Abnormal social reward responses in anorexia nervosa: an fMRI study
Open accessAbstract
Patients with anorexia nervosa (AN) display impaired social interactions, implicated in the development and prognosis of the disorder. Importantly, social behavior is modulated by reward-based processes, and dysfunctional at-brain-level reward responses have been involved in AN neurobiological models. However, no prior evidence exists of whether these neural alterations would be equally present in social contexts. In this study, we conducted a cross-sectional social-judgment functional magnetic resonance imaging (fMRI) study of 20 restrictive-subtype AN patients and 20 matched healthy controls. Brain activity during acceptance and rejection was investigated and correlated with severity measures (Eating Disorder Inventory -EDI-2) and with personality traits of interest known to modulate social behavior (The Sensitivity to Punishment and Sensitivity to Reward Questionnaire). Patients showed hypoactivation of the dorsomedial prefrontal cortex (DMPFC) during social acceptance and hyperactivation of visual areas during social rejection. Ventral striatum activation during rejection was positively correlated in patients with clinical severity scores. During acceptance, activation of the frontal opercula-anterior insula and dorsomedial/dorsolateral prefrontal cortices was differentially associated with reward sensitivity between groups. These results suggest an abnormal motivational drive for social stimuli, and involve overlapping social cognition and reward systems leading to a disruption of adaptive responses in the processing of social reward. The specific association of reward-related regions with clinical and psychometric measures suggests the putative involvement of reward structures in the maintenance of pathological behaviors in AN.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
At the neural level, areas of hypo- and hyperactivation have been identified in response to positive and negative social exchanges, respectively, in eating disorders.
“Evidence from behavioral studies suggests women with AN avoid looking at the faces and eyes of others and find them less rewarding compared to non-eating disorder controls (100), while at the neural level, areas of hypo- and hyperactivation have been identified in response to positive and negative social exchanges, respectively (101, 102).”
From A transdiagnostic perspective on social anhedonia (2019) · cites this paper as [102]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Diagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,841 · see citing works
Hamilton, M. (1960) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.23.1.56 · Cited by 32,817 · see citing works
The assessment of anxiety states by rating
HAMILTON, M. (1959) · British Journal of Medical Psychology · doi:10.1111/j.2044-8341.1959.tb00467.x · Cited by 11,455 · see citing works
Meeting of minds: the medial frontal cortex and social cognition
Amodio, D. M., & Frith, C. D. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1884 · Cited by 3,782 · see citing works
A Systematic Method for Clinical Description and Classification of Personality Variants: A Proposal
Cloninger, C. R. (1987) · Archives of General Psychiatry · doi:10.1001/archpsyc.1987.01800180093014 · Cited by 3,678 · see citing works
Liebowitz, M. R. (2015) · Modern Trends in Pharmacopsychiatry · doi:10.1159/000414022 · Cited by 2,266 · see citing works
Martı́nez, A. M. (1998) · Medical Entomology and Zoology · Cited by 1,982 · see citing works
Torrubia, R., Ávila, C., Moltó, J., & Caseras, X. (2001) · Personality and Individual Differences · doi:10.1016/s0191-8869(00)00183-5 · Cited by 1,348 · see citing works
Eating Disorder Inventory-2 ; Pro-fessional Manual
Garner, D. (1991) · Medical Entomology and Zoology · Cited by 1,283 · see citing works
Comorbidity of Anxiety Disorders With Anorexia and Bulimia Nervosa
Kaye, W. H., Bulik, C. M., Thornton, L., Barbarich, N., Masters, K., & the Price Foundation Collaborative Group (2004) · American Journal of Psychiatry · doi:10.1176/appi.ajp.161.12.2215 · Cited by 1,162 · see citing works
“Liking” and “wanting” food rewards: Brain substrates and roles in eating disorders
Berridge, K. C. (2009) · Physiology & Behavior · doi:10.1016/j.physbeh.2009.02.044 · Cited by 1,147 · see citing works
Associative learning of social value
Behrens, T. E. J., Hunt, L. T., Woolrich, M. W., & Rushworth, M. F. S. (2008) · Nature · doi:10.1038/nature07538 · Cited by 925 · see citing works
Schmidt, U. H., & Treasure, J. L. (2006) · British Journal of Clinical Psychology · doi:10.1348/014466505x53902 · Cited by 882 · see citing works
