Cited by 1,003Mitochondrial Function and PathologyAlzheimer's disease research and treatmentsNeuroprotection in Cerebral Ischemia

The DOI matches its Crossref record; 317 of the 317 references it cites were found in a registry or an index.

Brain energy rescue: an emerging therapeutic concept for neurodegenerative disorders of ageing

Open access

Cunnane, Stephen C., Trushina, Eugenia, Morland, Cecilie, Prigione, Alessandro, Casadesus, Gemma, Andrews, Zane B., Beal, M. Flint, Bergersen, Linda H., Brinton, Roberta D., de la Monte, Suzanne, Eckert, Anne, Harvey, Jenni, Jeggo, Ross, Jhamandas, Jack H., Kann, Oliver, la Cour, Clothide Mannoury, Martin, William F., Mithieux, Gilles, Moreira, Paula I., Murphy, Michael P., Nave, Klaus-Armin, Nuriel, Tal, Oliet, Stéphane H. R., Saudou, Frédéric, Mattson, Mark P., Swerdlow, Russell H., Millan, Mark J.·2020·Nature Reviews Drug Discovery

DOI 10.1038/s41573-020-0072-xPMC PMC7948516

Open this paper in CoChat — free account Open PDF

Abstract

The brain requires a continuous supply of energy in the form of ATP, most of which is produced from glucose by oxidative phosphorylation in mitochondria, complemented by aerobic glycolysis in the cytoplasm. When glucose levels are limited, ketone bodies generated in the liver and lactate derived from exercising skeletal muscle can also become important energy substrates for the brain. In neurodegenerative disorders of ageing, brain glucose metabolism deteriorates in a progressive, region-specific and disease-specific manner - a problem that is best characterized in Alzheimer disease, where it begins presymptomatically. This Review discusses the status and prospects of therapeutic strategies for countering neurodegenerative disorders of ageing by improving, preserving or rescuing brain energetics. The approaches described include restoring oxidative phosphorylation and glycolysis, increasing insulin sensitivity, correcting mitochondrial dysfunction, ketone-based interventions, acting via hormones that modulate cerebral energetics, RNA therapeutics and complementary multimodal lifestyle changes.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1038/s41573-020-0072-x

Cites

317 of 317 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Items 201–317 of 317

