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Cited by 99Circular RNAs in diseasesRNA Research and SplicingCancer-related molecular mechanisms research

Circular RNAs are temporospatially regulated throughout development and ageing in the rat

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Mahmoudi, E., Cairns, M. J.·2019·Scientific Reports
DOI 10.1038/s41598-019-38860-9PMC PMC6385508
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Abstract

Circular RNAs (circRNAs) are covalently closed structural isoforms of linear mRNA which have been observed across a broad range of species and tissues. Here, we provide a comprehensive circRNAs expression catalogue for the rat including 8 organs of both sexes during 4 developmental stages using a public RNAseq dataset. These analyses revealed thousands of circular RNA species, many expressed in an organ-specific manner along with their host genes which were enriched with tissue-specific biological functions. A large number of circRNAs also displayed a developmental-dependent expression pattern and are accumulated during ageing. CircRNAs also displayed some sexually dimorphic expression, with gender associated differences observed in various tissues and developmental stages. These observations suggest that circRNAs are dynamically expressed in a spatial-, temporal- and gender-specific manner in mammals, and may have important biological function in differentiation, development and aging.

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Authors
Mahmoudi, E., & Cairns, M. J.
Affiliations
Hunter Medical Research Institute (AU)
Corresponding author
Cairns, M. J.
ORCID
Venue
Scientific Reports
Publisher
Springer Science and Business Media LLC
Published
2019-02-22
Volume
9
Issue
1
Pages
2564-2564
ISSN
2045-2322 (ISSN-L)
DOI
10.1038/s41598-019-38860-9
PMC
PMC6385508
OpenAlex
W2915310464
Cited by
99
References
10
Citations by year
2026: 8 · 2025: 8 · 2024: 13 · 2023: 17 · 2022: 19 · 2021: 14 · 2020: 15 · 2019: 5
FWCI
4.38
Type
journal article
Language
en
Open access
Licence
Locations
  • Scientific Reports (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, other-oa)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Figshare (submittedVersion, cc-by)
  • NOVA (University of Newcastle Australia) (submittedVersion, cc-by)
Funders
National Health and Medical Research Council (1067137, 1121474)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Circular RNAs in diseases
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
Keywords
circular RNA, rats, developmental stages, aging, organ-specific gene expression, sex differences, host genes
MeSH terms
RNA, Circular, Aging, Animals, Female, Gene Expression Regulation, Male, Sex Characteristics, Gene Expression Profiling, Rats

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