Cited by 129Phagocytosis and Immune RegulationCell death mechanisms and regulationAutophagy in Disease and Therapy

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Cell death by phagocytosis

Brown, Guy C.·2024·Nature Reviews Immunology

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Abstract

Cells can die as a consequence of being phagocytosed by other cells - a form of cell death that has been called phagotrophy, cell cannibalism, programmed cell removal and primary phagocytosis. However, these are all different manifestations of cell death by phagocytosis (termed 'phagoptosis' for short). The engulfed cells die as a result of cytotoxic oxidants, peptides and degradative enzymes within acidic phagolysosomes. Cell death by phagocytosis was discovered by Metchnikov in the 1880s, but was neglected until recently. It is now known to contribute to developmental cell death in nematodes, Drosophila and mammals, and is central to innate and adaptive immunity against pathogens. Cell death by phagocytosis mediates physiological turnover of erythrocytes and other leucocytes, making it the most abundant form of cell death in the mammalian body. Immunity against cancer is also partly mediated by macrophage phagocytosis of cancer cells, but cancer cells can also phagocytose host cells and other cancer cells in order to survive. Recent evidence indicates neurodegeneration and other neuropathologies can be mediated by microglial phagocytosis of stressed neurons. Thus, despite cell death by phagocytosis being poorly recognized, it is one of the oldest, commonest and most important forms of cell death.

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Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018.
Galluzzi, L., Vitale, I., Aaronson, S. A., Abrams, J. M., Adam, D., Agostinis, P., Alnemri, E. S., Altucci, L., Amelio, I., Andrews, D. W., et al. (2018) · Cell Death & Differentiation · doi:10.1038/s41418-017-0012-4 · Cited by 6,680
Role of CD47 as a Marker of Self on Red Blood Cells
Oldenborg, P., Zheleznyak, A., Fang, Y., Lagenaur, C. F., Gresham, H. D., & Lindberg, F. P. (2000) · Science · doi:10.1126/science.288.5473.2051 · Cited by 2,018
Senescence surveillance of pre-malignant hepatocytes limits liver cancer development
Kang, T.-W., Yevsa, T., Woller, N., Hoenicke, L., Wuestefeld, T., Dauch, D., Hohmeyer, A., Gereke, M., Rudalska, R., Potapova, A., et al. (2011) · Nature · doi:10.1038/nature10599 · Cited by 1,621
CD47 Is Upregulated on Circulating Hematopoietic Stem Cells and Leukemia Cells to Avoid Phagocytosis
Jaiswal, S., Jamieson, C. H. M., Pang, W. W., Park, C. Y., Chao, M. P., Majeti, R., Traver, D. J., van Rooijen, N., & Weissman, I. L. (2009) · Cell · doi:10.1016/j.cell.2009.05.046 · Cited by 1,578
Cell-Surface Calreticulin Initiates Clearance of Viable or Apoptotic Cells through trans-Activation of LRP on the Phagocyte
Gardai, S. J., McPhillips, K. A., Frasch, S. C., Janssen, W. J., Starefeldt, A., Murphy-Ullrich, J. E., Bratton, D. L., Oldenborg, P.-A., Michalak, M., & Henson, P. M. (2005) · Cell · doi:10.1016/j.cell.2005.08.032 · Cited by 1,473
Programmed cell senescence during mammalian embryonic development
Muñoz-Espín, D., Cañamero, M., Maraver, A., Gómez-López, G., Contreras, J., Murillo-Cuesta, S., Rodríguez-Baeza, A., Varela-Nieto, I., Ruberte, J., Collado, M., et al. (2013) · Cell · doi:10.1016/j.cell.2013.10.019 · Cited by 1,428
CD24 signalling through macrophage Siglec-10 is a target for cancer immunotherapy
Barkal, A. A., Brewer, R. E., Markovic, M., Kowarsky, M., Barkal, S. A., Zaro, B. W., Krishnan, V., Hatakeyama, J., Dorigo, O., Barkal, L. J., et al. (2019) · Nature · doi:10.1038/s41586-019-1456-0 · Cited by 1,409
The multifaceted functions of neutrophils
Mayadas, T. N., Cullere, X., & Lowell, C. A. (2014) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-020712-164023 · Cited by 1,356
