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Transcriptional Architecture of Synaptic Communication Delineates GABAergic Neuron Identity

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The RHO Family GTPases: Mechanisms of Regulation and Signaling

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The on-off relationship of Rho and Rac during integrin-mediated adhesion and cell migration

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Rho GTPase signaling in cancer progression and dissemination

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Granule protein processing and regulated secretion in neutrophils

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Targeting Rac and Cdc42 GTPases in Cancer

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Dock-family exchange factors in cell migration and disease

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Deregulation of Rho GTPases in cancer

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The Rac GTPase in Cancer: From Old Concepts to New Paradigms

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DNA-PKcs-Mediated Transcriptional Regulation Drives Prostate Cancer Progression and Metastasis

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Rho signaling research: history, current status and future directions

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Paving the Rho in cancer metastasis: Rho GTPases and beyond

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Glycogen synthase kinase‐3β is a pivotal mediator of cancer invasion and resistance to therapy

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Small GTPases

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Mechanotransduction: from the cell surface to the nucleus via RhoA

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Approaches of targeting Rho GTPases in cancer drug discovery

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A RhoA–YAP–c-Myc signaling axis promotes the development of polycystic kidney diseasePreprint

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ECT2 regulates the Rho/ERK signalling axis to promote early recurrence in human hepatocellular carcinoma

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A Ca2+-dependent signalling circuit regulates influenza A virus internalization and infection

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Rho-guanine nucleotide exchange factors involved in cyclic stretch-induced reorientation of vascular endothelial cells

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Plasma membrane restricted RhoGEF activity is sufficient for RhoA-mediated actin polymerization

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Regulation and function of P-Rex family Rac-GEFs

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ESRP2 controls an adult splicing programme in hepatocytes to support postnatal liver maturation

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Rho GTPases: Anti- or pro-neoplastic targets?

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Function and regulation of the Rho guanine nucleotide exchange factor Trio

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Role of internalin proteins in the pathogenesis of Listeria monocytogenes

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Crosstalk between Rac1-mediated actin regulation and ROS production

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The Rac Inhibitor EHop-016 Inhibits Mammary Tumor Growth and Metastasis in a Nude Mouse Model

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I’m coming to GEF you: Regulation of RhoGEFs during cell migration

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Phosphatidylinositol 5-phosphate regulates invasion through binding and activation of Tiam1

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Dysregulation of Rho GTPases in Human Cancers

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Endothelin A receptor drives invadopodia function and cell motility through the β-arrestin/PDZ-RhoGEF pathway in ovarian carcinoma

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Cytoskeletal proteins in cortical development and disease: actin associated proteins in periventricular heterotopia

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The dynamics of spatio-temporal Rho GTPase signaling: formation of signaling patterns

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ARHGAP18: an endogenous inhibitor of angiogenesis, limiting tip formation and stabilizing junctions

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DOCK8 regulates signal transduction events to control immunity

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Redefining the specificity of phosphoinositide-binding by human PH domain-containing proteins

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CXCL8 Signaling in the Tumor Microenvironment

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Novel Activities of Select NSAID R-Enantiomers against Rac1 and Cdc42 GTPases

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The sirtuins promote Dishevelled-1 scaffolding of TIAM1, Rac activation and cell migration

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Structure and regulation of human epithelial cell transforming 2 protein

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Kalirin and Trio: RhoGEFs in Synaptic Transmission, Plasticity, and Complex Brain Disorders

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RHO GTPase family in hepatocellular carcinoma

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The role of Rac in tumor susceptibility and disease progression: from biochemistry to the clinic

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Regulators of Rho GTPases in the Nervous System: Molecular Implication in Axon Guidance and Neurological Disorders

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Interplay between Solo and keratin filaments is crucial for mechanical force–induced stress fiber reinforcement

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RAC2 and primary human immune deficiencies

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Enhanced Dendritic Actin Network Formation in Extended Lamellipodia Drives Proliferation in Growth-Challenged Rac1P29S Melanoma Cells

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The Phospholipase Cγ2 Mutants R665W and L845F Identified in Ibrutinib-resistant Chronic Lymphocytic Leukemia Patients Are Hypersensitive to the Rho GTPase Rac2 Protein

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Pleckstrin Homology [PH] domain, structure, mechanism, and contribution to human disease

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Identification of Prognostic Biomarkers by Combined mRNA and miRNA Expression Microarray Analysis in Pancreatic Cancer

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Progress in the therapeutic inhibition of Cdc42 signalling

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RAS and RHO family GTPase mutations in cancer: twin sons of different mothers?

