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Rho guanine nucleotide exchange factors: regulators of Rho GTPase activity in development and disease
Open accessAbstract
The aberrant activity of Ras homologous (Rho) family small GTPases (20 human members) has been implicated in cancer and other human diseases. However, in contrast to the direct mutational activation of Ras found in cancer and developmental disorders, Rho GTPases are activated most commonly in disease by indirect mechanisms. One prevalent mechanism involves aberrant Rho activation via the deregulated expression and/or activity of Rho family guanine nucleotide exchange factors (RhoGEFs). RhoGEFs promote formation of the active GTP-bound state of Rho GTPases. The largest family of RhoGEFs is comprised of the Dbl family RhoGEFs with 70 human members. The multitude of RhoGEFs that activate a single Rho GTPase reflects the very specific role of each RhoGEF in controlling distinct signaling mechanisms involved in Rho activation. In this review, we summarize the role of Dbl RhoGEFs in development and disease, with a focus on Ect2 (epithelial cell transforming squence 2), Tiam1 (T-cell lymphoma invasion and metastasis 1), Vav and P-Rex1/2 (PtdIns(3,4,5)P3 (phosphatidylinositol (3,4,5)-triphosphate)-dependent Rac exchanger).
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“DH GEFs constitute the larger of the two classes, with over 70 members (30, 31).”
From RHO to the DOCK for GDP disembarking: Structural insights into the DOCK GTPase nucleotide exchange factors (2021) · cites this paper as [30]
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Spindler, M. J., Burmeister, B. T., Huang, Y., Hsiao, E. C., Salomonis, N., Scott, M. J., Srivastava, D., Carnegie, G. K., & Conklin, B. R. (2013) · PLoS ONE · doi:10.1371/journal.pone.0062705 · Cited by 13
RetractedClustal W and Clustal X version 2.0
Larkin, M., Blackshields, G., Brown, N. P., Chenna, R., McGettigan, P., McWilliam, H., Valentin, F., Wallace, I. M., Wilm, A., López, R., et al. (2007) · Bioinformatics · doi:10.1093/bioinformatics/btm404 · Cited by 28,598
The Consensus Coding Sequences of Human Breast and Colorectal Cancers
Sjöblom, T., Jones, S., Wood, L. D., Parsons, D. W., Lin, J., Barber, T. D., Mandelker, D. L., Leary, R. J., Ptak, J., Silliman, N., et al. (2006) · Science · doi:10.1126/science.1133427 · Cited by 3,161
RHO GTPASES: Biochemistry and Biology
Jaffe, A. B., & Hall, A. (2005) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.21.020604.150721 · Cited by 3,009
A landscape of driver mutations in melanoma
Hodis, E., Watson, I. R., Kryukov, G. V., Arold, S. T., Imielinski, M., Theurillat, J.-P., Nickerson, E., Auclair, D., Li, L., Place, C., et al. (2012) · Cell · doi:10.1016/j.cell.2012.06.024 · Cited by 2,610
Rho GTPases and their effector proteins
Bishop, A. L., & Hall, A. (2000) · Biochemical Journal · doi:10.1042/bj3480241 · Cited by 2,019
GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors
Rossman, K. L., Der, C. J., & Sondek, J. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1587 · Cited by 1,697
Self-citationSahai, E., & Marshall, C. (2002) · Nature Reviews. Cancer · doi:10.1038/nrc725 · Cited by 1,575
The Ras superfamily at a glance
Wennerberg, K., Rossman, K. L., & Der, C. J. (2005) · Journal of Cell Science · doi:10.1242/jcs.01660 · Cited by 1,549
Self-citationRas oncogenes: split personalities
Karnoub, A. E., & Weinberg, R. A. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2438 · Cited by 1,467
Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma
Krauthammer, M., Kong, Y., Ha, B. H., Evans, P., Bacchiocchi, A., McCusker, J. P., Cheng, E., Davis, M. J., Goh, G., Choi, M., et al. (2012) · Nature Genetics · doi:10.1038/ng.2359 · Cited by 1,191
Rational design and characterization of a Rac GTPase-specific small molecule inhibitor
Gao, Y., Dickerson, J. B., Guo, F., Zheng, J., & Zheng, Y. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0307512101 · Cited by 1,091
Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy?
Vigil, D., Cherfils, J., Rossman, K. L., & Der, C. J. (2010) · Nature reviews. Cancer · doi:10.1038/nrc2960 · Cited by 850
Self-citationHardt, W., Chen, L., Schuebel, K. E., Bustelo, X. R., & Galán, J. E. (1998) · Cell · doi:10.1016/s0092-8674(00)81442-7 · Cited by 811
Development of PI3K inhibitors: lessons learned from early clinical trials
Rodon, J. A., Dienstmann, R., Serra, V., & Tabernero, J. M. (2013) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2013.10 · Cited by 787
Melanoma genome sequencing reveals frequent PREX2 mutations
Berger, M. F., Hodis, E., Heffernan, T. P., Deribe, Y. L., Lawrence, M. S., Protopopov, A., Ivanova, E., Watson, I. R., Nickerson, E., Ghosh, P., et al. (2012) · Nature · doi:10.1038/nature11071 · Cited by 756
Yang, Y., Hentati, A., Deng, H.-X., Dabbagh, O., Sasaki, T., Hirano, M., Hung, W.-Y., Ouahchi, K., Yan, J., Azim, A. C., et al. (2001) · Nature Genetics · doi:10.1038/ng1001-160 · Cited by 743
Ras history: The saga continues
Cox, A. D., & Der, C. J. (2010) · Small GTPases · doi:10.4161/sgtp.1.1.12178 · Cited by 706
Self-citationG12-G13–LARG–mediated signaling in vascular smooth muscle is required for salt-induced hypertension
Wirth, A., Benyó, Z., Lukasova, M., Leutgeb, B., Wettschureck, N., Gorbey, S., Örsy, P., Horváth, B., Maser‐Gluth, C., Greiner, E. F., et al. (2007) · Nature Medicine · doi:10.1038/nm1666 · Cited by 692
A gene encoding a putative GTPase regulator is mutated in familial amyotrophic lateral sclerosis 2
Hadano, S., Hand, C. K., Osuga, H., Yanagisawa, Y., Otomo, A., Devon, R. S., Miyamoto, N., Showguchi-Miyata, J., Okada, Y., Singaraja, R. R., et al. (2001) · Nature Genetics · doi:10.1038/ng1001-166 · Cited by 676
GTP‐binding proteins of the Rho/Rac family: regulation, effectors and functions in vivo
Bustelo, X. R., Sauzeau, V., & Berenjeno, I. M. (2007) · BioEssays · doi:10.1002/bies.20558 · Cited by 655
Maurer, T., Garrenton, L. S., Oh, A., Pitts, K., Anderson, D. J., Skelton, N. J., Fauber, B. P., Pan, B., Malek, S., Stokoe, D., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1116510109 · Cited by 618
Germline gain-of-function mutations in SOS1 cause Noonan syndrome
Roberts, A. E., Araki, T., Swanson, K. D., Montgomery, K. T., Schiripo, T. A., Joshi, V. A., Li, L., Yassin, Y., Tamburino, A. M., Neel, B. G., et al. (2007) · Nature Genetics · doi:10.1038/ng1926 · Cited by 605
Gain-of-function SOS1 mutations cause a distinctive form of Noonan syndrome
Tartaglia, M., Pennacchio, L. A., Zhao, C., Yadav, K. K., Fodale, V., Sárközy, A., Pandit, B., Oishi, K., Martinelli, S., Schackwitz, W., et al. (2006) · Nature Genetics · doi:10.1038/ng1939 · Cited by 587
Protein kinase C, an elusive therapeutic target?