Processing of Social and Monetary Rewards in the Human Striatum
Izuma, K., Saito, D. N., & Sadato, N. (2008) · Neuron · doi:10.1016/j.neuron.2008.03.020 · Cited by 855 · see citing works
New insights into symptoms and neurocircuit function of anorexia nervosa
Kaye, W. H., Fudge, J. L., & Paulus, M. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2682 · Cited by 843 · see citing works
The social brain in psychiatric and neurological disorders
Kennedy, D. P., & Adolphs, R. (2012) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2012.09.006 · Cited by 798 · see citing works
Reward‐Related Responses in the Human Striatum
DELGADO, M. R. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1390.002 · Cited by 736 · see citing works
Functional magnetic resonance imaging of reward prediction
Knutson, B., & Cooper, J. C. (2005) · Current Opinion in Neurology · doi:10.1097/01.wco.0000173463.24758.f6 · Cited by 736 · see citing works
Schizophrenia, neuroimaging and connectomics
Fornito, A., Zalesky, A., Pantelis, C., & Bullmore, E. T. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2011.12.090 · Cited by 716 · see citing works
The neural correlates of direct and reflected self-knowledge
Ochsner, K. N., Beer, J. S., Robertson, E. R., Cooper, J. C., Gabrieli, J. D. E., Kihsltrom, J. F., & D'Esposito, M. (2005) · NeuroImage · doi:10.1016/j.neuroimage.2005.06.069 · Cited by 562 · see citing works
Validity of the scaled version of the General Health Questionnaire (GHQ-28) in a Spanish population
Lobo, A., Perez-Echeverria, M. J., & Artal, J. (1986) · Psychological Medicine · doi:10.1017/s0033291700002579 · Cited by 535 · see citing works
Nothing tastes as good as skinny feels: the neurobiology of anorexia nervosa
Kaye, W. H., Wierenga, C. E., Bailer, U. F., Simmons, A. N., & Bischoff‐Grethe, A. (2013) · Trends in Neurosciences · doi:10.1016/j.tins.2013.01.003 · Cited by 527 · see citing works
The neural bases of social pain: Evidence for shared representations with physical pain
Eisenberger, N. I. (2012) · Psychosomatic Medicine · doi:10.1097/psy.0b013e3182464dd1 · Cited by 492 · see citing works
Harrison, A., Sullivan, S. A., Tchanturia, K., & Treasure, J. L. (2010) · Psychological Medicine · doi:10.1017/s0033291710000036 · Cited by 472 · see citing works
Individual differences in reward responding explain placebo-induced expectations and effects
Scott, D. J., Stohler, C. S., Egnatuk, C. M., Wang, H., Koeppe, R. A., & Zubieta, J.-K. (2007) · Neuron · doi:10.1016/j.neuron.2007.06.028 · Cited by 466 · see citing works
Social and monetary reward learning engage overlapping neural substrates
Lin, A., Adolphs, R., & Rangel, A. (2012) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsr006 · Cited by 351 · see citing works
Altered Reward Processing in Women Recovered From Anorexia Nervosa
Wagner, A., Aizenstein, H., Venkatraman, V. K., Fudge, J., May, J. C., Mazurkewicz, L., Frank, G. K., Bailer, U. F., Fischer, L., Nguyen, V., et al. (2007) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2007.07040575 · Cited by 342 · see citing works
Compulsive drug seeking by rats under punishment: effects of drug taking history
Pelloux, Y., Everitt, B. J., & Dickinson, A. (2007) · Psychopharmacology · doi:10.1007/s00213-007-0805-0 · Cited by 323 · see citing works
Anorexia nervosa and obesity are associated with opposite brain reward response
Frank, G. K. W., Reynolds, J. R., Shott, M. E., Jappe, L., Yang, T. T., Tregellas, J. R., & O'Reilly, R. C. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2012.51 · Cited by 311 · see citing works
Ochsner, K. N. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.04.024 · Cited by 300 · see citing works
Neurobiology of learning, emotion, and affect
Madden, J. (1991) · Raven Press eBooks · Cited by 295 · see citing works
Taste, olfactory, and food reward value processing in the brain
Rolls, E. T. (2015) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2015.03.002 · Cited by 287 · see citing works
Zucker, N. L., Losh, M., Bulik, C. M., LaBar, K. S., Piven, J., & Pelphrey, K. A. (2007) · Psychological Bulletin · doi:10.1037/0033-2909.133.6.976 · Cited by 284 · see citing works
Rieger, E., Van Buren, D. J., Bishop, M., Tanofsky-Kraff, M., Welch, R., & Wilfley, D. E. (2010) · Clinical Psychology Review · doi:10.1016/j.cpr.2010.02.001 · Cited by 279 · cited 1× · see citing works
“Data from behavioral studies have suggested a negative bias in social relationships: patients with AN perceive low reward from- and are avoidant of- social contexts and are oversensitive and attention-biased towards rejection [1,36–40].”
