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A framework for developing sex-specific engineered heart models
Open accessAbstract
The convergence of tissue engineering and patient-specific stem cell biology has enabled the engineering of in vitro tissue models that allow the study of patient-tailored treatment modalities. However, sex-related disparities in health and disease, from systemic hormonal influences to cellular-level differences, are often overlooked in stem cell biology, tissue engineering and preclinical screening. The cardiovascular system, in particular, shows considerable sex-related differences, which need to be considered in cardiac tissue engineering. In this Review, we analyse sex-related properties of the heart muscle in the context of health and disease, and discuss a framework for including sex-based differences in human cardiac tissue engineering. We highlight how sex-based features can be implemented at the cellular and tissue levels, and how sex-specific cardiac models could advance the study of cardiovascular diseases. Finally, we define design criteria for sex-specific cardiac tissue engineering and provide an outlook to future research possibilities beyond the cardiovascular system.
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Cites
Takahashi, K., & Yamanaka, S. (2006) · Cell · doi:10.1016/j.cell.2006.07.024 · Cited by 26,673
Heart Disease and Stroke Statistics—2019 Update: A Report From the American Heart Association
Benjamin, E. J., Muntner, P., Alonso, A., Bittencourt, M. S., Callaway, C. W., Carson, A. P., Chamberlain, A. M., Chang, A. R., Cheng, S., Das, S. R., et al. (2019) · Circulation · doi:10.1161/cir.0000000000000659 · Cited by 9,036
Lutolf, M. P., & Hubbell, J. A. (2005) · Nature Biotechnology · doi:10.1038/nbt1055 · Cited by 4,551
Reconstituting organ-level lung functions on a chip
Huh, D., Matthews, B. D., Mammoto, A., Montoya-Zavala, M., Hsin, H. Y., & Ingber, D. E. (2010) · Science · doi:10.1126/science.1188302 · Cited by 4,250
Bhatia, S. N., & Ingber, D. E. (2014) · Nature Biotechnology · doi:10.1038/nbt.2989 · Cited by 3,305
Perfusion-decellularized matrix: using nature's platform to engineer a bioartificial heart
Ott, H. C., Matthiesen, T. S., Goh, S.-K., Black, L. D., Kren, S. M., Netoff, T. I., & Taylor, D. A. (2008) · Nature Medicine · doi:10.1038/nm1684 · Cited by 2,650
X-inactivation profile reveals extensive variability in X-linked gene expression in females
Carrel, L., & Willard, H. F. (2005) · Nature · doi:10.1038/nature03479 · Cited by 2,097
RNA sequencing: the teenage years
Stark, R., Grzelak, M., & Hadfield, J. (2019) · Nature Reviews Genetics · doi:10.1038/s41576-019-0150-2 · Cited by 2,041
Sex and gender: modifiers of health, disease, and medicine
Mauvais-Jarvis, F., Bairey Merz, N., Barnes, P. J., Brinton, R. D., Carrero, J.-J., DeMeo, D. L., De Vries, G. J., Epperson, C. N., Govindan, R., Klein, S. L., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(20)31561-0 · Cited by 2,001
Printing three-dimensional tissue analogues with decellularized extracellular matrix bioink
Pati, F., Jang, J., Ha, D.-H., Won Kim, S., Rhie, J.-W., Shim, J.-H., Kim, D.-H., & Cho, D.-W. (2014) · Nature Communications · doi:10.1038/ncomms4935 · Cited by 1,904
3D bioprinting of collagen to rebuild components of the human heart
Lee, A., Hudson, A. R., Shiwarski, D. J., Tashman, J. W., Hinton, T. J., Yerneni, S., Bliley, J. M., Campbell, P. G., & Feinberg, A. W. (2019) · Science · doi:10.1126/science.aav9051 · Cited by 1,782
Cells of the adult human heart
Litviňuková, M., Talavera-López, C., Maatz, H., Reichart, D., Worth, C. L., Lindberg, E. L., Kanda, M., Polanski, K., Heinig, M., Lee, M., et al. (2020) · Nature · doi:10.1038/s41586-020-2797-4 · Cited by 1,729
Advanced maturation of human cardiac tissue grown from pluripotent stem cells
Ronaldson-Bouchard, K., Ma, S. P., Yeager, K., Chen, T., Song, L., Sirabella, D., Morikawa, K., Teles, D., Yazawa, M., & Vunjak-Novakovic, G. (2018) · Nature · doi:10.1038/s41586-018-0016-3 · Cited by 1,272
Self-citationAcute Myocardial Infarction in Women: A Scientific Statement From the American Heart Association
Mehta, L. S., Beckie, T. M., DeVon, H. A., Grines, C. L., Krumholz, H. M., Johnson, M. N., Lindley, K. J., Vaccarino, V., Wang, T. Y., Watson, K. E., et al. (2016) · Circulation · doi:10.1161/cir.0000000000000351 · Cited by 1,244
An in vivo model of functional and vascularized human brain organoids
Mansour, A. A., Gonçalves, J. T., Bloyd, C. W., Li, H., Fernandes, S., Quang, D., Johnston, S., Parylak, S. L., Jin, X., & Gage, F. H. (2018) · Nature Biotechnology · doi:10.1038/nbt.4127 · Cited by 1,211
Landscape of X chromosome inactivation across human tissues
GTEx Consortium, Tukiainen, T., Villani, A.-C., Yen, A., Rivas, M. A., Marshall, J. L., Satija, R., Aguirre, M., Gauthier, L., Fleharty, M., et al. (2017) · Nature · doi:10.1038/nature24265 · Cited by 1,138
3D Printing of Personalized Thick and Perfusable Cardiac Patches and Hearts
Noor, N., Shapira, A., Edri, R., Gal, I., Wertheim, L., & Dvir, T. (2019) · Advanced Science · doi:10.1002/advs.201900344 · Cited by 1,042
Biomanufacturing of organ-specific tissues with high cellular density and embedded vascular channels
Skylar‐Scott, M. A., Uzel, S. G. M., Nam, L. L., Ahrens, J. H., Truby, R. L., Damaraju, S., & Lewis, J. A. (2019) · Science Advances · doi:10.1126/sciadv.aaw2459 · Cited by 985
Female Gender as a Risk Factor for Torsades de Pointes Associated With Cardiovascular Drugs
Makkar, R. (1993) · JAMA · doi:10.1001/jama.270.21.2590 · Cited by 972
Biowire: a platform for maturation of human pluripotent stem cell–derived cardiomyocytes
Nunes, S. S., Miklas, J. W., Liu, J., Aschar-Sobbi, R., Xiao, Y., Zhang, B., Jiang, J., Massé, S., Gagliardi, M., Hsieh, A., et al. (2013) · Nature Methods · doi:10.1038/nmeth.2524 · Cited by 952
Self-citationSex-Based Differences in Susceptibility to Severe Acute Respiratory Syndrome Coronavirus Infection
Channappanavar, R., Fett, C., Mack, M., Eyck, P. T., Meyerholz, D. K., & Perlman, S. M. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1601896 · Cited by 896
Sex differences in heart failure