Mochly‐Rosen, D., Das, K., & Grimes, K. (2012) · Nature Reviews Drug Discovery · doi:10.1038/nrd3871 · Cited by 583
Hall, A. (2012) · Biochemical Society Transactions · doi:10.1042/bst20120103 · Cited by 573
The ‘invisible hand’: Regulation of RHO GTPases by RHOGDIs
Garcia-Mata, R., Boulter, E., & Burridge, K. (2011) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3153 · Cited by 560
vav, a novel human oncogene derived from a locus ubiquitously expressed in hematopoietic cells.
Katzav, S., Martı́n-Zanca, D., & Barbacid, M. (1989) · The EMBO Journal · doi:10.1002/j.1460-2075.1989.tb08354.x · Cited by 519
Habets, G. G. M., Scholtes, E. H. M., Zuydgeest, D., van der Kammen, R. A., Stam, J. C., Berns, A. J. M., & Collard, J. G. (1994) · Cell · doi:10.1016/0092-8674(94)90216-x · Cited by 510
Regulatory and Signaling Properties of the Vav Family
Bustelo, X. R. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.5.1461-1477.2000 · Cited by 507
Discovery of Small Molecules that Bind to K‐Ras and Inhibit Sos‐Mediated Activation
Sun, Q., Burke, J. P., Phan, J., Burns, M. C., Olejniczak, E. T., Waterson, A. G., Lee, T., Rossanese, O. W., & Fesik, S. W. (2012) · Angewandte Chemie International Edition · doi:10.1002/anie.201201358 · Cited by 490
P-Rex1, a PtdIns(3,4,5)P3- and Gβγ-Regulated Guanine-Nucleotide Exchange Factor for Rac
Welch, H. C. E., Coadwell, W. J., Ellson, C. D., Ferguson, G. J., Andrews, S., Erdjument‐Bromage, H., Tempst, P., Hawkins, P. T., & Stephens, L. (2002) · Cell · doi:10.1016/s0092-8674(02)00663-3 · Cited by 481
A role for the Ras signalling pathway in synaptic transmission and long-term memory
Brambilla, R., Gnesutta, N., Minichiello, L., White, G., Roylance, A. J., Herron, C. E., Ramsey, M., Wolfer, D. P., Cestari, V., Rossi‐Arnaud, C., et al. (1997) · Nature · doi:10.1038/36849 · Cited by 474
Brefeldin A Acts to Stabilize an Abortive ARF–GDP–Sec7 Domain Protein Complex
Peyroche, A., Antonny, B., Robineau, S., Acker, J., Cherfils, J., & Jackson, C. L. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80455-4 · Cited by 453
Inhibition of Invasion of Epithelial Cells by Tiam1-Rac Signaling
Hordijk, P. L., ten Klooster, J. P., van der Kammen, R. A., Michiels, F., Oomen, L. C. J. M., & Collard, J. G. (1997) · Science · doi:10.1126/science.278.5342.1464 · Cited by 441
Tatsumoto, T., Xie, X., Blumenthal, R., Okamoto, I., & Miki, T. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.147.5.921 · Cited by 431
Catalysis of guanine nucleotide exchange on the CDC42Hs protein by the dbloncogene product
Hart, M. J., Eva, A., Evans, T., Aaronson, S. A., & Cerione, R. A. (1991) · Nature · doi:10.1038/354311a0 · Cited by 425
Côté, J., & Vuori, K. (2002) · Journal of Cell Science · doi:10.1242/jcs.00219 · Cited by 421
Schnelzer, A., Prechtel, D., Knaus, U. G., Dehne, K., Gerhard, M., Graeff, H., Harbeck, N., Schmitt, M., & Lengyel, E. R. (2000) · Oncogene · doi:10.1038/sj.onc.1203621 · Cited by 419
Expression cDNA cloning of the KGF receptor by creation of a transforming autocrine loop.
