HMGB1: A multifunctional alarmin driving autoimmune and inflammatory disease

Release of chromatin protein HMGB1 by necrotic cells triggers inflammation

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HMG-1 as a Late Mediator of Endotoxin Lethality in Mice

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Immunosuppressive effects of apoptotic cells

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Involvement of Toll-like Receptors 2 and 4 in Cellular Activation by High Mobility Group Box 1 Protein

Park, J. S., Svetkauskaite, D., He, Q., Kim, J., Strassheim, D., Ishizaka, A., & Abraham, E. H. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m306793200 · Cited by 1,560 · see citing works

HMGB1 is a therapeutic target for sterile inflammation and infection

Andersson, U., & Tracey, K. J. (2011) · Annual Review of Immunology · doi:10.1146/annurev-immunol-030409-101323 · Cited by 1,437 · see citing works

High Mobility Group 1 Protein (Hmg-1) Stimulates Proinflammatory Cytokine Synthesis in Human Monocytes

Andersson, U., Wang, H., Palmblad, K., Aveberger, A.-C., Bloom, O., Erlandsson-Harris, H., Janson, A., Kokkola, R., Zhang, M., Yang, H., et al. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.4.565 · Cited by 1,401 · see citing works

Toll-like receptor 9–dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE

Tian, J., Avalos, A. M., Mao, S.-Y., Chen, B., Senthil, K., Wu, H., Parroche, P., Drabic, S., Golenbock, D., Sirois, C., et al. (2007) · Nature Immunology · doi:10.1038/ni1457 · Cited by 1,372 · see citing works

Monocytic cells hyperacetylate chromatin protein HMGB1 to redirect it towards secretion

Bonaldi, T., Talamo, F., Scaffidi, P., Ferrera, D., Porto, A., Bachi, A., Rubartelli, A., Agresti, A., & Bianchi, M. E. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg516 · Cited by 1,252 · see citing works

The Receptor for Advanced Glycation End Products (RAGE) Is a Cellular Binding Site for Amphoterin

Hori, O., Brett, J., Slattery, T., Cao, R., Zhang, J., Chen, J. X., Nagashima, M., Lundh, E. R., Vijay, S., Nitecki, D., et al. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.43.25752 · Cited by 1,151 · see citing works

Caspase‐1‐induced pyroptotic cell death

Miao, E. A., Rajan, J. V., & Aderem, A. A. (2011) · Immunological Reviews · doi:10.1111/j.1600-065x.2011.01044.x · Cited by 1,139 · see citing works

Reversing established sepsis with antagonists of endogenous high-mobility group box 1

Yang, H., Ochani, M., Li, J., Qiang, X., Tanovic, M., Harris, H. E., Susarla, S. M., Ulloa, L., Wang, H., DiRaimo, R., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2434651100 · Cited by 1,126 · see citing works

Human lupus autoantibody–DNA complexes activate DCs through cooperation of CD32 and TLR9

Means, T. K., Latz, E., Hayashi, F., Murali, M. R., Golenbock, D. T., & Luster, A. D. (2005) · Journal of Clinical Investigation · doi:10.1172/jci23025 · Cited by 849 · see citing works

A critical cysteine is required for HMGB1 binding to Toll-like receptor 4 and activation of macrophage cytokine release

Yang, H., Hreggvidsdottir, H. S., Palmblad, K., Wang, H., Ochani, M., Li, J., Lü, B., Chavan, S. S., Rosas‐Ballina, M., Al‐Abed, Y., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1003893107 · Cited by 812 · see citing works

CD24 and Siglec-10 Selectively Repress Tissue Damage–Induced Immune Responses

Chen, G.-Y., Tang, J., Zheng, P., & Liu, Y. (2009) · Science · doi:10.1126/science.1168988 · Cited by 786 · see citing works

Mechanisms of regulated unconventional protein secretion

Nickel, W., & Rabouille, C. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2617 · Cited by 703 · see citing works

Necrotic cells trigger a sterile inflammatory response through the Nlrp3 inflammasome

Iyer, S. S., Pulskens, W. P., Sadler, J. J., Butter, L. M., Teske, G. J., Ulland, T. K., Eisenbarth, S. C., Florquin, S., Flavell, R. A., Leemans, J. C., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0908698106 · Cited by 691 · see citing works

HMGB proteins function as universal sentinels for nucleic-acid-mediated innate immune responses

