Reduced functional connectivity in the thalamo-insular subnetwork in patients with acute anorexia nervosa
Open accessAbstract
The neural underpinnings of anorexia nervosa (AN) are poorly understood. Results from existing functional brain imaging studies using disorder‐relevant food‐ or body‐stimuli have been heterogeneous and may be biased due to varying compliance or strategies of the participants. In this study, resting state functional connectivity imaging was used. To explore the distributed nature and complexity of brain function we characterized network patterns in patients with acute AN. Thirty‐five unmedicated female acute AN patients and 35 closely matched healthy female participants underwent resting state functional magnetic resonance imaging. We used a network‐based statistic (NBS) approach [Zalesky et al., 2010a] to identify differences between groups by isolating a network of interconnected nodes with a deviant connectivity pattern. Group comparison revealed a subnetwork of connections with decreased connectivity including the amygdala, thalamus, fusiform gyrus, putamen and the posterior insula as the central hub in the patient group. Results were not driven by changes in intranodal or global connectivity. No network could be identified where AN patients had increased coupling. Given the known involvement of the identified thalamo‐insular subnetwork in interoception, decreased connectivity in AN patients in these nodes might reflect changes in the propagation of sensations that alert the organism to urgent homeostatic imbalances and pain‐processes that are known to be severely disturbed in AN and might explain the striking discrepancy between patient's actual and perceived internal body state. Hum Brain Mapp 36:1772–1781, 2015. © 2015 Wiley Periodicals, Inc.
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Decreased functional connectivity between the thalamus, putamen, and insula is observed in AN.
“as well as decreased functional connectivity between the thalamus, putamen and insula (Ehrlich et al., 2015).”
From Cortico-striatal-thalamic loop circuits of the salience network: A central pathway in psychiatric disease and treatment (2016) · cites this paper as Ehrlich et al., 2015
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- Authors
- Ehrlich, S., Lord, A. R., Geisler, D., Borchardt, V., Boehm, I., Seidel, M., Ritschel, F., Schulze, A., King, J. A., Weidner, K., Roessner, V., & Walter, M.
- Affiliations
- Harvard University (US)
- Leibniz Institute for Neurobiology (DE)
- University Hospital Carl Gustav Carus (DE)
- Center for Behavioral Brain Sciences (DE)
- ORCID
- Venue
- Human Brain Mapping
- Publisher
- Wiley
- Published
- 2015-01-22
- Volume
- 36
- Issue
- 5
- Pages
- 1772-1781
- ISSN
- 1065-9471 (ISSN-L)
- 1097-0193
- PMC
- PMC6869480
- OpenAlex
- W1910167135
- Cited by
- 65
- References
- 96
- Citations by year
- 2026: 4 · 2025: 8 · 2024: 4 · 2023: 2 · 2022: 7 · 2021: 11 · 2020: 6 · 2019: 3 · 2018: 9 · 2017: 4 · 2016: 7
- FWCI
- 4.01
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Human Brain Mapping (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Deutsche Forschungsgemeinschaft (EH 367/5-1, SFB 940, SFB 779)
- German Academic Exchange Service
- Swiss Anorexia Nervosa Foundation
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Mental Health Research Topics
- Keywords
- anorexia nervosa, resting-state functional connectivity, network-based statistics, amygdala, thalamus, posterior insula, fusiform gyrus, putamen, interoception, body image, homeostatic imbalance, pain processing, female patients
- MeSH terms
- Acute Disease, Adolescent, Anorexia Nervosa, Brain Mapping, Cerebral Cortex, Child, Female, Humans, Magnetic Resonance Imaging, Neural Pathways, Signal Processing, Computer-Assisted, Thalamus, Models, Statistical, Young Adult
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