Student or educator? Sign up with your school email and get 6 months of Pro free.
Cited by 96

The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.

p53-dependent gene repression through p21 is mediated by recruitment of E2F4 repression complexes

Benson, E K, Mungamuri, S K, Attie, O, Kracikova, M, Sachidanandam, R, Manfredi, J J, Aaronson, S A·2014·Oncogene

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1038/onc.2013.378

Cites

13 of 13 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 13 references

Research works printed but not linked: 56

  1. Mandinova A, Lee SW . The p53 pathway as a target in cancer therapeutics: obstacles and promise. Sci Transl Med 2011; 3: 64rv61. · DOI
  2. Brooks CL, Gu W . New insights into p53 activation. Cell Res 2010; 20: 614–621. · DOI · Paper page
  3. El-Deiry WS . The role of p53 in chemosensitivity and radiosensitivity. Oncogene 2003; 22: 7486–7495. · DOI · Paper page
  4. Alarcon-Vargas D, Ronai Z . p53-Mdm2–the affair that never ends. Carcinogenesis 2002; 23: 541–547. · DOI · Paper page
  5. Kannan K, Amariglio N, Rechavi G, Jakob-Hirsch J, Kela I, Kaminski N et al. DNA microarrays identification of primary and secondary target genes regulated by p53. Oncogene 2001; 20: 2225–2234. · DOI · Paper page
  6. Kitayner M, Rozenberg H, Kessler N, Rabinovich D, Shaulov L, Haran TE et al. Structural basis of DNA recognition by p53 tetramers. Mol Cell 2006; 22: 741–753. · DOI · Paper page
  7. Ho J, Benchimol S . Transcriptional repression mediated by the p53 tumour suppressor. Cell Death Differ 2003; 10: 404–408. · DOI · Paper page
  8. Bohlig L, Rother K . One function—multiple mechanisms: the manifold activities of p53 as a transcriptional repressor. J Biomed Biotechnol 2011; 2011: 464916. · DOI
  9. Sengupta S, Shimamoto A, Koshiji M, Pedeux R, Rusin M, Spillare EA et al. Tumor suppressor p53 represses transcription of RECQ4 helicase. Oncogene 2005; 24: 1738–1748. · DOI
  10. Rother K, Li YY, Tschop K, Kirschner R, Muller GA, Mossner J et al. Expression of cyclin-dependent kinase subunit 1 (Cks1) is regulated during the cell cycle by a CDE/CHR tandem element and is downregulated by p53 but not by p63 or p73. Cell Cycle 2007; 6: 853–862. · DOI
  11. Innocente SA, Lee JM . p53 is a NF-Y- and p21-independent, Sp1-dependent repressor of cyclin B1 transcription. FEBS Lett 2005; 579: 1001–1007. · DOI
  12. Imbriano C, Gurtner A, Cocchiarella F, Di Agostino S, Basile V, Gostissa M et al. Direct p53 transcriptional repression: in vivo analysis of CCAAT-containing G2/M promoters. Mol Cell Biol 2005; 25: 3737–3751. · DOI · Paper page
  13. Matsui T, Katsuno Y, Inoue T, Fujita F, Joh T, Niida H et al. Negative regulation of Chk2 expression by p53 is dependent on the CCAAT-binding transcription factor NF-Y. J Biol Chem 2004; 279: 25093–25100. · DOI
  14. Dalvai M, Mondesert O, Bourdon JC, Ducommun B, Dozier C . Cdc25B is negatively regulated by p53 through Sp1 and NF-Y transcription factors. Oncogene 2011; 30: 2282–2288. · DOI
  15. St Clair S, Giono L, Varmeh-Ziaie S, Resnick-Silverman L, Liu WJ, Padi A et al. DNA damage-induced downregulation of Cdc25C is mediated by p53 via two independent mechanisms: one involves direct binding to the cdc25C promoter. Mol Cell 2004; 16: 725–736. · DOI · Paper page
  16. Hoffman WH, Biade S, Zilfou JT, Chen J, Murphy M . Transcriptional repression of the anti-apoptotic survivin gene by wild type p53. J Biol Chem 2002; 277: 3247–3257. · DOI · Paper page
  17. Banerjee T, Nath S, Roychoudhury S . DNA damage induced p53 downregulates Cdc20 by direct binding to its promoter causing chromatin remodeling. Nucleic Acids Res 2009; 37: 2688–2698. · DOI
  18. Laptenko O, Prives C . Transcriptional regulation by p53: one protein, many possibilities. Cell Death Differ 2006; 13: 951–961. · DOI · Paper page
  19. Sherr CJ, Roberts JM . CDK inhibitors: positive and negative regulators of G1-phase progression. Genes Dev 1999; 13: 1501–1512. · DOI · Paper page
