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Disparities in the pace of biological aging among midlife adults of the same chronological age have implications for future frailty risk and policy

Elliott, Maxwell L., Caspi, Avshalom, Houts, Renate M., Ambler, Antony, Broadbent, Jonathan M., Hancox, Robert J., Harrington, HonaLee, Hogan, Sean, Keenan, Ross, Knodt, Annchen, Leung, Joan H., Melzer, Tracy R., Purdy, Suzanne C., Ramrakha, Sandhya, Richmond-Rakerd, Leah S., Righarts, Antoinette, Sugden, Karen, Thomson, W. Murray, Thorne, Peter R., Williams, Benjamin S., Wilson, Graham, Hariri, Ahmad R., Poulton, Richie, Moffitt, Terrie E.·2021·Nature Aging
DOI 10.1038/s43587-021-00044-4PMC PMC8009092

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  • DunedinPACE was developed by modeling within-individual multi-system physiological change across four timepoints in same-age individuals in the Dunedin Study 1972-1973 birth cohort, when participants were aged 26, 32, 38 and 45 yr.

    “DunedinPACE was developed by modeling within-individual multi-system physiological change across four timepoints in same-age individuals in the Dunedin Study 1972–1973 birth cohort60,61, when participants were aged 26, 32, 38 and 45 yr.”

    From Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial (2023) · cites this paper as [61]

    The Introduction and Methods (pages unavailable) describe modeling changes in multiple physiological systems in the same-age Dunedin 1972–1973 birth cohort at ages 26, 32, 38, and 45. They call the resulting measure the “Pace of Aging,” however; our copy does not say that this paper developed DunedinPACE. (LLM, conf=0.86)

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Research works printed but not linked: 67

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Metadata

Authors
Elliott, M. L., Caspi, A., Houts, R. M., Ambler, A., Broadbent, J. M., Hancox, R. J., Harrington, H., Hogan, S., Keenan, R., Knodt, A., Leung, J. H., Melzer, T. R., Purdy, S. C., Ramrakha, S., Richmond-Rakerd, L. S., Righarts, A., Sugden, K., Thomson, W. M., Thorne, P. R., Williams, B. S., Wilson, G., Hariri, A. R., Poulton, R., & Moffitt, T. E.
Venue
Nature Aging
Publisher
Springer Science and Business Media LLC
Published
2021-03-15
Volume
1
Issue
3
Pages
295-308
ISSN
2662-8465
DOI
10.1038/s43587-021-00044-4
PMC
PMC8009092
Cited by
316
References
17
Language
en
Licence
Funders
  • U.S. Department of Health & Human Services | NIH | National Institute on Aging (R01AG049789, F99AG068432-01, NIA P30 AG028716, NIA P30 AG034424)
  • National Science Foundation (DGE-1644868)
  • RCUK | Medical Research Council (MR/P005918/1)
  • Manatu Hauora | Health Research Council of New Zealand (15-265, 16-604)

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