Yanai, H., Ban, T., Wang, Z., Choi, M. K., Kawamura, T., Negishi, H., Nakasato, M., Lu, Y., Hangai, S., Koshiba, R., et al. (2009) · Nature · doi:10.1038/nature08512 · Cited by 683 · see citing works

Induction of Immunological Tolerance by Apoptotic Cells Requires Caspase-Dependent Oxidation of High-Mobility Group Box-1 Protein

Kazama, H., Ricci, J.-E., Herndon, J. M., Hoppe, G., Green, D. R., & Ferguson, T. A. (2008) · Immunity · doi:10.1016/j.immuni.2008.05.013 · Cited by 627 · see citing works

HMGB1 is an endogenous immune adjuvant released by necrotic cells

Rovere, P. Q., Capobianco, A., Scaffidi, P., Valentinis, B., Catalanotti, F., Giazzon, M., Dumitriu, I. E., Müller, S., Iannacone, M., Traversari, C., et al. (2004) · EMBO Reports · doi:10.1038/sj.embor.7400205 · Cited by 591 · see citing works

The extracellular release of HMGB1 during apoptotic cell death

Bell, C. W., Jiang, W., Reich, C. F., & Pisetsky, D. S. (2006) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00616.2005 · Cited by 538 · see citing works

The lack of chromosomal protein Hmg1 does not disrupt cell growth but causes lethal hypoglycaemia in newborn mice

Calogero, S., Grassi, F., Aguzzi, A., Voigtländer, T., Ferrier, P., Ferrari, S., & Bianchi, M. E. (1999) · Nature Genetics · doi:10.1038/10338 · Cited by 528 · see citing works

Induction of inflammatory and immune responses by HMGB1–nucleosome complexes: implications for the pathogenesis of SLE

Urbonaviciute, V., Fürnrohr, B. G., Meister, S., Munoz, L. E., Heyder, P., Marchis, F. D., Bianchi, M. E., Kirschning, C. J., Wagner, H., Manfredi, A. A., et al. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20081165 · Cited by 517 · see citing works

High mobility group box chromosomal protein 1 plays a role in the pathogenesis of rheumatoid arthritis as a novel cytokine

Taniguchi, N., Kawahara, K.-I., Yone, K., Hashiguchi, T., Yamakuchi, M., Goto, M., Inoue, K., Yamada, S., Ijiri, K., Matsunaga, S., et al. (2003) · Arthritis & Rheumatism · doi:10.1002/art.10859 · Cited by 482 · see citing works

A novel role for HMGB1 in TLR9-mediated inflammatory responses to CpG-DNA

Ivanov, S. S., Dragoi, A., Wang, X., Dallacosta, C., Louten, J., Musco, G., Sitia, G., Yap, G. S., Wan, Y., Biron, C. A., et al. (2007) · Blood · doi:10.1182/blood-2006-09-044776 · Cited by 472 · see citing works

Inflammasome-Dependent Release of the Alarmin HMGB1 in Endotoxemia

Lamkanfi, M., Sarkar, A., Walle, L. V., Vitari, A. C., Amer, A. O., Wewers, M. D., Tracey, K. J., Kanneganti, T., & Dixit, V. M. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1000803 · Cited by 468 · see citing works

HMGB1 Develops Enhanced Proinflammatory Activity by Binding to Cytokines

Sha, Y., Zmijewski, J. W., Xu, Z., & Abraham, E. H. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.4.2531 · Cited by 393 · see citing works

Rage and arthritis: The G82S polymorphism amplifies the inflammatory response

Hofmann, M. A., Drury, S., Hudson, B. I., Gleason, M. R., Qu, W., Lu, Y., Lalla, E., Chitnis, S., Monteiro, J., Stickland, M. H., et al. (2002) · Genes & Immunity · doi:10.1038/sj.gene.6363861 · Cited by 383 · see citing works

The type I interferon system in systemic lupus erythematosus

Rönnblom, L., Eloranta, M., & Alm, G. V. (2006) · Arthritis & Rheumatism · doi:10.1002/art.21571 · Cited by 340 · see citing works

Successful treatment of collagen‐induced arthritis in mice and rats by targeting extracellular high mobility group box chromosomal protein 1 activity

Kokkola, R., Li, J., Sundberg, E., Aveberger, A.-C., Palmblad, K., Yang, H., Tracey, K. J., Andersson, J., & Harris, H. E. (2003) · Arthritis & Rheumatism · doi:10.1002/art.11161 · Cited by 325 · see citing works

