Cited by 12Functional Brain Connectivity StudiesResearch Data Management PracticesInterdisciplinary Research and Collaboration

Current best practices and future opportunities for reproducible findings using large-scale neuroimaging in psychiatry

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Jahanshad, Neda, Lenzini, Petra, Bijsterbosch, Janine·2025·Neuropsychopharmacology

Abstract

Research into the brain basis of psychopathology is challenging due to the heterogeneity of psychiatric disorders, extensive comorbidities, underdiagnosis or overdiagnosis, multifaceted interactions with genetics and life experiences, and the highly multivariate nature of neural correlates. Therefore, increasingly larger datasets that measure more variables in larger cohorts are needed to gain insights. In this review, we present current “best practice” approaches for using existing databases, collecting and sharing new repositories for big data analyses, and future directions for big data in neuroimaging and psychiatry with an emphasis on contributing to collaborative efforts and the challenges of multi-study data analysis.

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Crossref · 10.1038/s41386-024-01938-8

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  • Small changes in normalization, imputation, or similarity metrics can substantially alter network topology and derived biological insights.

    “Small changes in normalization, imputation, or similarity metrics can substantially alter network topology and derived biological insights316,317.”

    From Artificial intelligence-driven multi-omics approaches in Alzheimer's disease: Progress, challenges, and future directions (2025) · cites this paper as [317]

    In “Opportunity 1: Incorporating new data with legacy data” (page unavailable), the paper says variations in image-processing pipelines can create reproducibility problems and affect which image features appear susceptible to workflow differences. It does not say that small changes in normalization, imputation, or similarity metrics substantially alter network topology or biological insights. (LLM, conf=0.84)

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  1. [123]Kennedy, E, S Vadlamani, HM. Lindse, KS Peterson, K D Oconnor et al. Linking Symptom Inventories using Semantic Textual Similarity. arXiv [cs.CL] (2023). PMC12169902 40200899

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Authors
Jahanshad, N., Lenzini, P., & Bijsterbosch, J.
Affiliations
  • University of Southern California (US)
  • Washington University in St. Louis (US)
Corresponding author
  • Jahanshad, Neda
  • Bijsterbosch, Janine
Venue
Neuropsychopharmacology
Published
2024-08-08
Volume
50
Issue
1
Pages
37-51
ISSN
  • 0893-133X (ISSN-L)
  • 1740-634X
OpenAlex
W4401419478
Cited by
12
References
145
Citations by year
2026: 4 · 2025: 7 · 2024: 1
FWCI
0.78
Type
journal article
Language
en
Open access
Locations
  • Neuropsychopharmacology (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Digital Commons@Becker (Washington University School of Medicine) (submittedVersion, cc-by)
Funders
U.S. Department of Health & Human Services | NIH | National Institute of Mental Health
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
  • Physical Sciences › Computer Science › Information Systems › Research Data Management Practices
  • Social Sciences › Decision Sciences › Information Systems and Management › Interdisciplinary Research and Collaboration
Keywords
reproducibility, mental illness, big data, neuroimaging repositories, data sharing, research collaboration, psychiatric comorbidity
MeSH terms
Big Data, Mental Disorders, Brain, Humans, Psychiatry, Reproducibility of Results, Databases, Factual, Neuroimaging

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