cGAS-STING signaling encourages immune cell overcoming of fibroblast barricades in pancreatic cancer
Open accessAbstract
Immune checkpoint blockade (ICB) treatment improves the prognosis of several types of solid tumors, however, responsiveness to ICB therapy remains low in pancreatic ductal adenocarcinoma (PDACs), which has a rich tumor microenvironment (TME). The TME is composed of various stromal cells, including cancer-associated fibroblasts (CAFs), which contribute to the establishment of an immunosuppressive microenvironment. The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway is an innate immune pathway that results in the upregulation of immune cell recruiting-cytokines and anti-tumor efficacy. In this study, we aimed to investigate the impact of cGAS-STING expression and the presence of CAFs upon immune cell infiltration in PDACs. cGAS and STING co-expressing PDAC cases showed favorable survival, with many cytotoxic CD8 + T cell infiltrations from the stromal component adjacent to the cancer cells toward cancer cells, but not in cGAS-STING signaling defected PDAC cases. The signatures of tumor-restrain CAFs were expressed in tumors with cGAS-STING signaling. Finally, transwell co-culture experiments demonstrated that immune cell infiltration was impeded by the presence of CAFs, but not by activation of cGAS-STING signaling. In conclusion, pro-infiltration signals, such as cGAS-STING, and characterization of CAFs are crucial in defeating CAF barricades and encouraging immune cell infiltration in PDACs.
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The current dogma dictates that the host-derived STING pathway is the converging critical responder.
“a finding that is in sharp contrast to the current dogma which dictates that host-derived STING pathway is the converging critical responder.79–81”
From Functional tumor cell-intrinsic STING, not host STING, drives local and systemic antitumor immunity and therapy efficacy following cryoablation (2023) · cites this paper as [81]
The Introduction (page unavailable) describes cGAS-STING as a crucial regulator of tumor immunity, supporting the pathway’s general importance. It does not identify host-derived STING as the converging critical responder. The Discussion (page unavailable) reports lower recruitment of CD8+ T cells toward cancer cells in stromal-STING-dominant cases than in cases with cancer-cell cGAS-STING expression, while cautioning that there were too few stromal-dominant cases for firm conclusions. (LLM, conf=0.78)
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Cites
Siegel, R. L., Miller, K. D., & Jemal, A. (2019) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.21551 · Cited by 20,160 · see citing works
STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity
Ishikawa, H., Ma, Z., & Barber, G. N. (2009) · Nature · doi:10.1038/nature08476 · Cited by 2,759 · see citing works
Regulation and Function of the PD-L1 Checkpoint
Sun, C., Mezzadra, R., & Schumacher, T. N. (2018) · Immunity · doi:10.1016/j.immuni.2018.03.014 · Cited by 2,187 · see citing works
Feig, C., Jones, J. O., Kraman, M., Wells, R. J. B., Deonarine, A., Chan, D. S., Connell, C. M., Roberts, E. W., Zhao, Q., Caballero, O. L., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1320318110 · Cited by 2,100 · see citing works
Kleeff, J., Korc, M., Apte, M., La Vecchia, C., Johnson, C. D., Biankin, A. V., Neale, R. E., Tempero, M., Tuveson, D. A., Hruban, R. H., et al. (2016) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2016.22 · Cited by 1,982 · see citing works
Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis
Thayer, S. P., di Magliano, M. P., Heiser, P. W., Nielsen, C. M., Roberts, D. J., Lauwers, G. Y., Qi, Y., Gysin, S., Castillo, C. F. F.-D., Yajnik, V., et al. (2003) · Nature · doi:10.1038/nature02009 · Cited by 1,479 · see citing works
