Cited by 223Neural and Behavioral Psychology StudiesDecision-Making and Behavioral EconomicsNeural dynamics and brain function

Triple dissociation of attention and decision computations across prefrontal cortex

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Hunt, Laurence T., Malalasekera, W. M. Nishantha, de Berker, Archy O., Miranda, Bruno, Farmer, Simon F., Behrens, Timothy E. J., Kennerley, Steven W.·2018·Nature Neuroscience

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Abstract

Naturalistic decision-making typically involves sequential deployment of attention to choice alternatives to gather information before a decision is made. Attention filters how information enters decision circuits, thus implying that attentional control may shape how decision computations unfold. We recorded neuronal activity from three subregions of the prefrontal cortex (PFC) while monkeys performed an attention-guided decision-making task. From the first saccade to decision-relevant information, a triple dissociation of decision- and attention-related computations emerged in parallel across PFC subregions. During subsequent saccades, orbitofrontal cortex activity reflected the value comparison between currently and previously attended information. In contrast, the anterior cingulate cortex carried several signals reflecting belief updating in light of newly attended information, the integration of evidence to a decision bound and an emerging plan for what action to choose. Our findings show how anatomically dissociable PFC representations evolve during attention-guided information search, supporting computations critical for value-guided choice.

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  1. [29]Passingham RE Wise SP The Neurobiology of the Prefrontal Cortex 2012 26 64 Oxford University Press Ch 2

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Authors
Hunt, L. T., Malalasekera, W. M. N., de Berker, A. O., Miranda, B., Farmer, S. F., Behrens, T. E. J., & Kennerley, S. W.
Affiliations
  • Wellcome Centre for Human Neuroimaging (GB)
  • University College London (GB)
  • Champalimaud Foundation (PT)
Corresponding author
  • Hunt, Laurence T.
  • Kennerley, Steven W.
Venue
Nature Neuroscience
Published
2018-09-26
Volume
21
Issue
10
Pages
1471-1481
ISSN
  • 1097-6256 (ISSN-L)
  • 1546-1726
OpenAlex
W2742165752
Cited by
222
References
57
Citations by year
2026: 26 · 2025: 28 · 2024: 21 · 2023: 25 · 2022: 22 · 2021: 45 · 2020: 34 · 2019: 17 · 2018: 3
FWCI
14.74
Type
journal article
Language
en
Open access
Locations
  • Nature Neuroscience (publishedVersion)
  • bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
  • UCL Discovery (University College London) (submittedVersion)
Funders
  • Brain and Behavior Research Foundation
  • James S. McDonnell Foundation (JSMF220020372)
  • National Alliance for Research on Schizophrenia and Depression
  • Wellcome Trust (104765/Z/14/Z, 208789/Z/17/Z, 096689/Z/11/Z, 098830/Z/12/Z, WT104765MA)
  • Astor Foundation
  • Rosetrees Trust
  • Medical Research Council
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Social Sciences › Decision Sciences › General Decision Sciences › Decision-Making and Behavioral Economics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords
prefrontal cortex, orbitofrontal cortex, anterior cingulate cortex, value comparison, belief updating, evidence integration, decision boundaries, action planning, naturalistic decision making, neuronal activity, saccades
MeSH terms
Action Potentials, Animals, Attention, Brain Mapping, Cues, Decision Making, Macaca mulatta, Male, Models, Neurological, Neurons, Reinforcement, Psychology, Saccades, Prefrontal Cortex, Patch-Clamp Techniques

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