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Cited by 60Epilepsy research and treatmentMicroRNA in disease regulationProtease and Inhibitor Mechanisms

Increased expression of matrix metalloproteinase 3 can be attenuated by inhibition of microRNA-155 in cultured human astrocytes

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Korotkov, Anatoly, Broekaart, Diede W. M., van Scheppingen, Jackelien, Anink, Jasper J., Baayen, Johannes C., Idema, Sander, Gorter, Jan A., Aronica, Eleonora +1 more·2018·Journal of Neuroinflammation
DOI 10.1186/s12974-018-1245-yPMC PMC6054845
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Abstract

BACKGROUND: Temporal lobe epilepsy (TLE) is a chronic neurological disease, in which about 30% of patients cannot be treated adequately with anti-epileptic drugs. Brain inflammation and remodeling of the extracellular matrix (ECM) seem to play a major role in TLE. Matrix metalloproteinases (MMPs) are proteolytic enzymes largely responsible for the remodeling of the ECM. The inhibition of MMPs has been suggested as a novel therapy for epilepsy; however, available MMP inhibitors lack specificity and cause serious side effects. We studied whether MMPs could be modulated via microRNAs (miRNAs). Several miRNAs mediate inflammatory responses in the brain, which are known to control MMP expression. The aim of this study was to investigate whether an increased expression of MMPs after interleukin-1β (IL-1β) stimulation can be attenuated by inhibition of the inflammation-associated miR-155. METHODS: We investigated the expression of MMP2, MMP3, MMP9, and MMP14 in cultured human fetal astrocytes after stimulation with the pro-inflammatory cytokine IL-1β. The cells were transfected with miR-155 antagomiR, and the effect on MMP3 expression was investigated using real-time quantitative PCR and Western blotting. Furthermore, we characterized MMP3 and miR-155 expression in brain tissue of TLE patients with hippocampal sclerosis (TLE-HS) and during epileptogenesis in a rat TLE model. RESULTS: Inhibition of miR-155 by the antagomiR attenuated MMP3 overexpression after IL-1β stimulation in astrocytes. Increased expression of MMP3 and miR-155 was also evident in the hippocampus of TLE-HS patients and throughout epileptogenesis in the rat TLE model. CONCLUSIONS: Our experiments showed that MMP3 is dynamically regulated by seizures as shown by increased expression in TLE tissue and during different phases of epileptogenesis in the rat TLE model. MMP3 can be induced by the pro-inflammatory cytokine IL-1β and is regulated by miR-155, suggesting a possible strategy to prevent epilepsy via reduction of inflammation.

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Authors
Korotkov, A., Broekaart, D. W. M., van Scheppingen, J., Anink, J. J., Baayen, J. C., Idema, S., Gorter, J. A., Aronica, E., & van Vliet, E. A.
Affiliations
  • Amsterdam University Medical Centers (NL)
  • University of Amsterdam (NL)
ORCID
Venue
Journal of Neuroinflammation
Publisher
Springer Science and Business Media LLC
Published
2018-07-21
Volume
15
Issue
1
Pages
211-211
ISSN
1742-2094 (ISSN-L)
DOI
10.1186/s12974-018-1245-y
PMC
PMC6054845
OpenAlex
W2883780596
Cited by
60
References
6
Citations by year
2026: 6 · 2025: 7 · 2024: 10 · 2023: 7 · 2022: 10 · 2021: 6 · 2020: 7 · 2019: 7
FWCI
3.93
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Neuroinflammation (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Pure Amsterdam UMC (publishedVersion, cc-by)
  • Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
  • UvA-DARE (University of Amsterdam) (submittedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
  • Amsterdam UMC (VU Amsterdam) - Institutional Repository (submittedVersion, other-oa)
Funders
  • European Union’s Seventh Framework Programme (grant agreement no. 602102 (EPITARGET))
  • European Union’s Horizon 2020 Research and Innovation Programme (Marie Sklodowska-Curie grant agreement no. 642881 (ECMED))
  • Dutch Epilepsy Foundation (16-05)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Epilepsy research and treatment
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Protease and Inhibitor Mechanisms
Keywords
matrix metalloproteinase-3, miR-155, temporal lobe epilepsy, astrocytes, IL-1β, extracellular matrix remodeling, hippocampal sclerosis, epileptogenesis, antagomir, neuroinflammation, MMP-2, MMP-9, MMP-14
MeSH terms
Adult, Aged, Aged, 80 and over, Animals, Astrocytes, Brain, Calcium-Binding Proteins, Disease Models, Animal, DNA-Binding Proteins, Electric Stimulation, Female, Fetus, Gene Expression Regulation, Humans, Male, Microfilament Proteins, Middle Aged, Nerve Tissue Proteins, Status Epilepticus, Cytokines, Matrix Metalloproteinase 3, MicroRNAs, Rats

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