DNA sensing by the cGAS–STING pathway in health and disease
Motwani, M., Pesiridis, S., & Fitzgerald, K. A. (2019) · Nature Reviews Genetics · doi:10.1038/s41576-019-0151-1 · Cited by 1,467 · see citing works
The Cytosolic DNA-Sensing cGAS–STING Pathway in Cancer
Kwon, J., & Bakhoum, S. F. (2020) · Cancer Discovery · doi:10.1158/2159-8290.cd-19-0761 · Cited by 1,293 · see citing works
Carcinoma–astrocyte gap junctions promote brain metastasis by cGAMP transfer
Chen, Q., Boire, A., Jin, X., Valiente, M., Er, E. E., Lopez-Soto, A., S. Jacob, L., Patwa, R., Shah, H., Xu, K., et al. (2016) · Nature · doi:10.1038/nature18268 · Cited by 969 · see citing works
Bayne, L. J., Beatty, G. L., Jhala, N., Clark, C. E., Rhim, A. D., Stanger, B. Z., & Vonderheide, R. H. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.04.025 · Cited by 947 · see citing works
Zhu, Y., Herndon, J. M., Sojka, D. K., Kim, K.-W., Knolhoff, B. L., Zuo, C., Cullinan, D. R., Luo, J. R., Bearden, A. R., Lavine, K. J., et al. (2017) · Immunity · doi:10.1016/j.immuni.2017.07.014 · Cited by 799 · see citing works
Yang, X., Lin, Y., Shi, Y., Li, B., Liu, W., Yin, W., Dang, Y., Chu, Y., Fan, J., & He, R. (2016) · Cancer Research · doi:10.1158/0008-5472.can-15-2973 · Cited by 748 · see citing works
Kumar, V., Donthireddy, L., Marvel, D., Condamine, T., Wang, F., Lavilla-Alonso, S., Hashimoto, A., Vonteddu, P., Behera, R., Goins, M. A., et al. (2017) · Cancer Cell · doi:10.1016/j.ccell.2017.10.005 · Cited by 653 · see citing works
Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP
Ablasser, A., Schmid-Burgk, J. L., Hemmerling, I., Horvath, G. L., Schmidt, T., Latz, E., & Hornung, V. (2013) · Nature · doi:10.1038/nature12640 · Cited by 649 · see citing works
Carstens, J. L., Correa de Sampaio, P., Yang, D., Barua, S., Wang, H., Rao, A., Allison, J. P., LeBleu, V. S., & Kalluri, R. (2017) · Nature Communications · doi:10.1038/ncomms15095 · Cited by 633 · see citing works
Tumor-stroma interactions in pancreatic ductal adenocarcinoma
Mahadevan, D., & Hoff, D. D. V. (2007) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-06-0686 · Cited by 602 · see citing works
Cancer-associated fibroblasts in gastrointestinal cancer
Kobayashi, H., Enomoto, A., Woods, S. L., Burt, A. D., Takahashi, M., & Worthley, D. L. (2019) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-019-0115-0 · Cited by 596 · see citing works
Xia, T., Konno, H., Ahn, J., & Barber, G. N. (2016) · Cell Reports · doi:10.1016/j.celrep.2015.12.029 · Cited by 589 · see citing works
Ene–Obong, A., Clear, A. J., Watt, J., Wang, J., Fatah, R., Riches, J. C., Marshall, J. F., Chin–Aleong, J., Chelala, C., Gribben, J. G., et al. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.07.025 · Cited by 579 · see citing works
Suppression of STING Associated with LKB1 Loss in KRAS-Driven Lung Cancer
Kitajima, S., Ivanova, E., Guo, S., Yoshida, R., Campisi, M., Sundararaman, S. K., Tange, S., Mitsuishi, Y., Thai, T. C., Masuda, S., et al. (2019) · Cancer Discovery · doi:10.1158/2159-8290.cd-18-0689 · Cited by 526 · see citing works
Stromal response to Hedgehog signaling restrains pancreatic cancer progression
Lee, J. J., Perera, R. M., Wang, H., Wu, D.-C., Liu, X. S., Han, S., Fitamant, J., Jones, P. D., Ghanta, K. S., Kawano, S., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1411679111 · Cited by 502 · see citing works
Type I interferon response and innate immune sensing of cancer
Fuertes, M. B., Woo, S.-R., Burnett, B., Fu, Y.-X., & Gajewski, T. F. (2013) · Trends in Immunology · doi:10.1016/j.it.2012.10.004 · Cited by 375 · see citing works
Stromal biology and therapy in pancreatic cancer: ready for clinical translation?
