The DOI matches its Crossref record; 317 of the 317 references it cites were found in a registry or an index.
Brain energy rescue: an emerging therapeutic concept for neurodegenerative disorders of ageing
Open accessAbstract
The brain requires a continuous supply of energy in the form of ATP, most of which is produced from glucose by oxidative phosphorylation in mitochondria, complemented by aerobic glycolysis in the cytoplasm. When glucose levels are limited, ketone bodies generated in the liver and lactate derived from exercising skeletal muscle can also become important energy substrates for the brain. In neurodegenerative disorders of ageing, brain glucose metabolism deteriorates in a progressive, region-specific and disease-specific manner - a problem that is best characterized in Alzheimer disease, where it begins presymptomatically. This Review discusses the status and prospects of therapeutic strategies for countering neurodegenerative disorders of ageing by improving, preserving or rescuing brain energetics. The approaches described include restoring oxidative phosphorylation and glycolysis, increasing insulin sensitivity, correcting mitochondrial dysfunction, ketone-based interventions, acting via hormones that modulate cerebral energetics, RNA therapeutics and complementary multimodal lifestyle changes.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“The brain alone consumes 20% of the total energy required by the body, and central nervous system (CNS) mitochondria meet a majority of this massive energy requirement for the brain”
From Mitochondrial DNA Damage in Substantia Nigra Pars Compacta Astrocytes Exacerbates Dopaminergic Neuron Loss in a 6-Hydroxydopamine Mouse Model of Parkinsonism (2026) · cites this paper as Cunnane et al. 2020
In the citing paper
“impaired brain energetics is a core feature across neurodegenerative diseases, including AD, PD, ALS, FTD, and HD.”
From Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases (2024) · cites this paper as [574]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Dapagliflozin and Cardiovascular Outcomes in Type 2 Diabetes
Wiviott, S. D., Raz, I., Bonaca, M. P., Mosenzon, O., Kato, E. T., Cahn, A., Silverman, M. G., Zelniker, T. A., Kuder, J. F., Murphy, S. A., et al. (2019) · New England Journal of Medicine · doi:10.1056/nejmoa1812389 · Cited by 6,382
AMPK: guardian of metabolism and mitochondrial homeostasis
Herzig, S., & Shaw, R. J. (2017) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.95 · Cited by 4,192
Ngandu, T., Lehtisalo, J., Solomon, A., Levälahti, E., Ahtiluoto, S., Antikainen, R., Bäckman, L., Hänninen, T., Jula, A., Laatikainen, T., et al. (2015) · The Lancet · doi:10.1016/s0140-6736(15)60461-5 · Cited by 3,689
The mechanisms of action of metformin
Rena, G., Hardie, D. G., & Pearson, E. R. (2017) · Diabetologia · doi:10.1007/s00125-017-4342-z · Cited by 2,287
Oxidative stress, dysfunctional glucose metabolism and Alzheimer disease
Butterfield, D. A., & Halliwell, B. (2019) · Nature Reviews Neuroscience · doi:10.1038/s41583-019-0132-6 · Cited by 1,954
Brain insulin resistance in type 2 diabetes and Alzheimer disease: concepts and conundrums
Arnold, S. E., Arvanitakis, Z., Macauley-Rambach, S. L., Koenig, A. M., Wang, H.-Y., Ahima, R. S., Craft, S., Gandy, S., Buettner, C., Stoeckel, L. E., et al. (2018) · Nature Reviews Neurology · doi:10.1038/nrneurol.2017.185 · Cited by 1,597