Neuronal Cell Death
Fricker, M., Tolkovsky, A. M., Borutaitė, V., Coleman, M. P., & Brown, G. C. (2018) · Physiological Reviews · doi:10.1152/physrev.00011.2017 · Cited by 1,152
Self-citation
C1q and Mannose Binding Lectin Engagement of Cell Surface Calreticulin and Cd91 Initiates Macropinocytosis and Uptake of Apoptotic Cells
Ogden, C. A., deCathelineau, A. M., Hoffmann, P. R., Bratton, D. L., Ghebrehiwet, B., Fadok, V. A., & Henson, P. M. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.194.6.781 · Cited by 1,148
Microglia Regulate the Number of Neural Precursor Cells in the Developing Cerebral Cortex
Cunningham, C. L., Martínez-Cerdeño, V., & Noctor, S. C. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.3441-12.2013 · Cited by 976
Phagocytosis checkpoints as new targets for cancer immunotherapy
Feng, M., Jiang, W., Kim, B. Y. S., Zhang, C. C., Fu, Y., & Weissman, I. L. (2019) · Nature reviews. Cancer · doi:10.1038/s41568-019-0183-z · Cited by 937
The clearance of dead cells by efferocytosis
Boada-Romero, E., Martinez, J., Heckmann, B. L., & Green, D. R. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-0232-1 · Cited by 924
UDP acting at P2Y6 receptors is a mediator of microglial phagocytosis
Koizumi, S., Shigemoto-Mogami, Y., Nasu-Tada, K., Shinozaki, Y., Ohsawa, K., Tsuda, M., Joshi, B. V., Jacobson, K. A., Kohsaka, S., & Inoue, K. (2007) · Nature · doi:10.1038/nature05704 · Cited by 802
Rhythmic Modulation of the Hematopoietic Niche through Neutrophil Clearance
Casanova-Acebes, M., Pitaval, C., Weiss, L. A., Nombela‐Arrieta, C., Chèvre, R., A-González, N., Kunisaki, Y., Zhang, D., van Rooijen, N., Silberstein, L. E., et al. (2013) · Cell · doi:10.1016/j.cell.2013.04.040 · Cited by 785
Calreticulin Is the Dominant Pro-Phagocytic Signal on Multiple Human Cancers and Is Counterbalanced by CD47
Chao, M. P., Jaiswal, S., Weissman-Tsukamoto, R., Alizadeh, A. A., Gentles, A. J., Volkmer, J., Weiskopf, K., Willingham, S. B., Raveh, T., Park, C. Y., et al. (2010) · Science Translational Medicine · doi:10.1126/scitranslmed.3001375 · Cited by 776
Microglia Promote the Death of Developing Purkinje Cells
Marı́n-Teva, J. L., Dusart, I., Colin, C., Gervais, A., van Rooijen, N., & Mallat, M. (2004) · Neuron · doi:10.1016/s0896-6273(04)00069-8 · Cited by 757
A Nonapoptotic Cell Death Process, Entosis, that Occurs by Cell-in-Cell Invasion
Overholtzer, M., Mailleux, A. A., Mouneimne, G., Normand, G., Schnitt, S. J., King, R. W., Cibas, E. S., & Brugge, J. S. (2007) · Cell · doi:10.1016/j.cell.2007.10.040 · Cited by 748
CD47-blocking antibodies restore phagocytosis and prevent atherosclerosis
Kojima, Y., Volkmer, J.-P., McKenna, K., Civelek, M., Lusis, A. J., Miller, C. L., Direnzo, D., Nanda, V., Ye, J., Connolly, A. J., et al. (2016) · Nature · doi:10.1038/nature18935 · Cited by 683
A complement–microglial axis drives synapse loss during virus-induced memory impairment
Vasek, M. J., Garber, C., Dorsey, D., Durrant, D. M., Bollman, B., Soung, A., Yu, J., Perez-Torres, C., Frouin, A., Wilton, D. K., et al. (2016) · Nature · doi:10.1038/nature18283 · Cited by 671
Phagocytosis: Our Current Understanding of a Universal Biological Process
Uribe-Querol, E., & Rosales, C. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01066 · Cited by 651
TAM receptors regulate multiple features of microglial physiology
Fourgeaud, L., Través, P. G., Tufail, Y., Leal-Bailey, H., Lew, E. D., Burrola, P. G., Callaway, P., Zagórska, A., Rothlin, C. V., Nimmerjahn, A., et al. (2016) · Nature · doi:10.1038/nature17630 · Cited by 600
Phagocytosis and antigen presentation in dendritic cells
Savina, A., & Amigorena, S. (2007) · Immunological Reviews · doi:10.1111/j.1600-065x.2007.00552.x · Cited by 562
Caspase-mediated cleavage of phospholipid flippase for apoptotic phosphatidylserine exposure
