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Resistin Gene Expression in Human Adipocytes Is Not Related to Insulin Resistance
Abstract
Objectives: Obesity is an important risk factor for the development of insulin resistance and type 2 diabetes. Recently, a newly described circulating hormone resistin, which is expressed primarily in adipocytes, has been shown to antagonize insulin action in mice. Resistin, therefore, has been suggested to play a role in the pathogenesis of insulin resistance. Research Methods and Procedures: We studied the expression of the resistin gene in primary cultured human adipocytes and preadipocytes. We also examined resistin gene expression in subcutaneous abdominal adipocytes in women (n = 24) over a wide range of body weight and insulin sensitivity. Results: Whereas resistin gene expression was barely detectable in mature adipocytes, it was highly expressed in preadipocytes. Adipogenic differentiation of preadipocytes was associated with a time‐dependent down‐regulation of resistin gene expression. There was no relationship between body weight, insulin sensitivity, or other metabolic parameters and adipocyte resistin gene expression in the clinical study. Discussion: Together these findings do not support an important role of adipose‐tissue resistin gene expression in human insulin resistance.
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Metadata
- Authors
- Janke, J., Engeli, S., Gorzelniak, K., Luft, F. C., & Sharma, A. M.
- Venue
- Obesity Research
- Publisher
- Wiley
- Published
- 2002-01
- Volume
- 10
- Issue
- 1
- Pages
- 1-5
- ISSN
- 1071-7323 (ISSN-L)
- 1550-8528
- OpenAlex
- W2027065577
- Cited by
- 319
- References
- 1
- FWCI
- 28.04
- Type
- journal article
- Language
- en
- Open access
- closed
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