Impairments in oxidative glucose metabolism in epilepsy and metabolic treatments thereof
McDonald, T., Puchowicz, M., & Borges, K. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00274 · Cited by 77
Post hoc analysis of the Exenatide‐ PD trial—Factors that predict response
Athauda, D. S., Maclagan, K., Budnik, N., Zampedri, L., Hibbert, S., Avilés-Olmos, I., Chowdhury, K., Skene, S. S., Limousin, P. D., & Foltynie, T. (2018) · European Journal of Neuroscience · doi:10.1111/ejn.14096 · Cited by 76
Time to Amyloid Positivity and Preclinical Changes in Brain Metabolism, Atrophy, and Cognition: Evidence for Emerging Amyloid Pathology in Alzheimer's Disease
Insel, P. S., Ossenkoppele, R., Gessert, D., Jagust, W., Landau, S. M., Hansson, O., Weiner, M. W., & Mattsson, N. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00281 · Cited by 75
Regional multimodal relationships between tau, hypometabolism, atrophy, and fractional anisotropy in atypical Alzheimer's disease
Sintini, I., Schwarz, C. G., Martin, P. R., Graff‐Radford, J., Machulda, M. M., Senjem, M. L., Reid, R. I., Spychalla, A. J., Drubach, D. A., Lowe, V. J., et al. (2018) · Human Brain Mapping · doi:10.1002/hbm.24473 · Cited by 75
Ketosis may promote brain macroautophagy by activating Sirt1 and hypoxia-inducible factor-1
McCarty, M. F., DiNicolantonio, J. J., & O’Keefe, J. H. (2015) · Medical Hypotheses · doi:10.1016/j.mehy.2015.08.002 · Cited by 74
Central Regulation of Glucose Homeostasis
Tups, A., Benzler, J., Sergi, D., Ladyman, S. R., & Williams, L. M. (2017) · Comprehensive physiology · doi:10.1002/cphy.c160015 · Cited by 74
Ghrelin and Neurodegenerative Disorders—a Review
Shi, L.-M., Du, X.-X., Jiang, H., & Xie, J.-X. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-9729-1 · Cited by 73
Mitochondrial impairments contribute to Spinocerebellar ataxia type 1 progression and can be ameliorated by the mitochondria-targeted antioxidant MitoQ
Stucki, D., Ruegsegger, C., Steiner, S., Radecke, J., Murphy, M. P., Zuber, B., & Saxena, S. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.07.005 · Cited by 73
Self-citation
Suppression of adiponectin receptor 1 promotes memory dysfunction and Alzheimer’s disease-like pathologies
Kim, M. W., Abid, N. B., Jo, M. G., Jo, M. G., Yoon, G. H., & Kim, M. O. (2017) · Scientific Reports · doi:10.1038/s41598-017-12632-9 · Cited by 72
Metabolism and epilepsy: Ketogenic diets as a homeostatic link
Masino, S. A., & Rho, J. M. (2018) · Brain Research · doi:10.1016/j.brainres.2018.05.049 · Cited by 72
Advances in Management of Neuropsychiatric Syndromes in Neurodegenerative Diseases
Cummings, J. L., Ritter, A. R., & Rothenberg, K. G. (2019) · Current Psychiatry Reports · doi:10.1007/s11920-019-1058-4 · Cited by 72
Nutritional ketosis for mild cognitive impairment in Parkinson's disease: A controlled pilot trial
Krikorian, R., Shidler, M., Summer, S., Sullivan, P., Duker, A., Isaacson, R., & Espay, A. (2019) · Clinical Parkinsonism & Related Disorders · doi:10.1016/j.prdoa.2019.07.006 · Cited by 71
Ketogenic diet in the treatment of schizoaffective disorder: Two case studies
Palmer, C. M. (2017) · Schizophrenia Research · doi:10.1016/j.schres.2017.01.053 · Cited by 70
Are Major Dementias Triggered by Poor Blood Flow to the Brain? Theoretical Considerations
de la Torre, J. C. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-161266 · Cited by 70
Diminished O-GlcNAcylation in Alzheimer's disease is strongly correlated with mitochondrial anomalies
Pinho, T. S., Correia, S. C., Perry, G., Ambrósio, A. F., & Moreira, P. I. (2019) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2018.10.037 · Cited by 70
Self-citation
18 F-FDG Is a Superior Indicator of Cognitive Performance Compared to 18 F-Florbetapir in Alzheimer’s Disease and Mild Cognitive Impairment Evaluation: A Global Quantitative Analysis
Khosravi, M., Peter, J., Wintering, N., Serruya, M. D., Shamchi, S. P., Werner, T. J., Alavi, A. A., & Newberg, A. B. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-190220 · Cited by 70
PPARδ activation by bexarotene promotes neuroprotection by restoring bioenergetic and quality control homeostasis
Dickey, A. S., Sanchez, D. N., Arreola, M., Sampat, K. R., Fan, W., Arbez, N., Akimov, S., Kanegan, M. J. V., Ohnishi, K., Gilmore-Hall, S. K., et al. (2017) · Science Translational Medicine · doi:10.1126/scitranslmed.aal2332 · Cited by 70
Ketogenic diet reverses behavioral abnormalities in an acute NMDA receptor hypofunction model of schizophrenia
Kraeuter, A.-K., Loxton, H., Lima, B. C., Rudd, D., & Sarnyai, Z. (2015) · Schizophrenia Research · doi:10.1016/j.schres.2015.10.041 · Cited by 69
Neuronal systems and circuits involved in the control of food intake and adaptive thermogenesis
Caron, A., & Richard, D. (2016) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13263 · Cited by 69
Tridecanoin is anticonvulsant, antioxidant, and improves mitochondrial function
Tan, K. N., Carrasco‐Pozo, C., McDonald, T. S., Puchowicz, M., & Borges, K. (2016) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x16659498 · Cited by 67