Disease-Associated Microglia: A Universal Immune Sensor of Neurodegeneration
Deczkowska, A., Keren-Shaul, H., Weiner, A., Colonna, M., Schwartz, M., & Amit, I. (2018) · Cell · doi:10.1016/j.cell.2018.05.003 · Cited by 1,474
Nusinersen versus Sham Control in Later-Onset Spinal Muscular Atrophy
Mercuri, E., Darras, B. T., Chiriboga, C. A., Day, J. W., Campbell, C., Connolly, A. M., Iannaccone, S. T., Kirschner, J., Kuntz, N. L., Saito, K., et al. (2018) · New England Journal of Medicine · doi:10.1056/nejmoa1710504 · Cited by 1,433
Lactate in the brain: from metabolic end-product to signalling molecule
Magistretti, P. J., & Allaman, I. (2018) · Nature Reviews Neuroscience · doi:10.1038/nrn.2018.19 · Cited by 1,298
Lifestyle interventions to prevent cognitive impairment, dementia and Alzheimer disease
Kivipelto, M., Mangialasche, F., & Ngandu, T. (2018) · Nature Reviews Neurology · doi:10.1038/s41582-018-0070-3 · Cited by 1,173
Cited by
Sorted by citations
Hallmarks of neurodegenerative diseases
Wilson, D. M., Cookson, M. R., Van Den Bosch, L., Zetterberg, H., Holtzman, D. M., & Dewachter, I. (2023) · Cell · doi:10.1016/j.cell.2022.12.032 · Cited by 1,789
Mitochondrial dysfunction: mechanisms and advances in therapy
Yao, Z., Li, H., Liao, P., Chen, L., Pan, Y., Zheng, Y., Zhang, C., Liu, D., Zheng, M., & Gao, J. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01839-8 · Cited by 1,382
Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases
Loh, J. S., Mak, W. Q., Tan, L. K. S., Ng, C. X., Chan, H. H., Yeow, S. H., Foo, J. B., Ong, Y. S., How, C. W., & Khaw, K. Y. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01743-1 · Cited by 1,193
Mitochondrial Dysfunction and Oxidative Stress in Alzheimer’s Disease
Misrani, A., Tabassum, S., & Yang, L. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.617588 · Cited by 654
Astrocyte-neuron metabolic cooperation shapes brain activity
Bonvento, G., & Bolaños, J. P. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2021.07.006 · Cited by 580
Effects of Ketone Bodies on Brain Metabolism and Function in Neurodegenerative Diseases
Jensen, N. J., Wodschow, H. Z., Nilsson, M., & Rungby, J. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21228767 · Cited by 450
Yin, F. (2023) · The FEBS Journal · doi:10.1111/febs.16344 · Cited by 441
Bao, H., Cao, J., Chen, M., Min, C., Chen, W., Chen, X., Chen, Y., Chen, Y., Chen, Y., Chen, Z., et al. (2023) · Science China Life Sciences · doi:10.1007/s11427-023-2305-0 · Cited by 402
Glutamate metabolism and recycling at the excitatory synapse in health and neurodegeneration
Andersen, J. V., Markussen, K. H., Jakobsen, E., Schousboe, A., Waagepetersen, H. S., Rosenberg, P. A., & Aldana, B. I. (2021) · Neuropharmacology · doi:10.1016/j.neuropharm.2021.108719 · Cited by 392
Association between age at diabetes onset and subsequent risk of dementia
Barbiellini Amidei, C., Fayosse, A., Dumurgier, J., Machado-Fragua, M. D., Tabak, A. G., van Sloten, T., Kivimäki, M., Dugravot, A., Sabia, S., & Singh-Manoux, A. (2021) · JAMA · doi:10.1001/jama.2021.4001 · Cited by 355
Mi, Y., Qi, G., Vitali, F., Shang, Y., Raikes, A. C., Wang, T., Jin, Y., Brinton, R. D., Gu, H., & Yin, F. (2023) · Nature Metabolism · doi:10.1038/s42255-023-00756-4 · Cited by 343
