The DOI matches its Crossref record; 170 of the 170 references it cites were found in a registry or an index.
Cell-cycle control and cortical development
Abstract
The spatio-temporal timing of the last round of mitosis, followed by the migration of neuroblasts to the cortical plate leads to the formation of the six-layered cortex that is subdivided into functionally defined cortical areas. Whereas many of the cellular and molecular mechanisms have been established in rodents, there are a number of unique features that require further elucidation in primates. Recent findings both in rodents and in primates indicate that regulation of the cell cycle, specifically of the G1 phase has a crucial role in controlling area-specific rates of neuron production and the generation of cytoarchitectonic maps.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“oRGs are present in large numbers in gyrencephalic primates22,23,40–44 and are considered pivotal to the evolutionary increase in human cortex size and complexity45,46.”
From The use of brain organoids to investigate neural development and disease (2017) · cites this paper as [43]
In the citing paper
“Interestingly, G1/S transition rates might be associated with these cell decisions as symmetric divisions can have shorter G1/S transition times than asymmetric divisions [93, 101].”
From The ASD Living Biology: from cell proliferation to clinical phenotype (2019) · cites this paper as [93]
Citations
Cites
Inhibitors of mammalian G1 cyclin-dependent kinases.Preprint
Sherr, C. J., & Roberts, J. M. (1995) · Genes & Development · doi:10.1101/gad.9.10.1149 · Cited by 3,242
Specification of Cerebral Cortical Areas
Rakic, P. (1988) · Science · doi:10.1126/science.3291116 · Cited by 3,127 · cited 1×
“Because these distinct proliferative programmes generate areal differences prior to the arrival of thalamic fibres, they imply the presence of an intrinsic, defined developmental programme and are compatible with the concept of the protomap theor”
ResultKing, M.-C., & Wilson, A. C. (1975) · Science · doi:10.1126/science.1090005 · Cited by 2,815
Noctor, S. C., Martínez-Cerdeño, V., Ivic, L., & Kriegstein, A. R. (2004) · Nature Neuroscience · doi:10.1038/nn1172 · Cited by 2,229
The cell biology of neurogenesis
Götz, M., & Huttner, W. B. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1739 · Cited by 2,130
Neurons derived from radial glial cells establish radial units in neocortex
Noctor, S. C., Flint, A. C., Weissman, T. A., Dammerman, R. S., & Kriegstein, A. R. (2001) · Nature · doi:10.1038/35055553 · Cited by 2,016
Nakayama, K., Ishida, N., Shirane, M., Inomata, A., Inoue, T., SHISHIDO, N., Horii, I., Loh, D. Y., & Nakayama, K. (1996) · Cell · doi:10.1016/s0092-8674(00)81237-4 · Cited by 1,548
Autoradiographic Study of Cell Migration during Histogenesis of Cerebral Cortex in the Mouse
ANGEVINE, J. B., & SIDMAN, R. L. (1961) · Nature · doi:10.1038/192766b0 · Cited by 1,530
Regulation of Cerebral Cortical Size by Control of Cell Cycle Exit in Neural Precursors
Chenn, A., & Walsh, C. A. (2002) · Science · doi:10.1126/science.1074192 · Cited by 1,431
Rakic, P. (1974) · Science · doi:10.1126/science.183.4123.425 · Cited by 1,161
Research works printed but not linked: 2
- Polleux, F., Dehay, C. & Kennedy, H. Gradients and timing of the arrival of thalamic axons in the mouse neocortex. Soc. Neurosci. Abstr. 22, 1012 (1996).
- Kennedy, H., Douglas, R. J., Knoblauch, K. & Dehay, C. Self-organization and pattern formation in cortical networks in the primate. Novartis Found. Symp. in the press.
Cited by
Sorted by citations
Items 601–654 of 654
Girirajan, S. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.732015148.793556414
Hippenmeyer, S. (2018) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.733715075.793551739
Ben‐Ari, Y. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.733499087.793568939
Robertson, S. P. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.733715075.793557713
Development of the Neocortical Area Map
Grove, E. A. (2023) · Wiley eBooks · doi:10.1002/9781119860914.ch22
Evolution and Development of Thalamocortical Relationships
Molnár, Z., Bandiera, S., & Clowry, G. J. (2023) · Oxford University Press eBooks · doi:10.1093/med/9780197676158.003.0058
de Haan, M. D. H., Johnson, M. H., & Dumontheil, I. (2023) · Developmental Cognitive Neuroscience · doi:10.1002/9781394260676.refs
(2015) · Developmental Cognitive Neuroscience · doi:10.1002/9781394259083.refs
The Role of Prefrontal Cortex and the Cell Cycle Regulation in Anxiety
Mendes‐Silva, A. P., Hollis, F., Gorman‐Sandler, E., Afjeh, S. S. A., Teimoury, K., Ahkbarian, N., Lisoway, A. J., & Ueira-Vieira, C. (2024) · Springer eBooks · doi:10.1007/978-3-031-32035-4_16-1
Molnár, Z., Kim, Y., Kronman, F. N., Mueller, M., & Price, D. J. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-23739-3.00003-1
Prenatal sodium channel dysfunction in Dravet syndrome alters cortical developmentPreprint
Zourray, C., Mills, J., Mills, J. D., Mainardi, M., Street, J., Bartkiewicz, J., Mihaylov, S. R., Sartorelli, J., O’Neill, N., Carpenter, J., et al. (2025) · Research Square · doi:10.21203/rs.3.rs-6566247/v1 · Cited by 1
The genetics of human brain enlargement
Heide, M., & Huttner, W. Β. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-27380-3.00023-3
Cárdenas, A., Celik, I., Espinós, A., Streicher, C., López-González, L., Anton, L., Fernández, V., Amin, S., Negri, E., Ortuño, E. F., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.05.22.655488
“Moreover, IPCs are largely absent in the reptile cortex, which lacks the neuron-abundant upper layers (Cheung et al , 2007, 2010), whereas primates typically display an expanded SVZ that produces massive numbers of IPCs and upper layer neurons (Dehay & Kennedy, 2007; Thor, 2024).”