Regulation of Hippocampal Synaptic Function by the Metabolic Hormone, Leptin: Implications for Health and Neurodegenerative Disease
McGregor, G., & Harvey, J. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00340 · Cited by 67
Self-citation
Energy defects in Huntington's disease: Why “in vivo” evidence matters
Liot, G., Valette, J., Pépin, J., Flament, J., & Brouillet, E. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.09.065 · Cited by 65
Emerging Roles for Glycogen in the CNS
Waitt, A. E., Reed, L., Ransom, B. R., & Brown, A. M. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00073 · Cited by 65
HIV-1 infection alters energy metabolism in the brain: Contributions to HIV-associated neurocognitive disorders
Cotto, B., Natarajanseenivasan, K., & Langford, D. (2019) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2019.101616 · Cited by 65
Evidence for altered insulin receptor signaling in Alzheimer's disease
Griffith, C. M., Eid, T., Rose, G. M., & Patrylo, P. R. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.01.008 · Cited by 64
Synaptic energy metabolism and neuronal excitability, in sickness and health
Oyarzábal, A., & Marin‐Valencia, I. (2019) · Journal of Inherited Metabolic Disease · doi:10.1002/jimd.12071 · Cited by 63
A 3-Month Aerobic Training Program Improves Brain Energy Metabolism in Mild Alzheimer’s Disease: Preliminary Results from a Neuroimaging Study
Castellano, C., Paquet, N., Dionne, I. J., Imbeault, H., Langlois, F., Croteau, É., Tremblay, S., Fortier, M., Matte, J. J., Lacombe, G., et al. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-161163 · Cited by 62
Self-citation
Triheptanoin Protects Motor Neurons and Delays the Onset of Motor Symptoms in a Mouse Model of Amyotrophic Lateral Sclerosis
Tefera, T. W., Wong, Y., Barkl‐Luke, M. E., Ngo, S. T., Thomas, N. K., McDonald, T. S., & Borges, K. (2016) · PLoS ONE · doi:10.1371/journal.pone.0161816 · Cited by 61
Alternate Day Fasting Improves Physiological and Molecular Markers of Aging in Healthy, Non-obese Humans
Stekovic, S., Hofer, S. J., Tripolt, N. J., Aon, M. A., Royer, P., Pein, L., Stadler, J. T., Pendl, T., Prietl, B., Url, J., et al. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.02.011 · Cited by 61
Down-regulation of ghrelin receptors on dopaminergic neurons in the substantia nigra contributes to Parkinson’s disease-like motor dysfunction
Suda, Y., Kuzumaki, N., Sone, T., Narita, M., Tanaka, K., Hamada, Y., Iwasawa, C., Shibasaki, M., Maekawa, A., Matsuo, M., et al. (2018) · Molecular Brain · doi:10.1186/s13041-018-0349-8 · Cited by 60
Increased translation as a novel pathogenic mechanism in Huntington’s disease
Creus‐Muncunill, J., Badillos-Rodríguez, R., García-Forn, M., Masana, M., Barriga, G. G.-D., Guisado-Corcoll, A., Alberch, J., Malagelada, C., Delgado-Garcia, J. M., Gruart, A., et al. (2019) · Brain · doi:10.1093/brain/awz230 · Cited by 60
Bioenergetic deficits in Huntington’s disease iPSC-derived neural cells and rescue with glycolytic metabolites
Kedaigle, A. J., Fraenkel, E., Atwal, R. S., Wu, M., Gusella, J. F., MacDonald, M. E., Kaye, J., Finkbeiner, S. M., Mattis, V. B., Tom, C. M., et al. (2019) · Human Molecular Genetics · doi:10.1093/hmg/ddy430 · Cited by 60
The efficacy of the ketogenic diet on motor functions in Parkinson's disease: A rat model.
Shaafi, S., Najmi, S., Aliasgharpour, H., Mahmoudi, J., Sadigh-Etemad, S., Farhoudi, M., & Baniasadi, N. (2016) · Europe PMC (PubMed Central) · Cited by 59
The Full Spectrum of Alzheimer’s Disease Is Rooted in Metabolic Derangements That Drive Type 3 Diabetes
de la Monte, S. M. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-981-13-3540-2_4 · Cited by 59
The Potential of CRISPR/Cas9 Gene Editing as a Treatment Strategy for Alzheimer's Disease
Rohn, T. T., Kim, N., Isho, N. F., & Mack, J. M. (2018) · Journal of Alzheimer’s Disease & Parkinsonism · doi:10.4172/2161-0460.1000439 · Cited by 58
N-acetylcysteine protects memory decline induced by streptozotocin in mice
Costa, M. D., Bernardi, J., Fiuza, T. D. L., Costa, L., Brandão, R., & Pereira, M. E. (2016) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2016.04.026 · Cited by 57
Systems biology identifies preserved integrity but impaired metabolism of mitochondria due to a glycolytic defect in Alzheimer's disease neurons
Theurey, P., Connolly, N. M. C., Fortunati, I., Basso, E., Lauwen, S., Ferrante, C., Pinho, C. M., Joselin, A. P., Gioran, A., Bano, D., et al. (2019) · Aging Cell · doi:10.1111/acel.12924 · Cited by 57
Apolipoprotein E4 mediates insulin resistance-associated cerebrovascular dysfunction and the post-prandial response
Johnson, L. A., Torres, E. R., Weber Boutros, S., Patel, E., Akinyeke, T., Alkayed, N. J., & Raber, J. (2019) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x17746186 · Cited by 56
Oxaloacetate enhances neuronal cell bioenergetic fluxes and infrastructure
