Generalizable representations of pain, cognitive control, and negative emotion in medial frontal cortex
Open accessAbstract
The medial frontal cortex, including anterior midcingulate cortex, has been linked to multiple psychological domains, including cognitive control, pain, and emotion. However, it is unclear whether this region encodes representations of these domains that are generalizable across studies and subdomains. Additionally, if there are generalizable representations, do they reflect a single underlying process shared across domains or multiple domain-specific processes? We decomposed multivariate patterns of functional MRI activity from 270 participants across 18 studies into study-specific, subdomain-specific, and domain-specific components and identified latent multivariate representations that generalized across subdomains but were specific to each domain. Pain representations were localized to anterior midcingulate cortex, negative emotion representations to ventromedial prefrontal cortex, and cognitive control representations to portions of the dorsal midcingulate. These findings provide evidence for medial frontal cortex representations that generalize across studies and subdomains but are specific to distinct psychological domains rather than reducible to a single underlying process.
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Recent studies suggest that pain and social rejection have distinct representations in the dACC and AI.
“recent studies suggest that pain and social rejection have distinct representations in the dACC and AI (Woo et al., 2014; Kragel et al., 2018)”
From Feeling left out or just surprised? Neural correlates of social exclusion and overinclusion in adolescence (2020) · cites this paper as Kragel et al., 2018
Prior meta-analyses have consistently implicated the anterior PFC in social exclusion, with recent work indicating that this region processes negative affect.
“Prior meta-analyses have consistently implicated the anterior PFC in social exclusion (Cacioppo et al., 2013; Vijayakumar et al., 2017), with recent work indicating that this region processes negative affect (Kragel et al., 2018).”
From Feeling left out or just surprised? Neural correlates of social exclusion and overinclusion in adolescence (2020) · cites this paper as Kragel et al., 2018
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- Authors
- Kragel, P. A., Kano, M., Van Oudenhove, L., Ly, H. G., Dupont, P., Rubio, A., Delon-Martin, C., Bonaz, B. L., Manuck, S. B., Gianaros, P. J., Ceko, M., Reynolds Losin, E. A., Woo, C.-W., Nichols, T. E., & Wager, T. D.
- Affiliations
- University of Colorado Boulder (US)
- Tohoku University (JP)
- KU Leuven (BE)
- Inserm (FR)
- University of Pittsburgh (US)
- Institute for Basic Science (KR)
- University of Oxford (GB)
- Corresponding author
- Kragel, Philip A.
- Wager, Tor D.
- ORCID
- Venue
- Nature Neuroscience
- Published
- 2018-01-01
- Volume
- 21
- Issue
- 2
- Pages
- 283-289
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- PMC
- PMC5801068
- OpenAlex
- W2776975398
- Cited by
- 272
- References
- 76
- Citations by year
- 2026: 19 · 2025: 38 · 2024: 34 · 2023: 30 · 2022: 34 · 2021: 38 · 2020: 34 · 2019: 28 · 2018: 17
- FWCI
- 12.39
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- HAL (submittedVersion)
- Funders
- Wellcome Trust (100309/A/12/Z)
- National Institutes of Health (5r01ag043463-05)
- Japan Society for the Promotion of Science (26460898)
- National Institute on Aging (R01-AG043463)
- National Heart, Lung, and Blood Institute (R01HL089850, P01HL040962)
- National Institute of Mental Health (R01MH076137, R01MH076136)
- National Institute on Drug Abuse (R01DA035484)
- National Cancer Institute (U01CA193632)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- medial frontal cortex, anterior midcingulate cortex, ventromedial prefrontal cortex, representation of pain, cognitive control, negative emotions, multivariate pattern analysis, domain-specific representations
- MeSH terms
- Adult, Brain Mapping, Cognition, Emotions, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Models, Neurological, Neural Pathways, Oxygen, Pain, Meta-Analysis as Topic, Prefrontal Cortex, Young Adult
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