Lam, C. S. P., Arnott, C. G., Beale, A. L., Chandramouli, C., Hilfiker‐Kleiner, D., Kaye, D. M., Ky, B., Santema, B. T., Sliwa, K. S., & Voors, A. A. (2019) · European Heart Journal · doi:10.1093/eurheartj/ehz835 · Cited by 873
Maschmeyer, I., Lorenz, A. K., Schimek, K., Hasenberg, T., Ramme, A. P., Hübner, J., Lindner, M., Drewell, C., Bauer, S., Thomas, A., et al. (2015) · Lab on a Chip · doi:10.1039/c5lc00392j · Cited by 861
Accordion-like honeycombs for tissue engineering of cardiac anisotropy
Engelmayr, G. C., Cheng, M., Bettinger, C. J., Borenstein, J. T., Langer, R., & Freed, L. E. (2008) · Nature Materials · doi:10.1038/nmat2316 · Cited by 848
Wang, G., McCain, M. L., Yang, L., He, A., Pasqualini, F. S., Agarwal, A., Yuan, H., Jiang, D., Zhang, D., Zangi, L., et al. (2014) · Nature Medicine · doi:10.1038/nm.3545 · Cited by 837
Biological markers of oxidative stress: Applications to cardiovascular research and practice
Ho, E. C., Galougahi, K. K., Liu, C., Bhindi, R., & Figtree, G. A. (2013) · Redox Biology · doi:10.1016/j.redox.2013.07.006 · Cited by 835
Sex differences in pharmacokinetics predict adverse drug reactions in women
Zucker, I., & Prendergast, B. J. (2020) · Biology of Sex Differences · doi:10.1186/s13293-020-00308-5 · Cited by 777
Nanowired three-dimensional cardiac patches
Dvir, T., Timko, B. P., Brigham, M. D., Naik, S. R., Karajanagi, S. S., Levy, O., Jin, H., Parker, K. K., Langer, R., & Kohane, D. S. (2011) · Nature Nanotechnology · doi:10.1038/nnano.2011.160 · Cited by 763
Gender in cardiovascular diseases: impact on clinical manifestations, management, and outcomes
Regitz‐Zagrosek, V., Oertelt‐Prigione, S., Prescott, E., Franconi, F., Gerdts, E., Foryst‐Ludwig, A., Maas, A. H. E. M., Kautzky‐Willer, A., Knappe-Wegner, D., Kintscher, U., et al. (2015) · European Heart Journal · doi:10.1093/eurheartj/ehv598 · Cited by 761
The impact of sex on gene expression across human tissues
Oliva, M., Muñoz-Aguirre, M., Kim-Hellmuth, S., Wucher, V., Gewirtz, A. D., Cotter, D. J., Parsana, P., Kasela, S., Balliu, B., Viñuela, A., et al. (2020) · Science · doi:10.1126/science.aba3066 · Cited by 697
Patient-specific induced pluripotent stem cells as a model for familial dilated cardiomyopathy
Sun, N., Yazawa, M., Liu, J., Han, L., Sanchez-Freire, V., Abilez, O. J., Navarrete, E. G., Hu, S., Wang, L., Lee, A., et al. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3003552 · Cited by 696
Tiburcy, M., Hudson, J. E., Balfanz, P., Schlick, S. F., Meyer, T., Liao, M.-L. C., Levent, E., Raad, F. S., Zeidler, S., Wingender, E., et al. (2017) · Circulation · doi:10.1161/circulationaha.116.024145 · Cited by 663
The extracellular matrix protein agrin promotes heart regeneration in mice
Bassat, E., Mutlak, Y. E., Genzelinakh, A., Shadrin, I. Y., Umansky, K. B., Yifa, O., Kain, D., Rajchman, D., Leach, J. P., Riabov-Bassat, D., et al. (2017) · Nature · doi:10.1038/nature22978 · Cited by 649
Generation of vascular endothelial and smooth muscle cells from human pluripotent stem cells
Patsch, C., Meylan, L. C., Thoma, E., Urich, E., Heckel, T., O’Sullivan, J., Grainger, S. J., Kapp, F., Sun, L., Christensen, K., et al. (2015) · Nature Cell Biology · doi:10.1038/ncb3205 · Cited by 643
Titin mutations in iPS cells define sarcomere insufficiency as a cause of dilated cardiomyopathy
Hinson, J. T., Chopra, A., Nafissi, N., Polacheck, W. J., Benson, C. C., Swist, S., Gorham, J., Yang, L., Schafer, S., Sheng, C. C., et al. (2015) · Science · doi:10.1126/science.aaa5458 · Cited by 638
Sex differences in the evolution of the electrocardiographic QT interval with age.
Rautaharju, P. M., Sh, Z., Wong, S., Hp, C., Berenson, G. S., Prineas, R., & Davignon, A. (1992) · PubMed · Cited by 635
Multi-tissue interactions in an integrated three-tissue organ-on-a-chip platform
Skardal, A., Murphy, S. V., Devarasetty, M., Mead, I., Kang, H.-W., Seol, Y.-J., Shrike Zhang, Y., Shin, S.-R., Zhao, L., Aleman, J., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-08879-x · Cited by 623
Nanoscale cues regulate the structure and function of macroscopic cardiac tissue constructs
Kim, D.-H., Lipke, E. A., Kim, P., Cheong, R., Thompson, S., Delannoy, M., Suh, K.-Y., Tung, L., & Levchenko, A. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0906504107 · Cited by 611
A Platform for Generation of Chamber-Specific Cardiac Tissues and Disease Modeling
Zhao, Y., Rafatian, N., Feric, N. T., Cox, B. J., Aschar-Sobbi, R., Wang, E. Y., Aggarwal, P., Zhang, B., Conant, G., Ronaldson-Bouchard, K., et al. (2019) · Cell · doi:10.1016/j.cell.2018.11.042 · Cited by 610
Self-citationZhang, B., Montgomery, M., Chamberlain, M. D., Ogawa, S., Korolj, A., Pahnke, A., Wells, L. A., Massé, S., Kim, J., Reis, L., et al. (2016) · Nature Materials · doi:10.1038/nmat4570 · Cited by 593
Self-citationAlegría-Torres, J. A., Baccarelli, A., & Bollati, V. (2011) · Epigenomics · doi:10.2217/epi.11.22 · Cited by 587
Zhang, D., Shadrin, I. Y., Lam, J., Xian, H.-Q., Snodgrass, H. R., & Bursac, N. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.04.026 · Cited by 565
Tissue engineering of vascularized cardiac muscle from human embryonic stem cells
Caspi, O., Lesman, A., Basevitch, Y., Gepstein, A., Arbel, G., Habib, I. H. M., Gepstein, L., & Levenberg, S. (2007) · Circulation Research · doi:10.1161/01.res.0000257776.05673.ff · Cited by 558
Musah, S., Mammoto, A., Ferrante, T. C., Jeanty, S. S. F., Hirano-Kobayashi, M., Mammoto, T., Roberts, K., Chung, S., Novak, R., Ingram, M., et al. (2017) · Nature Biomedical Engineering · doi:10.1038/s41551-017-0069 · Cited by 550
Naturally derived myocardial matrix as an injectable scaffold for cardiac tissue engineering
Singelyn, J. M., DeQuach, J. A., Seif-Naraghi, S. B., Littlefield, R. B., Schup-Magoffin, P. J., & Christman, K. L. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2009.06.045 · Cited by 535
Women’s involvement in clinical trials: historical perspective and future implications
Liu, K. A., & Mager, N. A. D. (2016) · Pharmacy Practice · doi:10.18549/pharmpract.2016.01.708 · Cited by 516
Small molecule absorption by PDMS in the context of drug response bioassays
van Meer, B. J., de Vries, H., Firth, K. S. A., van Weerd, J., Tertoolen, L. G. J., Karperien, H. B. J., Jonkheijm, P., Denning, C., IJzerman, A. P., & Mummery, C. L. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.11.062 · Cited by 502