High mobility group protein-1 (HMG-1) is a unique activator of p53Preprint

Jayaraman, L., Moorthy, N. C., Murthy, K. G. K., Manley, J. L., Bustin, M., & Prives, C. L. (1998) · Genes & Development · doi:10.1101/gad.12.4.462 · Cited by 319 · see citing works

High mobility group box chromosomal protein 1: A novel proinflammatory mediator in synovitis

Kokkola, R., Sundberg, E., Ulfgren, A. ‐., Palmblad, K., Li, J., Wang, H., Ulloa, L., Yang, H., Yan, X. ‐., Furie, R., et al. (2002) · Arthritis & Rheumatism · doi:10.1002/art.10540 · Cited by 290 · see citing works

The alarmin HMGB1 acts in synergy with endogenous and exogenous danger signals to promote inflammation

Hreggvidsdottir, H. S., Östberg, T., Wähämaa, H., Schierbeck, H., Aveberger, A.-C., Klevenvall, L., Palmblad, K., Ottosson, L., Andersson, U., & Harris, H. E. (2009) · Journal of Leukocyte Biology · doi:10.1189/jlb.0908548 · Cited by 289 · see citing works

Anti-double-stranded DNA antibodies and immunostimulatory plasmid DNA in combination mimic the endogenous IFN-alpha inducer in systemic lupus erythematosus.

Vallin, H., Perers, A., ALM, G. V., & Rönnblom, L. (1999) · PubMed · Cited by 284 · see citing works

Anti-Double-Stranded DNA Antibodies and Immunostimulatory Plasmid DNA in Combination Mimic the Endogenous IFN-α Inducer in Systemic Lupus Erythematosus

Vallin, H., Perers, A., Alm, G. V., & Rönnblom, L. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.11.6306 · Cited by 256 · see citing works

Cells migrating to sites of tissue damage in response to the danger signal HMGB1 require NF-κB activation

Palumbo, R., Gálvez, B. G., Pusterla, T., Marchis, F. D., Cossu, G., Marcu, K. B., & Bianchi, M. E. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200704015 · Cited by 247 · see citing works

Post-translational Methylation of High Mobility Group Box 1 (HMGB1) Causes Its Cytoplasmic Localization in Neutrophils

Ito, I., Fukazawa, J., & Yoshida, M. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m608467200 · Cited by 243 · see citing works

High Mobility Group Box 1 Release from Hepatocytes during Ischemia and Reperfusion Injury Is Mediated by Decreased Histone Deacetylase Activity

Evankovich, J. W., Cho, S. W., Zhang, R., Cardinal, J. S., Dhupar, R., Zhang, L., Klune, J. R., Zlotnicki, J. P., Billiar, T. R., & Tsung, A. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.128348 · Cited by 242 · see citing works

High-Mobility Group Box-1 Protein and Keratin-18, Circulating Serum Proteins Informative of Acetaminophen-Induced Necrosis and Apoptosis In Vivo

Antoine, D. J., Williams, D. P., Kipar, A., Jenkins, R. E., Regan, S. L., Sathish, J. G., Kitteringham, N. R., & Park, B. K. (2009) · Toxicological Sciences · doi:10.1093/toxsci/kfp235 · Cited by 223 · see citing works

Innate and adaptive immune responses to cell death

Rock, K. L., Lai, J., & Kono, H. (2011) · Immunological Reviews · doi:10.1111/j.1600-065x.2011.01040.x · Cited by 220 · see citing works

High mobility group box chromosomal protein 1, a DNA binding cytokine, induces arthritis

Pullerits, R., Jonsson, I., Verdrengh, M., Bokarewa, M. I., Andersson, U., Erlandsson-Harris, H., & Tarkowski, A. (2003) · Arthritis & Rheumatism · doi:10.1002/art.11028 · Cited by 191 · see citing works

Cholinergic Anti-Inflammatory Pathway Activity and High Mobility Group Box-1 (HMGB1) Serum Levels in Patients with Rheumatoid Arthritis

Goldstein, R. S., Bruchfeld, A. N., Yang, L., Qureshi, A. R., Gallowitsch‐Puerta, M., Patel, N. B., Huston, B. J., Chavan, S. S., Rosas‐Ballina, M., Gregersen, P. K., et al. (2007) · Molecular Medicine · doi:10.2119/2006-00108.goldstein · Cited by 187 · see citing works

HMGB1 Is Phosphorylated by Classical Protein Kinase C and Is Secreted by a Calcium-Dependent Mechanism

Oh, Y. J., Youn, J. H., Ji, Y., Lee, S. E., Lim, K. J., Choi, J. E., & Shin, J. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0801873 · Cited by 178 · see citing works