BackgroundRelevance to self: A brief review and framework of neural systems underlying appraisal
Schmitz, T. W., & Johnson, S. C. (2007) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2006.12.003 · Cited by 271 · see citing works
Wagner, A., Aizenstein, H., Mazurkewicz, L., Fudge, J., Frank, G. K., Putnam, K., Bailer, U. F., Fischer, L., & Kaye, W. H. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301443 · Cited by 261 · see citing works
Sensitivity to reward and punishment in eating disorders
Harrison, A., O'Brien, N., Lopez, C., & Treasure, J. (2010) · Psychiatry Research · doi:10.1016/j.psychres.2009.06.010 · Cited by 244 · see citing works
Increased neural processing of rewarding and aversive food stimuli in recovered anorexia nervosa
Cowdrey, F. A., Park, R. J., Harmer, C. J., & McCabe, C. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.05.028 · Cited by 233 · see citing works
Do you like me? Neural correlates of social evaluation and developmental trajectories
Gunther Moor, B., van Leijenhorst, L., Rombouts, S. A. R. B., Crone, E. A., & Van der Molen, M. W. (2010) · Social Neuroscience · doi:10.1080/17470910903526155 · Cited by 231 · see citing works
Response of the μ-opioid system to social rejection and acceptance
Hsu, D. T., Sanford, B. J., Meyers, K. K., Love, T. M., Hazlett, K. E., Wang, H., Ni, L., Walker, S. J., Mickey, B. J., Korycinski, S. T., et al. (2013) · Molecular Psychiatry · doi:10.1038/mp.2013.96 · Cited by 225 · see citing works
Chase, H. W., Kumar, P., Eickhoff, S. B., & Dombrovski, A. Y. (2015) · Cognitive Affective & Behavioral Neuroscience · doi:10.3758/s13415-015-0338-7 · Cited by 225 · see citing works
A Neural Signature of Anorexia Nervosa in the Ventral Striatal Reward System
Fladung, A.-K., Grön, G., Grammer, K., Herrnberger, B., Schilly, E., Grasteit, S., Wolf, R. C., Walter, H., & von Wietersheim, J. (2010) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2009.09010071 · Cited by 220 · see citing works
Predicting events of varying probability: uncertainty investigated by fMRI
Volz, K. G., Schubotz, R. I., & von Cramon, D. Y. (2003) · NeuroImage · doi:10.1016/s1053-8119(03)00122-8 · Cited by 214 · see citing works
A universal role of the ventral striatum in reward-based learning: Evidence from human studies
Daniel, R., & Pollmann, S. (2014) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2014.05.002 · Cited by 209 · see citing works
Altered Insula Response to Sweet Taste Processing After Recovery From Anorexia and Bulimia Nervosa
Oberndorfer, T. A., Frank, G., Simmons, A. N., Wagner, A., McCurdy, D., Fudge, J. L., Yang, T. T., Paulus, M. P., & Kaye, W. H. (2013) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2013.11111745 · Cited by 200 · see citing works
The rewarding nature of social interactions.
Krach, S. (2010) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2010.00022 · Cited by 196 · see citing works
Cardi, V., Matteo, R. D., Corfield, F., & Treasure, J. (2013) · The World Journal of Biological Psychiatry · doi:10.3109/15622975.2012.665479 · Cited by 176 · see citing works
Being liked activates primary reward and midline self‐related brain regions
Davey, C. G., Allen, N. B., Harrison, B. J., Dwyer, D. B., & Yücel, M. (2010) · Human Brain Mapping · doi:10.1002/hbm.20895 · Cited by 155 · see citing works
Reward processing in anorexia nervosa
Keating, C., Tilbrook, A. J., Rossell, S. L., Enticott, P. G., & Fitzgerald, P. B. (2012) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2012.01.036 · Cited by 151 · see citing works
Altered Brain Reward Circuits in Eating Disorders: Chicken or Egg?
Frank, G. (2013) · Current Psychiatry Reports · doi:10.1007/s11920-013-0396-x · Cited by 144 · see citing works
Neurobiology of learning, emotion and affect
Peyser, C. E. (1992) · Electroencephalography and Clinical Neurophysiology · doi:10.1016/0013-4694(92)90077-u · Cited by 136 · see citing works
Anorexia nervosa, self–starvation and the reward of stress
Bergh, C. E. K., & Södersten, P. (1996) · Nature Medicine · doi:10.1038/nm0196-21 · Cited by 135 · see citing works
A three-phase model of the social emotional functioning in eating disorders
Treasure, J., Corfield, F., & Cardi, V. (2012) · European Eating Disorders Review · doi:10.1002/erv.2181 · Cited by 128 · cited 1× · see citing works
“Current theoretical models describe AN as a multifactorial disorder [7,8] and, social factors, including both the impact of social environment and how individuals interact and process social information, are considered highly relevant to the development, maintenance and prognosis of the disorder [1,9].”
BackgroundSocial rewards and social networks in the human brain
Fareri, D. S., & Delgado, M. R. (2014) · The Neuroscientist · doi:10.1177/1073858414521869 · Cited by 124 · see citing works
Beck, I. M. E., Smits, D., Claes, L., Vandereycken, W., & Bijttebier, P. (2009) · Personality and Individual Differences · doi:10.1016/j.paid.2009.04.007 · Cited by 120 · see citing works
Mitchell, J. P., Cloutier, J., Banaji, M. R., & Macrae, C. N. (2006) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsl007 · Cited by 117 · see citing works
Theory of Mind and the Brain in Anorexia Nervosa: Relation to Treatment Outcome
Schulte‐Rüther, M., Mainz, V., Fink, G. R., Herpertz‐Dahlmann, B., & Konrad, K. (2012) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2012.06.007 · Cited by 107 · see citing works
Davey, C. G., Allen, N. B., Harrison, B. J., & Yücel, M. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.12.004 · Cited by 98 · see citing works
Sternheim, L., Konstantellou, A., Startup, H., & Schmidt, U. (2011) · European Eating Disorders Review · doi:10.1002/erv.1029 · Cited by 91 · cited 1× · see citing works
“Moreover, this response might be also associated with low tolerance to uncertainty and increased perception of lack of control in social relationships in AN patients [73], suggested to be compensated by increased control over eating, body shape and weight [10,27].”