Neeße, A., Bauer, C. A., Öhlund, D., Lauth, M., Buchholz, M., Michl, P., Tuveson, D. A., & Gress, T. M. (2018) · Gut · doi:10.1136/gutjnl-2018-316451 · Cited by 348 · see citing works
Meflin-Positive Cancer-Associated Fibroblasts Inhibit Pancreatic Carcinogenesis
Mizutani, Y., Kobayashi, H., Iida, T., Asai, N., Masamune, A., Hara, A., Esaki, N., Ushida, K., Mii, S., Shiraki, Y., et al. (2019) · Cancer Research · doi:10.1158/0008-5472.can-19-0454 · Cited by 339 · see citing works
Self-citationRegulatory T Cell Migration Is Dependent on Glucokinase-Mediated Glycolysis
Kishore, M., Cheung, K. C.-P., Fu, H., Bonacina, F., Wang, G., Coe, D., Ward, E. J., Colamatteo, A., Jangani, M., Baragetti, A., et al. (2017) · Immunity · doi:10.1016/j.immuni.2017.10.017 · Cited by 272 · see citing works
Decreased expression of STING predicts poor prognosis in patients with gastric cancer
Song, S., Peng, P., Tang, Z., Zhao, J., Wu, W., Li, H., Shao, M., Li, L., Yang, C., Duan, F., et al. (2017) · Scientific Reports · doi:10.1038/srep39858 · Cited by 216 · see citing works
Role of the cGAS–STING pathway in cancer development and oncotherapeutic approaches
Khoo, L. T., & Chen, L. (2018) · The EMBO Reports · doi:10.15252/embr.201846935 · Cited by 204 · see citing works
Loss of the Timp gene family is sufficient for the acquisition of the CAF-like cell state
Shimoda, M., Principe, S., Jackson, H. W., Luga, V., Fang, H., Molyneux, S. D., Shao, Y. W., Aiken, A., Waterhouse, P. D., Karamboulas, C., et al. (2014) · Nature Cell Biology · doi:10.1038/ncb3021 · Cited by 199 · see citing works
Hedgehog Signaling Is Required for Effective Regeneration of Exocrine Pancreas
Fendrich, V., Esni, F., Garay, M. V. R., Feldmann, G., Habbe, N., Jensen, J. N., Dor, Y., Stoffers, D., Jensen, J., Leach, S. D., et al. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.04.011 · Cited by 191 · see citing works
DNA-stimulated cell death: implications for host defence, inflammatory diseases and cancer
Paludan, S. R., Reinert, L. S., & Hornung, V. (2019) · Nature reviews. Immunology · doi:10.1038/s41577-018-0117-0 · Cited by 183 · see citing works
Zhu, Y., Herndon, J. M., Sojka, D. K., Kim, K.-W., Knolhoff, B. L., Zuo, C., Cullinan, D. R., Luo, J., Bearden, A. R., Lavine, K. J., et al. (2017) · Immunity · doi:10.1016/j.immuni.2017.08.018 · Cited by 180 · see citing works
Zhu, Q., Man, S. M., Gurung, P., Liu, Z., Vogel, P., Lamkanfi, M., & Kanneganti, T. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1402051 · Cited by 154 · see citing works
Fibroblasts in Pancreatic Ductal Adenocarcinoma: Biological Mechanisms and Therapeutic Targets
Whittle, M. C., & Hingorani, S. R. (2019) · Gastroenterology · doi:10.1053/j.gastro.2018.12.044 · Cited by 133 · see citing works
The cGAS-STING pathway is a therapeutic target in a preclinical model of hepatocellular carcinoma
Thomsen, M. K., Skouboe, M. K., Boularan, C., Vernejoul, F., Lioux, T., Leknes, S. L., Berthelsen, M. F., Riedel, M., Cai, H., Joseph, J. V., et al. (2019) · Oncogene · doi:10.1038/s41388-019-1108-8 · Cited by 102 · see citing works
