The effect of lesions of the insular cortex on instrumental conditioning: evidence for a role in incentive memory
Open accessAbstract
In three experiments, we assessed the effect of lesions aimed at the gustatory region of the insular cortex on instrumental conditioning in rats. In experiment 1, the lesion had no effect on the acquisition of either lever pressing or chain pulling in food-deprived rats whether these actions earned food pellets or a maltodextrin solution. The lesion did, however, attenuate the impact of outcome devaluation, induced by sensory-specific satiety, on instrumental performance but only when assessed in an extinction test. This effect was not secondary to an impairment in instrumental learning; in experiment 2, no evidence was found to suggest that the lesioned rats differed from shams in their ability to encode the specific action-outcome contingencies to which they were exposed during training. In experiment 3, however, lesioned rats were found to be insensitive to the impact of an incentive learning treatment conducted when they were undeprived; although, again, this deficit was confined to a test conducted in extinction. These results are consistent with the view that, in instrumental conditioning, the gustatory region of the insular cortex is involved in encoding the taste of food outcomes in memory and, hence, in encoding the incentive value assigned to these outcomes on the basis of prevailing motivational conditions.
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Lesions to the rat insula are associated with reduced encoding of the incentive value of instrumentally conditioned behaviour to obtain food.
“Lesions to the rat insula have also been associated with reduced encoding of the incentive value of instrumentally conditioned behaviour to obtain food”
From Atypical interoception as a common risk factor for psychopathology: A review (2021) · cites this paper as Balleine and Dickinson, 2000
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- Authors
- Balleine, B. W., & Dickinson, A.
- Affiliations
- University of California, Los Angeles (US)
- University of Cambridge (GB)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2000-12-01
- Volume
- 20
- Issue
- 23
- Pages
- 8954-8964
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6773086
- OpenAlex
- W1802685233
- Cited by
- 218
- References
- 3
- Citations by year
- 2026: 5 · 2025: 3 · 2024: 28 · 2023: 3 · 2022: 3 · 2021: 12 · 2020: 9 · 2019: 6 · 2018: 5 · 2017: 9 · 2016: 9 · 2015: 12 · 2014: 11 · 2013: 11 · 2012: 12
- FWCI
- 3.03
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- European Commission
- National Institute of Mental Health (R29MH056446, MH56446, R01MH056446)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- insula, operant conditioning, outcome devaluation, sensory-specific satiety, extinction, food reward, taste memory, incentive value, food deprivation, rats
- MeSH terms
- Analysis of Variance, Animals, Appetitive Behavior, Behavior, Animal, Cerebral Cortex, Choice Behavior, Conditioning, Operant, Male, Memory, Rats, Inbred Strains, Reward, Satiety Response, Taste, Rats
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