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Diverse roles of guanine nucleotide exchange factors in regulating collective cell migration

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Dock GEFs and their therapeutic potential: Neuroprotection and axon regeneration

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Establishment of epithelial polarity – GEF who's minding the GAP?

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Tensins are versatile regulators of Rho GTPase signalling and cell adhesion

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Spatiotemporal Control of Intracellular Membrane Trafficking by Rho GTPases

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Ovarian Tumor Microenvironment Signaling: Convergence on the Rac1 GTPase

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The DOCK protein family in vascular development and disease

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Endothelial RhoGEFs: A systematic analysis of their expression profiles in VEGF-stimulated and tumor endothelial cells

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The role of A-kinase anchoring proteins in cancer development

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RPEL-family rhoGAPs link Rac/Cdc42 GTP loading to G-actin availability

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Protein Kinase A (PKA) Type I Interacts with P-Rex1, a Rac Guanine Nucleotide Exchange Factor

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RHO Family GTPases in the Biology of Lymphoma

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Using light to shape chemical gradients for parallel and automated analysis of chemotaxis

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Cryo–electron microscopy structure and analysis of the P-Rex1–Gβγ signaling scaffold

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Aberrant Expression and Subcellular Localization of ECT2 Drives Colorectal Cancer Progression and Growth

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RHOA takes the RHOad less traveled to cancer

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Subtype-specific overexpression of the Rac-GEF P-REX1 in breast cancer is associated with promoter hypomethylation

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Hsc70 chaperone activity underlies Trio GEF function in axon growth and guidance induced by netrin-1

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VAV2, a guanine nucleotide exchange factor for Rac1, regulates glucose-stimulated insulin secretion in pancreatic beta cells

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DOCK8 is expressed in microglia, and it regulates microglial activity during neurodegeneration in murine disease models

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BAR domain proteins regulate Rho GTPase signaling

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Apical polarity proteins recruit the RhoGEF Cysts to promote junctional myosin assembly

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Rac Attack: Modulation of the Small GTPase Rac in Inflammatory Bowel Disease and Thiopurine Therapy

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Host-Parasite Interaction of Atlantic salmon (Salmo salar) and the Ectoparasite Neoparamoeba perurans in Amoebic Gill Disease

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Filling GAPs in our knowledge: ARHGAP11A and RACGAP1 act as oncogenes in basal-like breast cancers

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Tiam–Rac signaling mediates trans-endocytosis of ephrin receptor EphB2 and is important for cell repulsion

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FARP1, ARHGEF39, and TIAM2 are essential receptor tyrosine kinase effectors for Rac1-dependent cell motility in human lung adenocarcinoma

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RNAi screens for Rho GTPase regulators of cell shape and YAP/TAZ localisation in triple negative breast cancer

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Small-Molecule Protein-Protein Interaction Inhibitor of Oncogenic Rho Signaling

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Loss-of-function variants in TIAM1 are associated with developmental delay, intellectual disability, and seizures

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Gβγ Pathways in Cell Polarity and Migration Linked to Oncogenic GPCR Signaling: Potential Relevance in Tumor Microenvironment

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Rho GTPases and the emerging role of tunneling nanotubes in physiology and disease

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ARHGEF37 overexpression promotes extravasation and metastasis of hepatocellular carcinoma via directly activating Cdc42

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ERK/MAPK Signaling Drives Overexpression of the Rac-GEF, PREX1, in BRAF- and NRAS-Mutant Melanoma

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Local and global Cdc42 guanine nucleotide exchange factors for fission yeast cell polarity are coordinated by microtubules and the Tea1–Tea4–Pom1 axis

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The Intrinsic GDP/GTP Exchange Activities of Cdc42 and Rac1 Are Critical Determinants for Their Specific Effects on Mobilization of the Actin Filament System

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GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors

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Dbl family RhoGEFs in cancer: different roles and targeting strategies

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Guanine nucleotide exchange factors: Activators of the Ras superfamily of proteins

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New Mechanisms Underlying Oncogenesis in Dbl Family Rho Guanine Nucleotide Exchange Factors

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Defining Diverse Mechanisms that Regulate the Activity of Dbl-family Guanine Nucleotide Exchange Factors

Chhatriwala, M. K. (2019) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/b7rz-x027