Wilkins, H., Koppel, S. J., Carl, S. M., Ramanujan, S., Weidling, I. W., Michaelis, M. L., Michaelis, E. K., & Swerdlow, R. H. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13545 · Cited by 55
Self-citation
Peripheral Blood Adipokines and Insulin Levels in Patients with Alzheimer';s Disease: A Replication Study and Meta-Analysis
Ma, J., Zhang, W., Wang, H.-F., Wang, Z.-X., Jiang, T., Tan, M., Yu, J., & Tan, L. (2016) · Current Alzheimer Research · doi:10.2174/156720501303160217111434 · Cited by 55
Exercise Pills: At the Starting Line
Li, S., & Laher, I. (2015) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2015.08.014 · Cited by 54
Treating cognitive impairment with transcranial low level laser therapy
de la Torre, J. C. (2017) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/j.jphotobiol.2017.02.008 · Cited by 54
How reliable is cerebral blood flow to map changes in neuronal activity?
Lecrux, C., Bourourou, M., & Hamel, É. (2019) · Autonomic Neuroscience · doi:10.1016/j.autneu.2019.01.005 · Cited by 54
The impact of histone post-translational modifications in neurodegenerative diseases
Cobos, S. N., Bennett, S. A., & Torrente, M. P. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2018.10.019 · Cited by 53
Evidence for impaired glucose metabolism in the striatum, obtained postmortem, from some subjects with schizophrenia
Dean, B., Thomas, N., Scarr, E., & Udawela, M. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.226 · Cited by 52
Combination treatment with leptin and pioglitazone in a mouse model of Alzheimer's disease
Fernández-Martos, C. M., Atkinson, R. A. K., Chuah, M. I., King, A. E., & Vickers, J. C. (2016) · Alzheimer s & Dementia Translational Research & Clinical Interventions · doi:10.1016/j.trci.2016.11.002 · Cited by 52
A Mitochondrial Biomarker-Based Study of S-Equol in Alzheimer’s Disease Subjects: Results of a Single-Arm, Pilot Trial
Wilkins, H., Mahnken, J. D., Welch, P., Bothwell, R. J., Koppel, S. J., Jackson, R. L., Burns, J. M., & Swerdlow, R. H. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-170077 · Cited by 51
Self-citation
Amylin Treatment Reduces Neuroinflammation and Ameliorates Abnormal Patterns of Gene Expression in the Cerebral Cortex of an Alzheimer’s Disease Mouse Model
Wang, E., Zhu, H., Wang, X., Gower, A. C., Wallack, M., Blusztajn, J. K., Kowall, N. W., & Qiu, W. Q. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-160677 · Cited by 50
Amylin and Leptin: Co-Regulators of Energy Homeostasis and Neuronal Development
Levin, B. E., & Lutz, T. A. (2016) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2016.11.004 · Cited by 50
Dementia spectrum disorders: lessons learnt from decades with PET research
Wilson, H., Pagano, G., & Politis, M. (2019) · Journal of Neural Transmission · doi:10.1007/s00702-019-01975-4 · Cited by 50
Interneuron Deficit Associates Attenuated Network Synchronization to Mismatch of Energy Supply and Demand in Aging Mouse Brains
Jessen, S. B., Mathiesen, C., Lind, B. L., & Lauritzen, M. (2015) · Cerebral Cortex · doi:10.1093/cercor/bhv261 · Cited by 49
Glucose hypometabolism is highly localized, but lower cortical thickness and brain atrophy are widespread in cognitively normal older adults
Nugent, S., Castellano, C., Goffaux, P., Whittingstall, K., Lepage, M., Paquet, N., Bocti, C., Fülöp, T., & Cunnane, S. C. (2014) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00067.2014 · Cited by 49
Self-citation
Triheptanoin for the treatment of brain energy deficit: A 14‐year experience
Mochel, F. (2017) · Journal of Neuroscience Research · doi:10.1002/jnr.24111 · Cited by 49
Brain insulin signalling, glucose metabolism and females' reproductive aging: A dangerous triad in Alzheimer's disease
Duarte, A. I., Santos, M. S., Oliveira, C. R., & Moreira, P. I. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.01.044 · Cited by 49
Self-citation
MK-0677, a Ghrelin Agonist, Alleviates Amyloid Beta-Related Pathology in 5XFAD Mice, an Animal Model of Alzheimer’s Disease
Jeong, Y.-O., Shin, S. J., Park, J., Ku, B., Song, J.-S., Kim, J.-J., Jeon, S., Lee, S. M., & Moon, M. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19061800 · Cited by 48
Regional Brain Glucose Hypometabolism in Young Women with Polycystic Ovary Syndrome: Possible Link to Mild Insulin Resistance
Castellano, C., Baillargeon, J., Nugent, S., Tremblay, S., Fortier, M., Imbeault, H., Duval, J. M., & Cunnane, S. C. (2015) · PLoS ONE · doi:10.1371/journal.pone.0144116 · Cited by 47
Self-citation
Semaglutide seems to be more effective the other GLP-1Ras
Holst, J. J., & Madsbad, S. (2017) · Annals of Translational Medicine · doi:10.21037/atm.2017.11.10 · Cited by 47
2,4 DNP improves motor function, preserves medium spiny neuronal identity, and reduces oxidative stress in a mouse model of Huntington's disease
Wu, B., Jiang, M., Peng, Q., Li, G., Hou, Z., Milne, G. L., Mori, S., Alonso, R. J., Geisler, J. G., & Duan, W. (2017) · Experimental Neurology · doi:10.1016/j.expneurol.2017.03.020 · Cited by 46
Metabolic Dysregulation in Amyotrophic Lateral Sclerosis: Challenges and Opportunities