BackgroundTheoretical perspective on anorexia nervosa: The conflict of reward
Keating, C. (2009) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2009.07.004 · Cited by 90 · see citing works
Altered social reward and attention in anorexia nervosa
Watson, K. K. (2010) · Frontiers in Psychology · doi:10.3389/fpsyg.2010.00036 · Cited by 90 · see citing works
Krug, I., Penelo, E., Fernández‐Aranda, F., Anderluh, M. B., Bellodi, L., Cellini, E., Bernardo, M. D., Granero, R., Karwautz, A. F. K., Nacmias, B., et al. (2012) · Journal of Health Psychology · doi:10.1177/1359105311435946 · Cited by 90 · see citing works
Social emotional functioning and cognitive styles in eating disorders
Harrison, A., Tchanturia, K., Naumann, U., & Treasure, J. L. (2011) · British Journal of Clinical Psychology · doi:10.1111/j.2044-8260.2011.02026.x · Cited by 86 · see citing works
Vocks, S., Herpertz, S., Rosenberger, C., Senf, W., & Gizewski, E. R. (2010) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2010.07.012 · Cited by 82 · see citing works
Karwautz, A. F. K., Wagner, G., Waldherr, K., Nader, I. W., Fernández‐Aranda, F., Estivill, X., Holliday, J., Collier, D. A., & Treasure, J. L. (2010) · Molecular Psychiatry · doi:10.1038/mp.2010.125 · Cited by 81 · see citing works
Animal models of eating disorders
Kim, S. F. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.03.024 · Cited by 76 · see citing works
Approach and avoidance motivation in eating disorders
Harrison, A., Treasure, J. L., & Smillie, L. D. (2011) · Psychiatry Research · doi:10.1016/j.psychres.2011.04.022 · Cited by 76 · see citing works
Behavioral neuroendocrinology and treatment of anorexia nervosa
Södersten, P., Nergårdh, R., Bergh, C. E. K., Zandian, M., & Scheurink, A. J. W. (2008) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2008.06.001 · Cited by 73 · see citing works
Kontis, D., & Theochari, E. (2012) · Behavioural Pharmacology · doi:10.1097/fbp.0b013e328357e115 · Cited by 72 · see citing works
Disruption of brain white matter microstructure in women with anorexia nervosa
Via, E., Zalesky, A., Sánchez, I., Forcano, L., Harrison, B. J., Pujol, J., Fernández‐Aranda, F., Menchón, J. M., Soriano‐Mas, C., Cardoner, N., et al. (2014) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.130135 · Cited by 72 · see citing works
Matton, A., Goossens, L., Braet, C., & Vervaet, M. (2013) · European Eating Disorders Review · doi:10.1002/erv.2226 · Cited by 67 · see citing works
Who am I? How do I look? Neural differences in self-identity in anorexia nervosa.
McAdams, C. J., & Krawczyk, D. C. (2014) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nss093 · Cited by 66 · see citing works
What makes the dorsomedial frontal cortex active during reading the mental states of others?
Isoda, M., & Noritake, A. (2013) · Frontiers in Neuroscience · doi:10.3389/fnins.2013.00232 · Cited by 64 · see citing works
Schematic Models and Modes of Mind in Anorexia Nervosa I: A Novel Process Account
Park, R. J., Dunn, B. D., & Barnard, P. J. (2011) · International Journal of Cognitive Therapy · doi:10.1521/ijct.2011.4.4.415 · Cited by 63 · see citing works
Eating disorders: National Institute of Mental Health's perspective.