The NSL complex promotes neural development by preventing R-loop induced replication stressPreprint
Lingeman, J., van den Heuvel, D., van den Berg, J., Singh, J. K., van Hooijdonk, R., Wiegant, W. W., Boer, D. E. C., Lo, C. S. Y., Παναγόπουλος, Α., González‐Prieto, R., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.08.22.671281
The Role of Prefrontal Cortex and the Cell Cycle Regulation in Anxiety
Mendes‐Silva, A. P., Hollis, F., Gorman‐Sandler, E., Afjeh, S. S. A., Teimoury, K., Ahkbarian, N., Lisoway, A. J., & Ueira-Vieira, C. (2025) · Springer eBooks · doi:10.1007/978-3-031-73368-0_16
Emerging Technologies in Neurovisualization
Kariyappa, J. T., Bongers, A., Zanoni, S., Tong, L. J., Chanuvegowda, T. S., & Ashwell, K. W. S. (2025) · Biomedical visualization · doi:10.1007/978-3-032-07380-8_5
Temporal Transcriptional Regulation of Human Neuronal Differentiation via Forward Programming
Zhu, L., Wang, W., Zhang, J., Liu, L., Huang, M., Diao, L., Feng, S., Yang, Q., Qiu, H., Pan, B., et al. (2025) · Advanced Science · doi:10.1002/advs.202510641
Su, M., Ma, Y., Liu, X. H., Wu, Y., Peng, X., Xiong, X., Huang, K. Q., Zhang, S., & Li, Y. (2026) · Neurochemical Research · doi:10.1007/s11064-025-04646-x
“Numerous studies have confirmed that G1 phase plays a pivotal role in integrating extracellular signals to determine the direction of proliferation or differ - entiation [22–24].”
The Effect of Hypoxia on the Antioxidant System Formation of the Developing Brain
Klys, L. I., Галкина, О. В., Vetrovoy, O. V., & Eschenko, N. (2025) · Neurochemical Journal · doi:10.1134/s1819712425700655
N'gompaza‐Diarra, J. (2012) · theses.fr (ABES) · doi:10.70675/6f03bc10zd5a4z414eza3c0z67e0b10f79f6
Role of G1 phase regulators during corticogenesis
Pilaz, L. (2009) · theses.fr (ABES) · doi:10.70675/9f47e9acz5e06z4d39z83b5za3e00f543c58
Betizeau, M. (2013) · theses.fr (ABES) · doi:10.70675/96b2fd4ez61cfz4afeza473z7811a8b1fda6
Tisserand, J. C. (2016) · theses.fr (ABES) · doi:10.70675/75c7849fz8b54z4676zbd10z2a0e877439d8
Role of the Glycogen Synthase Kinase 3 for the Retinal Development and Homeostasis
Braginskaja, E. (2018) · theses.fr (ABES) · doi:10.70675/72532a81z164ez4786z8c84zaf55afbdfa1d
“In mouse retina, the main representative p27/Kip1 is expressed throughout retinogenesis in cells that exit the cell cycle and differentiate (Dehay and Kennedy, 2007).”
The role of Notch signaling pathway during neural delamination in the vertebrate embryo
Baek, C. (2018) · theses.fr (ABES) · doi:10.70675/89032e52z6b8bz423bzb1d0zc7069afe33bd
Caractérisation de la sénescence des cardiomyocytes et identification de marqueurs associés
Maggiorani, D. (2017) · theses.fr (ABES) · doi:10.70675/a58747bczd60bz4482za3b2z7ae33d26ffa4
“…Figure 8 : Expression et cibles des gènes du locus INK4-Arf (d'après Sherr and Roberts, 1995) ..........................36 Figure 9 : Rôle des inhibiteurs du cycle cellulaire CIP/KIP et INK (d'après Dehay and Kennedy, 2007) ................37 Figure 10.”