Joardar, A., Manzo, E., & Zarnescu, D. C. (2017) · Current Genetic Medicine Reports · doi:10.1007/s40142-017-0123-8 · Cited by 45
New insights into the role of microRNAs and long noncoding RNAs in most common neurodegenerative diseases
Maniati, M. S., Maniati, M., Yousefi, T., Ahangar, A. A., & Tehrani, S. S. (2019) · Journal of Cellular Biochemistry · doi:10.1002/jcb.28361 · Cited by 45
The frontal cortex as a network hub controlling mood and cognition: Probing its neurochemical substrates for improved therapy of psychiatric and neurological disorders
Millan, M. J., Rivet, J., & Gobert, A. (2016) · Journal of Psychopharmacology · doi:10.1177/0269881116672342 · Cited by 44
Self-citation
Ketogenic diet for schizophrenia: Nutritional approach to antipsychotic treatment
Włodarczyk, A., Wiglusz, M. S., & Cubała, W. J. (2018) · Medical Hypotheses · doi:10.1016/j.mehy.2018.06.022 · Cited by 44
Distinctive Structural and Molecular Features of Myelinated Inhibitory Axons in Human Neocortex
Micheva, K. D., Chang, E. F., Nana, A. L., Seeley, W. W., Ting, J. T., Cobbs, C., Lein, E. S., Smith, S. J., Weinberg, R. J., & Madison, D. V. (2018) · eNeuro · doi:10.1523/eneuro.0297-18.2018 · Cited by 44
Novel dual incretin agonist peptide with antidiabetic and neuroprotective potential
Pathak, N. M., Pathak, V., Gault, V. A., McClean, S., Irwin, N., & Flatt, P. R. (2018) · Biochemical Pharmacology · doi:10.1016/j.bcp.2018.07.021 · Cited by 44
A Leptin Fragment Mirrors the Cognitive Enhancing and Neuroprotective Actions of Leptin
Malekizadeh, Y., Holiday, A., Redfearn, D., Ainge, J. A., Doherty, G. H., & Harvey, J. (2016) · Cerebral Cortex · doi:10.1093/cercor/bhw272 · Cited by 43
Self-citation
Reduced severity of ischemic stroke and improvement of mitochondrial function after dietary treatment with the anaplerotic substance triheptanoin
Schwarzkopf, T. M., Koch, K. A., & Klein, J. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.05.014 · Cited by 41
Aiming for the target: Mitochondrial drug delivery in traumatic brain injury
Lamade, A. M., Kenny, E., Anthonymuthu, T. S., Soysal, E., Clark, R. S. B., Kagan, V. E., & Bayır, H. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.07.014 · Cited by 41
Ghrelin mediated neuroprotection - A possible therapy for Parkinson's disease?
Morgan, A. H., Rees, D. J., Andrews, Z. B., & Davies, J. S. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.12.027 · Cited by 40
Self-citation
Genetically altering organismal metabolism by leptin-deficiency benefits a mouse model of amyotrophic lateral sclerosis
Lim, M. A., Bence, K. K., Sandesara, I., Andreux, P. A., Auwerx, J. H., Ishibashi, J., Seale, P., & Kalb, R. G. (2014) · Human Molecular Genetics · doi:10.1093/hmg/ddu214 · Cited by 37
Disease-modifying effects of metabolic perturbations in ALS/FTLD
Jawaid, A., Khan, R., Polymenidou, M., & Schulz, P. E. (2018) · Molecular Neurodegeneration · doi:10.1186/s13024-018-0294-0 · Cited by 37
FDG-PET in Creutzfeldt-Jakob disease: Analysis of clinical-PET correlation
Renard, D., Castelnovo, G., Collombier, L., Thouvenot, É., & Boudousq, V. (2017) · Prion · doi:10.1080/19336896.2017.1387348 · Cited by 37
Glucose transportation in the brain and its impairment in Huntington disease: one more shade of the energetic metabolism failure?
Morea, V., Bidollari, E., Colotti, G., Fiorillo, A., Rosati, J. D., Filippis, L. D., Squitieri, F., & Ilari, A. (2017) · Amino Acids · doi:10.1007/s00726-017-2417-2 · Cited by 36
FDG-PET underscores the key role of the thalamus in frontotemporal lobar degeneration caused by C9ORF72 mutations
Diehl‐Schmid, J., Licata, A. E., Goldhardt, O., Förstl, H., Yakushew, I., Otto, M., Anderl‐Straub, S., Beer, A. J., Ludolph, A. C., Landwehrmeyer, G. B., et al. (2019) · Translational Psychiatry · doi:10.1038/s41398-019-0381-1 · Cited by 36
Short amylin receptor antagonist peptides improve memory deficits in Alzheimer’s disease mouse model
Soudy, R., Kimura, R., Patel, A., Fu, W., Kaur, K., Westaway, D. A., Yang, J., & Jhamandas, J. H. (2019) · Scientific Reports · doi:10.1038/s41598-019-47255-9 · Cited by 36
Self-citation
Gene-Based Approaches to Inherited Neurometabolic Diseases
Poletti, V., & Biffi, A. (2019) · Human Gene Therapy · doi:10.1089/hum.2019.190 · Cited by 35
Gene therapy targeting mitochondrial pathway in Parkinson’s disease
Choong, C., & Mochizuki, H. (2016) · Journal of Neural Transmission · doi:10.1007/s00702-016-1616-4 · Cited by 34
Imaging the Effects of β-Hydroxybutyrate on Peri-Infarct Neurovascular Function and Metabolism
Bazzigaluppi, P., Lake, E. M. R., Beckett, T. L., Koletar, M. M., Weisspapir, I., Heinen, S., Mester, J. R., Lai, A. Y., Janik, R., Dorr, A. E., et al. (2018) · Stroke · doi:10.1161/strokeaha.118.020586 · Cited by 34
Rescue of Transgenic Alzheimer’s Pathophysiology by Polymeric Cellular Prion Protein Antagonists
Gunther, E. C., Smith, L. M., Kostylev, M. A., Cox, T. O., Kaufman, A. C., Lee, S., Folta‐Stogniew, E. J., Maynard, G. D., Um, J. W., Stagi, M., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2018.12.021 · Cited by 34
