Altered Insula Response to Taste Stimuli in Individuals Recovered from Restricting-Type Anorexia Nervosa
Abstract
Anorexia nervosa (AN) is an illness characterized by aversion to ingestion of normally palatable foods. We examined whether there is a primary disturbance of taste processing and experience of pleasure using a sucrose/water task in conjunction with functional magnetic resonance imaging (fMRI). To avoid confounding effects of illness, 16 women recovered from restricting-type AN were compared to 16 control women (CW). We used a region of interest-based fMRI approach to test the idea that individuals with AN have differential neural activation in primary and secondary taste cortical regions after sucrose and water administration. Compared to CW, individuals recovered from AN showed a significantly lower neural activation of the insula, including the primary cortical taste region, and ventral and dorsal striatum to both sucrose and water. In addition, insular neural activity correlated with pleasantness ratings for sucrose in CW, but not in AN subjects. Altered taste processing may occur in AN, based on differences in activity in insular-striatal circuits. These data provide the first evidence that individuals with AN process taste stimuli differently than controls, based on differences in neural activation patterns.
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When tasting sucrose, subjects recovered from anorexia nervosa show less insular activation and no association with feelings of pleasantness as observed in controls.
“In contrast, when tasting sucrose, subjects who have recovered from anorexia nervosa show less insular activation and no association with feelings of pleasantness as observed in controls (145).”
From Obesity and addiction: Neurobiological overlaps (2013) · cites this paper as [145]
Subjects recovered from anorexia nervosa show less insular activation when tasting sucrose and no association of pleasantness with insular activation as controls do.
“In contrast, subjects who have recovered from anorexia nervosa show less insular activation when tasting sucrose and no association of feelings of pleasantness with insular activation as observed in control subjects (104).”
From The Addictive Dimensionality of Obesity (2013) · cites this paper as [104]
Subjects who have recovered from anorexia nervosa show less activation in the insula when tasting sucrose and no association of feelings of pleasantness with insular activation as observed in the normal controls.
“In contrast, subjects who have recovered from anorexia nervosa show less activation in the insula when tasting sucrose and no association of feelings of pleasantness with insular activation as observed in the normal controls (Wagner et al 2008).”
From Food and Drug Reward: Overlapping Circuits in Human Obesity and Addiction (2011) · cites this paper as Wagner et al 2008
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- Authors
- Wagner, A., Aizenstein, H., Mazurkewicz, L., Fudge, J., Frank, G. K., Putnam, K., Bailer, U. F., Fischer, L., & Kaye, W. H.
- Affiliations
- Goethe University Frankfurt (DE)
- University of Pittsburgh (US)
- University of Rochester Medicine (US)
- University of Cincinnati (US)
- Corresponding author
- Kaye, Walter H
- Venue
- Neuropsychopharmacology
- Published
- 2007-05-09
- Volume
- 33
- Issue
- 3
- Pages
- 513-523
- ISSN
- 0893-133X (ISSN-L)
- 1740-634X
- OpenAlex
- W2129856337
- Cited by
- 261
- References
- 70
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 7 · 2023: 11 · 2022: 12 · 2021: 5 · 2020: 11 · 2019: 15 · 2018: 13 · 2017: 21 · 2016: 19 · 2015: 29 · 2014: 18 · 2013: 15 · 2012: 25
- FWCI
- 12.54
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Neuropsychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (UL1TR000005)
- National Institute of Mental Health (K05MH001894, R01MH046001, MH04298, MH046001)
- National Center for Advancing Translational Sciences
- Topics
- Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Keywords
- anorexia nervosa, insula, taste processing, sucrose, food enjoyment, striatum, taste aversion, eating disorder recovery
- MeSH terms
- Adult, Anorexia Nervosa, Anxiety, Carbohydrates, Cerebral Cortex, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Psychiatric Status Rating Scales, Taste, Water, Body Mass Index
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