A microfluidic culture model of the human reproductive tract and 28-day menstrual cycle
Xiao, S., Coppeta, J. R., Rogers, H. B., Isenberg, B. C., Zhu, J., Olalekan, S. A., McKinnon, K. E., Đokić, D., Rashedi, A. S., Haisenleder, D. J., et al. (2017) · Nature Communications · doi:10.1038/ncomms14584 · Cited by 492
Interconnected Microphysiological Systems for Quantitative Biology and Pharmacology Studies
Edington, C. D., Chen, W. L. K., Geishecker, E., Kassis, T., Soenksen, L. R., Bhushan, B. M., Freake, D., Kirschner, J., Maass, C., Tsamandouras, N., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-22749-0 · Cited by 487
Ruan, J.-L., Tulloch, N. L., Razumova, M. V., Saiget, M., Muskheli, V., Pabon, L., Reinecke, H., Regnier, M., & Murry, C. E. (2016) · Circulation · doi:10.1161/circulationaha.114.014998 · Cited by 467
Sex Differences in Gene Expression and Regulatory Networks across 29 Human Tissues
Lopes‐Ramos, C. M., Chen, C.-Y., Kuijjer, M. L., Paulson, J. N., Sonawane, A. R., Fagny, M., Platig, J., Glass, K., Quackenbush, J. F., & DeMeo, D. L. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.107795 · Cited by 462
Deng, Q., Hu, B., Zhang, Y., Wang, H., Zhou, X., Hu, W., Cheng, Y., Yan, J., Ping, H., & Zhou, Q. T. (2020) · International Journal of Cardiology · doi:10.1016/j.ijcard.2020.03.087 · Cited by 455
Gender differences in cardiovascular disease
Gao, Z., Chen, Z., Sun, A., & Deng, X. (2019) · Medicine in Novel Technology and Devices · doi:10.1016/j.medntd.2019.100025 · Cited by 423
Shadrin, I. Y., Allen, B. W., Qian, Y., Jackman, C. P., Carlson, A. L., Juhas, M. E., & Bursac, N. (2017) · Nature Communications · doi:10.1038/s41467-017-01946-x · Cited by 420
Lee, J. H., Protze, S. I., Laksman, Z., Backx, P. H., & Keller, G. M. (2017) · Cell stem cell · doi:10.1016/j.stem.2017.07.003 · Cited by 404
Stramba‐Badiale, M., Fox, K. M., Priori, S. G., Collins, P. D., Daly, C., Graham, I. D., Jonsson, B., Schenck-Gustafsson, K. G., & Tendera, M. (2006) · European Heart Journal · doi:10.1093/eurheartj/ehi819 · Cited by 393
GELLER, S. E., Koch, A., Pellettieri, B. F., & Carnes, M. L. (2011) · Journal of Women s Health · doi:10.1089/jwh.2010.2469 · Cited by 379
Concise Review: Maturation Phases of Human Pluripotent Stem Cell-Derived Cardiomyocytes
Robertson, C., Tran, D., & George, S. C. (2013) · Stem Cells · doi:10.1002/stem.1331 · Cited by 372
Tallawi, M., Rosellini, E., Barbani, N., Cascone, M. G., Rai, R., Saint-Pierre, G., & Boccaccini, A. R. (2015) · Journal of The Royal Society Interface · doi:10.1098/rsif.2015.0254 · Cited by 368
Protze, S. I., Liu, J., Nussinovitch, U., Ohana, L., Backx, P. H., Gepstein, L., & Keller, G. M. (2017) · Nature Biotechnology · doi:10.1038/nbt.3745 · Cited by 366
Hirt, M. N., Boeddinghaus, J., Mitchell, A. N., Schaaf, S., Börnchen, C., Müller, C., Schulz, H., Hübner, N., Stenzig, J., Stoehr, A., et al. (2014) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2014.05.009 · Cited by 363
Ramaekers, D. (1998) · European Heart Journal · doi:10.1053/euhj.1998.1084 · Cited by 354
Sex Differences in Drug Disposition
Soldin, O. P., Chung, S. H., & Mattison, D. R. (2011) · BioMed Research International · doi:10.1155/2011/187103 · Cited by 353
Mazure, C. M., & Jones, D. P. (2015) · BMC Women s Health · doi:10.1186/s12905-015-0251-9 · Cited by 339
Patten, R. D., Pourati, I., Aronovitz, M. J., Baur, J., Celestin, F., Chen, X., Michael, A., Haq, S., Nuedling, S., Grohé, C., et al. (2004) · Circulation Research · doi:10.1161/01.res.0000144126.57786.89 · Cited by 333
Cardiovascular Disease and the Female Disadvantage
Woodward, M. (2019) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph16071165 · Cited by 329
Sex and Gender Differences in Myocarditis and Dilated Cardiomyopathy
Fairweather, D., Cooper, L. T., & Blauwet, L. A. (2013) · Current Problems in Cardiology · doi:10.1016/j.cpcardiol.2012.07.003 · Cited by 325
Gender differences in the effects of cardiovascular drugs
Tamargo, J. L., Rosano, G. M. C., Walther, T., Duarte, J., Niessner, A., Kaski, J., Ceconi, C., Drexel, H., Kjeldsen, K. P., Savarese, G., et al. (2016) · European Heart Journal - Cardiovascular Pharmacotherapy · doi:10.1093/ehjcvp/pvw042 · Cited by 325
The gestational foundation of sex differences in development and vulnerability
DiPietro, J. A., & Voegtline, K. M. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2015.07.068 · Cited by 316
Optical Imaging of Voltage and Calcium in Cardiac Cells & Tissues
Herron, T. J., Lee, P., & Jalife, J. (2012) · Circulation Research · doi:10.1161/circresaha.111.247494 · Cited by 303
Gender and the renin–angiotensin–aldosterone system
Komukai, K., Mochizuki, S., & Yoshimura, M. (2010) · Fundamental and Clinical Pharmacology · doi:10.1111/j.1472-8206.2010.00854.x · Cited by 295
McLellan, M. A., Skelly, D. A., Dona, M. S. I., Squiers, G. T., Farrugia, G. E., Gaynor, T. L., Cohen, C. D., Pandey, R., Diep, H., Vinh, A., et al. (2020) · Circulation · doi:10.1161/circulationaha.119.045115 · Cited by 289
Estrogen accelerates the resolution of inflammation in macrophagic cells
Villa, A. M., Rizzi, N., Vegeto, E., Ciana, P., & Maggi, A. C. (2015) · Scientific Reports · doi:10.1038/srep15224 · Cited by 283
Goldfracht, I., Protze, S. I., Shiti, A., Setter, N., Gruber, A., Shaheen, N., Nartiss, Y., Keller, G. M., & Gepstein, L. (2020) · Nature Communications · doi:10.1038/s41467-019-13868-x · Cited by 269
The landscape of sex-differential transcriptome and its consequent selection in human adults
Gershoni, M., & Pietrokovski, S. (2017) · BMC Biology · doi:10.1186/s12915-017-0352-z · Cited by 268
Social, behavioral, and biological factors, and sex differences in mortality
Rogers, R. G., Everett, B. G., Onge, J. M. S., & Krueger, P. M. (2010) · Demography · doi:10.1353/dem.0.0119 · Cited by 263
Early androgen exposure and human gender development
Hines, M., Constantinescu, M., & Spencer, D. (2015) · Biology of Sex Differences · doi:10.1186/s13293-015-0022-1 · Cited by 263
Composite scaffold provides a cell delivery platform for cardiovascular repair