The Adiponectin Homolog Osmotin Enhances Neurite Outgrowth and Synaptic Complexity via AdipoR1/NgR1 Signaling in Alzheimer’s Disease
Yoon, G., Shah, S. A., Ali, T., & Kim, M. O. (2018) · Molecular Neurobiology · doi:10.1007/s12035-017-0847-1 · Cited by 34
Discrete mitochondrial aberrations in the spinal cord of sporadic ALS patients
Delic, V., Kurien, C., Cruz, J., Zivkovic, S., Barretta, J., Thomson, A., Hennessey, D., Joseph, J., Ehrhart, J. C., Willing, A. E., et al. (2018) · Journal of Neuroscience Research · doi:10.1002/jnr.24249 · Cited by 34
Alterations in neuronal metabolism contribute to the pathogenesis of prion disease
Bourgognon, J.-M., Spiers, J. G., Scheiblich, H., Antonov, A., Bradley, S. J., Tobin, A. B., & Steinert, J. R. (2018) · Cell Death and Differentiation · doi:10.1038/s41418-018-0148-x · Cited by 34
Direct assessment of renal mitochondrial redox state using hyperpolarized 13C‐acetoacetate
von Morze, C., Ohliger, M. A., Marco‐Rius, I., Wilson, D. M., Flavell, R. R., Pearce, D., Vigneron, D. B., Kurhanewicz, J. V., & Wang, Z. J. (2018) · Magnetic Resonance in Medicine · doi:10.1002/mrm.27054 · Cited by 32
Links Between Metabolic and Structural Changes in the Brain of Cognitively Normal Older Adults: A 4-Year Longitudinal Follow-Up
Castellano, C., Hudon, C., Croteau, É., Fortier, M., St‐Pierre, V., Vandenberghe, C., Nugent, S., Tremblay, S., Paquet, N., Lepage, M., et al. (2019) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00015 · Cited by 32
Self-citation
Midlife Insulin Resistance as a Predictor for Late-Life Cognitive Function and Cerebrovascular Lesions
Toppala, S., Ekblad, L. L., Lötjönen, J. M. P., Helin, S., Hurme, S. A. M., Johansson, J. J., Jula, A., Karrasch, M., Koikkalainen, J. R., Laine, H. K., et al. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-190691 · Cited by 32
Rapid Adaptation of Rat Brain and Liver Metabolism to a Ketogenic Diet: An Integrated Study Using 1 H- and 13 C-NMR Spectroscopy
Roy, M., Beauvieux, M.-C., Naulin, J., Hamrani, D. E., Gallis, J., Cunnane, S. C., & Bouzier‐Sore, A. (2015) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2015.29 · Cited by 31
Self-citation
Amylin Signaling in Diabetes and Alzheimer's Disease: Therapy or Pathology?
Grizzanti, J., Corrigan, R. R., Servizi, S., & Casadesús, G. (2019) · Journal of Neurology and Neuromedicine · doi:10.29245/2572.942x/2019/1.1212 · Cited by 31
Alzheimer’s Disease and Histone Code Alterations
Narayan, P. J., & Dragunow, M. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-53889-1_17 · Cited by 30
A randomized trial of relamorelin for constipation in Parkinson's disease (MOVE-PD): Trial results and lessons learned.
1 (2017) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2017.02.003 · Cited by 30
Amylin in Alzheimer's disease: Pathological peptide or potential treatment?
Mietlicki‐Baase, E. G. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.12.016 · Cited by 30
Impaired Pentose Phosphate Pathway in the Spinal Cord of the hSOD1G93A Mouse Model of Amyotrophic Lateral Sclerosis
Tefera, T. W., Bartlett, K., Tran, S., Hodson, M. P., & Borges, K. (2019) · Molecular Neurobiology · doi:10.1007/s12035-019-1485-6 · Cited by 30
The Parkinson’s disease-linked Leucine-rich repeat kinase 2 (LRRK2) is required for insulin-stimulated translocation of GLUT4
Funk, N., Munz, M., Ott, T., Brockmann, K., Wenninger-Weinzierl, A., Kühn, R., Weisenhorn, D. M. V., Giesert, F., Wurst, W., Gasser, T., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-40808-y · Cited by 30
Is colonic propionate delivery a novel solution to improve metabolism and inflammation in overweight or obese subjects?
Cani, P. D. (2019) · Gut · doi:10.1136/gutjnl-2019-318776 · Cited by 29
Amylin Receptor: A Potential Therapeutic Target for Alzheimer’s Disease
Fu, W., Patel, A., Kimura, R., Soudy, R., & Jhamandas, J. H. (2017) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2017.06.003 · Cited by 28
Self-citation
Metabolic and Cognitive Outcomes of Subchronic Once-Daily Intranasal Insulin Administration in Healthy Men
Ritze, Y., Kern, W., Ebner, E.-M., Jahn, S., Benedict, C., & Hallschmid, M. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00663 · Cited by 28
Spatially Distributed Amyloid-β Reduces Glucose Metabolism in Mild Cognitive Impairment
Carbonell, F., Zijdenbos, A. P., Bedell, B. J., & Initiative, A. D. N. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-190560 · Cited by 28
Gene therapy for Glut1‐deficient mouse using an adeno‐associated virus vector with the human intrinsic GLUT1 promoter
Nakamura, S., Muramatsu, S., Takino, N., Ito, M., Jimbo, E. F., Shimazaki, K., Onaka, T., Ohtsuki, S., Terasaki, T., Yamagata, T., et al. (2018) · The Journal of Gene Medicine · doi:10.1002/jgm.3013 · Cited by 27
Neuroprotective Effects of the Amylin Analog, Pramlintide, on Alzheimer’s Disease Are Associated with Oxidative Stress Regulation Mechanisms
