Venlafaxine treatment reduces the deficit of executive control of attention in patients with major depressive disorder
Open accessAbstract
Attention plays an essential role in supporting other cognitive functions and behavior and disturbance of attention is one of the most common symptoms in major depressive disorder (MDD). Although treatment with venlafaxine for MDD symptoms has been shown to reduce deficits in cognition and emotion regulation, it remains unclear whether venlafaxine improves specific attentional functions. We used the Attention Network Test to measure the attentional functions of alerting, orienting and executive control before and after treatment with venlafaxine in patients with MDD compared to untreated healthy controls. Before treatment, the MDD group showed a selective impairment in alerting and executive control of attention, while there were no significant group differences in the orienting function. The interaction between group and session was significant for executive control and after treatment with venlafaxine, the performance of the MDD group on executive control of attention was not significantly different from that of controls. Reported symptoms of MDD were also significantly reduced after treatment with venlafaxine. These results demonstrate that treatment with venlafaxine selectively normalizes the executive control function of attention in addition to improving clinical symptoms in MDD.
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Selective noradrenergic agonists, including SNRIs, atomoxetine, and alpha2 agonists, have been shown to improve selective and sustained attention in some studies but not all.
“Selective noradrenergic agonists, including serotonin and norepinephrine reuptake inhibitors (SNRIs), atomoxetine, and the alpha2 agonists have been shown to improve selective121 and sustained attention in some studies103,122, but not all123,124.”
From Paying attention to attention in depression (2019) · cites this paper as [122]
Some studies found improvements in selective attention with venlafaxine and with duloxetine, but the results have been mixed.
“Some studies have found improvements in selective attention with venlafaxine122 and with duloxetine125, but the results have been mixed99,100.”
From Paying attention to attention in depression (2019) · cites this paper as [122]
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Cites
Folstein, M. F., Folstein, S. E., & McHugh, P. R. (1975) · Journal of Psychiatric Research · doi:10.1016/0022-3956(75)90026-6 · Cited by 88,282 · see citing works
Hirono, N., Mori, E., Ikejiri, Y., Imamura, T., Shimomura, T., Hashimoto, M., Yamashita, H., & Ikeda, M. (1997) · PubMed · Cited by 21,010 · see citing works
Kok, J. S., Berg, I. J., & Scherder, E. J. A. (2013) · Dementia and Geriatric Cognitive Disorders Extra · doi:10.1159/000353441 · Cited by 20,589 · see citing works
Older Adults' Reasons for Using Technology while Aging in Place
Peek, S. T. M., Luijkx, K. G., Rijnaard, M. D., Nieboer, M. E., van der Voort, C. S., Aarts, S., van Hoof, J., Vrijhoef, H. J., & Wouters, E. (2015) · Gerontology · doi:10.1159/000430949 · Cited by 19,803 · see citing works
Sensitivity and False Alarm Rate of a Fall Sensor in Long-Term Fall Detection in the Elderly
Kangas, M., Korpelainen, R., Vikman, I., Nyberg, L., & Jämsä, T. J. (2014) · Gerontology · doi:10.1159/000362720 · Cited by 19,003 · see citing works
A self-rating depression scale
ZUNG, W. W. K. (1965) · Archives of General Psychiatry · doi:10.1001/archpsyc.1965.01720310065008 · Cited by 9,813 · see citing works
Development of a Rating Scale for Primary Depressive Illness