High mobility group box 1 (HMGB1) and anti-HMGB1 antibodies and their relation to disease characteristics in systemic lupus erythematosus

Abdulahad, D. A., Westra, J., Bijzet, J., Limburg, P. C., Kallenberg, C. G. M., & Bijl, M. (2011) · Arthritis Research & Therapy · doi:10.1186/ar3332 · Cited by 168 · see citing works

Metformin inhibits HMGB1 release in LPS‐treated RAW 264.7 cells and increases survival rate of endotoxaemic mice

Tsoyi, K., Jang, H. J., Nizamutdinova, I. T., Kim, Y. M., Lee, Y. S., Kim, H. J., Seo, H. G., Lee, J. H., & Chang, K. C. (2010) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2010.01126.x · Cited by 158 · see citing works

Factors masking HMGB1 in human serum and plasma

Urbonaviciute, V., Fürnrohr, B. G., Weber, C., Haslbeck, M., Wilhelm, S., i, M. H., & Voll, R. E. (2006) · Journal of Leukocyte Biology · doi:10.1189/jlb.0306196 · Cited by 157 · see citing works

HMGB proteins and transcriptional regulation

Ueda, T., & Yoshida, M. (2010) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2009.11.005 · Cited by 154 · see citing works

Increased expression of the novel proinflammatory cytokine high mobility group box chromosomal protein 1 in skin lesions of patients with lupus erythematosus

Popovic, K., Ek, M., Espinosa, A., Padyukov, L., Harris, H. E., Wahren‐Herlenius, M., & Nyberg, F. (2005) · Arthritis & Rheumatism · doi:10.1002/art.21398 · Cited by 140 · see citing works

The lectin-like domain of thrombomodulin interferes with complement activation and protects against arthritis

de Wouwer, M. V., Plaisance, S., Vriese, A. D., Waelkens, E., Collen, D., Persson, J., Daha, M. R., & Conway, E. M. (2006) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2006.02033.x · Cited by 140 · see citing works

High mobility group box protein 1 in complex with lipopolysaccharide or IL-1 promotes an increased inflammatory phenotype in synovial fibroblasts

Wähämaa, H., Schierbeck, H., Hreggvidsdottir, H. S., Palmblad, K., Aveberger, A.-C., Andersson, U., & Harris, H. E. (2011) · Arthritis Research & Therapy · doi:10.1186/ar3450 · Cited by 138 · see citing works

Extracellular high mobility group box chromosomal protein 1 is a coupling factor for hypoxia and inflammation in arthritis

Hamada, T., Torikai, M., Kuwazuru, A., Tanaka, M., Horai, N., Fukuda, T., Yamada, S., Nagayama, S., Hashiguchi, K., Sunahara, N., et al. (2008) · Arthritis & Rheumatism · doi:10.1002/art.23729 · Cited by 130 · see citing works

Monoclonal Anti-HMGB1 (High Mobility Group Box Chromosomal Protein 1) Antibody Protection in Two Experimental Arthritis Models

Schierbeck, H., Lundbäck, P., Palmblad, K., Klevenvall, L., Erlandsson-Harris, H., Andersson, U., & Ottosson, L. (2011) · Molecular Medicine · doi:10.2119/molmed.2010.00264 · Cited by 122 · see citing works

Elevated plasma level of HMGB1 is associated with disease activity and combined alterations with IFN-alpha and TNF-alpha in systemic lupus erythematosus

Ma, C., Jiao, Y., Zhang, J., Yang, Q., Zhang, Z., Shen, Y., Chen, Z., & Zhao, Y. (2010) · Rheumatology International · doi:10.1007/s00296-010-1636-6 · Cited by 115 · see citing works

Down‐regulation of the aberrant expression of the inflammation mediator high mobility group box chromosomal protein 1 in muscle tissue of patients with polymyositis and dermatomyositis treated with corticosteroids

Ulfgren, A., Grundtman, C., Borg, K., Alexanderson, H., Andersson, U., Harris, H. E., & Lundberg, I. E. (2004) · Arthritis & Rheumatism · doi:10.1002/art.20220 · Cited by 113 · see citing works

High Mobility Group Box Protein 1 (HMGB1)-Partner Molecule Complexes Enhance Cytokine Production by Signaling Through the Partner Molecule Receptor