Chavez, M., & Insel, T. R. (2007) · American Psychologist · doi:10.1037/0003-066x.62.3.159 · Cited by 61 · see citing works
Heightened sensitivity to punishment and reward in anorexia nervosa
Glashouwer, K. A., Bloot, L., Veenstra, E. M., Franken, I. H. A., & de Jong, P. J. (2014) · Appetite · doi:10.1016/j.appet.2013.12.019 · Cited by 58 · see citing works
Neural correlates of intolerance of uncertainty
Schienle, A., Köchel, A., Ebner, F., Reishofer, G., & Schäfer, A. (2010) · Neuroscience Letters · doi:10.1016/j.neulet.2010.05.078 · Cited by 57 · see citing works
Anterior insular cortex regulation in autism spectrum disorders
Carìa, A., & de Falco, S. (2015) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2015.00038 · Cited by 54 · see citing works
Kim, Y., Kim, C., Park, S. J., Pyo, J., & Treasure, J. L. (2014) · PLoS ONE · doi:10.1371/journal.pone.0090721 · Cited by 53 · see citing works
Review of Attentional Bias Modification: A Brain‐directed Treatment for Eating Disorders
Renwick, B., Campbell, I. C., & Schmidt, U. H. (2013) · European Eating Disorders Review · doi:10.1002/erv.2248 · Cited by 53 · see citing works
Cracking the moody brain: The rewards of self starvation
Zink, C. F., & Weinberger, D. R. (2010) · Nature Medicine · doi:10.1038/nm1210-1382 · Cited by 52 · see citing works
Jiang, T., Soussignan, R., Rigaud, D., & Schaal, B. (2010) · Psychiatry Research · doi:10.1016/j.psychres.2010.04.041 · Cited by 49 · see citing works
Krug, I., Villarejo, C., Jiménez‐Múrcia, S., Perpiñá, C., Vilarrasa, N., Granero, R., Cebolla, A., Botella, C., de Bernabé, M. M., Penelo, E., et al. (2012) · European Eating Disorders Review · doi:10.1002/erv.2204 · Cited by 47 · see citing works
Reward Sensitivity Is Associated with Brain Activity during Erotic Stimulus Processing
Costumero, V., Barrós-Loscertales, A., Bustamante, J. C., Ventura-Campos, N., Fuentes, P., Rosell-Negre, P., & Ávila, C. (2013) · PLoS ONE · doi:10.1371/journal.pone.0066940 · Cited by 45 · see citing works
A cognitive neuroscience approach to individual differences in sensitivity to reward
Ávila, C., Parcet, M. A., & Barrós‐Loscertales, A. (2008) · Neurotoxicity Research · doi:10.1007/bf03033810 · Cited by 37 · see citing works
Making Sense of Real-Time Functional Magnetic Resonance Imaging (rtfMRI) and rtfMRI Neurofeedback
Brühl, A. B. (2015) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyv020 · Cited by 32 · see citing works
Emotional Processing of Infants Displays in Eating Disorders
Cardi, V., Corfield, F., Leppänen, J., Rhind, C., Deriziotis, S., Hadjimichalis, A., Hibbs, R., Micali, N., & Treasure, J. L. (2014) · PLoS ONE · doi:10.1371/journal.pone.0113191 · Cited by 17 · see citing works
Ivanov, I., Liu, X., Clerkin, S. M., Schulz, K. P., Fan, J., Friston, K. J., London, E. D., Schwartz, J., & Newcorn, J. H. (2014) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2014.01.017 · Cited by 12 · see citing works
Neurobiology of Learning, Emotion, and Affect
Bordi, F., & LeDoux, J. E. (1992) · Europe PMC (PubMed Central) · Cited by 6 · see citing works
Flagged first, then by citations
1 of the 90 references couldn’t be matched to a known paper.
Research works printed but not linked: 3
- [2]National Collaborating Centre or Mental Health commissioned by the National Institute for Clinical Excellence. National Clinical Practice Guideline Number CG9 (NICE Guidelines). Eating Disorders Core interventions in the treatment and management of anorexia nervosa, bulimia nervosa and related eating disorders. [Internet]. The British Psychological Society & The Royal College of Psychiatists; 2004. Available: http://www.nice.org.uk/guidance/cg9 23346610
- [50]First MB, Spitzer RL, Gibbon M, Williams JBW. Structured Clinical Interview for DSM-IV-TR Axis I Disorders, Research Version, Patient Edition. (SCID-I/P). New York: Biometrics Research;New York State Psychiatric Institute; 2002.
- [53]First MB, Spitzer RL, Gibbon M, Williams JB. Structured Clinical Interview for DSM-IV-RS Axis 1 Disorders—Non-patient edition (SCID-I/NP). New York: Biometrics Research, New York State Psychiatric Institute; 2007.
Cited by
Sorted by citations
Interacting neural ensembles in orbitofrontal cortex for social and feeding behaviour
Jennings, J. H., Kim, C. K., Marshel, J. H., Raffiee, M., Li, Y., Quirin, S., Pak, S., Ramakrishnan, C., & Deisseroth, K. A. (2019) · Nature · doi:10.1038/s41586-018-0866-8 · Cited by 208 · see citing works
A transdiagnostic perspective on social anhedonia
Barkus, E., & Badcock, J. C. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00216 · Cited by 165 · see citing works