Self-citationLee, J., & Kim, H.-J. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.931536 · Cited by 310
Metabolic and Signaling Roles of Ketone Bodies in Health and Disease
Puchalska, P., & Crawford, P. A. (2021) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-111120-111518 · Cited by 304
Energy matters: presynaptic metabolism and the maintenance of synaptic transmission
Li, S., & Sheng, Z. (2021) · Nature reviews. Neuroscience · doi:10.1038/s41583-021-00535-8 · Cited by 285
Programming axonal mitochondrial maintenance and bioenergetics in neurodegeneration and regeneration
Cheng, X., Huang, N., & Sheng, Z. (2022) · Neuron · doi:10.1016/j.neuron.2022.03.015 · Cited by 257
Andersen, J. V., Schousboe, A., & Verkhratsky, A. (2022) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2022.102331 · Cited by 263
Dewanjee, S., Chakraborty, P., Bhattacharya, H., Chacko, L., Singh, B., Chaudhary, A., Javvaji, K., Pradhan, S. R., Vallamkondu, J., Dey, A., et al. (2022) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2022.09.032 · Cited by 243
Glucose metabolic crosstalk and regulation in brain function and diseases
Zhang, S., Lachance, B. B., Mattson, M. P., & Jia, X. (2021) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2021.102089 · Cited by 213
Self-citationA ketogenic drink improves cognition in mild cognitive impairment: Results of a 6‐month RCT
Fortier, M., Castellano, C., St‐Pierre, V., Myette‐Côté, É., Langlois, F., Roy, M., Morin, M., Bocti, C., Fülöp, T., Godin, J., et al. (2020) · Alzheimer s & Dementia · doi:10.1002/alz.12206 · Cited by 190
Self-citationMitochondrial Dysfunction in Alzheimers Disease: Opportunities forDrug Development
Bhatia, S., Rawal, R., Sharma, P., Singh, T., Singh, M., & Singh, V. (2021) · Current Neuropharmacology · doi:10.2174/1570159x19666210517114016 · Cited by 209
Zheng, J., Xie, Y., Ren, L., Qi, L., Wu, L., Pan, X., Zhou, J., Zhou, C., & Liu, L. (2021) · Molecular Metabolism · doi:10.1016/j.molmet.2021.101180 · Cited by 190
Chamberlain, K. A., Huang, N., Xie, Y., Licausi, F., Li, S., Li, Y., & Sheng, Z. (2021) · Neuron · doi:10.1016/j.neuron.2021.08.011 · Cited by 184
Intranasal Insulin for Alzheimer’s Disease
Hallschmid, M. (2021) · CNS Drugs · doi:10.1007/s40263-020-00781-x · Cited by 188
Adenosine signalling to astrocytes coordinates brain metabolism and function
Theparambil, S. M., Kopach, O., Braga, A., Nizari, S., Hosford, P. S., Sági‐Kiss, V., Hadjihambi, A., Konstantinou, C., Esteras, N., del Arroyo, A. G., et al. (2024) · Nature · doi:10.1038/s41586-024-07611-w · Cited by 176
Microglia and lipids: how metabolism controls brain innate immunity
Chausse, B., Kakimoto, P. A., & Kann, O. (2021) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2020.08.001 · Cited by 181
Self-citationSun, Y., Zhang, H., Zhang, X., Wang, W., Chen, Y., Cai, Z., Wang, Q., Wang, J., & Shi, Y. (2023) · Redox Biology · doi:10.1016/j.redox.2023.102690 · Cited by 151
The role of mitophagy in the regulation of mitochondrial energetic status in neurons
Han, S., Zhang, M., Jeong, Y. Y., Margolis, D. J., & Cai, Q. (2021) · Autophagy · doi:10.1080/15548627.2021.1907167 · Cited by 151
Andersen, J. V., & Schousboe, A. (2023) · Journal of Neurochemistry · doi:10.1111/jnc.15811 · Cited by 161
Synapses: The Brain’s Energy-Demanding Sites
Faria‐Pereira, A., & Morais, V. A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23073627 · Cited by 152