Hreggvidsdottir, H. S., Lundberg, A. M., Aveberger, A.-C., Klevenvall, L., Andersson, U., & Harris, H. E. (2011) · Molecular Medicine · doi:10.2119/molmed.2011.00327 · Cited by 108 · see citing works

High mobility group box 1 potentiates the pro-inflammatory effects of interleukin-1β in osteoarthritic synoviocytes

García-Arnandis, I., Guillén, M. I., Sancho, F. G., Pelletier, J., Martel‐Pelletier, J., & Alcaraz, M. J. (2010) · Arthritis Research & Therapy · doi:10.1186/ar3124 · Cited by 106 · see citing works

Multiple Effects of High Mobility Group Box Protein 1 in Skeletal Muscle Regeneration

Mori, R. D., Straino, S., Carlo, A. D., Mangoni, A., Pompilio, G., Palumbo, R., Bianchi, M. E., Capogrossi, M. C., & Germani, A. (2007) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.107.153429 · Cited by 100 · see citing works

Intraarticular glucocorticoid treatment reduces inflammation in synovial cell infiltrations more efficiently than in synovial blood vessels

af Klint, E., Grundtman, C., Engström, M., Catrina, A. I., Makrygiannakis, D., Klareskog, L., Andersson, U., & Ulfgren, A. (2005) · Arthritis & Rheumatism · doi:10.1002/art.21488 · Cited by 98 · see citing works

HMGB1 interacts differentially with members of the Rel family of transcription factors

Agresti, A., Lupo, R., Bianchi, M. E., & Müller, S. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(03)00184-0 · Cited by 95 · see citing works

Translocation of the novel cytokine HMGB1 to the cytoplasm and extracellular space coincides with the peak of clinical activity in experimentally UV-induced lesions of cutaneous lupus erythematosus

Barkauskaite, V., Ek, M., Popović, K. J., Harris, H. E., Wahren‐Herlenius, M., & Nyberg, F. (2007) · Lupus · doi:10.1177/0961203307081895 · Cited by 88 · see citing works

Identification of lipopolysaccharide‐binding peptide regions within HMGB1 and their effects on subclinical endotoxemia in a mouse model

Youn, J. H., Kwak, M. S., Wu, J., Kim, E. S., Ji, Y., Min, H. J., Yoo, J., Choi, J. E., Cho, H., & Shin, J. (2011) · European Journal of Immunology · doi:10.1002/eji.201141391 · Cited by 86 · see citing works

Comparative analysis of the influence of the high-mobility group box 1 protein on DNA binding and transcriptional activation by the androgen, glucocorticoid, progesterone and mineralocorticoid receptors

Verrijdt, G., Haelens, A., Schoenmakers, E., Rombauts, W., & Claessens, F. (2002) · Biochemical Journal · doi:10.1042/0264-6021:3610097 · Cited by 83 · see citing works

Increased extracellular levels of the novel proinflammatory cytokine high mobility group box chromosomal protein 1 in minor salivary glands of patients with Sjögren's syndrome

Ek, M., Popovic, K., Harris, H. E., Söderberg‐Nauclér, C., & Wahren‐Herlenius, M. (2006) · Arthritis & Rheumatism · doi:10.1002/art.21969 · Cited by 82 · see citing works

Cyclophilin A release as a biomarker of necrotic cell death

Christofferson, D. E., & Yuan, J. (2010) · Cell Death and Differentiation · doi:10.1038/cdd.2010.123 · Cited by 80 · see citing works

Developments in the scientific understanding of lupus

Ardoin, S. P., & Pisetsky, D. S. (2008) · Arthritis Research & Therapy · doi:10.1186/ar2488 · Cited by 80 · see citing works

Expression of High Mobility Group Box Chromosomal Protein 1 and Its Modulating Effects on Downstream Cytokines in Systemic Lupus Erythematosus

LI, J., Xie, H., WEN, T., Liu, H., Zhu, W., & Chen, X. (2010) · The Journal of Rheumatology · doi:10.3899/jrheum.090663 · Cited by 78 · see citing works

Effects of HMGB1 on in vitro responses of isolated muscle fibers and functional aspects in skeletal muscles of idiopathic inflammatory myopathies

Grundtman, C., Bruton, J. D., Yamada, T., Östberg, T., Pisetsky, D. S., Harris, H. E., Andersson, U., Lundberg, I. E., & Westerblad, H. (2009) · The FASEB Journal · doi:10.1096/fj.09-144782 · Cited by 78 · see citing works