Vijayakumar, N., Cheng, T. W., & Pfeifer, J. H. (2017) · NeuroImage · doi:10.1016/j.neuroimage.2017.02.050 · Cited by 161 · see citing works
“…2014 48 (14) 15.48 (1.68), 11–17 Chatroom Event 0 Van Harmelen et al., 2014 46 (12) 1: 18.31 (1.23) Cyberball Events 8 Emerging adult Traditional (events) 2: 18.85 (1.90) Via et al., 2015 20 (0) 28.15 (8.62) Social Judgment Block 12 Will et al., 2015 28 (12) 20.7 (1.97) Cyberball Events 13…”
InfluentialNeural Network Alterations Across Eating Disorders: A Narrative Review of fMRI Studies
Steward, T., Menchón, J. M., Jiménez‐Múrcia, S., Soriano‐Mas, C., & Fernández‐Aranda, F. (2017) · Current Neuropharmacology · doi:10.2174/1570159x15666171017111532 · Cited by 162 · see citing works
Reinhard, M. A., Dewald‐Kaufmann, J., Wüstenberg, T., Musil, R., Barton, B. B., Jobst, A., & Padberg, F. (2019) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-019-01074-1 · Cited by 142 · see citing works
Davies, H. A., Wolz, I., Leppänen, J., Fernández‐Aranda, F., Schmidt, U. H., & Tchanturia, K. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.02.015 · Cited by 142 · see citing works
Cardi, V., Mallorquí-Bagué, N., Albano, G., Monteleone, A. M., Fernández-Aranda, F., & Treasure, J. (2018) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00012 · Cited by 83 · see citing works
Monteleone, A. M., Treasure, J. L., Kan, C., & Cardi, V. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.02.002 · Cited by 75 · see citing works
Haynos, A. F., Lavender, J. M., Nelson, J. D., Crow, S. J., & Peterson, C. B. (2020) · Clinical Psychology Review · doi:10.1016/j.cpr.2020.101872 · Cited by 72 · see citing works
Frintrop, L., Trinh, S., Liesbrock, J., Leunissen, C., Kempermann, J., Etdöger, S., Kas, M. J., Tolba, R. H., Heussen, N. M., Neulen, J., et al. (2019) · Translational Psychiatry · doi:10.1038/s41398-019-0493-7 · Cited by 72 · see citing works
Biased Interpretation of Ambiguous Social Scenarios in Anorexia Nervosa
Cardi, V., Turton, R., Schifano, S., Leppänen, J., Hirsch, C. R., & Treasure, J. L. (2016) · European Eating Disorders Review · doi:10.1002/erv.2493 · Cited by 69 · see citing works
Seidel, M., King, J. A., Ritschel, F., Boehm, I., Geisler, D., Bernardoni, F., Holzapfel, L., Diestel, S., Diers, K., Strobel, A., et al. (2018) · Translational Psychiatry · doi:10.1038/s41398-017-0004-7 · Cited by 67 · see citing works
Neural correlates of negative expectancy and impaired social feedback processing in social anxiety
Gu, R., Ao, X., Mo, L., & Zhang, D. (2020) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsaa038 · Cited by 64 · see citing works
Altered Medial Frontal Feedback Learning Signals in Anorexia Nervosa
Bernardoni, F., Geisler, D., King, J. A., Javadi, A., Ritschel, F., Murr, J., Reiter, A. M. F., Roessner, V., Smolka, M. N., Kiebel, S. J., et al. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.07.024 · Cited by 61 · see citing works
Donofry, S. D., Roecklein, K. A., Wildes, J. E., Miller, M. A., & Erickson, K. I. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.07.011 · Cited by 57 · see citing works
Psychedelics in the treatment of eating disorders: Rationale and potential mechanisms
Calder, A. E., Mock, S., Friedli, N., Pasi, P. R., & Hasler, G. (2023) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2023.05.008 · Cited by 48 · see citing works
The predictive value of the early maladaptive schemas in social situations in anorexia nervosa
Meneguzzo, P., Collantoni, E., Bonello, E., Busetto, P., Tenconi, E., & Favaro, A. (2020) · European Eating Disorders Review · doi:10.1002/erv.2724 · Cited by 48 · see citing works
Targeting Neural Endophenotypes of Eating Disorders with Non-invasive Brain Stimulation
Dunlop, K., Woodside, D. B., & Downar, J. H. (2016) · Frontiers in Neuroscience · doi:10.3389/fnins.2016.00030 · Cited by 44 · see citing works
Functional brain alterations in anorexia nervosa: a scoping review
Fuglset, T. S., Landrø, N. I., Reas, D. L., & Rø, Ø. (2016) · Journal of Eating Disorders · doi:10.1186/s40337-016-0118-y · Cited by 47 · see citing works
Puttevils, L., Vanderhasselt, M., Horczak, P., & Vervaet, M. (2021) · Comprehensive Psychiatry · doi:10.1016/j.comppsych.2021.152262 · Cited by 46 · see citing works
Simon, J. J., Stopyra, M. A., & Friederich, H. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8071047 · Cited by 44 · see citing works
de Paoli, T., Fuller-Tyszkiewicz, M., Halliwell, E., Puccio, F., & Krug, I. (2017) · European eating disorders review · doi:10.1002/erv.2537 · Cited by 35 · see citing works
Wonderlich, J. A., Bershad, M., & STEINGLASS, J. E. (2021) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s282554 · Cited by 41 · see citing works