Hamilton, M. (1967) · British Journal of Social and Clinical Psychology · doi:10.1111/j.2044-8260.1967.tb00530.x · Cited by 8,410 · see citing works
The attention system of the human brain
Posner, M. I., & Petersen, S. E. (1990) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.13.030190.000325 · Cited by 8,070 · see citing works
The cognitive control of emotion
OCHSNER, K., & GROSS, J. (2005) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2005.03.010 · Cited by 4,495 · see citing works
Testing the efficiency and independence of attentional networks
Fan, J., McCandliss, B. D., Sommer, T., Raz, A., & Posner, M. I. (2002) · Journal of Cognitive Neuroscience · doi:10.1162/089892902317361886 · Cited by 3,717 · see citing works
Self-citationVoluntary orienting is dissociated from target detection in human posterior parietal cortex
Corbetta, M., Kincade, J. M., Ollinger, J. M., McAvoy, M. P., & Shulman, G. L. (2000) · Nature Neuroscience · doi:10.1038/73009 · Cited by 1,816 · see citing works
Snyder, H. R. (2013) · Psychological Bulletin · doi:10.1037/a0028727 · Cited by 1,667 · see citing works
Suppressing unwanted memories by executive control
Anderson, M. C., & Green, C. (2001) · Nature · doi:10.1038/35066572 · Cited by 1,129 · see citing works
Cognitive Function Across Manic or Hypomanic, Depressed, and Euthymic States in Bipolar Disorder
Martínez‐Arán, A., Vieta, E., Reinares, M., Colom, F., Torrent, C., Sánchez‐Moreno, J., Benabarre, A., Goikolea, J. M., Comes, M., & Salamero, M. (2004) · American Journal of Psychiatry · doi:10.1176/appi.ajp.161.2.262 · Cited by 1,106 · see citing works
Opponent interactions between serotonin and dopamine
Daw, N. D., Kakade, S., & Dayan, P. (2002) · Neural Networks · doi:10.1016/s0893-6080(02)00052-7 · Cited by 844 · see citing works
Remission rates during treatment with venlafaxine or selective serotonin reuptake inhibitors
Thase, M. E., Entsuah, A. R., & Rudolph, R. L. (2001) · The British Journal of Psychiatry · doi:10.1192/bjp.178.3.234 · Cited by 801 · see citing works
McIntyre, R. S., Cha, D. S., Soczynska, J. K., Woldeyohannes, H. O., Gallaugher, L. A., Kudlow, P., Alsuwaidan, M., & Baskaran, A. (2013) · Depression and Anxiety · doi:10.1002/da.22063 · Cited by 765 · see citing works
Coull, J. T., Frith, C. D., Frackowiak, R. S. J., & Grasby, P. M. (1996) · Neuropsychologia · doi:10.1016/0028-3932(96)00029-2 · Cited by 566 · see citing works
Emerging principles of altered neural circuitry in schizophrenia
Benes, F. (2000) · Brain Research Reviews · doi:10.1016/s0165-0173(99)00041-7 · Cited by 513 · see citing works
Cognitive functioning in major depression – a summary
Hammar, Å. (2009) · Frontiers in Human Neuroscience · doi:10.3389/neuro.09.026.2009 · Cited by 491 · see citing works
Attention and executive functions in remitted major depression patients
Paelecke-Habermann, Y., Pohl, J., & Leplow, B. (2005) · Journal of Affective Disorders · doi:10.1016/j.jad.2005.09.006 · Cited by 487 · see citing works
Executive Dysfunction and Long-term Outcomes of Geriatric Depression
Alexopoulos, G. S., Meyers, B. S., Young, R. C., Kalayam, B., Kakuma, T., Gabrielle, M., Sirey, J. A., & Hull, J. (2000) · Archives of General Psychiatry · doi:10.1001/archpsyc.57.3.285 · Cited by 486 · see citing works
Logue, S. F., & Gould, T. J. (2014) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2013.08.007 · Cited by 477 · see citing works
Mapping the genetic variation of executive attention onto brain activity
Fan, J., Fossella, J., Sommer, T., Wu, Y., & Posner, M. I. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0732088100 · Cited by 464 · see citing works