New high mobility group box 1 assay system

Yamada, S., Yakabe, K., Ishii, J., Imaizumi, H., & Maruyama, I. (2006) · Clinica Chimica Acta · doi:10.1016/j.cca.2006.04.016 · Cited by 76 · see citing works

Autoantibodies to nonhistone chromosomal proteins HMG‐1 and HMG‐2 in sera of patients with juvenile rheumatoid arthritis

Wittemann, B., Neuer, G., Michels, H., Truckenbrodt, H., & Bautz, F. A. (1990) · Arthritis & Rheumatism · doi:10.1002/art.1780330910 · Cited by 75 · see citing works

High-Mobility Group Box 1 Release and Redox Regulation Accompany Regeneration and Remodeling of Skeletal Muscle

Vezzoli, M., Castellani, P., Corna, G., Castiglioni, A., Bosurgi, L., Monno, A., Brunelli, S., Manfredi, A. A., Rubartelli, A., & Rovere, P. Q. (2011) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3341 · Cited by 74 · see citing works

Cyclophilin A Is a Damage-Associated Molecular Pattern Molecule That Mediates Acetaminophen-Induced Liver Injury

Dear, J. W., Simpson, K. J., Nicolai, M. P. J., Catterson, J. H., Street, J. M., Huizinga, T., Craig, D. G. N., Dhaliwal, K., Webb, S., Bateman, D. N., et al. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1100165 · Cited by 73 · see citing works

Comparative analysis of the influence of the high-mobility group box 1 protein on DNA binding and transcriptional activation by the androgen, glucocorticoid, progesterone and mineralocorticoid receptors

Verrijdt, G., Haelens, A., Schoenmakers, E., Rombauts, W., & Claessens, F. (2001) · Biochemical Journal · doi:10.1042/bj3610097 · Cited by 64 · see citing works

Expression of high mobility group protein 1 in the sera of patients and mice with systemic lupus erythematosus

Jiang, W., & Pisetsky, D. S. (2008) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2007.074484 · Cited by 62 · see citing works

Suppression of immune responses by nonimmunogenic oligodeoxynucleotides with high affinity for high-mobility group box proteins (HMGBs)

Yanai, H., Chiba, S., Ban, T., Nakaima, Y., Onoe, T., Honda, K., Ohdan, H., & Taniguchi, T. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1108535108 · Cited by 62 · see citing works

High-Mobility Group Box-1 Protein (HMGB1) Is Increased in Antineutrophilic Cytoplasmatic Antibody (ANCA)-Associated Vasculitis with Renal Manifestations

Bruchfeld, A. N., Wendt, M., Bratt, J., Qureshi, A. R., Chavan, S. S., Tracey, K. J., Palmblad, K., & Gunnarsson, I. (2010) · Molecular Medicine · doi:10.2119/molmed.2010.00132 · Cited by 61 · see citing works

Protective targeting of high mobility group box chromosomal protein 1 in a spontaneous arthritis model

Östberg, T., Kawane, K., Nagata, S., Yang, H., Chavan, S. S., Klevenvall, L., Bianchi, M. E., Harris, H. E., Andersson, U., & Palmblad, K. (2010) · Arthritis & Rheumatism · doi:10.1002/art.27590 · Cited by 58 · see citing works

Contribution of Cyclophilin A to the Regulation of Inflammatory Processes in Rheumatoid Arthritis

Wang, L., Wang, C., Jia, J., Ma, X., Li, Y., Zhu, H., Tang, H., Chen, Z., & Zhu, P. (2009) · Journal of Clinical Immunology · doi:10.1007/s10875-009-9329-1 · Cited by 57 · see citing works

Pivotal Advance: Inhibition of HMGB1 nuclear translocation as a mechanism for the anti-rheumatic effects of gold sodium thiomalate

Zetterström, C. K., Jiang, W., Wähämaa, H., Östberg, T., Aveberger, A.-C., Schierbeck, H., Lotze, M. T., Andersson, U., Pisetsky, D. S., & Harris, H. E. (2007) · Journal of Leukocyte Biology · doi:10.1189/jlb.0507323 · Cited by 54 · see citing works

Determinants of HMGB Proteins Required To Promote RAG1/2-Recombination Signal Sequence Complex Assembly and Catalysis during V(D)J Recombination

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Serum HMGB1 levels are increased in active Wegener's granulomatosis and differentiate between active forms of ANCA-associated vasculitis

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Deacetylation-mediated interaction of SIRT1-HMGB1 improves survival in a mouse model of endotoxemia

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Role of Toll-like receptor-4 in renal graft ischemia-reperfusion injury