Godier-Furnémont, A., Martens, T. P., Koeckert, M. S., Wan, L. Q., Parks, J. J., Arai, K., Zhang, G., Hudson, B. I., Homma, S., & Vunjak‐Novakovic, G. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1104619108 · Cited by 263
Self-citationCardiovascular Disease Risk Factors and Myocardial Infarction in the Transgender Population
Alzahrani, T., Nguyen, T., Ryan, A., Dwairy, A., McCaffrey, J. A., Yunus, R. N., Forgione, J., Krepp, J. M., Nagy, C. D., Mazhari, R., et al. (2019) · Circulation Cardiovascular Quality and Outcomes · doi:10.1161/circoutcomes.119.005597 · Cited by 260
Decellularization of Human and Porcine Lung Tissues for Pulmonary Tissue Engineering
O’Neill, J. D., Anfang, R. R., Anandappa, A. J., Costa, J. A., Javidfar, J., Wobma, H., Singh, G., Freytes, D. O., Bacchetta, M. D., Sonett, J. R., et al. (2013) · The Annals of Thoracic Surgery · doi:10.1016/j.athoracsur.2013.04.022 · Cited by 258
Self-citationGarbern, J. C., Minami, E., Stayton, P. S., & Murry, C. E. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.11.075 · Cited by 254
Nontranscriptional Regulation of Cardiac Repolarization Currents by Testosterone
Bai, C., Kurokawa, J., Tamagawa, M., Nakaya, H., & Furukawa, T. (2005) · Circulation · doi:10.1161/circulationaha.104.523217 · Cited by 254
Freeman, I., & Cohen, S. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2008.12.057 · Cited by 252
Chung, A. K., Das, S. R., Leonard, D. S., Peshock, R. M., Kazi, F., Abdullah, S. M., Canham, R. M., Levine, B. D., & Drazner, M. H. (2006) · Circulation · doi:10.1161/circulationaha.105.574400 · Cited by 250
The Spectrum of Dilated Cardiomyopathy: The Johns Hopkins Experience with 1,278 Patients
Felker, G. M., Hu, W., Hare, J. M., Hruban, R. H., Baughman, K. L., & Kasper, E. K. (1999) · Medicine · doi:10.1097/00005792-199907000-00005 · Cited by 249
Mihic, A., Li, J., Miyagi, Y., Gagliardi, M., Li, S.-H., Zu, J., Weisel, R. D., Keller, G., & Li, R.-K. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2013.12.052 · Cited by 248
Boese, A. C., Kim, S. C., Yin, K., Lee, J., & Hamblin, M. H. (2017) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00217.2016 · Cited by 241
Controlling the contractile strength of engineered cardiac muscle by hierarchal tissue architecture
Feinberg, A. W., Alford, P. W., Jin, H., Ripplinger, C. M., Werdich, A. A., Sheehy, S. P., Grosberg, A., & Parker, K. K. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2012.04.043 · Cited by 240
Sex Drives Dimorphic Immune Responses to Viral Infections
Ghosh, S., & Klein, R. S. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1601166 · Cited by 238
Visualization of spiral and scroll waves in simulated and experimental cardiac tissue
Cherry, E. M., & Fenton, F. H. (2008) · New Journal of Physics · doi:10.1088/1367-2630/10/12/125016 · Cited by 237
Gender-Affirming Hormone Therapy, Vascular Health and Cardiovascular Disease in Transgender Adults
Connelly, P. J., Freel, E. M., Perry, C. G., Ewan, J., Touyz, R. M., Currie, G. E., & Delles, C. (2019) · Hypertension · doi:10.1161/hypertensionaha.119.13080 · Cited by 228
Han, H. W., Xie, L., Liu, R., Yang, J. W., Liu, F., Wu, K., Chen, L., Hou, W., Feng, Y., & Zhu, C. (2020) · Journal of Medical Virology · doi:10.1002/jmv.25809 · Cited by 228
A tissue-engineered scale model of the heart ventricle
MacQueen, L. A., Sheehy, S. P., Chantre, C. O., Zimmerman, J. F., Pasqualini, F. S., Liu, X., Goss, J. A., Campbell, P. H., Gonzalez, G. M., Park, S.-J., et al. (2018) · Nature Biomedical Engineering · doi:10.1038/s41551-018-0271-5 · Cited by 227
Endocrinology of the Menopause
Hall, J. E. (2015) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2015.05.010 · Cited by 223
Tsamandouras, N., Chen, W. L. K., Edington, C. D., Stokes, C. L., Griffith, L. G., & Cirit, M. (2017) · The AAPS Journal · doi:10.1208/s12248-017-0122-4 · Cited by 222
Cardiac Size and Sex-Matching in Heart Transplantation
Reed, R. M., Netzer, G., Hunsicker, L. G., Mitchell, B. D., Rajagopal, K., Scharf, S. M., & Eberlein, M. H. (2014) · JACC Heart Failure · doi:10.1016/j.jchf.2013.09.005 · Cited by 221
Engineering precision biomaterials for personalized medicine
Aguado, B. A., Grim, J. C., Rosales, A. M., Watson-Capps, J. J., & Anseth, K. S. (2018) · Science Translational Medicine · doi:10.1126/scitranslmed.aam8645 · Cited by 216
Electrical Stimulation Promotes Maturation of Cardiomyocytes Derived from Human Embryonic Stem Cells
Chan, Y.-C., Ting, S., Lee, Y.-K., Ng, K., Zhang, J., Chen, Z., Siu, C., Oh, S. K. W., & Tse, H. (2013) · Journal of Cardiovascular Translational Research · doi:10.1007/s12265-013-9510-z · Cited by 212
Growth factor delivery: Defining the next generation platforms for tissue engineering
Aguilar, L. M. C., Silva, S. M., & Moulton, S. E. (2019) · Journal of Controlled Release · doi:10.1016/j.jconrel.2019.05.028 · Cited by 211
From Arteries to Capillaries: Approaches to Engineering Human Vasculature
Fleischer, S., Tavakol, D. N., & Vunjak‐Novakovic, G. (2020) · Advanced Functional Materials · doi:10.1002/adfm.201910811 · Cited by 208
Self-citationCardiac Actions of Erythromycin
Drici, M., Knollmann, B. C., Wang, W.-X., & Woosley, R. L. (1998) · JAMA · doi:10.1001/jama.280.20.1774 · Cited by 197
Leonard, A., Bertero, A., Powers, J. D., Beussman, K. M., Bhandari, S., Regnier, M., Murry, C. E., & Sniadecki, N. J. (2018) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2018.03.016 · Cited by 196
Lehmann, M. H., Timothy, K. W., Frankovich, D., Fromm, B. S., Keating, M. T., Locati, E. H., Taggart, R. T., Towbin, J. A., Moss, A. J., Schwartz, P. J., et al. (1997) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(96)00454-8 · Cited by 192
Mastikhina, O., Moon, B., Williams, K., Hatkar, R., Gustafson, D., Mourad, O., Sun, X., Koo, M., Lam, A. Y. L., Sun, Y., et al. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2019.119741 · Cited by 192
Estrogen-related mechanisms in sex differences of hypertension and target organ damage
Sabbatini, A. R., & Kararigas, G. (2020) · Biology of Sex Differences · doi:10.1186/s13293-020-00306-7 · Cited by 191
Kararigas, G., Dworatzek, E., Petrov, G., Summer, H., Schulze, T. M., Baczkó, I., Knosalla, C., Gölz, S., Hetzer, R., & Regitz‐Zagrosek, V. (2014) · European Journal of Heart Failure · doi:10.1002/ejhf.171 · Cited by 188
