Ecological and molecular perspectives on responders and non-responders to probiotics and prebiotics
Open accessAbstract
Bifidobacteria are widely used as a probiotic for their health-promoting effects. To promote their growth, bifidogenic prebiotics, including human milk oligosaccharides (HMOs), have been added to supplements and infant formula. However, the efficacy of both probiotic and prebiotic interventions is often debated, as clinical responses vary significantly by case. Here, we review clinical studies that aimed to proliferate human-residential Bifidobacterium (HRB) strains in the gut, and we highlight the difference between responders and non-responders to such interventions through an ecological, niche-based perspective and an examination of the prevalence of genes responsible for prebiotic assimilation in HRB genomes. We discuss the criteria necessary to better evaluate the efficacy of probiotic and prebiotic interventions and the recent therapeutic potential shown by synbiotics.
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Some individuals, regardless of age, show no response to probiotic interventions.
“some individuals, regardless of age (infants or adults), show no response to probiotic interventions.9”
From Gut microbiota drives structural variation of exogenous probiotics to enhance colonization (2025) · cites this paper as [9]
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Whole exome sequencing in the rat
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Anti-inflammatory effects of bifidobacteria by inhibition of LPS-induced NF-κB activation
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Complete genome sequence of Bifidobacterium pseudocatenulatum JCM 1200T isolated from infant feces
Morita, H., Toh, H., Oshima, K., Nakano, A., Arakawa, K., Takayama, Y., Kurokawa, R., Takanashi, K., Honda, K., & Hattori, M. (2015) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2015.06.416 · Cited by 8 · see citing works
Safe esophageal function testing during the COVID‐19 pandemic: A modified surgical mask for patients
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Flagged first, then by citations
3 of the 101 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Ojima, M. N., Jiang, L., Arzamasov, A. A., Yoshida, K., Odamaki, T., Xiao, J., Nakajima, A., Kitaoka, M., Hirose, J., Urashima, T., et al. (2022) · The ISME Journal · doi:10.1038/s41396-022-01270-3 · Cited by 118 · see citing works
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Classifying compounds as prebiotics — scientific perspectives and recommendations
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The Future of Synbiotics: Rational Formulation and Design
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Prebiotic Effects of α- and β-Galactooligosaccharides: The Structure-Function Relation
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The interaction between gut microbiome and bone health
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Self-citationMilk glycan metabolism by intestinal bifidobacteria: insights from comparative genomics
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“9 This can be attributed to the highly individual-specificity of the human microbiome, 10,11 shaped by genetics, diet, age, geography, disease status, and intrinsic host factors.”
Kok, C. R., Rose, D. J., Cui, J., Whisenhunt, L. A., & Hutkins, R. L. (2024) · BMC Microbiology · doi:10.1186/s12866-024-03344-y · Cited by 16 · see citing works
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New high-specificity fibers with strong and consistent responses across individuals
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Ecological insights into the assembly of bifidobacterial communities in the infant gut
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Human milk oligosaccharides and infant gut microbiome in Mongolian mother-infant dyads
Davaanyam, E., Otgonbaatar, U., Nakajima, A., Sakanaka, M., Ojima, M. N., Kozakai, T., Katoh, T., Odamaki, T., Javzan, B., Dagvadorj, E., et al. (2025) · Journal of Dairy Science · doi:10.3168/jds.2025-26865 · Cited by 3 · see citing works
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Applying microbial ecology frameworks to microbial therapies for wildlife
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局在解析から明らかになったビフィズス菌と他菌種のヒト腸内における競争関係
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- Authors
- Ojima, M. N., Yoshida, K., Sakanaka, M., Jiang, L., Odamaki, T., & Katayama, T.
- Affiliations
- Kyoto University (JP)
- Morinaga Milk Industry Co., Ltd. (Japan) (JP)
- Georgia Institute of Technology (US)
- Corresponding author
- Katayama, Takane
- Venue
- Current Opinion in Biotechnology
- Publisher
- Elsevier BV
- Published
- 2022-02
- Volume
- 73
- Pages
- 108-120
- ISSN
- 0958-1669 (ISSN-L)
- OpenAlex
- W3187369076
- Cited by
- 46
- References
- 101
- Citations by year
- 2026: 9 · 2025: 11 · 2024: 11 · 2023: 5 · 2022: 9 · 2021: 1
- FWCI
- 0.90
- Type
- journal article
- Language
- en
- Open access
- Licence
- Locations
- Current Opinion in Biotechnology (publishedVersion)
- PubMed (publishedVersion)
- Institutional Repositories DataBase (IRDB) (submittedVersion)
- Kyoto University Research Information Repository (Kyoto University) (submittedVersion, cc-by-nc-nd)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
- Keywords
- probiotics, prebiotics, human milk oligosaccharides, Bifidobacterium, synbiotics, infant formula, probiotic efficacy
- MeSH terms
- Bifidobacterium, Humans, Milk, Human, Oligosaccharides, Probiotics, Prebiotics, Synbiotics
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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