Cited by 47Infant Nutrition and HealthProbiotics and Fermented FoodsMicrobial Metabolites in Food Biotechnology

Ecological and molecular perspectives on responders and non-responders to probiotics and prebiotics

Open access
Ojima, Miriam N, Yoshida, Keisuke, Sakanaka, Mikiyasu, Jiang, Lin, Odamaki, Toshitaka, Katayama, Takane·2022·Current Opinion in Biotechnology

Abstract

Bifidobacteria are widely used as a probiotic for their health-promoting effects. To promote their growth, bifidogenic prebiotics, including human milk oligosaccharides (HMOs), have been added to supplements and infant formula. However, the efficacy of both probiotic and prebiotic interventions is often debated, as clinical responses vary significantly by case. Here, we review clinical studies that aimed to proliferate human-residential Bifidobacterium (HRB) strains in the gut, and we highlight the difference between responders and non-responders to such interventions through an ecological, niche-based perspective and an examination of the prevalence of genes responsible for prebiotic assimilation in HRB genomes. We discuss the criteria necessary to better evaluate the efficacy of probiotic and prebiotic interventions and the recent therapeutic potential shown by synbiotics.

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Crossref · 10.1016/j.copbio.2021.06.023

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Authors
Ojima, M. N., Yoshida, K., Sakanaka, M., Jiang, L., Odamaki, T., & Katayama, T.
Affiliations
  • Kyoto University (JP)
  • Morinaga Milk Industry Co., Ltd. (Japan) (JP)
  • Georgia Institute of Technology (US)
Corresponding author
Katayama, Takane
Venue
Current Opinion in Biotechnology
Publisher
Elsevier BV
Published
2022-02
Volume
73
Pages
108-120
ISSN
0958-1669 (ISSN-L)
OpenAlex
W3187369076
Cited by
46
References
101
Citations by year
2026: 9 · 2025: 11 · 2024: 11 · 2023: 5 · 2022: 9 · 2021: 1
FWCI
0.90
Type
journal article
Language
en
Locations
  • Current Opinion in Biotechnology (publishedVersion)
  • PubMed (publishedVersion)
  • Institutional Repositories DataBase (IRDB) (submittedVersion)
  • Kyoto University Research Information Repository (Kyoto University) (submittedVersion, cc-by-nc-nd)
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
  • Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
Keywords
probiotics, prebiotics, human milk oligosaccharides, Bifidobacterium, synbiotics, infant formula, probiotic efficacy
MeSH terms
Bifidobacterium, Humans, Milk, Human, Oligosaccharides, Probiotics, Prebiotics, Synbiotics

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