Patrick, S., Corrigan, R. R., Grizzanti, J., Mey, M., Blair, J., Pallàs, M., Camins, A., Lee, H., & Casadesús, G. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-180421 · Cited by 27
DPP4 Inhibitors Can Be a Drug of Choice for Type 3 Diabetes: A Mini Review
Chalichem, N. S. S., Gonugunta, C., Krishnamurthy, P. T., & Basavan, D. (2017) · American Journal of Alzheimer s Disease & Other Dementias® · doi:10.1177/1533317517722005 · Cited by 26
Involvement of Astrocytes in Mediating the Central Effects of Ghrelin
Frago, L. M., & Chowen, J. A. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18030536 · Cited by 24
Effect of D-Ala 2 GIP, a stable GIP receptor agonist on MPTP-induced neuronal impairments in mice
Verma, M. K., Goel, R. N., Nandakumar, K., & Nemmani, K. V. S. (2017) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2017.03.059 · Cited by 24
The Metabolic Activity of Caudate and Prefrontal Cortex Negatively Correlates with the Severity of Idiopathic Parkinson’s Disease
Chu, J., Liu, T., Wang, K., Han, C., Liu, Y.-P., Michitomo, S., Zhang, J., Fang, T., & Meng, F. (2018) · Aging and Disease · doi:10.14336/ad.2018.0814 · Cited by 24
Oligodendrocytes Do Not Export NAA-Derived Aspartate In Vitro
Amaral, A. I., Hadera, M. G., Kotter, M., & Sonnewald, U. (2016) · Neurochemical Research · doi:10.1007/s11064-016-1985-y · Cited by 23
Fascicle- and Glucose-Specific Deterioration in White Matter Energy Supply in Alzheimer’s Disease
Roy, M., Rheault, F., Croteau, É., Castellano, C., Fortier, M., St‐Pierre, V., Houde, J., Turcotte, É. E., Bocti, C., Fülöp, T., et al. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-200213 · Cited by 23
Self-citation
Two Weeks of Interval Training Enhances Fat Oxidation during Exercise in Obese Adults with Prediabetes.
Gaitán, J. M., Eichner, N. Z. M., Gilbertson, N. M., Heiston, E. M., WELTMAN, A. L., & Malin, S. K. (2019) · PubMed Central · Cited by 22
Exogenous β-amyloid peptide interferes with GLUT4 localization in neurons
de Oliveira, L. T., Leon, G., Provance, D. W., Mello, F. G. D., Sorenson, M. M., & Salerno, V. P. (2015) · Brain Research · doi:10.1016/j.brainres.2015.04.026 · Cited by 20
The hidden variables problem in Alzheimer's disease clinical trial design
Liyanage, S., Santos, C., & Weaver, D. F. (2018) · Alzheimer's & Dementia · doi:10.1016/j.trci.2018.09.003 · Cited by 20
Efficient Coding and Energy Efficiency Are Promoted by Balanced Excitatory and Inhibitory Synaptic Currents in Neuronal Network
Yu, L., Shen, Z., Wang, C., & Yu, Y. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00123 · Cited by 20
Metabolic modulation of neuronal gamma-band oscillations
Vodovozov, W., Schneider, J., Elzoheiry, S., Hollnagel, J., Lewen, A., & Kann, O. (2018) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-018-2156-6 · Cited by 16
Self-citation
Stroke management — recent advances and residual challenges
Norrving, B. G. (2019) · Nature Reviews Neurology · doi:10.1038/s41582-018-0129-1 · Cited by 16
Ghrelin‐mediated improvements in the metabolic phenotype in the R6/2 mouse model of Huntington's disease
Rudenko, O., Springer, C., Skov, L. J., Madsen, A. N., Hasholt, L., Nørremølle, A., & Holst, B. (2019) · Journal of Neuroendocrinology · doi:10.1111/jne.12699 · Cited by 16
Adult neurogenic and antidepressant effects of adiponectin: a potential replacement for exercise?
Li, A., Yau, S., Machado, S. E. D. C., Yuan, T., & So, K. (2015) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527315666151111125533 · Cited by 14
How the cognitive reserve interacts with β-amyloid deposition in mitigating FDG metabolism
Carapelle, E., Serra, L., Modoni, S., Falcone, M., Caltagirone, C., Bozzali, M., Specchio, L. M., & Avolio, C. (2017) · Medicine · doi:10.1097/md.0000000000005876 · Cited by 13
Rescue of Transgenic Alzheimer’s Pathophysiology by Polymeric Cellular Prion Protein Antagonists
Gunther, E. C., Smith, L. M., Kostylev, M. A., Cox, T. O., Kaufman, A. C., Lee, S., Folta‐Stogniew, E. J., Maynard, G. D., Um, J. W., Stagi, M., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.01.064 · Cited by 12
Corrigendum: Evaluation of Metformin on Cognitive Improvement in Patients With Non-dementia Vascular Cognitive Impairment and Abnormal Glucose Metabolism
Lin, Y., Wang, K., Ma, C., Wang, X., Gong, Z., Zhang, R., Zang, D., & Cheng, Y. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00322 · Cited by 12
Role of hypertonic sodium lactate in traumatic brain injury management
Arifianto, M. R., Ma'ruf, A. Z., Ibrahim, A., & Bajamal, A. H. (2018) · Asian Journal of Neurosurgery · doi:10.4103/ajns.ajns_10_17 · Cited by 11
One decade ago, one decade ahead in huntington's disease
Wild, E. J., & Tabrizi, S. J. (2019) · Movement Disorders · doi:10.1002/mds.27849 · Cited by 11
A clinician's guide to inpatient low carbohydrate diets for remission of type 2 diabetes : toward a standard of care protocol
Cucuzzella, M. T., Hite, A. H., Patterson, K., & Saslow, L. R. (2019) · Diabetes Management · doi:10.37532/1758-1907.2019.9(1).7-19 · Cited by 6