Insulin resistance in ischemic stroke: Mechanisms and therapeutic approaches
Ding, P.-F., Zhang, H., Wang, J., Gao, Y., Mao, J.-N., Hang, C., & Li, W. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.1092431 · Cited by 143
Glia fuel neurons with locally synthesized ketone bodies to sustain memory under starvation
Silva, B., Mantha, O. L., Schor, J., Pascual, A., Plaçais, P.-Y., Pavlowsky, A., & Préat, T. (2022) · Nature Metabolism · doi:10.1038/s42255-022-00528-6 · Cited by 145
Rehman, M. U., Sehar, N., Dar, N. J., Khan, A., Arafah, A., Rashid, S., Rashid, S. M., & Ganaie, M. A. (2023) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104961 · Cited by 130
Oligodendroglial fatty acid metabolism as a central nervous system energy reserve
Asadollahi, E., Trevisiol, A., Saab, A. S., Looser, Z. J., Dibaj, P., Ebrahimi, R., Kusch, K., Ruhwedel, T., Möbius, W., Jahn, O., et al. (2024) · Nature Neuroscience · doi:10.1038/s41593-024-01749-6 · Cited by 130
Self-citationMitochondrial complex I as a therapeutic target for Alzheimer's disease
Trushina, E. V., Trushin, S., & Hasan, M. F. (2021) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2021.11.003 · Cited by 131
Self-citationBrain Metabolic Alterations in Alzheimer’s Disease
Ardanaz, C. G., Ramírez, M. J., & Solas, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23073785 · Cited by 135
Wang, Z.-J., Li, X.-R., Chai, S.-F., Li, W.-R., Li, S., Hou, M., Li, J.-L., Ye, Y.-C., Cai, H.-Y., Hölscher, C., et al. (2023) · Neuropharmacology · doi:10.1016/j.neuropharm.2023.109716 · Cited by 125
ESPEN guideline on nutrition and hydration in dementia – Update 2024
Volkert, D., Beck, A. M., Irving, G. F., Frühwald, T., Hooper, L., Keller, H., Porter, J. A., Rothenberg, E. M., Suominen, M. H., Wirth, R., et al. (2024) · Clinical Nutrition · doi:10.1016/j.clnu.2024.04.039 · Cited by 138
Aggregation-Induced Emission Luminogen: Role in Biopsy for Precision Medicine
Duo, Y., Han, L., Yang, Y., Wang, Z., Wang, L., Chen, J., Xiang, Z., Yoon, J., Luo, G., & Tang, B. Z. (2024) · Chemical Reviews · doi:10.1021/acs.chemrev.4c00244 · Cited by 119
Effects of dietary restriction on neuroinflammation in neurodegenerative diseases
Fontana, L., Ghezzi, L., Cross, A. H., & Piccio, L. M. (2020) · The Journal of Experimental Medicine · doi:10.1084/jem.20190086 · Cited by 119
Han, H., Zhao, Y., Du, J., Wang, S., Yang, X., Li, W., Song, J., Zhang, S., Zhang, Z., Tan, Y., et al. (2023) · Immunity & Ageing · doi:10.1186/s12979-023-00390-4 · Cited by 122
Aging drives cerebrovascular network remodeling and functional changes in the mouse brain
Bennett, H. C., Zhang, Q., Wu, Y.-T., Manjila, S. B., Chon, U., Shin, D., Vanselow, D. J., Pi, H.-J., Drew, P. J., & Kim, Y. (2024) · Nature Communications · doi:10.1038/s41467-024-50559-8 · Cited by 115
Hallschmid, M. (2021) · Journal of Neuroendocrinology · doi:10.1111/jne.12934 · Cited by 113
Cheng, G., Liu, Y., Ma, R., Cheng, G., Guan, Y., Chen, X., Wu, Z., & Chen, T. (2022) · Nano-Micro Letters · doi:10.1007/s40820-022-00847-z · Cited by 113
Deng, D., Cui, Y., Gan, S., Xie, Z., Cui, S., Cao, K., Wang, S., Shi, G., Yang, L., Bai, S., et al. (2022) · Phytomedicine · doi:10.1016/j.phymed.2022.154395 · Cited by 110
Lactate metabolism in neurodegenerative diseases
Yang, C., Pan, R., Guan, F., & Yuan, Z. (2023) · Neural Regeneration Research · doi:10.4103/1673-5374.374142 · Cited by 115