Arwert, E. N., Milford, E. L., Rullan, A., Derzsi, S., Hooper, S., Kato, T., Mansfield, D., Melcher, A., Harrington, K. J., & Sahai, E. (2020) · Nature Cell Biology · doi:10.1038/s41556-020-0527-7 · Cited by 90 · see citing works
Piao, W., Xiong, Y., Famulski, K. S., Brinkman, C. C., Li, L., Toney, N., Wagner, C., Saxena, V., Simon, T., & Bromberg, J. S. (2018) · Nature Communications · doi:10.1038/s41467-018-05412-0 · Cited by 44 · see citing works
Kabashima, A., Hirsova, P., Bronk, S. F., Hernandez, M. C., Truty, M. J., Ilyas, S. I., Kaufmann, S. H., & Gores, G. J. (2018) · Journal of Hepatology · doi:10.1016/j.jhep.2018.01.026 · Cited by 22 · see citing works
Self-citationRecent advances in immunotherapy for pancreatic cancer
Chi, J., Patel, R., Rehman, H., Goyal, S. P., & Saif, M. W. (2020) · Journal of Cancer Metastasis and Treatment · doi:10.20517/2394-4722.2020.90 · Cited by 15 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Demystifying the cGAS-STING pathway: precision regulation in the tumor immune microenvironment
Wang, Q., Yu, Y., Zhuang, J., Liu, R., & Sun, C. (2025) · Molecular Cancer · doi:10.1186/s12943-025-02380-0 · Cited by 141 · see citing works
cGAS–STING signalling in cancer: striking a balance with chromosomal instability
Beernaert, B., & Parkes, E. E. (2023) · Biochemical Society Transactions · doi:10.1042/bst20220838 · Cited by 59 · see citing works
Zhang, X., Tang, D., Xiao, H., Li, B., Shang, K., & Zhao, D. (2025) · ACS Nano · doi:10.1021/acsnano.4c12237 · Cited by 48 · see citing works
Wu, Y., Lu, W., Cui, Q.-R., Zhou, J., & Lu, G. (2025) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2025.06.002 · Cited by 44 · see citing works
Colangelo, N. W., Gerber, N. K., Vatner, R. E., & Cooper, B. T. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1383000 · Cited by 41 · see citing works
Emerging mechanisms and implications of cGAS-STING signaling in cancer immunotherapy strategies
Zhang, J., Yu, S., Peng, Q., Wang, P., & Fang, L. (2024) · Cancer Biology and Medicine · doi:10.20892/j.issn.2095-3941.2023.0440 · Cited by 35 · see citing works
Benkhaled, S., Peters, C., Jullian, N., Arsenijevic, T., Navez, J., Gestel, D. V., Moretti, L., Laethem, J. V., & Bouchart, C. (2023) · Cancers · doi:10.3390/cancers15030768 · Cited by 29 · see citing works
Cancer cell-specific cGAS/STING Signaling pathway in the era of advancing cancer cell biology
Kumar, V., Bauer, C., & Stewart, J. H. (2023) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2023.151338 · Cited by 30 · see citing works
Hajiabadi, S., Alidadi, S., Farahi, Z. M., Seno, M. M. G., Farzin, H., & Haghparast, A. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1258691 · Cited by 28 · see citing works
Korneenko, T. V., Pestov, N. B., Nevzorov, I. A., Daks, A. A., Николаевич, Т. К., Солопова, О. Н., & Barlev, N. A. (2023) · Pharmaceuticals · doi:10.3390/ph16121675 · Cited by 28 · see citing works
Suzuki, Y., SATO, T. A., Sugimori, M., Kanemaru, Y., Onodera, S., Tsuchiya, H., Nakamori, Y., Tsuyuki, S., Ikeda, A., Ikeda, R., et al. (2024) · Scientific Reports · doi:10.1038/s41598-024-68061-y · Cited by 22 · see citing works
CAFs and T cells interplay: The emergence of a new arena in cancer combat