Sorted by citations

Hallmarks of neurodegenerative diseases
Wilson, D. M., Cookson, M. R., Van Den Bosch, L., Zetterberg, H., Holtzman, D. M., & Dewachter, I. (2023) · Cell · doi:10.1016/j.cell.2022.12.032 · Cited by 1,789
Mitochondrial dysfunction: mechanisms and advances in therapy
Yao, Z., Li, H., Liao, P., Chen, L., Pan, Y., Zheng, Y., Zhang, C., Liu, D., Zheng, M., & Gao, J. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01839-8 · Cited by 1,382
Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases
Loh, J. S., Mak, W. Q., Tan, L. K. S., Ng, C. X., Chan, H. H., Yeow, S. H., Foo, J. B., Ong, Y. S., How, C. W., & Khaw, K. Y. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01743-1 · Cited by 1,193
Mitochondrial Dysfunction and Oxidative Stress in Alzheimer’s Disease
Misrani, A., Tabassum, S., & Yang, L. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.617588 · Cited by 654
Astrocyte-neuron metabolic cooperation shapes brain activity
Bonvento, G., & Bolaños, J. P. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2021.07.006 · Cited by 580

See all 1,003

Authors: Cunnane, S. C., Trushina, E., Morland, C., Prigione, A., Casadesus, G., Andrews, Z. B., Beal, M. F., Bergersen, L. H., Brinton, R. D., de la Monte, S., Eckert, A., Harvey, J., Jeggo, R., Jhamandas, J. H., Kann, O., la Cour, C. M., Martin, W. F., Mithieux, G., Moreira, P. I., Murphy, M. P., Nave, K.-A., Nuriel, T., Oliet, S. H. R., Saudou, F., Mattson, M. P., Swerdlow, R. H., & Millan, M. J.
Affiliations: Université de Sherbrooke (CA)
Mayo Clinic (US)
University of Oslo (NO)
Heinrich Heine University Düsseldorf (DE)
Monash University (AU)
Weill Cornell Medicine (US)
University of Arizona (US)
University of Basel (CH)
University of Dundee (GB)
Institut de Recherches Internationales Servier (France) (FR)
University of Alberta (CA)
Heidelberg University (DE)
Inserm (FR)
University of Coimbra (PT)
University of Cambridge (GB)
Columbia University Irving Medical Center (US)
Université de Bordeaux (FR)
Johns Hopkins University (US)
University of Kansas (US)
Corresponding author: Cunnane, Stephen C.
Millan, Mark J.
ORCID: Cunnane, Stephen C.
Trushina, Eugenia
Morland, Cecilie
Prigione, Alessandro
Andrews, Zane B.
Bergersen, Linda H.
Brinton, Roberta D.
Eckert, Anne
Harvey, Jenni
Jhamandas, Jack H.
Kann, Oliver
Martin, William F.
Mithieux, Gilles
Moreira, Paula I.
Murphy, Michael P.
Nave, Klaus-Armin
Nuriel, Tal
Oliet, Stéphane H. R.
Saudou, Frédéric
Mattson, Mark P.
Swerdlow, Russell H.
Millan, Mark J.
Venue: Nature Reviews Drug Discovery
Publisher: Springer Science and Business Media LLC
Published: 2020-07-24
Volume: 19
Issue: 9
Pages: 609-633
ISSN: 1474-1776 (ISSN-L)
1474-1784
DOI: 10.1038/s41573-020-0072-x
PMC: PMC7948516
OpenAlex: W3044114834
Cited by: 1,003
References: 317
Citations by year: 2026: 174 · 2025: 203 · 2024: 175 · 2023: 174 · 2022: 146 · 2021: 112 · 2020: 19
FWCI: 10.79
Type: journal article
Language: en
Open access: green
discovery.dundee.ac.uk
Licence: other-oa
www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature Reviews Drug Discovery (publishedVersion)
PubMed (publishedVersion)
Discovery Research Portal (University of Dundee) (acceptedVersion, other-oa)
PubMed Central (acceptedVersion)
HAL (submittedVersion, cc-by)
MPG.PuRe (Max Planck Society) (submittedVersion)
NORA - Norwegian Open Research Archives (submittedVersion, other-oa)
Funders: National Science Foundation (P30 AG035982, R37AG053589, R01AG057931)
Alzheimer's Association (P30AG035982)
Wellcome Trust (110159/Z/ 15/Z, /Z/15/Z)
Alzheimer's Society
European Commission (PEst-C/SAU/LA0001/2013, HORIZON2020)
Deutsche Forschungsgemeinschaft (CRC 1134)
Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (31003A, 179294)
Servier
National Institutes of Health (UIDB/04539/2020, 7r21ag064479-03, 1rf1ag062135-01, AG035982, AG026572)
Canadian Institutes of Health Research
Natural Sciences and Engineering Research Council of Canada
Fonds de Recherche du Québec - Santé
Medical Research Council (MC_UU_00015/3, U105663142, MC-U105663142)
National Health and Medical Research Council (1154974)
National Institute on Aging (AG026572, RF1AG059093, R21 AG064479, AG035982, RF1-AG062135, P30AG035982, R15AG050292, R01AG061194, RO1AG062135, R01AG057931, RF1AG55549, R01AG060733, RF1AG055549, R37AG053589, P01AG026572)
National Institute of Neurological Disorders and Stroke (R01NS107265, UH3NS113776)
H2020 European Research Council (834317)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Life Sciences › Neuroscience › Neurology › Neuroprotection in Cerebral Ischemia
Keywords: brain energy metabolism, Alzheimer's disease, glucose metabolism, oxidative phosphorylation, aerobic glycolysis, ketone bodies, mitochondrial dysfunction, insulin sensitivity, RNA therapeutics, lifestyle intervention, treatment options
MeSH terms: Aging, Animals, Brain, Energy Metabolism, Glycolysis, Humans, Oxidative Phosphorylation, Neurodegenerative Diseases

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Brain energy rescue: an emerging therapeutic concept for neurodegenerative disorders of ageing

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks