The DOI matches its Crossref record; 227 of the 230 references it cites were found in a registry or an index.
Rho guanine nucleotide exchange factors: regulators of Rho GTPase activity in development and disease
Open accessAbstract
The aberrant activity of Ras homologous (Rho) family small GTPases (20 human members) has been implicated in cancer and other human diseases. However, in contrast to the direct mutational activation of Ras found in cancer and developmental disorders, Rho GTPases are activated most commonly in disease by indirect mechanisms. One prevalent mechanism involves aberrant Rho activation via the deregulated expression and/or activity of Rho family guanine nucleotide exchange factors (RhoGEFs). RhoGEFs promote formation of the active GTP-bound state of Rho GTPases. The largest family of RhoGEFs is comprised of the Dbl family RhoGEFs with 70 human members. The multitude of RhoGEFs that activate a single Rho GTPase reflects the very specific role of each RhoGEF in controlling distinct signaling mechanisms involved in Rho activation. In this review, we summarize the role of Dbl RhoGEFs in development and disease, with a focus on Ect2 (epithelial cell transforming squence 2), Tiam1 (T-cell lymphoma invasion and metastasis 1), Vav and P-Rex1/2 (PtdIns(3,4,5)P3 (phosphatidylinositol (3,4,5)-triphosphate)-dependent Rac exchanger).
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“DH GEFs constitute the larger of the two classes, with over 70 members (30, 31).”
From RHO to the DOCK for GDP disembarking: Structural insights into the DOCK GTPase nucleotide exchange factors (2021) · cites this paper as [30]
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1 retracted
Spindler, M. J., Burmeister, B. T., Huang, Y., Hsiao, E. C., Salomonis, N., Scott, M. J., Srivastava, D., Carnegie, G. K., & Conklin, B. R. (2013) · PLoS ONE · doi:10.1371/journal.pone.0062705 · Cited by 13
RetractedClustal W and Clustal X version 2.0
Larkin, M., Blackshields, G., Brown, N. P., Chenna, R., McGettigan, P., McWilliam, H., Valentin, F., Wallace, I. M., Wilm, A., López, R., et al. (2007) · Bioinformatics · doi:10.1093/bioinformatics/btm404 · Cited by 28,598
The Consensus Coding Sequences of Human Breast and Colorectal Cancers
Sjöblom, T., Jones, S., Wood, L. D., Parsons, D. W., Lin, J., Barber, T. D., Mandelker, D. L., Leary, R. J., Ptak, J., Silliman, N., et al. (2006) · Science · doi:10.1126/science.1133427 · Cited by 3,161
RHO GTPASES: Biochemistry and Biology
Jaffe, A. B., & Hall, A. (2005) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.21.020604.150721 · Cited by 3,009
A landscape of driver mutations in melanoma
Hodis, E., Watson, I. R., Kryukov, G. V., Arold, S. T., Imielinski, M., Theurillat, J.-P., Nickerson, E., Auclair, D., Li, L., Place, C., et al. (2012) · Cell · doi:10.1016/j.cell.2012.06.024 · Cited by 2,610
Rho GTPases and their effector proteins
Bishop, A. L., & Hall, A. (2000) · Biochemical Journal · doi:10.1042/bj3480241 · Cited by 2,019
GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors
Rossman, K. L., Der, C. J., & Sondek, J. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1587 · Cited by 1,697
Self-citationSahai, E., & Marshall, C. (2002) · Nature Reviews. Cancer · doi:10.1038/nrc725 · Cited by 1,575
The Ras superfamily at a glance
Wennerberg, K., Rossman, K. L., & Der, C. J. (2005) · Journal of Cell Science · doi:10.1242/jcs.01660 · Cited by 1,549
Self-citationRas oncogenes: split personalities
Karnoub, A. E., & Weinberg, R. A. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2438 · Cited by 1,467
Flagged first, then by citations
3 of the 230 references couldn’t be matched to a known paper.
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Rho GTPases: Regulation and roles in cancer cell biology
Haga, R. B., & Ridley, A. J. (2016) · Small GTPases · doi:10.1080/21541248.2016.1232583 · Cited by 572
Rho GTPase signaling complexes in cell migration and invasion
Lawson, C. D., & Ridley, A. J. (2018) · Journal of Cell Biology · doi:10.1083/jcb.201612069 · Cited by 539
Common Molecular Subtypes Among Asian Hepatocellular Carcinoma and Cholangiocarcinoma
Chaisaingmongkol, J., Budhu, A., Dang, H., Rabibhadana, S., Pupacdi, B., Kwon, S. M., Forgues, M., Pomyen, Y., Bhudhisawasdi, V., Lertprasertsuke, N., et al. (2017) · Cancer Cell · doi:10.1016/j.ccell.2017.05.009 · Cited by 434
Transcriptional Architecture of Synaptic Communication Delineates GABAergic Neuron Identity
Paul, A., Crow, M., Raudales, R., He, M., Gillis, J., & Huang, Z. J. (2017) · Cell · doi:10.1016/j.cell.2017.08.032 · Cited by 421
The RHO Family GTPases: Mechanisms of Regulation and Signaling
Mosaddeghzadeh, N., & Ahmadian, M. R. (2021) · Cells · doi:10.3390/cells10071831 · Cited by 385
Metadata
- Authors
- Cook, D. R., Rossman, K. L., & Der, C. J.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- Corresponding author
- Der, C J
- ORCID
- Venue
- Oncogene
- Published
- 2013-09-16
- Volume
- 33
- Issue
- 31
- Pages
- 4021-4035
- ISSN
- 0950-9232 (ISSN-L)
- 1476-5594
- PMC
- PMC4875565
- OpenAlex
- W2024222958
- Cited by
- 378
- References
- 230
- Citations by year
- 2026: 14 · 2025: 15 · 2024: 17 · 2023: 26 · 2022: 35 · 2021: 45 · 2020: 43 · 2019: 33 · 2018: 37 · 2017: 29 · 2016: 34 · 2015: 24 · 2014: 23 · 2013: 3
- FWCI
- 2.64
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Oncogene (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
- UNC Libraries
- Funders
- Pancreatic Cancer Action Network
- National Institutes of Health (5r01ca042978-30)
- National Cancer Institute (CA159821, CA 71341, R01-CA042978, F31CA159821, T32CA071341)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Hippo pathway signaling and YAP/TAZ
- Keywords
- RhoGEF, Rho GTPases, ECT2, Tiam1, Vav, Rho activation, cancer, developmental disorders, phosphatidylinositol 3,4,5-trisphosphate, small GTPase signaling
- MeSH terms
- Congenital Abnormalities, Animals, Cell Division, Humans, Neoplasms, Gene Expression Regulation, Neoplastic, rho GTP-Binding Proteins, Genetic Diseases, Inborn, Proto-Oncogene Proteins c-vav, Rho Guanine Nucleotide Exchange Factors
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