Segawa, K., Kurata, S., Yanagihashi, Y., Brummelkamp, T. R., Matsuda, F., & Nagata, S. (2014) · Science · doi:10.1126/science.1252809 · Cited by 528
Redox Reactions and Microbial Killing in the Neutrophil Phagosome
Winterbourn, C. C., & Kettle, A. J. (2013) · Antioxidants & Redox Signaling · doi:10.1089/ars.2012.4827 · Cited by 468
Microglial phagocytosis of living photoreceptors contributes to inherited retinal degeneration
Zhao, L., Zabel, M. K., Wang, X., Ma, W., Shah, P., Fariss, R. N., Qian, H., Parkhurst, C. N., Gan, W., & Wong, W. T. (2015) · EMBO Molecular Medicine · doi:10.15252/emmm.201505298 · Cited by 457
How macrophages deal with death
Lemke, G. (2019) · Nature reviews. Immunology · doi:10.1038/s41577-019-0167-y · Cited by 446
Calreticulin and cancer
Fucikova, J. P., Špíšek, R., Kroemer, G., & Galluzzi, L. (2020) · Cell Research · doi:10.1038/s41422-020-0383-9 · Cited by 422
Inhibition of Microglial Phagocytosis Is Sufficient To Prevent Inflammatory Neuronal Death
Neher, J. J., Neniskyte, U., Zhao, J.-W., Bal-Price, A., Tolkovsky, A. M., & Brown, G. C. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1003600 · Cited by 373
Self-citation
Phagocytosis executes delayed neuronal death after focal brain ischemia
Neher, J. J., Emmrich, J., Fricker, M., Mander, P. K., Théry, C., & Brown, G. C. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1308679110 · Cited by 364
Self-citation
Phagocytosis promotes programmed cell death in C. elegans
Reddien, P. W., Cameron, S., & Horvitz, H. R. (2001) · Nature · doi:10.1038/35084096 · Cited by 354
Mechanism of removal of senescent cells by human macrophages in situ.
Kay, M. M. B. (1975) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.72.9.3521 · Cited by 349
Biochemical and functional characterization of the interaction between pentraxin 3 and C1q
Nauta, A. J., Bottazzi, B., Mantovani, A., Salvatori, G., Kishore, U., Schwaeble, W., Gingras, A. R., Tzima, S., Vivanco, F., Egido, J., et al. (2003) · European Journal of Immunology · doi:10.1002/immu.200310022 · Cited by 348
CD47 functions as a molecular switch for erythrocyte phagocytosis
Burger, P., Hilarius-Stokman, P., de Korte, D., van den Berg, T. K., & van Bruggen, R. (2012) · Blood · doi:10.1182/blood-2011-10-386805 · Cited by 338
The origin of Metazoa: a unicellular perspective
Sebé-Pedrós, A., Degnan, B. M., & Ruiz-Trillo, I. (2017) · Nature Reviews Genetics · doi:10.1038/nrg.2017.21 · Cited by 332
Engulfment genes cooperate with ced-3 to promote cell death in Caenorhabditis elegans
Hoeppner, D. J., Hengartner, M. O., & Schnabel, R. (2001) · Nature · doi:10.1038/35084103 · Cited by 295
Microglial phagocytosis of neurons in neurodegeneration, and its regulation
Butler, C. A., Popescu, A. S., Kitchener, E. J. A., Allendorf, D. H., Puigdellívol, M., & Brown, G. C. (2021) · Journal of Neurochemistry · doi:10.1111/jnc.15327 · Cited by 295
Self-citation
Cannibalism of Live Lymphocytes by Human Metastatic but Not Primary Melanoma Cells
Lugini, L., Matarrese, P., Tinari, A., Lozupone, F., Federici, C., Iessi, E., Gentile, M., Luciani, F., Parmiani, G., Rivoltini, L., et al. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-3204 · Cited by 289
Macrophages eliminate circulating tumor cells after monoclonal antibody therapy
Gül, N., Babes, L., Siegmund, K., Korthouwer, R., Bögels, M., Braster, R., Vidarsson, G., ten Hagen, T. L. M., Kubes, P., & van Egmond, M. (2014) · Journal of Clinical Investigation · doi:10.1172/jci66776 · Cited by 283
From the Cradle to the Grave: The Role of Macrophages in Erythropoiesis and Erythrophagocytosis
Klei, T. R. L., Meinderts, S. M., van den Berg, T. K., & van Bruggen, R. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00073 · Cited by 279
bcl-2 inhibits apoptosis of neutrophils but not their engulfment by macrophages.