Chen, M., Chen, F., Gao, Z., Li, X., Hu, L., Yang, S., Zhao, S., & Song, Z. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.117045 · Cited by 20 · see citing works
Killer instincts: natural killer cells as multifactorial cancer immunotherapy
Nersesian, S., Carter, E. B., Lee, S. N., Westhaver, L. P., & Boudreau, J. E. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1269614 · Cited by 18 · see citing works
DTX3L mediated ubiquitination of cGAS suppresses antitumor immunity in pancreatic cancer
Lin, S. (2023) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2023.09.073 · Cited by 15 · see citing works
Alshebremi, M., Tomchuck, S. L., Myers, J. T., Kingsley, D. T., Eid, S., Abiff, M., Bonner, M., Saab, S. T., Choi, S. H., & Huang, A. Y.-C. (2023) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2022-006608 · Cited by 14 · see citing works
Ghukasyan, R., Liang, K., Chau, K., Li, L., Chan, C., Abt, E. R., Le, T. M., Park, J. Y., Wu, N., Premji, A., et al. (2023) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-22-3322 · Cited by 14 · see citing works
Pu, Z., Liu, J., Liu, Z., Peng, F., Zhu, Y., Wang, X., He, J., Yi, P., Hu, X., Fan, X., et al. (2022) · Cancer Cell International · doi:10.1186/s12935-022-02734-4 · Cited by 14 · see citing works
Gruber, S., Kleinwächter, A., Popova, K., Kneringer, A., Appel, L.-M., Stasny, K., Rohrer, A. M., Dias, A. B., Benedum, J., Walch, L., et al. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1286942 · Cited by 14 · see citing works
TAX1BP1-dependent autophagic degradation of STING1 impairs anti-tumor immunity
Zhang, R., Yu, C., Zeh, H. J., Kroemer, G., Klionsky, D. J., Tang, D., & Kang, R. (2025) · Autophagy · doi:10.1080/15548627.2025.2471736 · Cited by 13 · see citing works
Liu, C., Tang, L., Yang, W., Gu, Y., Xu, W., Liang, Z., & Jiang, J. (2024) · Oncology Reports · doi:10.3892/or.2024.8848 · Cited by 12 · see citing works
Role of cGAS-STING pathway in fibrotic disease
Feng, L., Zhang, F., Cao, J., & Xiong, W. (2025) · Pharmacological Research · doi:10.1016/j.phrs.2025.107971 · Cited by 12 · see citing works
Sanchez-Manas, J. M., de Gracia, N. P., Perales, S., Martínez-Galán, J., Torres, C., & Real, P. J. (2024) · Extracellular Vesicles and Circulating Nucleic Acids · doi:10.20517/evcna.2023.68 · Cited by 9 · see citing works
Li, R., Liu, R., Xu, Y., Zhang, S., Yang, P., Zeng, W., Wang, H., Liu, Y., Yang, H., Yue, X., et al. (2024) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.4c00379 · Cited by 9 · see citing works
Jeong, M., Yoon, J., Kim, K., Wang, J., Koo, Y., Sailor, M. J., Joo, J., & Park, J. (2025) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.4c19425 · Cited by 6 · see citing works
Piseddu, I., Endres, R., Lanzl, F., Hammann, L., Bérouti, M., Thaler, M. B., Fahr, L., Fischer, H., Varlamova, V., Gärtig, J., et al. (2026) · Gastroenterology · doi:10.1053/j.gastro.2026.01.031 · Cited by 6 · see citing works
Jiang, H. B., Li, Z., Li, X. X., Yu, L., Sun, J., Shen, Y., Sun, H., & Qi, L. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2026.1844637 · Cited by 6 · see citing works
Decoding STING’s roles in cancer: immunity, pain, dormancy, and autophagy
Lin, H., Tang, Y., & Liang, X. (2025) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-025-05281-4 · Cited by 6 · see citing works
