Bifidobacteria or Fiber Protects against Diet-Induced Microbiota-Mediated Colonic Mucus Deterioration
Open accessAbstract
Diet strongly affects gut microbiota composition, and gut bacteria can influence the colonic mucus layer, a physical barrier that separates trillions of gut bacteria from the host. However, the interplay between a Western style diet (WSD), gut microbiota composition, and the intestinal mucus layer is less clear. Here we show that mice fed a WSD have an altered colonic microbiota composition that causes increased penetrability and a reduced growth rate of the inner mucus layer. Both barrier defects can be prevented by transplanting microbiota from chow-fed mice. In addition, we found that administration of Bifidobacterium longum was sufficient to restore mucus growth, whereas administration of the fiber inulin prevented increased mucus penetrability in WSD-fed mice. We hypothesize that the presence of distinct bacteria is crucial for proper mucus function. If confirmed in humans, these findings may help to better understand diseases with an affected mucus layer, such as ulcerative colitis.
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Feeding mice a western-style diet induces depletion of fiber-degrading bacteria, including Bacteroidetes and Actinobacteria, accompanied by reduced SCFAs production, reduced inner mucus growth rate, and increased mucus penetrability.
“feeding mice a western-style diet characterized by low dietary fiber, high fats, and high simple carbohydrates induces depletion of fiber-degrading bacteria, including Bacteroidetes (family S24-7) and Actinobacteria (Bifidobacterium). This was accompanied by reduced SCFAs production, reduced inner mucus growth rate, and increased mucus penetrability.”
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- Authors
- Schroeder, B. O., Birchenough, G. M. H., Ståhlman, M., Arike, L., Johansson, M. E. V., Hansson, G. C., & Bäckhed, F.
- Affiliations
- University of Gothenburg (SE)
- University of Copenhagen (DK)
- Corresponding author
- Hansson, Gunnar C.
- Bäckhed, Fredrik
- ORCID
- Venue
- Cell Host & Microbe
- Publisher
- Elsevier BV
- Published
- 2018-01
- Volume
- 23
- Issue
- 1
- Pages
- 27-40.e7
- ISSN
- 1931-3128 (ISSN-L)
- PMC
- PMC5764785
- OpenAlex
- W2780398151
- Cited by
- 713
- References
- 64
- Citations by year
- 2026: 40 · 2025: 79 · 2024: 91 · 2023: 99 · 2022: 111 · 2021: 107 · 2020: 74 · 2019: 70 · 2018: 42
- FWCI
- 20.77
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell Host & Microbe (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (publishedVersion, other-oa)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- HAL (submittedVersion)
- Funders
- Göteborgs Universitet
- European Research Council (615362, 622909 – MUCUS AND METABOLISM, 694181 – MUC2GO)
- National Institutes of Health
- Novo Nordisk Fonden
- Hjärt-Lungfonden
- National Institute of Allergy and Infectious Diseases (U01AI095473)
- Hasselbladstiftelsen
- Knut och Alice Wallenbergs Stiftelse
- Västra Götalandsregionen
- Vetenskapsrådet
- Sahlgrenska Universitetssjukhuset
- Göran Gustafssons Stiftelser
- Seventh Framework Programme
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Keywords
- colonic mucus layer, gut microbiota, Western diet, Bifidobacterium longum, inulin, dietary fiber, mucus barrier, microbiota transplantation, ulcerative colitis
- MeSH terms
- Gastrointestinal Microbiome, Fecal Microbiota Transplantation, Bifidobacterium longum, Animals, Colon, Dietary Fiber, Intestinal Mucosa, Inulin, Male, Mice, Inbred C57BL, Obesity, Mice, Knockout, Dietary Supplements, Mice, Diet, Western
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