Effects of Ketogenic Diet on Neuroinflammation in Neurodegenerative Diseases
Jiang, Z., Yin, X., Wang, M., Chen, T., Wang, Y., Gao, Z., & Wang, Z. (2022) · Aging and Disease · doi:10.14336/ad.2021.1217 · Cited by 116
Microtubules and cardiovascular diseases: insights into pathology and therapeutic strategies
Wu, Q., Wang, Y., Liu, J., Guan, X., Chang, X., Liu, Z., & Liu, R. (2024) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2024.106650 · Cited by 112
Jang, J., Kim, S. R., Lee, J. E., Lee, S.-Y., Son, H. J., Choe, W., Yoon, K., Kim, S. S., Yeo, E., & Kang, I. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms25010124 · Cited by 116
Wang, Z., Wang, C., Yuan, B., Liu, L., Zhang, H., Zhu, M., Chai, H., Peng, J., Huang, Y. H., Zhou, S., et al. (2025) · Microbiome · doi:10.1186/s40168-024-02001-w · Cited by 125
A Potential Link Between Visceral Obesity and Risk of Alzheimer’s Disease
Al-Kuraishy, H. M., Al-Gareeb, A. I., Alsayegh, A. A., Hakami, Z. H., Khamjan, N. A., Saad, H. M., Batiha, G. E., & WAARD, M. M. D. (2022) · Neurochemical Research · doi:10.1007/s11064-022-03817-4 · Cited by 106
Andersen, J. V., Skotte, N. H., Christensen, S. K., Polli, F. S., Shabani, M., Markussen, K. H., Haukedal, H., Westi, E. W., Diaz-delCastillo, M., Sun, R. C., et al. (2021) · Cell Death & Disease · doi:10.1038/s41419-021-04237-y · Cited by 104
Health Benefits, Food Applications, and Sustainability of Microalgae-Derived N-3 PUFA
Liu, Y., Ren, X., Fan, C., Wu, W., Zhang, W., & Wang, Y. (2022) · Foods · doi:10.3390/foods11131883 · Cited by 115
Hwang, C. Y., Choe, W., Yoon, K., Ha, J., Kim, S. S., Yeo, E., & Kang, I. (2022) · Nutrients · doi:10.3390/nu14224932 · Cited by 115
Altered Metabolism in Alzheimer Disease Brain: Role of Oxidative Stress
Rummel, N. G., & Butterfield, D. A. (2021) · Antioxidants and Redox Signaling · doi:10.1089/ars.2021.0177 · Cited by 111
Focusing on mitochondria in the brain: from biology to therapeutics
Song, N., Mei, S., Wang, X.-X., Hu, G., & Lu, M. (2024) · Translational Neurodegeneration · doi:10.1186/s40035-024-00409-w · Cited by 111
Jadiya, P., Garbincius, J. F., & Elrod, J. W. (2021) · Acta Neuropathologica Communications · doi:10.1186/s40478-021-01224-4 · Cited by 94
Axonal energy metabolism, and the effects in aging and neurodegenerative diseases
Yang, S., Park, J. H., & Lu, H.-C. (2023) · Molecular Neurodegeneration · doi:10.1186/s13024-023-00634-3 · Cited by 94
Austad, S. N., Ballinger, S. W., Buford, T. W., Carter, C. S., Smith, D. L., Darley-Usmar, V. M., & Zhang, J. (2021) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2021.06.014 · Cited by 94
Glucose metabolism, neural cell senescence and Alzheimer's disease
Wang, Q., Duan, L., Li, X., Wang, Y., Guo, W., Guan, F., & Ma, S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23084351 · Cited by 90
Schilling, S., Chausse, B., Dikmen, H. O., Almouhanna, F., Hollnagel, J., Lewen, A., & Kann, O. (2021) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2021.05.013 · Cited by 91
Self-citationAndersen, J. V., Westi, E. W., Jakobsen, E., Urruticoechea, N., Borges, K., & Aldana, B. I. (2021) · Molecular Brain · doi:10.1186/s13041-021-00842-2 · Cited by 89
Glial Glutamine Homeostasis in Health and Disease
Andersen, J. V., & Schousboe, A. (2022) · Neurochemical Research · doi:10.1007/s11064-022-03771-1 · Cited by 92
