Oxidation of Guanine in Cellular DNA by Solar UV Radiation: Biological Role†

Douki, Thierry; Perdiz, Daniel; Grof, Pal; Kuluncsics, Zéno; Moustacchi, Ethel; Cadet, Jean; Sage, Evelyne

doi:10.1111/j.1751-1097.1999.tb07988.x

Cited by 133DNA Repair MechanismsCarcinogens and Genotoxicity AssessmentSkin Protection and Aging

Oxidation of Guanine in Cellular DNA by Solar UV Radiation: Biological Role†

Douki, Thierry, Perdiz, Daniel, Grof, Pal, Kuluncsics, Zéno, Moustacchi, Ethel, Cadet, Jean, Sage, Evelyne·1999·Photochemistry and Photobiology

DOI 10.1111/j.1751-1097.1999.tb07988.x

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Abstract

Abstract. The formation of cyclobutane pyrimidine dimers (CPD) and 8‐oxo‐7,8‐dihydro‐2′‐deoxyguanosine (8‐oxodGuo) was investigated in Chinese hamster ovary cells upon exposure to either UVC, UVB, UVA or simulated sunlight (SSL). Two cell lines were used, namely AT3‐2 and UVL9, the latter being deficient in nucleotide excision repair and consequently UV sensitive. For all types of radiation, including UVA, CPD were found to be the predominant lesions quantitatively. At the biologically relevant doses used, UVC, UVB and SSL irradiation yielded 8‐oxodGuo at a rather low level, whereas UVA radiation produced relatively higher amounts. The formation of CPD was 10 2 and 10 2 more effective upon UVC than UVB and UVA exposure. These yields of formation followed DNA absorption, even in the UVA range. The calculated relative spectral effectiveness in the production of the two lesions showed that efficient induction of 8‐oxodGuo upon UVA irradiation was shifted toward longer wavelengths, in comparison with those for CPD formation, in agreement with a photosensitization mechanism. In addition, after exposure to SSL, about 19% and 20% of 8‐oxodGuo were produced between 290–320 nm and 320–340 nm, respectively, whereas CPD were essentially (90%) induced in the UVB region. However, the ratio of CPD to 8‐oxodGuo greatly differed from one source of light to the other: it was over 100 for UVB but only a few units for UVA source. The extent of 8‐oxodGuo and CPD was also compared to the lethality for the different types of radiation. The involvement of 8‐oxodGuo in cell killing by solar UV radiation was clearly ruled out. In addition, our previously reported mutation

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8-oxoGua is generated in significant yields upon UVA exposure of cultured cells and skin.
“A much more common biomarker of oxidatively generated damage to DNA is 8-oxoGua that has been found to be generated in significant yields upon exposure of cultured cells (85,112,113) and skin (61) to UVA radiation.”
From Photoinduced Damage to Cellular DNA: Direct and Photosensitized Reactions† (2012) · cites this paper as [112]

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Authors: Douki, T., Perdiz, D., Grof, P., Kuluncsics, Z., Moustacchi, E., Cadet, J., & Sage, E.
Affiliations: Commissariat à l'Énergie Atomique et aux Énergies Alternatives (FR)
Centre National de la Recherche Scientifique (FR)
Semmelweis University (HU)
ORCID: Douki, Thierry
Perdiz, Daniel
Cadet, Jean
Venue: Photochemistry and Photobiology
Publisher: Wiley
Published: 1999-08
Volume: 70
Issue: 2
Pages: 184-190
ISSN: 0031-8655 (ISSN-L)
1751-1097
DOI: 10.1111/j.1751-1097.1999.tb07988.x
OpenAlex: W2146700501
Cited by: 133
References: 57
Citations by year: 2025: 4 · 2024: 2 · 2023: 4 · 2022: 4 · 2021: 3 · 2020: 5 · 2019: 1 · 2018: 4 · 2017: 6 · 2016: 4 · 2015: 4 · 2014: 4 · 2013: 6 · 2012: 4
FWCI: 2.18
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 3076 d)
Locations: Photochemistry and Photobiology (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Carcinogens and Genotoxicity Assessment
Health Sciences › Medicine › Dermatology › Skin Protection and Aging
Keywords: guanine oxidation, 8-oxo-7,8-dihydro-2'-deoxyguanosine, cyclobutane pyrimidine dimers, solar ultraviolet radiation, UVA, UV-B radiation, UV-C, simulated sunlight, nucleotide excision repair deficiency, photosensitization, DNA damage, cell lethality, UV mutagenesis, CHO cells
MeSH terms: Animals, DNA, DNA Damage, Guanine, Cricetinae, Mutation, Oxidation-Reduction, Pyrimidine Dimers, Sunlight, CHO Cells, Photobiology

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Oxidation of Guanine in Cellular DNA by Solar UV Radiation: Biological Role†

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