Zhang, H., Tian, L., Shen, M., Tu, C., Wu, H., Gu, M., Paik, D. T., & Wu, J. C. (2019) · Circulation Research · doi:10.1161/circresaha.119.315491 · Cited by 187
A Comprehensive Mouse Transcriptomic BodyMap across 17 Tissues by RNA-seq
Li, B., Qing, T., Zhu, J., Wen, Z., Yu, Y., Fukumura, R., Zheng, Y., Gondo, Y., & Shi, L. (2017) · Scientific Reports · doi:10.1038/s41598-017-04520-z · Cited by 184
Engineering a perfusable 3D human liver platform from iPS cells
Schepers, A. G., Li, C. Y., Chhabra, A., Tschudy-Seney, B., & Bhatia, S. N. (2016) · Lab on a Chip · doi:10.1039/c6lc00598e · Cited by 179
Sex-chromosome dosage effects on gene expression in humans
Raznahan, A., Parikshak, N. N., Chandran, V., Blumenthal, J. D., Clasen, L. S., Alexander-Bloch, A. F., Zinn, A. R., Wangsa, D., Wise, J., Murphy, D. G. M., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1802889115 · Cited by 179
Menopause-Related Estrogen Decrease and the Pathogenesis of HFpEF
Sabbatini, A. R., & Kararigas, G. (2020) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2019.12.049 · Cited by 177
Wavelength‐Controlled Photocleavage for the Orthogonal and Sequential Release of Multiple Proteins
Azagarsamy, M. A., & Anseth, K. S. (2013) · Angewandte Chemie International Edition · doi:10.1002/anie.201308174 · Cited by 176
X Inactivation and Escape: Epigenetic and Structural Features
Fang, H., Distèche, C. M., & Berletch, J. B. (2019) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2019.00219 · Cited by 168
Matsa, E., Burridge, P. W., Yu, K.-H., Ahrens, J. H., Termglinchan, V., Wu, H., Liu, C., Shukla, P., Sayed, N., Churko, J. M., et al. (2016) · Cell stem cell · doi:10.1016/j.stem.2016.07.006 · Cited by 164
Khush, K. K., Kubo, J. T., & Desai, M. (2012) · The Journal of Heart and Lung Transplantation · doi:10.1016/j.healun.2012.02.005 · Cited by 163
Moldable elastomeric polyester-carbon nanotube scaffolds for cardiac tissue engineering
Ahadian, S., Huyer, L. D., Estili, M., Yee, B., Smith, N., Xu, Z., Sun, Y., & Radisic, M. (2016) · Acta Biomaterialia · doi:10.1016/j.actbio.2016.12.009 · Cited by 163
Self-citationPhysiologic force-frequency response in engineered heart muscle by electromechanical stimulation
Godier-Furnémont, A., Tiburcy, M., Wagner, E., Dewenter, M., Lämmle, S., El‐Armouche, A., Lehnart, S. E., Vunjak‐Novakovic, G., & Zimmermann, W. (2015) · Biomaterials · doi:10.1016/j.biomaterials.2015.03.055 · Cited by 162
Self-citationAtrial-like Engineered Heart Tissue: An In Vitro Model of the Human Atrium
Lemme, M., Ulmer, B. M., Lemoine, M. D., Zech, A. T. L., Flenner, F., Ravens, U., Reichenspurner, H. C., Rol-Garcia, M., Smith, G. L., Hansen, A., et al. (2018) · Stem Cell Reports · doi:10.1016/j.stemcr.2018.10.008 · Cited by 160
Can We Engineer a Human Cardiac Patch for Therapy?
Zhang, J. J., Zhu, W., Radisic, M., & Vunjak‐Novakovic, G. (2018) · Circulation Research · doi:10.1161/circresaha.118.311213 · Cited by 159
Self-citationSex Differences in Circulating Biomarkers of Cardiovascular Disease
Lau, E. S., Paniagua, S. M., Guseh, J. S., Bhambhani, V., Zanni, M. V., Courchesne, P. L., Lyass, A., Larson, M. G., Levy, D. A., & Ho, J. E. (2019) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2019.06.077 · Cited by 159
Transcriptome of human foetal heart compared with cardiomyocytes from pluripotent stem cells
van den Berg, C. W., Okawa, S., Lopes, S. M. C. D. S., van Iperen, L., Passier, R. C., Braam, S. R., Tertoolen, L. G. J., del Sol, A., Davis, R. P., & Mummery, C. L. (2015) · Development · doi:10.1242/dev.123810 · Cited by 158
Increased afterload induces pathological cardiac hypertrophy: a new in vitro model
Hirt, M. N., Sörensen, N. A., Bartholdt, L. M., Boeddinghaus, J., Schaaf, S., Eder, A., Vollert, I., Stöhr, A., Schulze, T., Witten, A., et al. (2012) · Basic Research in Cardiology · doi:10.1007/s00395-012-0307-z · Cited by 154
Modular assembly of thick multifunctional cardiac patches
Fleischer, S., Shapira, A., Feiner, R., & Dvir, T. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1615728114 · Cited by 154
Self-citationKhalifa, A. R. M., Abdel‐Rahman, E. A., Mahmoud, A. M., Ali, M. H., Noureldin, M., Saber, S. H., Mohsen, M., & Ali, S. S. (2017) · Physiological Reports · doi:10.14814/phy2.13125 · Cited by 154
The Impact of Donor-Recipient Sex Matching on Survival After Orthotopic Heart Transplantation
Weiss, E. S., Allen, J. G., Patel, N., Russell, S. D., Baumgartner, W. A., Shah, A. S., & Conte, J. V. (2009) · Circulation Heart Failure · doi:10.1161/circheartfailure.108.844183 · Cited by 153
Sex Differences in the Biology and Pathology of the Aging Heart
Keller, K. M., & Howlett, S. E. (2016) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2016.03.017 · Cited by 152
Sex-Related Differences in Heart Failure With Preserved Ejection Fraction
Dewan, P., Rørth, R., Raparelli, V., Campbell, R. T., Shen, L., Jhund, P. S., Petrie, M. C., Anand, I. S., Carson, P. E., Desai, A. S., et al. (2019) · Circulation Heart Failure · doi:10.1161/circheartfailure.119.006539 · Cited by 151
Liu, X. (2002) · Cardiovascular Research · doi:10.1016/s0008-6363(02)00673-9 · Cited by 150
Aging and sex hormones in males
Decaroli, M. C., & Rochira, V. (2016) · Virulence · doi:10.1080/21505594.2016.1259053 · Cited by 150
Gurvich, C., Hoy, K., Thomas, N., & Kulkarni, J. (2018) · Brain Sciences · doi:10.3390/brainsci8090163 · Cited by 150
Sex differences in mechanisms of cardiac excitation–contraction coupling
Parks, R. J., & Howlett, S. E. (2013) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-013-1233-0 · Cited by 148
Sex- and Age-Based Differences in the Natural History and Outcome of Dilated Cardiomyopathy
Halliday, B. P., Gulati, A., Ali, A., Newsome, S., Lota, A. S., Tayal, U., Vassiliou, V. S., Aržanauskaitė, M., İzgi, C., Krishnathasan, K., et al. (2018) · European Journal of Heart Failure · doi:10.1002/ejhf.1216 · Cited by 148
Fong, A. H., Romero-López, M., Heylman, C. M., Keating, M., Tran, D. D., Sobrino, A., Tran, A. Q., Pham, H. H., Fimbres, C., Gershon, P. D., et al. (2016) · Tissue Engineering Part A · doi:10.1089/ten.tea.2016.0027 · Cited by 145
Gender-related differences in lifestyle may affect health status.