Zhao, H., Perez, J. S., Lu, K., George, A. J. T., & Ma, D. (2014) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00469.2013 · Cited by 117 · see citing works

HMGB1 and Its Hyperacetylated Isoform are Sensitive and Specific Serum Biomarkers to Detect Asbestos Exposure and to Identify Mesothelioma Patients

Napolitano, A., Antoine, D. J., Pellegrini, L., Baumann, F., Pagano, I., Pastorino, S., Goparaju, C. M. V., Prokrym, K., Canino, C., Pass, H. I., et al. (2016) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-15-1130 · Cited by 117 · see citing works

HMGB1 protein as a novel target for cancer

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A Janus Tale of Two Active High Mobility Group Box 1 (HMGB1) Redox States

Tang, D., Billiar, T. R., & Lotze, M. T. (2012) · Molecular Medicine · doi:10.2119/molmed.2012.00314 · Cited by 112 · see citing works

Melatonin attenuates sepsis-induced cardiac dysfunction via a PI3K/Akt-dependent mechanism

An, R. F., Zhao, L., Xi, C., Li, H., Shen, G., Liu, H., Zhang, S., & Sun, L. (2015) · Basic Research in Cardiology · doi:10.1007/s00395-015-0526-1 · Cited by 113 · see citing works

Innate immune memory: Implications for host responses to damage‐associated molecular patterns

Crișan, T. O., Netea, M. G., & Joosten, L. A. B. (2016) · European Journal of Immunology · doi:10.1002/eji.201545497 · Cited by 112 · see citing works

Fully reduced HMGB1 accelerates the regeneration of multiple tissues by transitioning stem cells to G Alert

Lee, G., Santo, A. I. E., Zwingenberger, S., Cai, L. X., Vogl, T., Feldmann, M., Horwood, N. J., Chan, J. K.-K., & Nanchahal, J. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1802893115 · Cited by 112 · see citing works

Damage-associated molecular patterns (DAMPs) in diseases: implications for therapy

Lin, H., Xiong, W. G., Fu, L., Yi, J., & Yang, J. (2025) · Molecular Biomedicine · doi:10.1186/s43556-025-00305-3 · Cited by 118 · see citing works

Clear and present danger? Engineered nanoparticles and the immune system

Fadeel, B. (2012) · Swiss Medical Weekly · doi:10.4414/smw.2012.13609 · Cited by 112 · see citing works

Necrostatin-1 reduces intestinal inflammation and colitis-associated tumorigenesis in mice.

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Ds-HMGB1 and fr-HMGB induce depressive behavior through neuroinflammation in contrast to nonoxid-HMGB1

Lian, Y., Gong, H., Wu, T., Su, W., Zhang, Y., Yang, Y., Wei, P., Zhang, T., Zhou, J., Jiang, C., et al. (2016) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2016.09.017 · Cited by 105 · see citing works

Potential Neuroprotective Effect of the HMGB1 Inhibitor Glycyrrhizin in Neurological Disorders

Paudel, Y. N., Angelopoulou, E., Semple, B. D., Piperi, C., Othman, I., & Shaikh, M. F. (2020) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.9b00640 · Cited by 105 · see citing works

RIP3 AND pMLKL promote necroptosis-induced inflammation and alter membrane permeability in intestinal epithelial cells

Negroni, A., Colantoni, E., Pierdomenico, M., Palone, F., Costanzo, M., Oliva, S., Tiberti, A., Cucchiara, S., & Stronati, L. (2017) · Digestive and Liver Disease · doi:10.1016/j.dld.2017.08.017 · Cited by 103 · see citing works

Molecular mechanisms of lidocaine

Karnina, R., Arif, S. K., Hatta, M., & Bukhari, A. (2021) · Annals of Medicine and Surgery · doi:10.1016/j.amsu.2021.102733 · Cited by 110 · see citing works

Programmed Cell Death Pathways in the Pathogenesis of Systemic Lupus Erythematosus

Yang, F., He, Y., Zhai, Z., & Sun, E. (2019) · Journal of Immunology Research · doi:10.1155/2019/3638562 · Cited by 101 · see citing works

Ribosome biogenesis restricts innate immune responses to virus infection and DNA

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Probing the phenomenon of trained immunity in invertebrates during a transgenerational study, using brine shrimp Artemia as a model system

Norouzitallab, P., Baruah, K., Biswas, P., Vanrompay, D. C. G., & Bossier, P. (2016) · Scientific Reports · doi:10.1038/srep21166 · Cited by 101 · see citing works

Anxiolytic and antidepressive potentials of rosmarinic acid: A review with focus on antioxidant and anti-inflammatory effects.