Miki, T., Fleming, T., Bottaro, D., Rubin, J., Ron, D., & Aaronson, S. (1991) · Science · doi:10.1126/science.1846048 · Cited by 410
Defective antigen receptor-mediated proliferation of B and T cells in the absence of Vav
Tarakhovsky, A., Turner, M., Schaal, S., Mee, P. J., Duddy, L. P., Rajewsky, K., & Tybulewicz, V. L. J. (1995) · Nature · doi:10.1038/374467a0 · Cited by 402
Zhang, R., Alt, F. W., Davidson, L., Orkin, S. H., & Swat, W. (1995) · Nature · doi:10.1038/374470a0 · Cited by 390
Mice deficient in the Rac activator Tiam1 are resistant to Ras-induced skin tumours
Malliri, A., van der Kammen, R. A., Clark, K., van der Valk, M., Michiels, F., & Collard, J. G. (2002) · Nature · doi:10.1038/nature00848 · Cited by 384
Aghazadeh, B., Lowry, W. E., Huang, X.-Y., & Rosen, M. K. (2000) · Cell · doi:10.1016/s0092-8674(00)00085-4 · Cited by 383
Rac1 is required for the formation of three germ layers during gastrulation
Sugihara, K., Nakatsuji, N., Nakamura, K., Nakao, K., Hashimoto, R., Otani, H., Sakagami, H., Kondo, H., Nozawa, S., Aiba, A., et al. (1998) · Oncogene · doi:10.1038/sj.onc.1202595 · Cited by 331
Aspenström, P. (1999) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(99)80011-8 · Cited by 326
Tiam1 mediates Ras activation of Rac by a PI(3)K-independent mechanism
Lambert, J. M., Lambert, Q. T., Reuther, G. W., Malliri, A., Siderovski, D. P., Sondek, J., Collard, J. G., & Der, C. J. (2002) · Nature Cell Biology · doi:10.1038/ncb833 · Cited by 326
Self-citationVAV proteins as signal integrators for multi-subunit immune-recognition receptors
Turner, M., & Billadeau, D. D. (2002) · Nature reviews. Immunology · doi:10.1038/nri840 · Cited by 320
Common Themes in the Design and Function of Bacterial Effectors
Galán, J. E. (2009) · Cell Host & Microbe · doi:10.1016/j.chom.2009.04.008 · Cited by 319
Rho‐associated kinases in tumorigenesis: re‐considering ROCK inhibition for cancer therapy
Rath, N., & Olson, M. F. (2012) · EMBO Reports · doi:10.1038/embor.2012.127 · Cited by 306
Pasteris, N. G., Cadle, A. B., Logie, L. J., Porteous, M. E., Schwartz, C. E., Stevenson, R. E., Glover, T. W., Wilroy, R. S., & Gorski, J. L. (1994) · Cell · doi:10.1016/0092-8674(94)90552-5 · Cited by 297
Defective T-cell receptor signalling and positive selection of Vav-deficient CD4+CDS+thymocytes
Fischer, K., Zmuidzinas, A., Gardner, S. L., Barbacid, M., Bernstein, A., & Guidos, C. J. (1995) · Nature · doi:10.1038/374474a0 · Cited by 296
Product of vav proto-oncogene defines a new class of tyrosine protein kinase substrates
Bustelo, X. R., Ledbetter, J. A., & Barbacid, M. (1992) · Nature · doi:10.1038/356068a0 · Cited by 291
Bourguignon, L., Zhu, H., Shao, L., & Chen, Y. W. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.3.1829 · Cited by 284
A new family of RhoGEFs activates the Rop molecular switch in plants
Berken, A., Thomas, C., & Wittinghofer, A. (2005) · Nature · doi:10.1038/nature03883 · Cited by 281
Oncogene ect2 is related to regulators of small GTP-binding proteins
Miki, T., Smith, C. L., Long, J. E., Eva, A., & Fleming, T. P. (1993) · Nature · doi:10.1038/362462a0 · Cited by 281
CZH proteins: a new family of Rho-GEFs
Meller, N., Merlot, S., & Guda, C. (2005) · Journal of Cell Science · doi:10.1242/jcs.02671 · Cited by 280
Biological and Regulatory Properties of Vav-3, a New Member of the Vav Family of Oncoproteins
Movilla, N., & Bustelo, X. R. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.11.7870 · Cited by 271
The GDP-GTP Exchange Factor Collybistin: An Essential Determinant of Neuronal Gephyrin Clustering
Harvey, K., Duguid, I., Alldred, M. J., Beatty, S. E., Ward, H., Keep, N., Lingenfelter, S., Pearce, B., Lundgren, J., Owen, M., et al. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.1184-04.2004 · Cited by 270
Vav2 Is an Activator of Cdc42, Rac1, and RhoA
Abe, K., Rossman, K. L., Liu, B., Ritola, K., Chiang, D. Y., Campbell, S. L., Burridge, K., & Der, C. J. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.14.10141 · Cited by 264
Self-citationIdentification of a Bacterial Type III Effector Family with G Protein Mimicry Functions
Alto, N. M., Shao, F., Lazar, C. S., Brost, R. L., Chua, G., Mattoo, S., McMahon, S. A., Ghosh, P., Hughes, T. R., Boone, C. M., et al. (2006) · Cell · doi:10.1016/j.cell.2005.10.031 · Cited by 262
Cloning of a novel human Rac1b splice variant with increased expression in colorectal tumors
Jordan, P., Brazão, R., Boavida, M. G., Gespach, C. P., & Chastre, E. (1999) · Oncogene · doi:10.1038/sj.onc.1203233 · Cited by 261
Schuebel, K. E., Movilla, N., Rosa, J. L., & Bustelo, X. R. (1998) · The EMBO Journal · doi:10.1093/emboj/17.22.6608 · Cited by 261
Otomo, A. (2003) · Human Molecular Genetics · doi:10.1093/hmg/ddg184 · Cited by 250
Mossessova, E., Corpina, R. A., & Goldberg, J. D. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00475-1 · Cited by 244
Rational Design of Small Molecule Inhibitors Targeting RhoA Subfamily Rho GTPases
Shang, X., Marchioni, F., Sipes, N. S., Evelyn, C. R., Jerabek‐Willemsen, M., Duhr, S., Seibel, W. L., Wortman, M. D., & Zheng, Y. (2012) · Chemistry & Biology · doi:10.1016/j.chembiol.2012.05.009 · Cited by 240
Activation of the PI3K Pathway in Cancer Through Inhibition of PTEN by Exchange Factor P-REX2a
Fine, B. M., Hodakoski, C., Koujak, S., Su, T., Saal, L. H., Maurer, M., Hopkins, B. D., Keniry, M. E., Sulis, M. L., Mense, S. M., et al. (2009) · Science · doi:10.1126/science.1173569 · Cited by 238
