T., Tsutsui, Y., Inoue, N., & Kosugi, I. (2014) · Annals of Clinical and Translational Neurology · doi:10.1002/acn3.88 · Cited by 34
“5) and then collected fetal brains at 5 dpi (E18.”
InfluentialSparse reconstruction of brain circuits: Or, how to survive without a microscopic connectome
da Costa, N. M., & Martin, K. A. C. (2013) · NeuroImage · doi:10.1016/j.neuroimage.2013.04.054 · Cited by 30
Nomura, T., Yamashita, W., Gotoh, H., & Ono, K. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00045 · Cited by 32
“Recent advances of developmental neurobiology have illuminated the molecular mechanisms that govern these complicated cellular events during corticogenesis (Campbell, 2005; Flames and Marin, 2005; Dehay and Kennedy, 2007; Molyneaux et al., 2007; Kumamoto and Hanashima, 2014).”
BackgroundInfluentialDynamic Distribution of Histone H4 Arginine 3 Methylation Marks in the Developing Murine Cortex
Chittka, A. (2010) · PLoS ONE · doi:10.1371/journal.pone.0013807 · Cited by 32
“5 a very clear layering of the cerebral cortex is visible, containing ventricular and a newly formed subventricular zones, as well as the subplate and the cortical plate populated by post-mitotic neurons [16].”
Engineering a mammalian super producer
Dietmair, S., Nielsen, L. K., & Timmins, N. E. (2011) · Journal of Chemical Technology & Biotechnology · doi:10.1002/jctb.2576 · Cited by 31
Zubler, F., Hauri, A., Pfister, S., Bauer, R., Anderson, J. C., Whatley, A., & Douglas, R. J. (2013) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1003173 · Cited by 35
“Differentiating neurons arising from the VZ precursor pool will form the lower layers of the cortex, whereas the SVZ precursor pool form the neurons of the more superficial layers [17].”
BackgroundVIP blockade leads to microcephaly in mice via disruption of Mcph1-Chk1 signaling
Passemard, S., Ghouzzi, V. E., Nasser, H., Verney, C., Vodjdani, G., Lacaud, A., Lebon, S., Laburthe, M., Robberecht, P., Nardelli, J., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci43824 · Cited by 31
Evolutionary Forces Shape the Human RFPL1,2,3 Genes toward a Role in Neocortex Development
Bonnefont, J., Nikolaev, S. I., Perrier, A. L., Guo, S., Cartier, L., Sorce, S., Laforge, T., Aubry, L., Khaitovich, P., Peschanski, M., et al. (2008) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2008.07.007 · Cited by 32
“It has been reported that the cell-cycle parameters of the progenitors evolved in primates increasing the number of cortical cells produced;(4) such an increase contributes to changes in neocortex development.(3,5,6) However, the genetic basis of primate brain evolution remains obscure.”
BackgroundOTX1 regulates cell cycle progression of neural progenitors in the developing cerebral cortex
Huang, B., Li, X., Tu, X., Zhao, W., Zhu, D., Feng, Y., Si, X., & Chen, J.-G. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.ra117.001249 · Cited by 30
“Our data are consistent with previous studies that the cortical precursors with a shortened G1 phase and a fastened G1/S transition prefer to stay in rather than to exit from the cell cycle (1, 15).”
BackgroundResult
Metadata
- Authors
- Dehay, C., & Kennedy, H.
- Affiliations
- Lyon 1 Université (FR)
- Corresponding author
- Dehay, Colette
- Venue
- Nature Reviews Neuroscience
- Published
- 2007-06
- Volume
- 8
- Issue
- 6
- Pages
- 438-450
- ISSN
- 1471-003X (ISSN-L)
- 1471-0048
- OpenAlex
- W2010852678
- Cited by
- 655
- References
- 170
- Citations by year
- 2026: 9 · 2025: 15 · 2024: 17 · 2023: 28 · 2022: 18 · 2021: 30 · 2020: 39 · 2019: 30 · 2018: 47 · 2017: 36 · 2016: 39 · 2015: 34 · 2014: 61 · 2013: 52 · 2012: 47
- FWCI
- 3.18
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nature reviews. Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
- Keywords
- cortical development, cell cycle regulation, G1 phase, neuronal proliferation, neuronal differentiation, neuroblast migration, cortical plate, cortical lamination, cortical regions, cytoarchitecture, primate cortex, rodent cortex
- MeSH terms
- Animals, Cell Communication, Cell Cycle, Cell Differentiation, Cerebral Cortex, Humans, Neurons, Stem Cells, Signal Transduction, G1 Phase, Cell Cycle Proteins, Cell Proliferation
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
