Accordion-like honeycombs for tissue engineering of cardiac anisotropy
Open accessAbstract
Tissue-engineered grafts may be useful in myocardial repair; however, previous scaffolds have been structurally incompatible with recapitulating cardiac anisotropy. Here, we use microfabrication techniques to create an accordion-like honeycomb microstructure in poly(glycerol sebacate), which yields porous, elastomeric three-dimensional (3D) scaffolds with controllable stiffness and anisotropy. Accordion-like honeycomb scaffolds with cultured neonatal rat heart cells demonstrated utility through: (1) closely matched mechanical properties compared to native adult rat right ventricular myocardium, with stiffnesses controlled by polymer curing time; (2) heart cell contractility inducible by electric field stimulation with directionally dependent electrical excitation thresholds (p<0.05); and (3) greater heart cell alignment (p<0.0001) than isotropic control scaffolds. Prototype bilaminar scaffolds with 3D interconnected pore networks yielded electrically excitable grafts with multi-layered neonatal rat heart cells. Accordion-like honeycombs can thus overcome principal structural-mechanical limitations of previous scaffolds, promoting the formation of grafts with aligned heart cells and mechanical properties more closely resembling native myocardium.
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There is good consistency in stress-strain curves along the CIRC and LONG direction among the corresponding FEA calculations, experimental measurement, and native adult rat heart tissue, indicating that the combined theoretical calculations and EHD printing can provide an accurate and effective pathway for the generation of scaffold-reinforced 3D assembled LVD tissues with cardiac-tissue-like非线性机械
“Figure 6d demonstrates good consistency in stress-strain curves along the CIRC and LONG direction among the corresponding FEA calculations, experimental measurement, and native adult rat heart tissue (the data was acquired from the previous literature 10 ), indicating that the combined theoretical calculations and EHD printing can provide an accurate and effective pathway for the generation of the”
From Leaf-venation-directed cellular alignment for macroscale cardiac constructs with tissue-like functionalities (2023) · cites this paper as [10]
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- Authors
- Engelmayr, G. C., Cheng, M., Bettinger, C. J., Borenstein, J. T., Langer, R., & Freed, L. E.
- Affiliations
- Harvard–MIT Division of Health Sciences and Technology (US)
- Draper Laboratory (US)
- Corresponding author
- Freed, Lisa E.
- Venue
- Nature Materials
- Published
- 2008-11-02
- Volume
- 7
- Issue
- 12
- Pages
- 1003-1010
- ISSN
- 1476-1122 (ISSN-L)
- 1476-4660
- PMC
- PMC2613200
- OpenAlex
- W2110162714
- Cited by
- 848
- References
- 56
- Citations by year
- 2026: 13 · 2025: 18 · 2024: 33 · 2023: 31 · 2022: 46 · 2021: 50 · 2020: 46 · 2019: 47 · 2018: 49 · 2017: 58 · 2016: 69 · 2015: 50 · 2014: 65 · 2013: 72 · 2012: 61
- FWCI
- 47.07
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature Materials (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Centre International de Recherche sur le Cancer
- National Institutes of Health
- National Heart, Lung, and Blood Institute (F32HL084968)
- National Institute of Dental and Craniofacial Research (DE013023, R01DE013023)
- Topics
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Keywords
- cardiac anisotropy, cardiac tissue engineering, poly(glycerol sebacate), elastomeric scaffolds, scaffold stiffness, cell alignment, electrical field stimulation, pore network, myocardial repair, microfabrication
- MeSH terms
- Animals, Biomechanical Phenomena, Decanoates, Electric Conductivity, Glycerol, Heart, Myocardium, Polymers, Ventricular Function, Anisotropy, Tissue Engineering, Rats, Lasers, Excimer, Tissue Scaffolds
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