  20. Tang X, Milyavsky M, Shats I, Erez N, Goldfinger N, Rotter V . Activated p53 suppresses the histone methyltransferase EZH2 gene. Oncogene 2004; 23: 5759–5769. · DOI · Paper page
  21. Gottifredi V, Karni-Schmidt O, Shieh SS, Prives C . p53 down-regulates CHK1 through p21 and the retinoblastoma protein. Mol Cell Biol 2001; 21: 1066–1076. · DOI · Paper page
  22. Esteve PO, Chin HG, Pradhan S . Molecular mechanisms of transactivation and doxorubicin-mediated repression of survivin gene in cancer cells. J Biol Chem 2007; 282: 2615–2625. · DOI
  23. Murphy M, Ahn J, Walker KK, Hoffman WH, Evans RM, Levine AJ et al. Transcriptional repression by wild-type p53 utilizes histone deacetylases, mediated by interaction with mSin3a. Genes Dev 1999; 13: 2490–2501. · DOI · Paper page
  24. Roperch JP, Alvaro V, Prieur S, Tuynder M, Nemani M, Lethrosne F et al. Inhibition of presenilin 1 expression is promoted by p53 and p21WAF-1 and results in apoptosis and tumor suppression. Nat Med 1998; 4: 835–838. · DOI · Paper page
  25. Godefroy N, Bouleau S, Gruel G, Renaud F, Rincheval V, Mignotte B et al. Transcriptional repression by p53 promotes a Bcl-2-insensitive and mitochondria-independent pathway of apoptosis. Nucleic Acids Res 2004; 32: 4480–4490. · DOI
  26. Tewey KM, Rowe TC, Yang L, Halligan BD, Liu LF . Adriamycin-induced DNA damage mediated by mammalian DNA topoisomerase II. Science 1984; 226: 466–468. · DOI · Paper page
  27. Sugrue MM, Shin DY, Lee SW, Aaronson SA . Wild-type p53 triggers a rapid senescence program in human tumor cells lacking functional p53. Proc Natl Acad Sci USA 1997; 94: 9648–9653. · DOI · Paper page
  28. Zhu W, Giangrande PH, Nevins JR . E2Fs link the control of G1/S and G2/M transcription. EMBO J 2004; 23: 4615–4626. · DOI · Paper page
  29. Chen HZ, Tsai SY, Leone G . Emerging roles of E2Fs in cancer: an exit from cell cycle control. Nat Rev Cancer 2009; 9: 785–797. · DOI · Paper page
  30. Crosby ME, Almasan A . Opposing roles of E2Fs in cell proliferation and death. Cancer Biol Ther 2004; 3: 1208–1211. · DOI
  31. Lammens T, Li J, Leone G, De Veylder L . Atypical E2Fs: new players in the E2F transcription factor family. Trends Cell Biol 2009; 19: 111–118. · DOI · Paper page
  32. Cartharius K, Frech K, Grote K, Klocke B, Haltmeier M, Klingenhoff A et al. MatInspector and beyond: promoter analysis based on transcription factor binding sites. Bioinformatics 2005; 21: 2933–2942. · DOI · Paper page
  33. Di Stefano L, Jensen MR, Helin K . E2F7, a novel E2F featuring DP-independent repression of a subset of E2F-regulated genes. EMBO J 2003; 22: 6289–6298. · DOI · Paper page
  34. Zeng Y, Kotake Y, Pei XH, Smith MD, Xiong Y . p53 binds to and is required for the repression of Arf tumor suppressor by HDAC and polycomb. Cancer Res 2011; 71: 2781–2792. · DOI
  35. Bindra RS, Glazer PM . Basal repression of BRCA1 by multiple E2Fs and pocket proteins at adjacent E2F sites. Cancer Biol Ther 2006; 5: 1400–1407. · DOI
  36. Nor Rashid N, Yusof R, Watson RJ . Disruption of repressive p130-DREAM complexes by human papillomavirus 16 E6/E7 oncoproteins is required for cell-cycle progression in cervical cancer cells. J Gen Virol 2011; 92: 2620–2627. · DOI
  37. Tsang NM, Little JB . Effect of restoration of retinoblastoma gene function on the radiosensitivity of cells of human tumor cell lines. Radiat Res 1994; 140: 172–179. · DOI
  38. Lee BK, Bhinge AA, Iyer VR . Wide-ranging functions of E2F4 in transcriptional activation and repression revealed by genome-wide analysis. Nucleic Acids Res 2011; 39: 3558–3573. · DOI
  39. Huang da W, Sherman BT, Lempicki RA . Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists. Nucleic Acids Res 2009; 37: 1–13. · DOI · Paper page
  40. Wang B, Xiao Z, Ko HL, Ren EC . The p53 response element and transcriptional repression. Cell Cycle 2010; 9: 870–879. · DOI