He, Y., Zeng, X., Liu, Q., Zhou, L., Tang, Y., Liu, S., Wang, X., Shen, S., Ji, J., Liu, Z., et al. (2026) · Molecular Cancer · doi:10.1186/s12943-026-02634-5 · Cited by 5 · see citing works
Rathod, H., Jain, P., Verma, D., Dharme, K. K., Verma, G., & ., A. (2026) · Current Drug Targets · doi:10.2174/0113894501434141251223120435 · Cited by 4 · see citing works
JUN–ENPP1–cGAS–STING axis mediates immune evasion and tumor progression in bladder cancer
You, C., Fang, Q., Qing, L., Xiao, X., Liu, Y., Yang, W., Li, Q., Li, R., Wang, Y., & Dong, Z. (2025) · Journal of Translational Medicine · doi:10.1186/s12967-025-07275-8 · Cited by 4 · see citing works
The cGAS–STING pathway in cancer immunotherapy: prognostic value and therapeutic potential
Alabi, F. A., Imodoye, S. O., Adedokun, K. A., Eltokhy, M. A., Curcic, M., Okoyeocha, E., Thapa, I., Tiwari, S., Ogundele, A. V., Ayo, T. E., et al. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1760947 · Cited by 4 · see citing works
Sun, G., Yang, Z., Fang, K., Xiong, Y., Tu, S., Yi, S., & Xiao, W. (2023) · Oncology Letters · doi:10.3892/ol.2023.13847 · Cited by 4 · see citing works
Myint., H. T., Saranaruk, P., Paungpan, N., Waraasawapati, S., Pairojkul, C., Saisomboon, S., Settha, N., Pattanachot, J., Okada, S., Seubwai, W., et al. (2025) · PeerJ · doi:10.7717/peerj.19800 · Cited by 4 · see citing works
Zhang, Z., Deng, H., Zhang, X., Li, J., Zhao, J., Liu, J., Deng, C., Yang, Y., & Liang, Z. (2026) · APOPTOSIS · doi:10.1007/s10495-026-02268-4 · Cited by 3 · see citing works
The cGAS-STING pathway as a novel therapeutic strategy for pancreatic diseases
Pei, Z., & Tian, M. (2024) · Cytokine · doi:10.1016/j.cyto.2024.156801 · Cited by 3 · see citing works
Ding, H., Mao, Y., Yao, Z., Xing, K., Yang, Q., Wang, R., (5906), J. W., Liu, Y., Guo, H., Wang, Z., et al. (2026) · Journal of Biomedical Science · doi:10.1186/s12929-026-01226-1 · Cited by 2 · see citing works
Pu, Z., Liu, J., Liu, Z., Peng, F., Zhu, Y., Wang, X., He, J., Yi, P., Hu, X., Fan, X., et al. (2022) · Figshare · doi:10.6084/m9.figshare.21321611
Pu, Z., Liu, J., Liu, Z., Peng, F., Zhu, Y., Wang, X., He, J., Yi, P., Hu, X., Fan, X., et al. (2022) · Figshare · doi:10.6084/m9.figshare.21321632
Pu, Z., Liu, J., Liu, Z., Peng, F., Zhu, Y., Wang, X., He, J., Yi, P., Hu, X., Fan, X., et al. (2022) · Figshare · doi:10.6084/m9.figshare.21321602
Pu, Z., Liu, J., Liu, Z., Peng, F., Zhu, Y., Wang, X., He, J., Yi, P., Hu, X., Fan, X., et al. (2022) · Figshare · doi:10.6084/m9.figshare.21321629
Pu, Z., Liu, J., Liu, Z., Peng, F., Zhu, Y., Wang, X., He, J., Yi, P., Hu, X., Fan, X., et al. (2022) · Figshare · doi:10.6084/m9.figshare.21321593
Pu, Z., Liu, J., Liu, Z., Peng, F., Zhu, Y., Wang, X., He, J., Yi, P., Hu, X., Fan, X., et al. (2022) · Figshare · doi:10.6084/m9.figshare.21321587
Pu, Z., Liu, J., Liu, Z., Peng, F., Zhu, Y., Wang, X., He, J., Yi, P., Hu, X., Fan, X., et al. (2022) · Figshare · doi:10.6084/m9.figshare.21321596
Pu, Z., Liu, J., Liu, Z., Peng, F., Zhu, Y., Wang, X., He, J., Yi, P., Hu, X., Fan, X., et al. (2022) · Figshare · doi:10.6084/m9.figshare.21321605