Lagasse, E., & Weissman, I. L. (1994) · The Journal of Experimental Medicine · doi:10.1084/jem.179.3.1047 · Cited by 274
Programmed cell removal: a new obstacle in the road to developing cancer
Chao, M. P., Majeti, R., & Weissman, I. L. (2011) · Nature reviews. Cancer · doi:10.1038/nrc3171 · Cited by 246
Receptor for advanced glycation end products binds to phosphatidylserine and assists in the clearance of apoptotic cells
He, M. T., Kubo, H., Morimoto, K., Fujino, N., Suzuki, T., Takahasi, T., Yamada, M., Yamaya, M., Maekawa, T., Yamamoto, Y., et al. (2011) · EMBO Reports · doi:10.1038/embor.2011.28 · Cited by 232
Membrane phosphatidylserine distribution as a non-apoptotic signalling mechanism in lymphocytes
Elliott, J. I., Surprenant, A., Marelli‐Berg, F. M., Cooper, J. C., Cassady-Cain, R. L., Wooding, C., Linton, K. J., Alexander, D. R., & Higgins, C. F. (2005) · Nature Cell Biology · doi:10.1038/ncb1279 · Cited by 228
Neuronal Death Induced by Nanomolar Amyloid β Is Mediated by Primary Phagocytosis of Neurons by Microglia
Neniškytė, U., Neher, J. J., & Brown, G. C. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.267583 · Cited by 215
Self-citation
Constitutive exposure of phosphatidylserine on viable cells
Segawa, K., Suzuki, J., & Nagata, S. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1114799108 · Cited by 212
Binding and Phagocytosis of Apoptotic Vascular Smooth Muscle Cells Is Mediated in Part by Exposure of Phosphatidylserine
Bennett, M. R., Gibson, D. F., Schwartz, S. M., & Tait, J. F. (1995) · Circulation Research · doi:10.1161/01.res.77.6.1136 · Cited by 206
Regulated Externalization of Phosphatidylserine at the Cell Surface
Balasubramanian, K., Mirnikjoo, B., & Schroit, A. J. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m700202200 · Cited by 197
The receptor DNGR-1 signals for phagosomal rupture to promote cross-presentation of dead-cell-associated antigens
Canton, J., Blees, H., Henry, C. M., Buck, M. D., Schulz, O., Rogers, N. C., Childs, E., Zelenay, S., Rhys, H. I., Domart, M., et al. (2020) · Nature Immunology · doi:10.1038/s41590-020-00824-x · Cited by 197
Fractalkine-Dependent Microglial Pruning of Viable Oligodendrocyte Progenitor Cells Regulates Myelination
Nemes-Baran, A. D., White, D. R., & DeSilva, T. M. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.108047 · Cited by 196
Living Neurons with Tau Filaments Aberrantly Expose Phosphatidylserine and Are Phagocytosed by Microglia
Brelstaff, J., Tolkovsky, A. M., Ghetti, B., Goedert, M., & Spillantini, M. G. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.07.072 · Cited by 195
Sex differences in microglial phagocytosis in the neonatal hippocampus
Nelson, L. H., Warden, S., & Lenz, K. M. (2017) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2017.03.010 · Cited by 189
Reduced expression of CD47 during murine red blood cell (RBC) senescence and its role in RBC clearance from the circulation
Khandelwal, S., van Rooijen, N., & Saxena, R. K. (2007) · Transfusion · doi:10.1111/j.1537-2995.2007.01348.x · Cited by 185
High Mobility Group Protein-1 Inhibits Phagocytosis of Apoptotic Neutrophils through Binding to Phosphatidylserine
Liu, G., Wang, J., Park, Y.-J., Tsuruta, Y., Lorne, E., Zhao, X., & Abraham, E. H. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.6.4240 · Cited by 185
