Cited by 19Nuclear Structure and FunctionCellular Mechanics and InteractionsSkin and Cellular Biology Research

Nuclear envelope proteins, mechanotransduction, and their contribution to breast cancer progression

Open access
Henretta, Sarah, Lammerding, Jan·2025·npj Biological Physics and Mechanics

Abstract

Breast cancer cells frequently exhibit changes in the expression of nuclear envelope (NE) proteins such as lamins and emerin that determine the physical properties of the nucleus and contribute to cellular mechanotransduction. This review explores the emerging interplay between NE proteins, the physical challenges incurred during metastatic progression, and mechanotransduction. Improved insights into the underlying mechanisms may ultimately lead to better prognostic tools and treatment strategies for metastatic breast cancer.

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Crossref · 10.1038/s44341-025-00018-2

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  • The matrix supports spheroid assembly and imposes physical constraints that activate intracellular signaling cascades, including MAPK, PI3K/Akt, and YAP/TAZ pathways.

    “The matrix not only supports spheroid assembly but also imposes physical constraints that activate intracellular signaling cascades, including MAPK, PI3K/Akt, and YAP/TAZ pathways [214,215,216].”

    From Modeling Tumor Microenvironment Complexity In Vitro: Spheroids as Physiologically Relevant Tumor Models and Strategies for Their Analysis (2025) · cites this paper as [215]

    The unnumbered ERK/MAPK, PI3K/AKT, and YAP/TAZ sections describe mechanical cues, including matrix stiffness, activating or regulating these pathways. The paper does not establish the separate claim that the matrix supports spheroid assembly. (LLM, conf=0.88)

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Authors
Henretta, S., & Lammerding, J.
Affiliations
Cornell University (US)
Corresponding author
Lammerding, Jan
Venue
npj Biological Physics and Mechanics
Published
2025-05-05
Volume
2
Issue
1
Pages
14-14
ISSN
3004-863X (ISSN-L)
OpenAlex
W4410079222
Cited by
19
References
159
Citations by year
2026: 13 · 2025: 6
FWCI
1.68
Type
journal article
Language
en
Open access
Locations
  • npj Biological Physics and Mechanics. (publishedVersion, cc-by-nc-nd)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (R01 HL082792)
  • National Science Foundation (URoL-2022048)
  • Volkswagen Foundation (A130142)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Structure and Function
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Skin and Cellular Biology Research
Keywords
nuclear envelope proteins, mechanotransduction, breast cancer progression, metastasis, nuclear lamins, emerin, nuclear mechanics, nuclear lamina, prognostic factors

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