  41. Li B, Lee MY . Transcriptional regulation of the human DNA polymerase delta catalytic subunit gene POLD1 by p53 tumor suppressor and Sp1. J Biol Chem 2001; 276: 29729–29739. · DOI
  42. Jung YS, Qian Y, Chen X . Examination of the expanding pathways for the regulation of p21 expression and activity. Cell Signal 2010; 22: 1003–1012. · DOI · Paper page
  43. Ucar D, Beyer A, Parthasarathy S, Workman CT . Predicting functionality of protein-DNA interactions by integrating diverse evidence. Bioinformatics 2009; 25: i137–i144. · DOI
  44. Burger A, Walczak AM, Wolynes PG . Abduction and asylum in the lives of transcription factors. Proc Natl Acad Sci USA 2010; 107: 4016–4021. · DOI
  45. Helmbold H, Komm N, Deppert W, Bohn W . Rb2/p130 is the dominating pocket protein in the p53-p21 DNA damage response pathway leading to senescence. Oncogene 2009; 28: 3456–3467. · DOI
  46. Takahashi Y, Rayman JB, Dynlacht BD . Analysis of promoter binding by the E2F and pRB families in vivo: distinct E2F proteins mediate activation and repression. Genes Dev 2000; 14: 804–816. · DOI · Paper page
  47. Litovchick L, Florens LA, Swanson SK, Washburn MP, DeCaprio JA . DYRK1A protein kinase promotes quiescence and senescence through DREAM complex assembly. Genes Dev 2011; 25: 801–813. · DOI · Paper page
  48. Komori H, Enomoto M, Nakamura M, Iwanaga R, Ohtani K . Distinct E2F-mediated transcriptional program regulates p14ARF gene expression. EMBO J 2005; 24: 3724–3736. · DOI
  49. Aslanian A, Iaquinta PJ, Verona R, Lees JA . Repression of the Arf tumor suppressor by E2F3 is required for normal cell cycle kinetics. Genes Dev 2004; 18: 1413–1422. · DOI · Paper page
  50. Mirza A, Wu Q, Wang L, McClanahan T, Bishop WR, Gheyas F et al. Global transcriptional program of p53 target genes during the process of apoptosis and cell cycle progression. Oncogene 2003; 22: 3645–3654. · DOI · Paper page
  51. Kho PS, Wang Z, Zhuang L, Li Y, Chew JL, Ng HH et al. p53-regulated transcriptional program associated with genotoxic stress-induced apoptosis. J Biol Chem 2004; 279: 21183–21192. · DOI
  52. Hammond EM, Mandell DJ, Salim A, Krieg AJ, Johnson TM, Shirazi HA et al. Genome-wide analysis of p53 under hypoxic conditions. Mol Cell Biol 2006; 26: 3492–3504. · DOI
  53. Roy S, Jeffrey R, Tenniswood M . Array-based analysis of the effects of trichostatin A and CG-1521 on cell cycle and cell death in LNCaP prostate cancer cells. Mol Cancer Ther 2008; 7: 1931–1939. · DOI
  54. Fang L, Igarashi M, Leung J, Sugrue MM, Lee SW, Aaronson SA . p21Waf1/Cip1/Sdi1 induces permanent growth arrest with markers of replicative senescence in human tumor cells lacking functional p53. Oncogene 1999; 18: 2789–2797. · DOI · Paper page
  55. Akiri G, Cherian MM, Vijayakumar S, Liu G, Bafico A, Aaronson SA . Wnt pathway aberrations including autocrine Wnt activation occur at high frequency in human non-small-cell lung carcinoma. Oncogene 2009; 28: 2163–2172. · DOI
  56. Benson EK, Lee SW, Aaronson SA . Role of progerin-induced telomere dysfunction in HGPS premature cellular senescence. J Cell Sci 2010; 123: 2605–2612. · DOI · Paper page

Cited by

See all 96

Metadata

Authors
Benson, E. K., Mungamuri, S. K., Attie, O., Kracikova, M., Sachidanandam, R., Manfredi, J. J., & Aaronson, S. A.
Venue
Oncogene
Published
2013-10-07
Volume
33
Issue
30
Pages
3959-3969
ISSN
  • 0950-9232
  • 1476-5594
Cited by
96
References
13
Language
en
Licence
creativecommons.org/licenses/by-nc-nd/3.0/ (tdm)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: p53-dependent gene repression through p21 is mediated by recruitment of E2F4 repression complexes. https://app.cochat.ai/papers/10.1038/onc.2013.378
The paper
Benson, E. K., Mungamuri, S. K., Attie, O., Kracikova, M., Sachidanandam, R., Manfredi, J. J., & Aaronson, S. A. (2014). p53-dependent gene repression through p21 is mediated by recruitment of E2F4 repression complexes. Oncogene. https://doi.org/10.1038/onc.2013.378

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.