Alterations of brain structure and functions in anorexia nervosa
Scharner, S., & Stengel, A. (2019) · Clinical Nutrition Experimental · doi:10.1016/j.yclnex.2019.02.001 · Cited by 42 · see citing works
An updated transdiagnostic review of social cognition and eating disorder psychopathology
Mason, T. B., Lantz, E. L., Dolgon-Krutolow, A., Wonderlich, S. A., & Smith, K. E. (2020) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2020.11.019 · Cited by 39 · see citing works
Zhang, S., Hu, S., Chao, H. H., & Li, C.-S. R. (2017) · Brain Structure and Function · doi:10.1007/s00429-016-1358-y · Cited by 38 · see citing works
Subliminal and supraliminal processing of reward-related stimuli in anorexia nervosa
Boehm, I., King, J. A., Bernardoni, F., Geisler, D., Seidel, M., Ritschel, F., Goschke, T., Haynes, J., Roessner, V., & Ehrlich, S. (2017) · Psychological Medicine · doi:10.1017/s0033291717002161 · Cited by 34 · see citing works
Sfärlea, A., Greimel, E., Platt, B., Bartling, J., Schulte‐Körne, G., & Dieler, A. C. (2016) · Biological Psychology · doi:10.1016/j.biopsycho.2016.06.006 · Cited by 25 · see citing works
Neurobiology of social reward valuation in adults with a history of anorexia nervosa
Sweitzer, M. M., Watson, K. K., Erwin, S., Winecoff, A., Datta, N., Huettel, S. A., Platt, M. L., & Zucker, N. L. (2018) · PLoS ONE · doi:10.1371/journal.pone.0205085 · Cited by 24 · see citing works
Zhang, D., Ao, X., Zheng, Z., Shen, J., Zhang, Y., & Gu, R. (2022) · NeuroImage · doi:10.1016/j.neuroimage.2022.118967 · Cited by 17 · see citing works
Emotion Recognition in Face and Body Motion in Bulimia Nervosa
Dapelo, M. M., Surguladze, S., Morris, R. G., & Tchanturia, K. (2017) · European Eating Disorders Review · doi:10.1002/erv.2554 · Cited by 17 · see citing works
Computer-aided therapeutic diagnosis for anorexia
Spińczyk, D., Bas, M., Dzieciątko, M., Maćkowski, M., Rojewska, K., & Maćkowska, S. (2020) · BioMedical Engineering OnLine · doi:10.1186/s12938-020-00798-9 · Cited by 16 · see citing works
Boehm, I., Mohr, H., King, J. A., Steding, J., Geisler, D., Wronski, M., Weigel, K., Roessner, V., Ruge, H., & Ehrlich, S. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01630-1 · Cited by 15 · see citing works
McAdams, C. J., Efseroff, B., McCoy, J., Ford, L., & Timko, C. A. (2022) · Current Psychiatry Reports · doi:10.1007/s11920-022-01395-4 · Cited by 15 · see citing works
Via, E., Calvo, A., de la Serna, E., Blázquez, A., Lázaro, L., Andrés-Perpiñá, S., Plana, M. T., Flamarique, I., Martínez, E., Pariente, J. C., et al. (2021) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-021-01880-w · Cited by 14 · see citing works
Critical incidents in anorexia nervosa: perspectives of those with a lived experience
Leppänen, J., Tosunlar, L., Blackburn, R., Williams, S., Tchanturia, K., & Sedgewick, F. (2021) · Journal of Eating Disorders · doi:10.1186/s40337-021-00409-5 · Cited by 11 · see citing works
An FMRI meta-analysis of interoception in eating disorders
Datta, N., Hughes, A. E., Modafferi, M., & Klabunde, M. (2024) · NeuroImage · doi:10.1016/j.neuroimage.2024.120933 · Cited by 11 · see citing works
Activity-Based Anorexia in Adolescent Female Rats Causes Changes in Brain Mitochondrial Dynamics
Bhasin, H., O’Brien, S. C., Cordner, Z. A., Aston, S. A., Tamashiro, K. L., & Moran, T. H. (2022) · Physiology & Behavior · doi:10.1016/j.physbeh.2022.114072 · Cited by 9 · see citing works
Attachment Insecurity Predicts Punishment Sensitivity in Anorexia Nervosa
Keating, C., Castle, D. J., Newton, R., Huang, C., & Rossell, S. L. (2016) · The Journal of Nervous and Mental Disease · doi:10.1097/nmd.0000000000000569 · Cited by 8 · see citing works
Calabrese, J. R., Goetschius, L. G., Murray, L., Kaplan, M. R., Lopez‐Duran, N. L., Mitchell, C. M., Hyde, L. W., & Monk, C. S. (2022) · Brain Research · doi:10.1016/j.brainres.2022.147803 · Cited by 8 · see citing works
Reward contamination in restrictive anorexia nervosa: A meta-analysis of functional MRI studies
Rye, C. S., Amorim, F. E., Ward, L. H. E., & Milton, A. L. (2025) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2025.174031 · Cited by 8 · see citing works
Hopkins, S. C., & Martinelli, C. (2025) · Journal of Eating Disorders · doi:10.1186/s40337-025-01261-7 · Cited by 9 · see citing works
King, J. A., Braem, S., Korb, F. M., Diekmann, L.-S., Roessner, V., Steding, J., & Ehrlich, S. (2021) · Journal of Psychopathology and Clinical Science · doi:10.1037/abn0000713 · Cited by 8 · see citing works
Behavioral separation of liking and wanting in response to olfactory and visual food cues