Varı́, R., Scazzocchio, B., d’Amore, A., Giovannini, C., Gessani, S., & Masella, R. (2016) · Annali dell Istituto Superiore di Sanità · doi:10.4415/ann_16_02_06 · Cited by 143
Sex Chromosome Effects Unmasked in Angiotensin II–Induced Hypertension
Ji, H., Zheng, W. H., Wu, X., Liu, J., ECELBARGER, C. A., Watkins, R., Arnold, A. P., & Sandberg, K. L. (2010) · Hypertension · doi:10.1161/hypertensionaha.109.144949 · Cited by 142
Bioengineered uterine tissue supports pregnancy in a rat model
Hellström, M., Moreno-Moya, J. M., Bandstein, S., Bom, E., Akouri, R., Miyazaki, K., Maruyama, T., & Brännström, M. (2016) · Fertility and Sterility · doi:10.1016/j.fertnstert.2016.03.048 · Cited by 141
Mayne, B. T., Bianco-Miotto, T., Buckberry, S., Breen, J., Clifton, V., Shoubridge, C., & Roberts, C. T. (2016) · Frontiers in Genetics · doi:10.3389/fgene.2016.00183 · Cited by 140
Biowire Model of Interstitial and Focal Cardiac Fibrosis
Wang, E. Y., Rafatian, N., Zhao, Y., Lee, A., Lai, B. F. L., Lu, R. X. Z., Jekic, D., Huyer, L. D., Knee‐Walden, E. J., Bhattacharya, S., et al. (2019) · ACS Central Science · doi:10.1021/acscentsci.9b00052 · Cited by 128
Self-citationZhang, Y., Ouyang, P., Post, W. S., Dalal, D., Vaidya, D. M., Blasco‐Colmenares, E., Soliman, E. Z., Tomaselli, G. F., & Güallar, E. (2011) · American Journal of Epidemiology · doi:10.1093/aje/kwr172 · Cited by 127
Sidorov, V. Y., Samson, P. C., Sidorova, T. N., Davidson, J. M., Lim, C. C., & Wikswo, J. P. (2016) · Acta Biomaterialia · doi:10.1016/j.actbio.2016.11.009 · Cited by 127
Jiang, L., Chen, D., Wang, Z., Zhang, Z., Xia, Y., Xue, H., & Liu, Y. (2019) · Applied Biochemistry and Biotechnology · doi:10.1007/s12010-019-02967-6 · Cited by 124
Sex-Related Differences in the Extent of Myocardial Fibrosis in Patients With Aortic Valve Stenosis
Tastet, L. L., Kwieciński, J., Pîbarot, P., Capoulade, R., Everett, R. J., Newby, D. E., Shen, M., Guzzetti, E., Arsenault, M., Bédard, É., et al. (2019) · JACC. Cardiovascular imaging · doi:10.1016/j.jcmg.2019.06.014 · Cited by 124
Biohybrid cardiac ECM-based hydrogels improve long term cardiac function post myocardial infarction
Efraim, Y., Sarig, H., Anavy, N. C., Sarig, U., de-Berardinis, E., Chaw, S. Y., Krishnamoorthi, M. K., Kalifa, J., Bogireddi, H., Duc, T. V., et al. (2016) · Acta Biomaterialia · doi:10.1016/j.actbio.2016.12.015 · Cited by 123
Sex differences in the mechanisms underlying long QT syndrome
Salama, G., & Bett, G. C. L. (2014) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00864.2013 · Cited by 121
Quantitative analysis of Y-Chromosome gene expression across 36 human tissuesPreprint
Godfrey, A. K., Naqvi, S., Chmátal, L., Chick, J. M., Mitchell, R. N., Gygi, S. P., Skaletsky, H., & Page, D. C. (2020) · Genome Research · doi:10.1101/gr.261248.120 · Cited by 121
Measuring mitochondrial function in intact cardiac myocytes
Dedkova, E. N., & Blatter, L. A. (2011) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2011.08.030 · Cited by 118
Spring-like fibers for cardiac tissue engineering
Fleischer, S., Feiner, R., Shapira, A., Ji, J., Sui, X., Wagner, H. D., & Dvir, T. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.07.054 · Cited by 118
Self-citationDunlay, S. M., & Roger, V. L. (2012) · Current Heart Failure Reports · doi:10.1007/s11897-012-0107-7 · Cited by 118
Gender‐Specific Effects on Verapamil Pharmacokinetics and Pharmacodynamics in Humans
KRECICSHEPARD, M., Barnas, C., SLIMKO, J., Jones, M. P., & Schwartz, J. B. (2000) · The Journal of Clinical Pharmacology · doi:10.1177/00912700022008883 · Cited by 116
Cocker, M. S., Abdel-Aty, H., Strohm, O., & Friedrich, M. G. (2009) · Heart · doi:10.1136/hrt.2008.164061 · Cited by 115
Generation of mesenchyme free intestinal organoids from human induced pluripotent stem cells
Mithal, A., Capilla, A., Heinze, D. M., Berical, A. C., Villacorta-Martín, C., Vedaie, M., Jacob, A., Abo, K. M., Szymaniak, A. D., Peasley, M., et al. (2020) · Nature Communications · doi:10.1038/s41467-019-13916-6 · Cited by 115
Timing and Duration of Menopausal Hormone Treatment May Affect Cardiovascular Outcomes
Harman, S. M., Vittinghoff, E., Brinton, E. A., Budoff, M. J., Cedars, M. I., Løbo, R. A., Merriam, G. R., Miller, V. M., Naftolin, F. N., Pal, L., et al. (2011) · The American Journal of Medicine · doi:10.1016/j.amjmed.2010.09.021 · Cited by 114
Sex Chromosome Effects on Male–Female Differences in Mammals
Snell, D. M., & Turner, J. M. A. (2018) · Current Biology · doi:10.1016/j.cub.2018.09.018 · Cited by 114
Gene-by-Sex Interactions in Mitochondrial Functions and Cardio-Metabolic Traits
Norheim, F., Hasin-Brumshtein, Y., Vergnes, L., Krishnan, K. C., Pan, C., Seldin, M. M., Hui, S. T. Y., Mehrabian, M., Zhou, Z., Gupta, S., et al. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2018.12.013 · Cited by 110
Biomaterializing the promise of cardiac tissue engineering
Pomeroy, J. E., Helfer, A., & Bursac, N. (2019) · Biotechnology Advances · doi:10.1016/j.biotechadv.2019.02.009 · Cited by 108
Modelling Torsade de Pointes arrhythmias in vitro in 3D human iPS cell-engineered heart tissue
Kawatou, M., Masumoto, H., Fukushima, H., Morinaga, G., Sakata, R., Ashihara, T., & Yamashita, J. K. (2017) · Nature Communications · doi:10.1038/s41467-017-01125-y · Cited by 106
Genome Editing in Human Stem Cells