Dahchour, A. (2022) · Pharmacological Research · doi:10.1016/j.phrs.2022.106421 · Cited by 93 · see citing works

The rodent endovascular puncture model of subarachnoid hemorrhage: mechanisms of brain damage and therapeutic strategies

Kooijman, E., Nijboer, C. H. A., van Velthoven, C. T. J., Kavelaars, A., Kesecioğlu, J., & Heijnen, C. J. (2014) · Journal of Neuroinflammation · doi:10.1186/1742-2094-11-2 · Cited by 99 · see citing works

High Mobility Group Box 1 Mediates TMAO-Induced Endothelial Dysfunction

Singh, G. B., Zhang, Y., Boini, K. M., & Koka, S. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20143570 · Cited by 102 · see citing works

Oxidative Stress Elicits Platelet/Leukocyte Inflammatory Interactions via HMGB1: A Candidate for Microvessel Injury in Sytemic Sclerosis

Maugeri, N., Rovere, P. Q., Baldini, M., Baldissera, E. M., Sabbadini, M. G., Bianchi, M. E., & Manfredi, A. A. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2013.5298 · Cited by 97 · see citing works

Mechanical Ventilation Induces Neutrophil Extracellular Trap Formation

Yildiz, C., Palaniyar, N., Otulakowski, G., Khan, M. A., Post, M., Kuebler, W. M., Tanswell, K. A., Belcastro, R., Masood, A., Engelberts, D., et al. (2015) · Anesthesiology · doi:10.1097/aln.0000000000000605 · Cited by 97 · see citing works

Immune mechanisms in polymyositis and dermatomyositis and potential targets for therapy

Venalis, P., & Lundberg, I. E. (2013) · Lara D. Veeken · doi:10.1093/rheumatology/ket279 · Cited by 97 · see citing works

HMGB1 released from nociceptors mediates inflammation

Yang, H., Zeng, Q., Silverman, H. A., Gunasekaran, M., George, S. J., Devarajan, A., Addorisio, M. E., Li, J., Tsaava, T., Shah, V. D., et al. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2102034118 · Cited by 99 · see citing works

Extracellular High-Mobility Group Box 1 Protein (HMGB1) as a Mediator of Persistent Pain

Agalave, N. M., & Svensson, C. I. (2014) · Molecular Medicine · doi:10.2119/molmed.2014.00176 · Cited by 97 · see citing works

Expression and regulation of toll-like receptors (TLRs) in human intervertebral disc cells

Klawitter, M., Hakozaki, M., Kobayashi, H., Krupkova, O., Quero, L., Ospelt, C., Gay, S., Hausmann, O. N., Liebscher, T., Meier, U., et al. (2014) · European Spine Journal · doi:10.1007/s00586-014-3442-4 · Cited by 95 · see citing works

The Role of High Mobility Group Box 1 in Ischemic Stroke

Ye, Y., Zeng, Z. R., Jin, T., Zhang, H., Xiong, X., & Gu, L. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00127 · Cited by 93 · see citing works

Emerging role of HMGB 1 in fibrotic diseases

Li, L., Gao, J., & Li, J. (2014) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.12419 · Cited by 93 · see citing works

The role of HMGB1 in the pathogenesis of rheumatic disease

Andersson, U., & Harris, H. E. (2010) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2009.11.003 · Cited by 126 · see citing works

The Role of HMGB1 in the Pathogenesis of Inflammatory and Autoimmune Diseases

Magna, M., & Pisetsky, D. S. (2014) · Molecular Medicine · doi:10.2119/molmed.2013.00164 · Cited by 358 · see citing works

High-mobility group box protein 1 (HMGB1): an alarmin mediating the pathogenesis of rheumatic disease

Pisetsky, D. S., Erlandsson-Harris, H., & Andersson, U. (2008) · Arthritis Research & Therapy · doi:10.1186/ar2440 · Cited by 188 · see citing works

HMGB1 and Toll-like receptors: potential therapeutic targets in autoimmune diseases

Ren, W., Zhao, L., Sun, Y., Wang, X.-C., & Shi, X.-G. (2023) · Molecular Medicine · doi:10.1186/s10020-023-00717-3 · Cited by 104 · see citing works

The Role of HMGB1 in Rheumatic Diseases

Dong, Y., Ming, B., & Dong, L. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.815257 · Cited by 40 · see citing works