Qian, K., Bao, X., Li, Y., Wang, P., Guo, Q., Yang, P., Xu, S., Yu, F., Meng, R., Cheng, Y., et al. (2022) · ACS Nano · doi:10.1021/acsnano.2c05795 · Cited by 87
Mehta, R. I., & Schneider, J. A. (2021) · Current Opinion in Neurology · doi:10.1097/wco.0000000000000912 · Cited by 87
Dietary nutrition for neurological disease therapy: Current status and future directions
Mao, X., Yin, X., Guan, Q.-W., Xia, Q., Yang, N., Zhou, H., Liu, Z., & Jin, W. (2021) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2021.107861 · Cited by 85
Oxygen metabolism abnormality and Alzheimer's disease: An update
Liu, G., Yang, C., Wang, X., Chen, X., Wang, Y., & Le, W. (2023) · Redox Biology · doi:10.1016/j.redox.2023.102955 · Cited by 87
The roles of microglia and astrocytes in neuroinflammation of Alzheimer’s disease
Han, J., Zhang, Z., Zhang, P., Yu, Q., Cheng, Q., Lu, Z., & Zong, S. (2025) · Frontiers in Neuroscience · doi:10.3389/fnins.2025.1575453 · Cited by 97
Wong, J. H., Barron, A. M., & Abdullah, J. M. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.687935 · Cited by 79
Neurotoxic β-amyloid oligomers cause mitochondrial dysfunction—the trigger for PANoptosis in neurons
Meng, X., Song, Q., Liu, Z., Liu, X., Wang, Y., & Liu, J. (2024) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2024.1400544 · Cited by 84
Carelli, S., Rey, F., Ottolenghi, S., Zuccotti, G., & Samaja, M. (2021) · Neural Regeneration Research · doi:10.4103/1673-5374.322430 · Cited by 80
Salcedo, C., Andersen, J. V., Vinten, K. T., Pinborg, L. H., Waagepetersen, H. S., Freude, K., & Aldana, B. I. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.736580 · Cited by 80
From Obesity to Hippocampal Neurodegeneration: Pathogenesis and Non-Pharmacological Interventions
Lee, T. H.-Y., & Yau, S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms22010201 · Cited by 78
Wang, C., Zheng, D., Weng, F., Jin, Y., & He, L. (2021) · Psychopharmacology · doi:10.1007/s00213-021-06025-0 · Cited by 84
Chaulagain, B., Gothwal, A., Lamptey, R. N. L., Trivedi, R., Mahanta, A. K., Layek, B., & Singh, J. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24032710 · Cited by 89
Han, F. Y., Conboy-Schmidt, L., Quist‐Rybachuk, G., Volk, H. A., Zanghi, B. M., Pan, Y., & Borges, K. (2021) · Epilepsia · doi:10.1111/epi.16972 · Cited by 76
Zhang, Q., Song, Q., Yu, R., Wang, A., Jiang, G., Huang, Y., Chen, J., Xu, J., Wang, D., Chen, H., et al. (2023) · Advanced Science · doi:10.1002/advs.202204596 · Cited by 74
Emerging Roles of Endothelial Nitric Oxide in Preservation of Cognitive Health
Katusic, Z. S., d’Uscio, L. V., & He, T. (2023) · Stroke · doi:10.1161/strokeaha.122.041444 · Cited by 73
Galizzi, G., & Carlo, M. D. (2022) · Biology · doi:10.3390/biology11060943 · Cited by 77
He, Y., Wang, K., Su, N., Yuan, C., Zhang, N., Hu, X., Fu, Y., & Zhao, F. (2024) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.70099 · Cited by 83
Stojakovic, A., Trushin, S., Sheu, A., Khalili, L., Chang, S.-Y., Li, X., Christensen, T., Salisbury, J. L., Geroux, R. E., Gateno, B., et al. (2021) · Communications Biology · doi:10.1038/s42003-020-01584-y · Cited by 72
Self-citationLi, H., Kou, B., Yuan, Y., Chai, Y., & Yuan, R. (2021) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2021.113758 · Cited by 71
Can nutrition support healthy cognitive ageing and reduce dementia risk?
