Nuclear envelope proteins, mechanotransduction, and their contribution to breast cancer progression
Open accessAbstract
Breast cancer cells frequently exhibit changes in the expression of nuclear envelope (NE) proteins such as lamins and emerin that determine the physical properties of the nucleus and contribute to cellular mechanotransduction. This review explores the emerging interplay between NE proteins, the physical challenges incurred during metastatic progression, and mechanotransduction. Improved insights into the underlying mechanisms may ultimately lead to better prognostic tools and treatment strategies for metastatic breast cancer.
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The matrix supports spheroid assembly and imposes physical constraints that activate intracellular signaling cascades, including MAPK, PI3K/Akt, and YAP/TAZ pathways.
“The matrix not only supports spheroid assembly but also imposes physical constraints that activate intracellular signaling cascades, including MAPK, PI3K/Akt, and YAP/TAZ pathways [214,215,216].”
From Modeling Tumor Microenvironment Complexity In Vitro: Spheroids as Physiologically Relevant Tumor Models and Strategies for Their Analysis (2025) · cites this paper as [215]
The unnumbered ERK/MAPK, PI3K/AKT, and YAP/TAZ sections describe mechanical cues, including matrix stiffness, activating or regulating these pathways. The paper does not establish the separate claim that the matrix supports spheroid assembly. (LLM, conf=0.88)
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Shah, S., & D’Souza, G. G. M. (2025) · Cells · doi:10.3390/cells14100732 · Cited by 66 · see citing works
- Authors
- Henretta, S., & Lammerding, J.
- Affiliations
- Cornell University (US)
- Corresponding author
- Lammerding, Jan
- Venue
- npj Biological Physics and Mechanics
- Published
- 2025-05-05
- Volume
- 2
- Issue
- 1
- Pages
- 14-14
- ISSN
- 3004-863X (ISSN-L)
- PMC
- PMC12052594
- OpenAlex
- W4410079222
- Cited by
- 19
- References
- 159
- Citations by year
- 2026: 13 · 2025: 6
- FWCI
- 1.68
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- npj Biological Physics and Mechanics. (publishedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (R01 HL082792)
- National Science Foundation (URoL-2022048)
- Volkswagen Foundation (A130142)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Structure and Function
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Skin and Cellular Biology Research
- Keywords
- nuclear envelope proteins, mechanotransduction, breast cancer progression, metastasis, nuclear lamins, emerin, nuclear mechanics, nuclear lamina, prognostic factors
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