Byrne, S. M., Mali, P., & Church, G. M. (2014) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/b978-0-12-801185-0.00006-4 · Cited by 101
Cashman, T. J., Josowitz, R., Johnson, B. V., Gelb, B. D., & Costa, K. D. (2016) · PLOS ONE · doi:10.1371/journal.pone.0146697 · Cited by 101
Gender Differences in Cardiovascular Pharmacotherapy—the Example of Hypertension: A Mini Review
Kalibala, J., Péchère-Bertschi, A., & Desmeules, J. A. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.00564 · Cited by 101
Sex Differences in Aging: Genomic Instability
Fischer, K. E., & Riddle, N. C. (2017) · The Journals of Gerontology Series A · doi:10.1093/gerona/glx105 · Cited by 100
Effects of aging on cardiac extracellular matrix in men and women
Dworatzek, E., Baczkó, I., & Kararigas, G. (2015) · PROTEOMICS - CLINICAL APPLICATIONS · doi:10.1002/prca.201500031 · Cited by 99
Sex differences in the metabolic effects of the renin-angiotensin system
White, M., Fleeman, R. M., & Arnold, A. C. (2019) · Biology of Sex Differences · doi:10.1186/s13293-019-0247-5 · Cited by 99
Albumin fiber scaffolds for engineering functional cardiac tissues
Fleischer, S., Shapira, A., Regev, O., Nseir, N., Zussman, E., & Dvir, T. (2014) · Biotechnology and Bioengineering · doi:10.1002/bit.25185 · Cited by 97
Self-citationEngineering Precision Medicine
Sun, W., Lee, J., Zhang, S., Benyshek, C., Dokmeci, M. R., & Khademhosseini, A. (2018) · Advanced Science · doi:10.1002/advs.201801039 · Cited by 96
Bergenfeldt, H., Stehlik, J., Höglund, P., Andersson, B., & Nilsson, J. (2017) · The Journal of Heart and Lung Transplantation · doi:10.1016/j.healun.2017.02.002 · Cited by 93
Cook, C. D., Hill, A. S., Guo, M. G., Stockdale, L., Papps, J. P., Isaacson, K., Lauffenburger, D. A., & Griffith, L. G. (2017) · Integrative Biology · doi:10.1039/c6ib00245e · Cited by 93
The Current Trends of Biosensors in Tissue Engineering
Li, Y. E., & Lee, I. (2020) · Biosensors · doi:10.3390/bios10080088 · Cited by 93
Murakami, T., Yoshikawa, T., Maekawa, Y., Ueda, T., Isogai, T., Sakata, K., Nagao, K., Yamamoto, T., & Takayama, M. (2015) · PLoS ONE · doi:10.1371/journal.pone.0136655 · Cited by 92
Sex differences in cardiovascular epigenetics—a systematic review
Hartman, R. J. G., Huisman, S. E., & den Ruijter, H. M. (2018) · Biology of Sex Differences · doi:10.1186/s13293-018-0180-z · Cited by 92
Parks, R. J., Ray, G., Bienvenu, L. A., Rose, R. A., & Howlett, S. E. (2014) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2014.07.006 · Cited by 91
Howlett, S. E. (2009) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00214.2009 · Cited by 91
Sex Differences in Drug Effects: Interaction with Sex Hormones in Adult Life
Spoletini, I., Vitale, C., Malorni, W., & Rosano, G. M. C. (2012) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-30726-3_5 · Cited by 90
Significant role of estrogen in maintaining cardiac mitochondrial functions
Rattanasopa, C., Phungphong, S., Wattanapermpool, J., & Bupha‐Intr, T. (2014) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2014.11.009 · Cited by 88
Schoen, B., Avrahami, R., Baruch, L., Efraim, Y., Goldfracht, I., Elul, O., Davidov, T., Gepstein, L., Zussman, E., & Machluf, M. (2017) · Advanced Functional Materials · doi:10.1002/adfm.201700427 · Cited by 88
Measurement of Estradiol—Challenges Ahead
Stanczyk, F. Z., & Clarke, N. J. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-2905 · Cited by 87
Comparison of clinical findings in idiopathic dilated cardiomyopathy in women versus men
Maria, R. D., Gavazzi, A., Recalcati, F., Baroldi, G., Vita, C. D., & Camerini, F. (1993) · The American Journal of Cardiology · doi:10.1016/0002-9149(93)90355-g · Cited by 85
Wang, M., Smith, K., Yu, Q., Miller, C. A., Singh, K., & Sen, C. K. (2019) · Basic Research in Cardiology · doi:10.1007/s00395-019-0759-5 · Cited by 84
Sexual Dimorphism in the Expression of Mitochondria-Related Genes in Rat Heart at Different Ages
Vijay, V., Han, T., Moland, C. L., Kwekel, J. C., Fuscoe, J. C., & Desai, V. G. (2015) · PLoS ONE · doi:10.1371/journal.pone.0117047 · Cited by 83
Hartman, R. J. G., Kapteijn, D., Haitjema, S., Bekker, M. N., Mokrý, M., Pasterkamp, G., Civelek, M., & den Ruijter, H. M. (2020) · Scientific Reports · doi:10.1038/s41598-020-69451-8 · Cited by 82
Cardiac tissue engineering: current state-of-the-art materials, cells and tissue formation
Rodrigues, I. C. P., Kaasi, A., Filho, R. M., Jardini, A. L., & Gabriel, L. P. (2018) · Einstein (São Paulo) · doi:10.1590/s1679-45082018rb4538 · Cited by 80
Sex-Specific Characteristics of the Microcirculation
Huxley, V. H., & Kemp, S. S. (2018) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-77932-4_20 · Cited by 78
Kubo, T., Kitaoka, H., Okawa, M., Hirota, T., Hayato, K., Yamasaki, N., Matsumura, Y., Yabe, T., & Doi, Y. (2010) · Journal of Cardiology · doi:10.1016/j.jjcc.2010.07.004 · Cited by 76
Decellularized liver scaffolds promote liver regeneration after partial hepatectomy
Shimoda, H., Yagi, H., Higashi, H., Tajima, K., Kuroda, K., Abe, Y., Kitago, M., Shinoda, M., & Kitagawa, Y. (2019) · Scientific Reports · doi:10.1038/s41598-019-48948-x · Cited by 76
Ghazi, L., & Drawz, P. E. (2017) · F1000Research · doi:10.12688/f1000research.9692.1 · Cited by 72
Development of a novel human recellularized endometrium that responds to a 28-day hormone treatment†