Antigen recognition induces phosphatidylserine exposure on the cell surface of human CD8+ T cells
Fischer, K., Völkl, S., Berger, J., Andreesen, R., Pomorski, T. G., & Mackensen, A. (2006) · Blood · doi:10.1182/blood-2006-03-011742 · Cited by 169
Mechanisms of phagocytosis and host clearance of Pseudomonas aeruginosa
Lovewell, R. R., Patankar, Y. R., & Berwin, B. L. (2014) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00335.2013 · Cited by 166
Programmed cell removal by calreticulin in tissue homeostasis and cancer
Feng, M., Marjon, K. D., Zhu, F., Weissman-Tsukamoto, R., Levett, A., Sullivan, K., Kao, K. S., Markovic, M., Bump, P. A., Jackson, H. M., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-05211-7 · Cited by 159
Lipid peroxidation causes endosomal antigen release for cross-presentation
Dingjan, I., Verboogen, D. R. J., Paardekooper, L. M., Revelo, N. H., Sittig, S. P., Visser, L. J., von Mollard, G. F., Henriet, S., Figdor, C. G., ter Beest, M., et al. (2016) · Scientific Reports · doi:10.1038/srep22064 · Cited by 153
Inhibition of UDP/P2Y6 purinergic signaling prevents phagocytosis of viable neurons by activated microglia in vitro and in vivo
Neher, J. J., Neniškytė, U., Hornik, T. C., & Brown, G. C. (2014) · Glia · doi:10.1002/glia.22693 · Cited by 149
Self-citation
Scavenger receptors in host defense: from functional aspects to mode of action
Taban, Q., Mumtaz, P. T., Masoodi, K. Z., Haq, E., & Ahmad, S. M. (2022) · Cell Communication and Signaling · doi:10.1186/s12964-021-00812-0 · Cited by 136
Chemotherapy-induced senescent cancer cells engulf other cells to enhance their survival
Tonnessen-Murray, C. A., Frey, W. D., Rao, S. G., Shahbandi, A., Ungerleider, N. A., Olayiwola, J. O., Murray, L. B., Vinson, B. T., Chrisey, D. B., Lord, C. J., et al. (2019) · Journal of Cell Biology · doi:10.1083/jcb.201904051 · Cited by 127
The Phagocytic Code Regulating Phagocytosis of Mammalian Cells
Cockram, T. O. J., Dundee, J. M., Popescu, A. S., & Brown, G. C. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.629979 · Cited by 117
Self-citation
Senescent cells suppress macrophage-mediated corpse removal via upregulation of the CD47-QPCT/L axis
Schloesser, D., Lindenthal, L., Sauer, J., Chung, K., Chavakis, T., Griesser, E., Baskaran, P., Maier-Habelsberger, U., Fundel‐Clemens, K., Schlotthauer, I., et al. (2022) · The Journal of Cell Biology · doi:10.1083/jcb.202207097 · Cited by 117
Massive oxidation of phospholipid membranes leads to pore creation and bilayer disintegration
Cwiklik, L., & Jungwirth, P. (2010) · Chemical Physics Letters · doi:10.1016/j.cplett.2010.01.010 · Cited by 112
Complement Targets Newborn Retinal Ganglion Cells for Phagocytic Elimination by Microglia
Anderson, S., Zhang, J., Steele, M. R., Romero, C. O., Kautzman, A. G., Schafer, D. P., & Vetter, M. L. (2019) · Journal of Neuroscience · doi:10.1523/jneurosci.1854-18.2018 · Cited by 111
Microglial efferocytosis: Diving into the Alzheimer’s disease gene pool
Romero-Molina, C., Garretti, F., Andrews, S. J., Marcora, E., & Goate, A. M. (2022) · Neuron · doi:10.1016/j.neuron.2022.10.015 · Cited by 111 · cited 1×
“Genome-wide association studies have linked Alzheimer disease risk to variants of many genes regulating microglial phagocytosis 117 .”