Pu, Z., Liu, J., Liu, Z., Peng, F., Zhu, Y., Wang, X., He, J., Yi, P., Hu, X., Fan, X., et al. (2022) · Figshare · doi:10.6084/m9.figshare.21321614
Pu, Z., Liu, J., Liu, Z., Peng, F., Zhu, Y., Wang, X., He, J., Yi, P., Hu, X., Fan, X., et al. (2022) · Figshare · doi:10.6084/m9.figshare.21321626
Pu, Z., Liu, J., Liu, Z., Peng, F., Zhu, Y., Wang, X., He, J., Yi, P., Hu, X., Fan, X., et al. (2022) · Figshare · doi:10.6084/m9.figshare.21321599
Pu, Z., Liu, J., Liu, Z., Peng, F., Zhu, Y., Wang, X., He, J., Yi, P., Hu, X., Fan, X., et al. (2022) · Figshare · doi:10.6084/m9.figshare.21321608
Pu, Z., Liu, J., Liu, Z., Peng, F., Zhu, Y., Wang, X., He, J., Yi, P., Hu, X., Fan, X., et al. (2022) · Figshare · doi:10.6084/m9.figshare.21321617
Pu, Z., Liu, J., Liu, Z., Peng, F., Zhu, Y., Wang, X., He, J., Yi, P., Hu, X., Fan, X., et al. (2022) · Figshare · doi:10.6084/m9.figshare.21321620
Pu, Z., Liu, J., Liu, Z., Peng, F., Zhu, Y., Wang, X., He, J., Yi, P., Hu, X., Fan, X., et al. (2022) · Figshare · doi:10.6084/m9.figshare.21321584
Diao, Z., Wang, Y., Mu, S., Wu, X., Yu, S., & Wang, Z. (2026) · Frontiers in Oncology · doi:10.3389/fonc.2026.1756245
Yoshitake, H., Negoto, T., Moritsubo, M., Furuta, T., Jo, M., Hirota, T., Sakata, K., Nakamura, H., & Morioka, M. (2026) · Neuro-Oncology Advances · doi:10.1093/noajnl/vdag179
Hou, Y., & Tan, Z. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1942345
Chen, T., Zhang, J., Sun, J., Zhang, H., Huang, D., & Ye, H. (2026) · International Journal of Oncology · doi:10.3892/ijo.2026.5944
- Authors
- Kabashima, A., Matsuo, Y., Ito, S., Akiyama, Y., Ishii, T., Shimada, S., Masamune, A., Tanabe, M., & Tanaka, S.
- Affiliations
- Tokyo Medical and Dental University (JP)
- Mayo Clinic (US)
- Tohoku University (JP)
- Corresponding author
- Kabashima, Ayano
- Tanaka, Shinji
- Venue
- Scientific Reports
- Published
- 2022-06-30
- Volume
- 12
- Issue
- 1
- Pages
- 10466-10466
- ISSN
- 2045-2322 (ISSN-L)
- PMC
- PMC9247053
- OpenAlex
- W4283734650
- Cited by
- 55
- References
- 38
- Citations by year
- 2026: 11 · 2025: 9 · 2024: 9 · 2023: 10 · 2022: 16
- FWCI
- 4.60
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Scientific Reports (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- The Ministry of Education, Culture, Sports, Science and Technology of Japan (20K17606, 19H01055)
- Research Grant from the Princess Takamatsu Cancer Research Fund
- Agency for Medical Research and Development (P-CREATE JP19cm0106540)
- Topics
- Health Sciences › Medicine › Oncology › Pancreatic and Hepatic Oncology Research
- Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
- Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
- Keywords
- cGAS-STING pathway, pancreatic ductal adenocarcinoma, cancer-associated fibroblasts, tumor microenvironment, immune cell infiltration, CD8+ T cells, immune checkpoint blockade, innate immunity, immunosuppression, stromal barriers
- MeSH terms
- Cancer-Associated Fibroblasts, STING Protein, Cyclic Guanosine Monophosphate-Adenosine Monophosphate Synthase, Humans, Membrane Proteins, Nucleotidyltransferases, Pancreatic Neoplasms, Signal Transduction, Carcinoma, Pancreatic Ductal, Tumor Microenvironment
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