Olalekan, S. A., Burdette, J. E., Getsios, S., Woodruff, T. K., & Kim, J. J. (2017) · Biology of Reproduction · doi:10.1093/biolre/iox039 · Cited by 72
Comparison of 10 Control hPSC Lines for Drug Screening in an Engineered Heart Tissue Format
Mannhardt, I., Saleem, U., Mosqueira, D., Loos, M., Ulmer, B. M., Lemoine, M. D., Larsson, C., Améen, C., de Korte, T., Vlaming, M. L. H., et al. (2020) · Stem Cell Reports · doi:10.1016/j.stemcr.2020.09.002 · Cited by 72
Menazza, S., Sun, J., Appachi, S., Chambliss, K. L., Kim, S. H., Aponte, A. M., Khan, S., Katzenellenbogen, J. A., Katzenellenbogen, B. S., Shaul, P. W., et al. (2017) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2017.04.004 · Cited by 71
Sex Differences at the Time of Myectomy in Hypertrophic Cardiomyopathy
Nijenkamp, L. L. A. M., Bollen, I. A. E., van Velzen, H. G., Regan, J. A., van Slegtenhorst, M., Niessen, H. W. M., Schinkel, A. F. L., Krüger, M., Poggesi, C., Ho, C. Y., et al. (2018) · Circulation Heart Failure · doi:10.1161/circheartfailure.117.004133 · Cited by 71
Feiner, R., Wertheim, L., Gazit, D., Kalish, O., Mishal, G., Shapira, A., & Dvir, T. (2019) · Small · doi:10.1002/smll.201805526 · Cited by 71
Yang, X., Chen, G., Papp, R., DeFranco, D. B., Zeng, F., & Salama, G. (2011) · The Journal of Physiology · doi:10.1113/jphysiol.2011.219501 · Cited by 69
Tissue-specific sex differences in human gene expression
Kassam, I., Wu, Y., Yang, J., Visscher, P. M., & McRae, A. F. (2019) · Human Molecular Genetics · doi:10.1093/hmg/ddz090 · Cited by 68
Gender differences in the etiology of heart failure: A systematic review
Azad, N. A., Anusha, K., Shabnam, M., Hébert, P. C., & Fergusson, D. A. (2011) · 老年心脏病学杂志:英文版 · doi:10.3724/sp.j.1263.2011.00015 · Cited by 67
Impact of Age and Sex on QT Prolongation in Patients Receiving Psychotropics
Rabkin, S. W. (2015) · The Canadian Journal of Psychiatry · doi:10.1177/070674371506000502 · Cited by 66
Peter, I., Shearman, A. M., Vasan, R. S., Zucker, D. R., Schmid, C. H., Demissie, S., Cupples, L. A., Kuvin, J. T., Karas, R. H., & Mendelsohn, M. E. (2005) · American Journal of Hypertension · doi:10.1016/j.amjhyper.2005.05.023 · Cited by 66
Female Sex as a Risk Factor for In-Hospital Mortality Among Children Undergoing Cardiac Surgery
Chang, R. R., Chen, A. Y., & Klitzner, T. S. (2002) · Circulation · doi:10.1161/01.cir.0000029104.94858.6f · Cited by 66
Kijlstra, J. D., Hu, D., Mittal, N., Kausel, E., van der Meer, P., Garakani, A., & Domian, I. J. (2015) · Stem Cell Reports · doi:10.1016/j.stemcr.2015.10.017 · Cited by 66
Cardiomyocytes facing fibrotic conditions re-express extracellular matrix transcripts
Heras-Bautista, C. O., Mikhael, N., Lam, J., Shinde, V., Katsen‐Globa, A., Dieluweit, S., Molčányi, M., Uvarov, V., Jütten, P., Sahito, R. G. A., et al. (2019) · Acta Biomaterialia · doi:10.1016/j.actbio.2019.03.017 · Cited by 66
Sex Differences in Heart Failure
Savarese, G., & D’Amario, D. (2018) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-77932-4_32 · Cited by 63
Sex Differences in the Long-term Prognosis of Dilated Cardiomyopathy
Cannata, A. N., Fabris, E., Merlo, M., Artico, J., Gentile, P., Gava, C. P. L. D., Ballaben, A., Ramani, F., Barbati, G., & Sinagra, G. (2019) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2019.05.031 · Cited by 63
Human Tissue-Engineered Model of Myocardial Ischemia–Reperfusion Injury
Chen, T. F., & Vunjak‐Novakovic, G. (2018) · Tissue Engineering Part A · doi:10.1089/ten.tea.2018.0212 · Cited by 62
Self-citation
Research works printed but not linked: 2
- Ferri, F. in Ferri’s Clinical Advisor 2019 1st edn (Elsevier, 2018).
- Turnbull, I. C. et al. in Experimental Models of Cardiovascular Diseases: Methods and Protocols (ed. Ishikawa, K.) 145–159 (Springer, 2018).
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Self-citationStrengthening cardiac therapy pipelines using human pluripotent stem cell-derived cardiomyocytes
Raniga, K., Nasir, A., Vo, N. T. N., Vaidyanathan, R., Dickerson, S., Hilcove, S. A., Mosqueira, D., Mirams, G. R., Clements, P., Hicks, R., et al. (2024) · Cell stem cell · doi:10.1016/j.stem.2024.01.007 · Cited by 39
Metadata
- Authors
- Lock, R., Al Asafen, H., Fleischer, S., Tamargo, M., Zhao, Y., Radisic, M., & Vunjak-Novakovic, G.
- Affiliations
- Columbia University (US)
- University of Toronto (CA)
- Venue
- Nature Reviews Materials
- Published
- 2021-10-20
- Volume
- 7
- Issue
- 4
- Pages
- 295-313
- ISSN
- 2058-8437 (ISSN-L)
- PMC
- PMC8527305
- OpenAlex
- W3207902372
- Cited by
- 50
- References
- 275
- Citations by year
- 2026: 6 · 2025: 8 · 2024: 14 · 2023: 12 · 2022: 9 · 2021: 1
- FWCI
- 2.17
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Nature Reviews Materials (publishedVersion, cc-by)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Science Foundation (NSF16478)
- National Aeronautics and Space Administration (NNX16AO69A)
- National Institutes of Health (2r01hl076485-16, NSF16478, EB027062, HL076485, EB025765)
- National Heart, Lung, and Blood Institute (R01-HL076485)
- National Institute of Biomedical Imaging and Bioengineering (UG3EB025765, UH3EB025765, P41EB027062)
- Topics
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Sex and Gender in Healthcare
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
- Keywords
- sex differences, cardiac tissue engineering, cardiovascular disease, in vitro cardiac models
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