BackgroundLe cortex vocal chez le primate : une investigation anatomo-fonctionnelle
Bodin, C. (2019) · theses.fr (ABES) · doi:10.70675/94d67f43z2595z41abza479z96567259e48e
Carpentieri, J. A. (2020) · theses.fr (ABES) · doi:10.70675/1e00c88fzf627z42c5za72ez7da656ac6044
Del-Pozo-Rodríguez, J. (2020) · theses.fr (ABES) · doi:10.70675/c4e031efz0a8bz4cfaz93abza990eb954d53
Development and specification of cortical areas in the non human primate
Pace, C. (2020) · theses.fr (ABES) · doi:10.70675/b7094400z9034z4ec5zb776zde051009bafa
Penisson, M. (2020) · theses.fr (ABES) · doi:10.70675/ad2c850ezf9cfz4390za05azc0cd02a0c5f0
Álvarez, G. O. (2020) · theses.fr (ABES) · doi:10.70675/c245dc66z5428z4d00z9ce9z00ea191284cb
Migration of neural stem cells during human neocortical development
Wimmer, R. (2024) · theses.fr (ABES) · doi:10.70675/2c5a181cz0cdaz4afdza39bz5e5cb0197aef
Chandini, S., Dey, D., Gulati, T., Mishra, A., & Adlakha, Y. K. (2026) · Molecular Neurobiology · doi:10.1007/s12035-026-05904-x
Herrera-Cid, C., Thomsen, O. K., Désarbre, L., Marin, R. B., Doğanlı, C., Pedersen, L. B., Larsen, L. A., & Christensen, S. T. (2026) · Biochemical Society Transactions · doi:10.1042/bst20253108
“Emerging evidence indicates that disruption of ciliary structure or function can cause premature differentiation or failure to properly exit the cell cycle, depleting neural progenitor pools and impairing brain development [99,100].”
The atypical RHO-GTPase RND3/RHOE interacts with FLRT3 to regulate cortical migration and foldingPreprint
Zammou, B., Marfull‐Oromí, P., Aghrabatt, S., Nicholson-Sabaté, N., Pampols, M., Ll, V., Berbeira-Santana, M., Fernandez, V., Nagerl, D., Chauhan, D., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.07.10.737444
Coordinated neural progenitor adaptations contribute to primate neocortical downscaling
Tynianskaia, L., Betancourt, C. M. B., Grewe, E. M., Kniep, J., Liutikaite, N., Eşiyok, N., Göloğlu, İ. B., Heide, S., Rüger, N., Lindenwald, D. L., et al. (2026) · Science Advances · doi:10.1126/sciadv.aeg5563 · Cited by 1
“…and notably bRG ( 14 , 20 ); lower diversity and proliferative potential of progenitors in the oSVZ ( 22 , 23 ); a bias toward neurogenic versus self-renewing divisions ( 17 , 24 ); and differences in progenitor cell-cycle dynamics, such as longer G 1 or reduced proliferative capacity ( 25 , 26 ).”
FBRSL1 couples ncPRC1.3 to CoREST to repress cell-cycle genes during human neuronal differentiationPreprint
Liu, S., Chang, H.-W., & Reinberg, D. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.10.20.760506
Regionalized gene expression during human neocorticogenesis
Ip, B. K. (2011) · OpenGrey (Institut de l'Information Scientifique et Technique)
Study of Wolfram Syndrome in neuronal cell models
Gharanei, S. (2013) · University of Birmingham Institutional Research Archive (University of Birmingham)
Metadata
- Authors
- Dehay, C., & Kennedy, H.
- Affiliations
- Lyon 1 Université (FR)
- Corresponding author
- Dehay, Colette
- Venue
- Nature Reviews Neuroscience
- Published
- 2007-06
- Volume
- 8
- Issue
- 6
- Pages
- 438-450
- ISSN
- 1471-003X (ISSN-L)
- 1471-0048
- OpenAlex
- W2010852678
- Cited by
- 655
- References
- 170
- Citations by year
- 2026: 9 · 2025: 15 · 2024: 17 · 2023: 28 · 2022: 18 · 2021: 30 · 2020: 39 · 2019: 30 · 2018: 47 · 2017: 36 · 2016: 39 · 2015: 34 · 2014: 61 · 2013: 52 · 2012: 47
- FWCI
- 3.18
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nature reviews. Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
- Keywords
- cortical development, cell cycle regulation, G1 phase, neuronal proliferation, neuronal differentiation, neuroblast migration, cortical plate, cortical lamination, cortical regions, cytoarchitecture, primate cortex, rodent cortex
- MeSH terms
- Animals, Cell Communication, Cell Cycle, Cell Differentiation, Cerebral Cortex, Humans, Neurons, Stem Cells, Signal Transduction, G1 Phase, Cell Cycle Proteins, Cell Proliferation
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