Jennings, A., Cunnane, S. C., & Minihane, A. M. (2020) · BMJ · doi:10.1136/bmj.m2269 · Cited by 69
Self-citationFasting: From Physiology to Pathology
Tang, D., Tang, Q., Huang, W., Zhang, Y., Tian, Y., & Fu, X. (2023) · Advanced Science · doi:10.1002/advs.202204487 · Cited by 74
State of the science on brain insulin resistance and cognitive decline due to Alzheimer's disease
Rhea, E. M., Leclerc, M., Yassine, H. N., Capuano, A. W., Tong, H., Petyuk, V. A., Macauley, S. L., Fioramonti, X., Carmichael, O., Calon, F., et al. (2023) · Aging and disease · doi:10.14336/ad.2023.0814 · Cited by 70
Wang, Y., Li, P., Xu, Y., Feng, L., Fang, Y., Song, G., Li, X., Zhu, Z., Wang, W., Mei, Q., et al. (2024) · Journal of Neuroinflammation · doi:10.1186/s12974-024-03303-4 · Cited by 77
Liang, Z., Currais, A. J. M., Soriano‐Castell, D., Schubert, D. A., & Maher, P. A. (2020) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2020.107749 · Cited by 71
Metabolic reprogramming in ischemic stroke: when glycolytic overdrive meets lipid storm
Wang, Y., Ge, M., Wang, J., Xu, Y., Wang, N., & Xu, S. (2025) · Cell Death and Disease · doi:10.1038/s41419-025-08114-w · Cited by 83
Intracellular energy controls dynamics of stress-induced ribonucleoprotein granules
Wang, T., Tian, X., Kim, H. B., Jang, Y., Huang, Z., Na, C. H., & Wang, J. (2022) · Nature Communications · doi:10.1038/s41467-022-33079-1 · Cited by 71
Lactate Supply Overtakes Glucose When Neural Computational and Cognitive Loads Scale Up
Dembitskaya, Y., Piette, C., Siaume‐Perez, S., Berry, H., Magistretti, P. J., & Venance, L. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2212004119 · Cited by 70
The pyruvate dehydrogenase complex: Life’s essential, vulnerable and druggable energy homeostat
Stacpoole, P. W., & McCall, C. E. (2023) · Mitochondrion · doi:10.1016/j.mito.2023.02.007 · Cited by 70
Metabolic Crosstalk between Liver and Brain: From Diseases to Mechanisms
Yang, X., Qiu, K., Jiang, Y., Huang, Y., Zhang, Y., & Liao, Y. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25147621 · Cited by 75
The Brain–Gut Axis, an Important Player in Alzheimer and Parkinson Disease: A Narrative Review
Caradonna, E., Nemni, R., Bifone, A., Gandolfo, P., Costantino, L., Giordano, L., Mormone, E., Macula, A., Cuomo, M., Difruscolo, R., et al. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13144130 · Cited by 80
The metabolic costs of cognition
Jamadar, S. D., Behler, A., Deery, H. A., & Breakspear, M. J. (2025) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2024.11.010 · Cited by 81
Brain NAD Is Associated With ATP Energy Production and Membrane Phospholipid Turnover in Humans
Cuenoud, B. M., İpek, Ö., Shevlyakova, M., Beaumont, M., Cunnane, S. C., Rolf Gruetter, A., & Xin, L. (2020) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2020.609517 · Cited by 66
Self-citationAberrant energy metabolism in Alzheimer’s disease
Yu, L., Jin, J., Xu, Y., & Zhu, X. (2022) · Journal of Translational Internal Medicine · doi:10.2478/jtim-2022-0024 · Cited by 65
Organelle‐Targeting Nanoparticles
Soukar, J., Peppas, N. A., & Gaharwar, A. K. (2025) · Advanced Science · doi:10.1002/advs.202411720 · Cited by 69
Pathophysiology of Lipid Droplets in Neuroglia
Smolič, T., Zorec, R., & Vardjan, N. (2021) · Antioxidants · doi:10.3390/antiox11010022 · Cited by 71
Decourt, B., D’Souza, G. X., Shi, J., Ritter, A., Suazo, J., & Sabbagh, M. N. (2022) · Aging and disease · doi:10.14336/ad.2021.0529 · Cited by 69
Chen, W., Guo, C., Feng, H., & Chen, Y. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2020.615451 · Cited by 64
Disentangling the Relationship Between Chronic Kidney Disease and Cognitive Disorders
Kelly, D., & Rothwell, P. M. (2022) · Frontiers in Neurology · doi:10.3389/fneur.2022.830064 · Cited by 70
Metadata
- Authors
- Cunnane, S. C., Trushina, E., Morland, C., Prigione, A., Casadesus, G., Andrews, Z. B., Beal, M. F., Bergersen, L. H., Brinton, R. D., de la Monte, S., Eckert, A., Harvey, J., Jeggo, R., Jhamandas, J. H., Kann, O., la Cour, C. M., Martin, W. F., Mithieux, G., Moreira, P. I., Murphy, M. P., Nave, K.-A., Nuriel, T., Oliet, S. H. R., Saudou, F., Mattson, M. P., Swerdlow, R. H., & Millan, M. J.