Fujikawa, K., Miletic, A. V., Alt, F. W., Faccio, R., Brown, T., Hoog, J., Fredericks, J., Nishi, S., Mildiner, S., Moores, S. L., et al. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20030874 · Cited by 228
Wolfe, B. A., Takaki, T., Petronczki, M., & Glotzer, M. (2009) · PLoS Biology · doi:10.1371/journal.pbio.1000110 · Cited by 225
Eymard-Pierre, É., Lesca, G., Dollet, S., Santorelli, F. M., Capua, M. D., Bertini, E., & Boespflug‐Tanguy, O. (2002) · The American Journal of Human Genetics · doi:10.1086/342359 · Cited by 222
Ectopic expression of VAV1 reveals an unexpected role in pancreatic cancer tumorigenesis
Fernández-Zapico, M. E., Gonzalez-Paz, N. C., Weiss, E. A., Savoy, D. N., Molina, J. R., Fonseca, R., Smyrk, T. C., Chari, S. T., Urrutia, R. A., & Billadeau, D. D. (2005) · Cancer Cell · doi:10.1016/j.ccr.2004.11.024 · Cited by 221
New Human Transforming Genes Detected by a Tumorigenicity Assay
Fasano, O., Birnbaum, D., Edlund, L., Fogh, J. M., & Wigler, M. H. (1984) · Molecular and Cellular Biology · doi:10.1128/mcb.4.9.1695 · Cited by 219
Isolation of a new human oncogene from a diffuse B-cell lymphoma
Eva, A., & Aaronson, S. A. (1985) · Nature · doi:10.1038/316273a0 · Cited by 212
Vav proteins, adaptors and cell signaling
Bustelo, X. R. (2001) · Oncogene · doi:10.1038/sj.onc.1204780 · Cited by 211
Identification of the Rac-GEF P-Rex1 as an Essential Mediator of ErbB Signaling in Breast Cancer
Sosa, M. S., López‐Haber, C., Yang, C., Wang, H., Lemmon, M. A., Busillo, J. M., Luo, J., Benovic, J., Klein–Szanto, A. J., Yagi, H., et al. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.11.029 · Cited by 211
Papadopoulos, T. G., Körte, M., Eulenburg, V., Kubota, H., Retiounskaia, M., Harvey, R. J., Harvey, K., O’Sullivan, G. A., Laube, B., Hülsmann, S., et al. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601819 · Cited by 204
Tolias, K. F., Bikoff, J. B., Kane, C. G., Tolias, C. S., Hu, L. S., & Greenberg, M. E. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0702044104 · Cited by 201
Buchsbaum, R. J., Connolly, B. A., & Feig, L. A. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.12.4073-4085.2002 · Cited by 198
Increased neutrophil respiratory burst in bcr-null mutants
Voncken, J. W., van Schaick, H., Kaartinen, V., Deemer, K., Coates, T. D., Landing, B. H., Pattengale, P. K., Dorseuil, O., Bokoch, G., Groffen, J., et al. (1995) · Cell · doi:10.1016/0092-8674(95)90350-x · Cited by 196
Burkard, M. E., Maciejowski, J., Rodríguez-Bravo, V., Repka, M., Lowery, D. M., Clauser, K. R., Zhang, C., Shokat, K. M., Carr, S. A., Yaffe, M. B., et al. (2009) · PLoS Biology · doi:10.1371/journal.pbio.1000111 · Cited by 192
Salhia, B., Tran, N. L., Chan, A. Y., Wolf, A., Nakada, M., Rutka, F., Ennis, M. J., McDonough, W. S., Berens, M. E., Symons, M. H., et al. (2008) · American Journal Of Pathology · doi:10.2353/ajpath.2008.080043 · Cited by 192
Alsin Is a Rab5 and Rac1 Guanine Nucleotide Exchange Factor
Topp, J. D., Gray, N. W., Gerard, R. D., & Horazdovsky, B. F. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m313504200 · Cited by 191
Whitehead, I. P., Kirk, H., Tognon, C. E., Trigo‐Gonzalez, G., & Kay, R. J. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.31.18388 · Cited by 191
Horii, Y., Beeler, J. F., Sakaguchi, K., TACHIBANA, M., & Miki, T. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06803.x · Cited by 188
P-Rex1 is required for efficient melanoblast migration and melanoma metastasis
Lindsay, C. R., Lawn, S. O., Campbell, A. D., Faller, W. J., Rambow, F., Mort, R. L., Timpson, P., Li, A., Cammareri, P., Ridgway, R. A., et al. (2011) · Nature Communications · doi:10.1038/ncomms1560 · Cited by 181
Self-citationSignal transduction through Vav-2 participates in humoral immune responses and B cell maturation
Doody, G. M., Bell, S. E., Vigorito, E., Clayton, E., McAdam, S., Tooze, R. M., Fernandez, C., Lee, I. J., & Turner, M. (2001) · Nature Immunology · doi:10.1038/88748 · Cited by 177
Leung, C. C. Y., & Glover, J. N. M. (2011) · Cell Cycle · doi:10.4161/cc.10.15.16312 · Cited by 175
Skeletal muscle deformity and neuronal disorder in Trio exchange factor-deficient mouse embryos
O'Brien, S. P., Seipel, K., Medley, Q. G., Bronson, R. T., Segal, R. A., & Streuli, M. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.22.12074 · Cited by 173
Kalirin regulates cortical spine morphogenesis and disease-related behavioral phenotypes
Cahill, M. E., Xie, Z., Day, M., Photowala, H., Barbolina, M. V., Miller, C. A., Weiss, C., Radulovic, J., Sweatt, J. D., Disterhoft, J. F., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0904636106 · Cited by 170
Kalirin-7 Is Required for Synaptic Structure and Function
Ma, X., Kiraly, D. D., Gaier, E. D., Wang, Y., Kim, E., Levine, E. S., Eipper, B. A., & Mains, R. E. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.4269-08.2008 · Cited by 169
P-Rex1 Regulates Neutrophil Function
Welch, H. C. E., Condliffe, A. M., Milne, L., Ferguson, G. J., Hill, K., Webb, L. M. C., Okkenhaug, K., Coadwell, W. J., Andrews, S., Thelen, M., et al. (2005) · Current Biology · doi:10.1016/j.cub.2005.09.050 · Cited by 166
Delague, V., Jacquier, A., Hamadouche, T., Poitelon, Y., Baudot, C., Boccaccio, I., Chouery, É., Chaouch, M., Kassouri, N., Jabbour, R. A., et al. (2007) · The American Journal of Human Genetics · doi:10.1086/518428 · Cited by 166
Compensation between Vav-1 and Vav-2 in B cell development and antigen receptor signaling
Tedford, K., Nitschke, L., Girkontaitė, I., Charlesworth, A. G., Chan, G., Sakk, V., Barbacid, M., & Fischer, K.-D. (2001) · Nature Immunology · doi:10.1038/88756 · Cited by 165
Small-molecule inhibitors targeting G-protein–coupled Rho guanine nucleotide exchange factors
Shang, X., Marchioni, F., Evelyn, C. R., Sipes, N. S., Zhou, X., Seibel, W. L., Wortman, M. D., & Zheng, Y. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1212324110 · Cited by 163
Lsc is required for marginal zone B cells, regulation of lymphocyte motility and immune responses
Girkontaitė, I., Missy, K., Sakk, V., Harenberg, A., Tedford, K., Pötzel, T., Pfeffer, K., & Fischer, K. (2001) · Nature Immunology · doi:10.1038/ni0901-855 · Cited by 161
Balakrishnan, A., Bleeker, F. E., Lamba, S., Rodolfo, M., Daniotti, M., Scarpa, A., van Tilborg, A. A., Leenstra, S., Zanon, C., & Bardelli, A. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-0065 · Cited by 161
Accumulation of GTP-bound RhoA during Cytokinesis and a Critical Role of ECT2 in This Accumulation
Kimura, K., Tsuji, T., Takada, Y., Miki, T., & Narumiya, S. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.c000212200 · Cited by 161
Structural and Energetic Mechanisms of Cooperative Autoinhibition and Activation of Vav1
Yu, B., Martins, I. R. S., Li, P., Amarasinghe, G. K., Umetani, J., Fernandez-Zapico, M. E., Billadeau, D. D., Machius, M., Tomchick, D. R., & Rosen, M. K. (2010) · Cell · doi:10.1016/j.cell.2009.12.033 · Cited by 156
Wu, G., Li, H., & Yang, Z. (2000) · PLANT PHYSIOLOGY · doi:10.1104/pp.124.4.1625 · Cited by 150
Robineau, S., Chabre, M., & Antonny, B. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.170290597 · Cited by 149
REGRESSION OF LIVER METASTASES FOLLOWING TREATMENT WITH YTTRIUM‐90 MICROSPHERES
Gray, B. N., Anderson, J., Burton, M. A., van Hazel, G., Codde, J., Morgan, C. A., & Klemp, P. (1992) · Australian and New Zealand Journal of Surgery · doi:10.1111/j.1445-2197.1992.tb00006.x · Cited by 147
Stam, J. C., Sander, E. E., Michiels, F., van Leeuwen, F. N., Kain, H. E. T., van der Kammen, R. A., & Collard, J. G. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.45.28447 · Cited by 144
Andrographolide derivatives inhibit guanine nucleotide exchange and abrogate oncogenic Ras function
Hocker, H. J., Cho, K.-J., Chen, C.-Y. K., Rambahal, N., Sagineedu, S. R., Shaari, K., Stanslas, J., Hancock, J. F., & Gorfe, A. A. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1300016110 · Cited by 144
Isolation and characterization of murine vav2, a member of the vav family of proto-oncogenes.
Schuebel, K. E., Bustelo, X. R., Nielsen, D. A., Song, B. J., Barbacid, M., Goldman, D. A., & Lee, I. J. (1996) · PubMed · Cited by 143
Early Requirement of Rac1 in a Mouse Model of Pancreatic Cancer
Heid, I., Lubeseder–Martellato, C., Sipos, B., Mazur, P. K., Lesina, M., Schmid, R. M., & Siveke, J. T. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.04.043 · Cited by 141
Stendel, C., Roos, A., Deconinck, T., Pereira, J. A., Castagner, F., Niemann, A., Kirschner, J., Korinthenberg, R., Ketelsen, U., Battaloğlu, E., et al. (2007) · American Journal of Human Genetics · doi:10.1086/518770 · Cited by 140
Ect2 links the PKCι–Par6α complex to Rac1 activation and cellular transformation
Justilien, V., & Fields, A. P. (2009) · Oncogene · doi:10.1038/onc.2009.217 · Cited by 139
Upregulation of PIP3-dependent Rac exchanger 1 (P-Rex1) promotes prostate cancer metastasis
Qin, J., Xie, Y., Wang, B., Hoshino, M., Wolff, D. W., Zhao, J., Scofield, M. A., Dowd, F. J., Lin, M.-F., & Tu, Y. (2009) · Oncogene · doi:10.1038/onc.2009.30 · Cited by 139
Devon, R. S., Orban, P. C., Gerrow, K., Barbieri, M. A., Schwab, C., Cao, L. P., Helm, J., Bissada, N., Cruz-Aguado, R., Davidson, T., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0510197103 · Cited by 139
Giese, K.-P., Friedman, E., Telliez, J., Fedorov, N. B., Wines, M., Feig, L. A., & Silva, A. J. (2001) · Neuropharmacology · doi:10.1016/s0028-3908(01)00096-x · Cited by 138
Kalscheuer, V., Musante, L., Fang, C., Hoffmann, K., Fuchs, C., Carta, E., Deas, E., Venkateswarlu, K., Menzel, C., Ullmann, R., et al. (2009) · Human Mutation · doi:10.1002/humu.20814 · Cited by 138
Obscurin determines the architecture of the longitudinal sarcoplasmic reticulum
Lange, S., Ouyang, K., Meyer, G. A., Cui, L., Cheng, H., Lieber, R. L., & Chen, J. (2009) · Journal of Cell Science · doi:10.1242/jcs.046193 · Cited by 138
Hadano, S., Benn, S. C., Kakuta, S., Otomo, A., Sudo, K., Kunita, R., Suzuki-Utsunomiya, K., Mizumura, H., Shefner, J. M., Cox, G. A., et al. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi440 · Cited by 138
Structural basis for the reversible activation of a Rho protein by the bacterial toxin SopE
Buchwald, G., Friebel, A., Galán, J. E., Hardt, W., Wittinghofer, A., & Scheffzek, K. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf329 · Cited by 135
Yang, Z., & Watson, J. C. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.18.8732 · Cited by 132
Saito, S., Liu, X.-F., Kamijo, K., Raziuddin, R., Tatsumoto, T., Okamoto, I., Chen, X., Lee, C.-C., Lorenzi, M. V., Ohara, N., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m306725200 · Cited by 132
Cai, H., Lin, X. Z., Xie, C., Laird, F. M., Lai, C., Wen, H., Chiang, H., Shim, H., Farah, M. H., Höke, A., et al. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.1645-05.2005 · Cited by 130
Bartolomé, R. A., Molina‐Ortiz, I., Samaniego, R., Sánchez‐Mateos, P., Bustelo, X. R., & Teixidó, J. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-2489 · Cited by 128
Activation of Rho GTPases by DOCK Exchange Factors Is Mediated by a Nucleotide Sensor
Yang, J., Zhang, Z., Roe, S. M., Marshall, C. J., & Barford, D. (2009) · Science · doi:10.1126/science.1174468 · Cited by 123
The Rac Activator Tiam1 Is a Wnt-responsive Gene That Modifies Intestinal Tumor Development
Malliri, A., Rygiel, T. P., van der Kammen, R. A., Song, J., Engers, R., Hurlstone, A. F. L., Clevers, H. C., & Collard, J. G. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m507582200 · Cited by 122
Roversi, G., Pfundt, R., Moroni, R. F., Magnani, I., van Reijmersdal, S. V., Pollo, B., Straatman, H., Larizza, L., & Schoenmakers, E. (2005) · Oncogene · doi:10.1038/sj.onc.1209177 · Cited by 121
Qian, X., Esteban, L., Vass, W. C., Upadhyaya, C. D., Papageorge, A. G., Yienger, K., Ward, J. M., Lowy, D. R., & Santos, E. (2000) · The EMBO Journal · doi:10.1093/emboj/19.4.642 · Cited by 117
Buchsbaum, R. J., Connolly, B. A., & Feig, L. A. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m207876200 · Cited by 117
The guanine nucleotide exchange factor (GEF) Ect2 is an oncogene in human cancer
Fields, A., & Justilien, V. (2009) · Advances in Enzyme Regulation · doi:10.1016/j.advenzreg.2009.10.010 · Cited by 110
Citterio, C., Menacho-Márquez, M., García‐Escudero, R., Larive, R. M., Barreiro, O., Sánchez‐Madrid, F., Paramio, J. M., & Bustelo, X. R. (2012) · Science Signaling · doi:10.1126/scisignal.2002962 · Cited by 110
Engers, R., Springer, E., Michiels, F., Collard, J. G., & Gabbert, H. E. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m105049200 · Cited by 109
P‐Rex2, a new guanine‐nucleotide exchange factor for Rac
Donald, S., Hill, K., Lécureuil, C., Barnouin, R., Vermeren, S., Coadwell, W. J., Andrews, S., Walker, S. A., Hawkins, P. T., Stephens, L., et al. (2004) · FEBS Letters · doi:10.1016/j.febslet.2004.06.096 · Cited by 109
Kim, J., Billadeau, D. D., & Chen, J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m409298200 · Cited by 108
Tiam1 regulates cell adhesion, migration and apoptosis in colon tumor cells
Minard, M. E., Ellis, L. M., & Gallick, G. E. (2006) · Clinical & Experimental Metastasis · doi:10.1007/s10585-006-9040-z · Cited by 108
Ramakers, G. J. A., Wolfer, D. P., Rosenberger, G., Kuchenbecker, K., Kreienkamp, H., Prange‐Kiel, J., Rune, G. M., Richter, K., Langnaese, K., Masneuf, S., et al. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddr457 · Cited by 108
Toksoz, D., & Williams, D. A. (1994) · PubMed · Cited by 106
P‐REX2, a novel PI‐3‐kinase sensitive Rac exchange factor
Rosenfeldt, H. M., Vázquez‐Prado, J., & Gutkind, J. S. (2004) · FEBS Letters · doi:10.1016/j.febslet.2004.06.097 · Cited by 105
Guanine nucleotide exchange factors for RhoGTPases: Good therapeutic targets for cancer therapy?
Lazer, G., & Katzav, S. (2010) · Cellular Signalling · doi:10.1016/j.cellsig.2010.10.022 · Cited by 103
Hoshino, M., Sone, M., Fukata, M., Kuroda, S., Kaibuchi, K., Nabeshima, Y.-I., & Hama, C. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.25.17837 · Cited by 102
Hirata, D., Yamabuki, T., Miki, D., Ito, T., Tsuchiya, E., Fujita, M., Hosokawa, M., Chayama, K., Nakamura, Y., & Daigo, Y. (2008) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-08-1672 · Cited by 102
Rasgrf1 Imprinting Is Regulated by a CTCF-Dependent Methylation-Sensitive Enhancer Blocker
Yoon, B., Herman, H., Hu, B. Y., Park, Y. J., Lindroth, A. M., Bell, A. C., West, A. G., Chang, Y., Stablewski, A. B., Piel, J. C., et al. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.24.11184-11190.2005 · Cited by 102
Imprinted gene in postnatal growth role
Itier, J., Tremp, G. L., Léonard, J., Multon, M.-C., Ret, G., Schweighoffer, F., Tocqué, B., Bluet‐Pajot, M., Cormier‐Daire, V., & Dautry, F. (1998) · Nature · doi:10.1038/30120 · Cited by 101
Kanekura, K., Hashimoto, Y., Kita, Y. A., Sasabe, J., Aiso, S., Nishimoto, I., & Matsuoka, M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m410508200 · Cited by 98
A bacterial effector targets host DH‐PH domain RhoGEFs and antagonizes macrophage phagocytosis
Dong, N., Liu, L., & Shao, F. (2010) · The EMBO Journal · doi:10.1038/emboj.2010.33 · Cited by 98
Devon, R., Helm, J., Rouleau, G. A., Leitner, Y., Lerman‐Sagie, T., Lev, D., & Hayden, M. R. (2003) · Clinical Genetics · doi:10.1034/j.1399-0004.2003.00138.x · Cited by 98
Jung, Y., Lee, S., Choi, H.-S., Kim, S.-N., Lee, E., Shin, Y., Seo, J., Kim, B., Jung, Y., Kim, W., et al. (2011) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-10-1300 · Cited by 96
Tiam1 mediates neurite outgrowth induced by ephrin‐B1 and EphA2
Tanaka, M., Ohashi, R., Nakamura, R., Shinmura, K., Kamo, T., Sakai, R., & Sugimura, H. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600128 · Cited by 94
Ras‐GRF1 signaling is required for normal β‐cell development and glucose homeostasis
de Mora, J. F., Esteban, L. M., Burks, D. J., Núñez, A., Garcés, C., García‐Barrado, M. J., Osma, M. D. C. I., Moratinos, J., Ward, J. M., & Santos, E. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg280 · Cited by 93
Whitehead, I. P., Khosravi‐Far, R., Kirk, H., Trigo‐Gonzalez, G., Der, C. J., & Kay, R. J. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.31.18643 · Cited by 90
Self-citationMontero, J. C., Seoane, S., Ocaña, A., & Pandiella, A. (2010) · Oncogene · doi:10.1038/onc.2010.489 · Cited by 90
Isolation of a novel oncogene, NET1, from neuroepithelioma cells by expression cDNA cloning.
Chan, A. M.-L., Takai, S., Yamada, K., & Miki, T. (1996) · PubMed · Cited by 89
Peng, Y., He, W., Tang, J. Y., Tao, T., Chen, C., Gao, Y., Zhang, W., He, X., Dai, Y., Zhu, N.-C., et al. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.096537 · Cited by 88
Shimojima, K. Y., Sugawara, M., Shichiji, M., Mukaida, S., Takayama, R., Imai, K., & Yamamoto, T. (2011) · Journal of Human Genetics · doi:10.1038/jhg.2011.58 · Cited by 88
Adam, L., Vadlamudi, R. K., McCrea, P. D., & Kumar, R. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m009769200 · Cited by 87
P-Rex2 regulates Purkinje cell dendrite morphology and motor coordination
Donald, S., Humby, T., Fyfe, I., Segonds-Pichon, A., Walker, S. A., Andrews, S., Coadwell, W. J., Emson, P. C., Wilkinson, L. S., & Welch, H. C. E. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0712324105 · Cited by 87
Lane, J., Martin, T. A., Mansel, R. E., & Jiang, W. G. (2008) · International Seminars in Surgical Oncology · doi:10.1186/1477-7800-5-23 · Cited by 85
Prognostic relevance of Tiam1 protein expression in prostate carcinomas
Engers, R., Mueller, M., Walter, A., Collard, J. G., Willers, R., & Gabbert, H. E. (2006) · British Journal of Cancer · doi:10.1038/sj.bjc.6603385 · Cited by 84
Bacterial Guanine Nucleotide Exchange Factors SopE-Like and WxxxE Effectors
Bulgin, R. R., Raymond, B., Garnett, J. A., Frankel, G. M., Crepin, V. F., Berger, C. N., & Arbeloa, A. (2010) · Infection and Immunity · doi:10.1128/iai.01250-09 · Cited by 84
Francis, S. A., Shen, X., Young, J. K., Kaul, P., & Lerner, D. J. (2005) · Blood · doi:10.1182/blood-2005-03-1164 · Cited by 82
Dong, Z., Liu, Y., Lu, S., Wang, A. Y., Lee, K., Wang, L., Revelo, M. P., & Lu, S. (2006) · Molecular Endocrinology · doi:10.1210/me.2006-0048 · Cited by 82
Nagawa, S., Xu, T., & Yang, Z. (2010) · Small GTPases · doi:10.4161/sgtp.1.2.14544 · Cited by 82
Identification of VAV2 on 9q34 and its exclusion as the tuberous sclerosis gene TSC1
Henske, E. P., Short, M. P., Jóźwiak, S., BOVEY, C. M., Ramlakhan, S. K., Haines, J. L., & Kwiatkowski, D. J. (1995) · Annals of Human Genetics · doi:10.1111/j.1469-1809.1995.tb01603.x · Cited by 80
Wang, D. Z., Hammond, V. E., Abud, H. E., Bertoncello, I., McAvoy, J. W., & Bowtell, D. D. L. (1997) · Genes & Development · doi:10.1101/gad.11.3.309 · Cited by 79
Expression level of ECT2 proto-oncogene correlates with prognosis in glioma patients
Sano, M., Genkai, N., Yajima, N., Tsuchiya, N., Homma, J., Tanaka, R., Miki, T., & Yamanaka, R. (2006) · Oncology Reports · doi:10.3892/or.16.5.1093 · Cited by 78
Progressive spinal axonal degeneration and slowness in ALS2‐deficient mice
Yamanaka, K., Miller, T. M., McAlonis‐Downes, M., Chun, S. J., & Cleveland, D. W. (2006) · Annals of Neurology · doi:10.1002/ana.20888 · Cited by 77
Rubtsov, A. V., Strauch, P., DiGiacomo, A. M., Hu, J., Pelanda, R., & Torres, R. M. (2005) · Immunity · doi:10.1016/j.immuni.2005.09.018 · Cited by 77
Whitehead, I. P., Kirk, H., & Kay, R. (1995) · PubMed · Cited by 77
Lyons, L. S., & Burnstein, K. L. (2005) · Molecular Endocrinology · doi:10.1210/me.2005-0346 · Cited by 74
Neuronal Rho GEFs in Synaptic Physiology and Behavior
Miller, M. B., Yan, Y., Eipper, B. A., & Mains, R. E. (2013) · The Neuroscientist · doi:10.1177/1073858413475486 · Cited by 74
Uhlenbrock, K., Eberth, A., Herbrand, U., Daryab, N., Stege, P., Meier, F. E., Friedl, P., Collard, J. G., & Ahmadian, M. R. (2004) · Journal of Cell Science · doi:10.1242/jcs.01367 · Cited by 72
Epithelial Cell Transforming Sequence 2 in Human Oral Cancer
Iyoda, M., Kasamatsu, A., Ishigami, T., Nakashima, D., Endo‐Sakamoto, Y., Ogawara, K., Shiiba, M., Tanzawa, H., & Uzawa, K. (2010) · PLoS ONE · doi:10.1371/journal.pone.0014082 · Cited by 72
Marco, E. J., Abidi, F., Bristow, J. D., Dean, W. B., Cotter, P. D., Jeremy, R. J., Schwartz, C., & Sherr, E. H. (2007) · Journal of Medical Genetics · doi:10.1136/jmg.2007.052324 · Cited by 72
Ruiz, S., Santos, E., & Bustelo, X. R. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.00912-07 · Cited by 71
Ras-Guanine Nucleotide Exchange Factor Sos2 Is Dispensable for Mouse Growth and Development
Esteban, L. M., Fernández‐Medarde, A., López, E., Yienger, K., Guerrero, C., Ward, J. M., Tessarollo, L., & Santos, E. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.17.6410-6413.2000 · Cited by 71
Src Kinase Inhibitors: Promising Cancer Therapeutics?
Creedon, H., & Brunton, V. G. (2012) · Critical Reviews™ in Oncogenesis · doi:10.1615/critrevoncog.v17.i2.20 · Cited by 69
The Rho Guanine Nucleotide Exchange Factor AKAP13 (BRX) Is Essential for Cardiac Development in Mice
Mayers, C. M., Wadell, J., McLean, K., Venere, M., Malik, M., Shibata, T., Driggers, P. H., Kino, T., Guo, X. C., Koide, H., et al. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.106856 · Cited by 68
Vega, F. M. D. L., & Ridley, A. J. (2007) · Cell · doi:10.1016/j.cell.2007.06.021 · Cited by 67
Ligand-independent activation of androgen receptors by Rho GTPase signaling in prostate cancer.
Lyons, L. S., Rao, S., Balkan, W., Faysal, J., Maiorino, C. A., & Burnstein, K. L. (2008) · Molecular Endocrinology · doi:10.1210/me.2007-0158 · Cited by 67
Abnormal function of astroglia lackingAbrandBcrRacGAPs
Kaartinen, V., González-Gómez, I., Voncken, J. W., Haataja, L., Faure, E., Nagy, A. R., Groffen, J., & Heisterkamp, N. (2001) · Development · doi:10.1242/dev.128.21.4217 · Cited by 67
The haematopoietic specific signal transducer Vav1 is expressed in a subset of human neuroblastomas
Hornstein, I., Pikarsky, E., Groysman, M., Amir, G., Peylan‐Ramu, N., & Katzav, S. (2003) · The Journal of Pathology · doi:10.1002/path.1314 · Cited by 67
Kalirin, a Key Player in Synapse Formation, Is Implicated in Human Diseases
Mandela, P., & Ma, X. (2012) · Neural Plasticity · doi:10.1155/2012/728161 · Cited by 65
Lazer, G., Idelchuk, Y., Schapira, V., Pikarsky, E., & Katzav, S. (2009) · The Journal of Pathology · doi:10.1002/path.2579 · Cited by 63
Saito, S., Tatsumoto, T., Lorenzi, M. V., Chedid, M., Kapoor, V., Sakata, H., Rubin, J. S., & Miki, T. (2003) · Journal of Cellular Biochemistry · doi:10.1002/jcb.10688 · Cited by 62
Mikelis, C. M., Palmby, T. R., Simaan, M., Li, W., Szabo, R., Lyons, R. J., Martı́n, D., Yagi, H., Fukuhara, S., Chikumi, H., et al. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.428599 · Cited by 61
Rho GEFs and Cancer: Linking Gene Expression and Metastatic Dissemination
Barrio‐Real, L., & Kazanietz, M. G. (2012) · Science Signaling · doi:10.1126/scisignal.2003543 · Cited by 57
Rao, S., Lyons, L. S., Fahrenholtz, C. D., Wu, F., Farooq, A., Balkan, W., & Burnstein, K. L. (2011) · Oncogene · doi:10.1038/onc.2011.273 · Cited by 55
Solski, P. A., Wilder, R., Rossman, K. L., Sondek, J., Cox, A. D., Campbell, S. L., & Der, C. J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m313792200 · Cited by 54
Self-citationChan, A. M.-L., Mcgovern, E. S., Catalano, G., Fleming, T. P., & Miki, T. (1994) · PubMed · Cited by 54
Chen, J., Su, I., Leu, Y., Young, K., & Sun, H. S. (2011) · International Journal of Cancer · doi:10.1002/ijc.26117 · Cited by 53
Ras/MAPK syndromes and childhood hemato-oncological diseases
Aoki, Y., & Matsubara, Y. (2012) · International Journal of Hematology · doi:10.1007/s12185-012-1239-y · Cited by 51
BRCT domains: A little more than kin, and less than kind
Gerloff, D. L., Woods, N. T., Farago, A. A., & Monteiro, Á. N. A. (2012) · FEBS Letters · doi:10.1016/j.febslet.2012.05.005 · Cited by 51
Distal axonopathy in an alsin-deficient mouse model
Deng, H., Zhai, H., Fu, R., Shi, Y., Gorrie, G., Yang, Y., Liu, E., Canto, M. C. D., Mugnaini, E., & Siddique, T. (2007) · Human Molecular Genetics · doi:10.1093/hmg/ddm251 · Cited by 51
Regulation of Immature Dendritic Cell Migration by RhoA Guanine Nucleotide Exchange Factor Arhgef5
Wang, Z., Kumamoto, Y., Wang, P., Gan, X., Lehmann, D. M., Smrcka, A. V., Cohn, L. E., Iwasaki, A., Li, L., & Wu, D. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.047282 · Cited by 50
Liu, L., Zhang, Q., Zhang, Y., Wang, S., & Ding, Y. (2006) · Neoplasia · doi:10.1593/neo.06364 · Cited by 50
Regulation of Vav proteins by intramolecular events
Bustelo, X. R. (2002) · Frontiers in bioscience · doi:10.2741/a766 · Cited by 50
ECT2 and RASAL2 Mediate Mesenchymal-Amoeboid Transition In Human Astrocytoma Cells
Weeks, A., Okolowsky, N., Golbourn, B. J., Ivanchuk, S. M., Smith, C. A., & Rutka, J. T. (2012) · American Journal Of Pathology · doi:10.1016/j.ajpath.2012.04.011 · Cited by 49
Lesca, G., Till, M., Labalme, A., Vallée, D., Hugonenq, C., Philip, N., Edery, P., & Sanlaville, D. (2011) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.34004 · Cited by 48
Chiu, C.-Y., Leng, S., Martin, K. A., Kim, E., Gorman, S., & Duhl, D. M. J. (1999) · Genomics · doi:10.1006/geno.1999.5936 · Cited by 48
Liu, Y., Mo, J. Q., Hu, Q., Boivin, G. P., Levin, L., Lu, S., Yang, D., Dong, Z., & Lu, S. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-0645 · Cited by 45
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Metadata
- Authors
- Cook, D. R., Rossman, K. L., & Der, C. J.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- Corresponding author
- Der, C J
- ORCID
- Venue
- Oncogene
- Published
- 2013-09-16
- Volume
- 33
- Issue
- 31
- Pages
- 4021-4035
- ISSN
- 0950-9232 (ISSN-L)
- 1476-5594
- PMC
- PMC4875565
- OpenAlex
- W2024222958
- Cited by
- 378
- References
- 230
- Citations by year
- 2026: 14 · 2025: 15 · 2024: 17 · 2023: 26 · 2022: 35 · 2021: 45 · 2020: 43 · 2019: 33 · 2018: 37 · 2017: 29 · 2016: 34 · 2015: 24 · 2014: 23 · 2013: 3
- FWCI
- 2.64
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Oncogene (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
- UNC Libraries
- Funders
- Pancreatic Cancer Action Network
- National Institutes of Health (5r01ca042978-30)
- National Cancer Institute (CA159821, CA 71341, R01-CA042978, F31CA159821, T32CA071341)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Hippo pathway signaling and YAP/TAZ
- Keywords
- RhoGEF, Rho GTPases, ECT2, Tiam1, Vav, Rho activation, cancer, developmental disorders, phosphatidylinositol 3,4,5-trisphosphate, small GTPase signaling
- MeSH terms
- Congenital Abnormalities, Animals, Cell Division, Humans, Neoplasms, Gene Expression Regulation, Neoplastic, rho GTP-Binding Proteins, Genetic Diseases, Inborn, Proto-Oncogene Proteins c-vav, Rho Guanine Nucleotide Exchange Factors
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