Savva, A., Dijkman, R., Bulik, C. M., & Seubert, J. (2024) · Appetite · doi:10.1016/j.appet.2024.107717 · Cited by 5 · see citing works
Giner‐Bartolomé, C., Steward, T., Wolz, I., Jiménez‐Múrcia, S., Granero, R., Tárrega, S., Fernández‐Formoso, J. A., Soriano‐Mas, C., Menchón, J. M., & Fernández‐Aranda, F. (2016) · European Eating Disorders Review · doi:10.1002/erv.2446 · Cited by 5 · see citing works
Neuroimaging and Eating Disorders
Koithan, E. M., King, J. A., Ehrlich, S., & Haynos, A. F. (2023) · Springer eBooks · doi:10.1007/978-3-030-97416-9_41-1 · Cited by 3 · see citing works
Neurobiology of social reward valuation in adults with a history of anorexia nervosa
Platt, M. L., Datta, N., Winecoff, A., Watson, K. K., Zucker, N. L., Huettel, S. A., Sweitzer, M. M., & Erwin, S. (2018) · doi:10.7924/r4df6pn9p · Cited by 5 · see citing works
Neurobiology of social reward valuation in adults with a history of anorexia nervosa
Sweitzer, M. M., Watson, K. K., Erwin, S., Platt, M. L., Datta, N., Zucker, N. L., Winecoff, A., & Huettel, S. A. (2018) · doi:10.7924/r45t3km1m · Cited by 2 · see citing works
Membrives, S., López‐Solà, M., Fernández‐Aranda, F., Sánchez, I., Martínez‐Zalacaín, I., Palao, D. J., Pujol, J., Menchón, J. M., Davey, C. G., Harrison, B. J., et al. (2021) · International Journal of Eating Disorders · doi:10.1002/eat.23604 · Cited by 1 · see citing works
Peel, H. J., Reggente, N., Strober, M., & Feusner, J. D. (2025) · NeuroImage Clinical · doi:10.1016/j.nicl.2025.103896 · Cited by 1 · see citing works
Lawford‐Smith, H. (2015)
Structural and functional brain alterations in women recovered from anorexia nervosa
Bang, L. (2016) · NORA - Norwegian Open Research Archives
Imagerie cérébrale dans les TCA
Galusca, B. (2017) · doi:10.1016/b978-2-294-74878-3.00019-8
Tracking the ventral striatum temporal response during social feedback in anorexia nervosa
Membrives, S., Via, E., López‐Solà, M., Fernández‐Aranda, F., Sánchez, I., Martínez‐Zalacaín, I., Palao, D. J., Pujol, J., Davey, C. G., Harrison, B. J., et al. (2019) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2018.11.344
Neuroimaging and Eating Disorders
Koithan, E. M., King, J. A., Ehrlich, S., & Haynos, A. F. (2024) · Springer eBooks · doi:10.1007/978-3-031-46096-8_41
Social Cognition and Processing in Eating Disorders
McAdams, C. J., & Harrison, A. (2025) · doi:10.1093/9780197675212.003.0010
Reward Processing and Reinforcement Learning in Eating Disorders
Johnson, A., Venables, K. M., & Haynos, A. F. (2025) · Oxford University Press eBooks · doi:10.1093/9780197675212.003.0008
- Authors
- Via, E., Soriano-Mas, C., Sánchez, I., Forcano, L., Harrison, B. J., Davey, C. G., Pujol, J., Martínez-Zalacaín, I., Menchón, J. M., Fernández-Aranda, F., & Cardoner, N.
- Affiliations
- The University of Melbourne (AU)
- Bellvitge University Hospital (ES)
- Instituto de Salud Carlos III (ES)
- Centro de Investigación Biomédica en Red de Salud Mental (ES)
- ORCID
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2015-07-21
- Volume
- 10
- Issue
- 7
- Pages
- e0133539
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC4510264
- OpenAlex
- W991942487
- Cited by
- 56
- References
- 90
- Citations by year
- 2025: 5 · 2024: 3 · 2023: 2 · 2022: 5 · 2021: 7 · 2020: 5 · 2019: 7 · 2018: 4 · 2017: 8 · 2016: 9 · 2015: 1
- FWCI
- 9.92
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- PLoS ONE (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- RECERCAT (Consorci de Serveis Universitaris de Catalunya) (publishedVersion, other-oa)
- Dipòsit Digital de Documents de la UAB (Universitat Autònoma de Barcelona) (submittedVersion, cc-by)
- Dipòsit Digital de la Universitat de Barcelona (Universitat de Barcelona) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Figshare (submittedVersion, cc-by)
- Minerva Access (University of Melbourne) (submittedVersion, cc-by)
- Repositori digital de la UPF (Universitat Pompeu Fabra) (submittedVersion, cc-by)
- Funders
- Centro de Investigación Biomédica en Red de Salud Mental
- Medical Research Council
- National Health and Medical Research Council (628509, 1061757)
- Instituto de Salud Carlos III (PI11/, PI14/, PI11/210, CP10/00604)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- anorexia nervosa, social reward, social acceptance, social rejection, social judgment, dorsomedial prefrontal cortex, ventral striatum, reward sensitivity, punishment sensitivity, anterior insula, social cognition, eating disorder severity
- MeSH terms
- Adolescent, Adult, Anorexia Nervosa, Brain, Female, Humans, Magnetic Resonance Imaging, Middle Aged, Reward, Social Behavior, Case-Control Studies
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