- Affiliations
- Université de Sherbrooke (CA)
- Mayo Clinic (US)
- University of Oslo (NO)
- Heinrich Heine University Düsseldorf (DE)
- Monash University (AU)
- Weill Cornell Medicine (US)
- University of Arizona (US)
- University of Basel (CH)
- University of Dundee (GB)
- Institut de Recherches Internationales Servier (France) (FR)
- University of Alberta (CA)
- Heidelberg University (DE)
- Inserm (FR)
- University of Coimbra (PT)
- University of Cambridge (GB)
- Columbia University Irving Medical Center (US)
- Université de Bordeaux (FR)
- Johns Hopkins University (US)
- University of Kansas (US)
- Corresponding author
- Cunnane, Stephen C.
- Millan, Mark J.
- ORCID
- Cunnane, Stephen C.
- Trushina, Eugenia
- Morland, Cecilie
- Prigione, Alessandro
- Andrews, Zane B.
- Bergersen, Linda H.
- Brinton, Roberta D.
- Eckert, Anne
- Harvey, Jenni
- Jhamandas, Jack H.
- Kann, Oliver
- Martin, William F.
- Mithieux, Gilles
- Moreira, Paula I.
- Murphy, Michael P.
- Nave, Klaus-Armin
- Nuriel, Tal
- Oliet, Stéphane H. R.
- Saudou, Frédéric
- Mattson, Mark P.
- Swerdlow, Russell H.
- Millan, Mark J.
- Venue
- Nature Reviews Drug Discovery
- Published
- 2020-07-24
- Volume
- 19
- Issue
- 9
- Pages
- 609-633
- ISSN
- 1474-1776 (ISSN-L)
- 1474-1784
- PMC
- PMC7948516
- OpenAlex
- W3044114834
- Cited by
- 1,003
- References
- 317
- Citations by year
- 2026: 174 · 2025: 203 · 2024: 175 · 2023: 174 · 2022: 146 · 2021: 112 · 2020: 19
- FWCI
- 10.79
- Type
- journal article
- Language
- en
- Open access
- Licence
- Locations
- Nature Reviews Drug Discovery (publishedVersion)
- PubMed (publishedVersion)
- Discovery Research Portal (University of Dundee) (acceptedVersion, other-oa)
- PubMed Central (acceptedVersion)
- HAL (submittedVersion, cc-by)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- NORA - Norwegian Open Research Archives (submittedVersion, other-oa)
- Funders
- National Science Foundation (P30 AG035982, R37AG053589, R01AG057931)
- Alzheimer's Association (P30AG035982)
- Wellcome Trust (110159/Z/ 15/Z, /Z/15/Z)
- Alzheimer's Society
- European Commission (PEst-C/SAU/LA0001/2013, HORIZON2020)
- Deutsche Forschungsgemeinschaft (CRC 1134)
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (31003A, 179294)
- Servier
- National Institutes of Health (UIDB/04539/2020, 7r21ag064479-03, 1rf1ag062135-01, AG035982, AG026572)
- Canadian Institutes of Health Research
- Natural Sciences and Engineering Research Council of Canada
- Fonds de Recherche du Québec - Santé
- Medical Research Council (MC_UU_00015/3, U105663142, MC-U105663142)
- National Health and Medical Research Council (1154974)
- National Institute on Aging (AG026572, RF1AG059093, R21 AG064479, AG035982, RF1-AG062135, P30AG035982, R15AG050292, R01AG061194, RO1AG062135, R01AG057931, RF1AG55549, R01AG060733, RF1AG055549, R37AG053589, P01AG026572)
- National Institute of Neurological Disorders and Stroke (R01NS107265, UH3NS113776)
- H2020 European Research Council (834317)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neuroprotection in Cerebral Ischemia
- Keywords
- brain energy metabolism, Alzheimer's disease, glucose metabolism, oxidative phosphorylation, aerobic glycolysis, ketone bodies, mitochondrial dysfunction, insulin sensitivity, RNA therapeutics, lifestyle intervention, treatment options
- MeSH terms
- Aging, Animals, Brain, Energy Metabolism, Glycolysis, Humans, Oxidative Phosphorylation, Neurodegenerative Diseases
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