PAI-1 inhibits neutrophil efferocytosis
Park, Y.-J., Liu, G., Lorne, E., Zhao, X., Wang, J., Tsuruta, Y., Zmijewski, J. W., & Abraham, E. H. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0801394105 · Cited by 110
TREM2 triggers microglial density and age-related neuronal loss
Linnartz‐Gerlach, B., Bodea, L., Klaus, C., Ginolhac, A., Halder, R., Sinkkonen, L., Walter, J., Colonna, M., & Neumann, H. (2019) · Glia · doi:10.1002/glia.23563 · Cited by 104
Ion Transport in Eryptosis, the Suicidal Death of Erythrocytes
Föller, M., & Lang, F. J. W. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00597 · Cited by 103
Microglia engulf viable newborn cells in the epileptic dentate gyrus
Luo, C., Koyama, R., & Ikegaya, Y. (2016) · Glia · doi:10.1002/glia.23018 · Cited by 97
Resolvin D1 reprograms energy metabolism to promote microglia to phagocytize neutrophils after ischemic stroke
Li, L., Cheng, S.-Q., Sun, Y., Yu, J.-B., Huang, X.-X., Dong, Y., Ji, J., Zhang, X.-Y., Hu, G., & Sun, X. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112617 · Cited by 97
Naturally-aged microglia exhibit phagocytic dysfunction accompanied by gene expression changes reflective of underlying neurologic disease
Thomas, A. L., Lehn, M. A., Janssen, E. M., Hildeman, D. A., & Chougnet, C. A. (2022) · Scientific Reports · doi:10.1038/s41598-022-21920-y · Cited by 94
TIM-4, a Receptor for Phosphatidylserine, Controls Adaptive Immunity by Regulating the Removal of Antigen-Specific T Cells
Albacker, L. A., Karisola, P., Chang, Y., Umetsu, S. E., Zhou, M., Akbari, O., Kobayashi, N., Baumgarth, N., Freeman, G. J., Umetsu, D. T., et al. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1001360 · Cited by 93
Homotypic cell cannibalism, a cell‐death process regulated by the nuclear protein 1, opposes to metastasis in pancreatic cancer
Cano, C. E., Sandí, M. J., Hamidi, T., Calvo, E. L., Turrini, O., Bartholin, L., Loncle, C., Secq, V., Garcia, S., Lomberk, G. A., et al. (2012) · EMBO Molecular Medicine · doi:10.1002/emmm.201201255 · Cited by 88
Microglial Phagocytosis of Neurons: Diminishing Neuronal Loss in Traumatic, Infectious, Inflammatory, and Autoimmune CNS Disorders
Yanuck, S. F. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00712 · Cited by 88
NADPH oxidase activation regulates apoptotic neutrophil clearance by murine macrophages
Bagaitkar, J., Huang, J., Zeng, M. Y., Pech, N. K., Monlish, D. A., Perez‐Zapata, L. J., Miralda, I., Schuettpelz, L. G., & Dinauer, M. C. (2018) · Blood · doi:10.1182/blood-2017-09-809004 · Cited by 83
Cleavage of Mer Tyrosine Kinase (MerTK) from the Cell Surface Contributes to the Regulation of Retinal Phagocytosis
Law, A.-L., Parinot, C., Chatagnon, J., Gravez, B., Sahel, J., Bhattacharya, S. S., & Nandrot, E. F. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.628297 · Cited by 81
Phosphatidylserine Exposure Controls Viral Innate Immune Responses by Microglia
Tufail, Y., Cook, D., Fourgeaud, L., Powers, C. J., Merten, K., Clark, C. L., Hoffman, E. A., Ngo, A., Sekiguchi, K. J., O’Shea, C. C., et al. (2017) · Neuron · doi:10.1016/j.neuron.2016.12.021 · Cited by 81
The microglial P2Y6 receptor mediates neuronal loss and memory deficits in neurodegeneration
Puigdellívol, M., Milde, S., Vilalta, A., Cockram, T. O. J., Allendorf, D. H., Lee, Y. S., Dundee, J. M., Pampuščenko, K., Borutaitė, V., Nuthall, H. N., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.110148 · Cited by 79
Self-citation
Lactadherin/ MFG ‐E8 is essential for microglia‐mediated neuronal loss and phagoptosis induced by amyloid β
Neniškytė, U., & Brown, G. C. (2013) · Journal of Neurochemistry · doi:10.1111/jnc.12288 · Cited by 78
Self-citation
The origin of phagocytosis in Earth history
Mills, D. B. (2020) · Interface Focus · doi:10.1098/rsfs.2020.0019 · Cited by 78
Internalization of NK cells into tumor cells requires ezrin and leads to programmed cell-in-cell death
Wang, S., Guo, Z., Xia, P., Liu, T., Wang, J., Li, S., Sun, L., Lu, J., Wen, Q., Zhou, M., et al. (2009) · Cell Research · doi:10.1038/cr.2009.114 · Cited by 76
Phagocytosis genes nonautonomously promote developmental cell death in the Drosophila ovary
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Xie, R., Gao, C., Li, W., Zhu, J., Novakovic, V. A., Wang, J., Ma, R., Zhou, J., Gilbert, G. E., & Shi, J. (2011) · Blood · doi:10.1182/blood-2011-06-362186 · Cited by 50
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Tau aggregation and its relation to selected forms of neuronal cell death.
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Live Imaging of Phagoptosis in ex vivo Drosophila Testis
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Amino acids and mechanistic target of rapamycin regulate the fate of live engulfed cells
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LPS-stimulated microglial cells promote ganglion cell death in organotypic cultures of quail embryo retina
Sierra, A., Navascués, J., Neubrand, V. E., Sepúlveda, M. R., Martín‐Oliva, D., Cuadros, M. Á., & Marín‐Teva, J. L. (2023) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2023.1120400 · Cited by 4
Erratum To: Homotypic cell cannibalism, a cell‐death process regulated by the nuclear protein 1, opposes to metastasis in pancreatic cancer
Cano, C. E., Sandí, M. J., Hamidi, T., Calvo, E. L., Turrini, O., Bartholin, L., Loncle, C., Secq, V., Garcia, S., Lomberk, G. A., et al. (2021) · EMBO Molecular Medicine · doi:10.15252/emmm.202114243 · Cited by 2

Research works printed but not linked: 3

Metchnikoff, E. in The Evolutionary Biology Papers of Elie Metchnikoff (eds Gourko, H. et al.) (Springer, 2000).
Sherr, E. B. & Sherr, B. F. in Aquatic Microbial Ecology and Biogeochemistry: A Dual Perspective (eds Glibert P., Kana T.) (Springer, 2016).
Murakami, M., Sugita, A. & Hamasaki, M. Scanning electron microscopic observations of the vas deferens in man and monkey with special reference to spermiophagy in its ampullary region. Scan Electron. Microsc. 3, 1333–1339 (1982).

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Authors: Brown, G. C.
Affiliations: University of Cambridge (GB)
Corresponding author: Brown, Guy C.
ORCID: Brown, Guy C.
Venue: Nature Reviews Immunology
Publisher: Springer Science and Business Media LLC
Published: 2023-08-21
Volume: 24
Issue: 2
Pages: 91-102
ISSN: 1474-1733 (ISSN-L)
1474-1741
DOI: 10.1038/s41577-023-00921-6
OpenAlex: W4386026077
Cited by: 129
References: 141
Citations by year: 2026: 41 · 2025: 62 · 2024: 26
FWCI: 3.58
Type: journal article
Language: en
Open access: closed
Licence: www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
Locations: Nature reviews. Immunology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
Keywords: phagocytosis, cell death, phagolysosomes, erythrocyte turnover, developmental cell death, neurodegeneration, innate immunity, adaptive immunity
MeSH terms: Animals, Humans, Macrophages, Mammals, Neurons, Phagocytosis, Cell Death, Microglia

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