Self-citationPosner, M. I., & Fan, J. (2008) · Cambridge University Press eBooks · doi:10.1017/cbo9780511541681.005 · Cited by 385 · see citing works
Self-citationGenetic and neurochemical modulation of prefrontal cognitive functions in children
Diamond, A., Briand, L., Fossella, J., & Gehlbach, L. (2004) · American Journal of Psychiatry · doi:10.1176/appi.ajp.161.1.125 · Cited by 381 · see citing works
Dopaminergic A10 neurones are involved in cognitive functions
Simon, H., Scatton, B., & Moal, M. L. (1980) · Nature · doi:10.1038/286150a0 · Cited by 364 · see citing works
SNaRIs, NaSSAs, and NaRIs: new agents for the treatment of depression
KENT, J. M. (2000) · The Lancet · doi:10.1016/s0140-6736(99)11381-3 · Cited by 329 · see citing works
Cognitive dysfunction in unipolar depression: Implications for treatment
Trivedi, M. H., & Greer, T. L. (2014) · Journal of Affective Disorders · doi:10.1016/j.jad.2013.09.012 · Cited by 294 · see citing works
Luciana, M., Collins, P., & Depue, R. (1998) · Cerebral Cortex · doi:10.1093/cercor/8.3.218 · Cited by 291 · see citing works
Millan, M. J., Dekeyne, A., & Gobert, A. (1998) · Neuropharmacology · doi:10.1016/s0028-3908(98)00078-1 · Cited by 283 · see citing works
Cognitive control and attentional functions
Mackie, M.-A., Van Dam, N. T., & Fan, J. (2013) · Brain and Cognition · doi:10.1016/j.bandc.2013.05.004 · Cited by 235 · see citing works
Self-citationFan, J., & Posner, M. (2004) · Psychiatrische Praxis · doi:10.1055/s-2004-828484 · Cited by 204 · see citing works
Self-citationAn information theory account of cognitive control
Fan, J. (2014) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2014.00680 · Cited by 203 · see citing works
Self-citationBondareff, W., Alpert, M., Friedhoff, A. J., Richter, E. M., Clary, C. M., & Batzar, E. D. (2000) · American Journal of Psychiatry · doi:10.1176/appi.ajp.157.5.729 · Cited by 202 · see citing works
Local Infusion of Scopolamine Into Intraparietal Cortex Slows Covert Orienting in Rhesus Monkeys
Davidson, M. C., & Marrocco, R. T. (2000) · Journal of Neurophysiology · doi:10.1152/jn.2000.83.3.1536 · Cited by 188 · see citing works
Rynn, M. A., Riddle, M. A., Yeung, P. P., & Kunz, N. R. (2007) · American Journal of Psychiatry · doi:10.1176/ajp.2007.164.2.290 · Cited by 185 · see citing works
Horst, W. D., & Preskorn, S. (1998) · Journal of Affective Disorders · doi:10.1016/s0165-0327(98)00222-5 · Cited by 182 · see citing works
Selective impairment of attentional networks of orienting and executive control in schizophrenia
Wang, K., Fan, J., Dong, Y., Wang, C., Lee, T. M. C., & Posner, M. I. (2005) · Schizophrenia Research · doi:10.1016/j.schres.2005.01.019 · Cited by 174 · see citing works
Self-citationRedrobe, J. P., Bourin, M., Colombel, M. C., & Baker, G. B. (1998) · Psychopharmacology · doi:10.1007/s002130050638 · Cited by 163 · see citing works
Witte, E. A., & Marrocco, R. T. (1997) · Psychopharmacology · doi:10.1007/s002130050351 · Cited by 152 · see citing works
Gyurak, A., Patenaude, B., Korgaonkar, M. S., Grieve, S. M., Williams, L. M., & Etkin, A. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.02.037 · Cited by 149 · see citing works
Lifetime prevalence and inter-cohort variation in DSM-IV disorders in metropolitan China
Lee, S., Tsang, A., Zhang, M., Huang, Y., He, Y., Liu, Z., Shen, Y., & Kessler, R. C. (2006) · Psychological Medicine · doi:10.1017/s0033291706008993 · Cited by 149 · see citing works
The Safety and Tolerability of Venlafaxine Hydrochloride: Analysis of the Clinical Trials Database
Rudolph, R. L., & Derivan, A. (1996) · Journal of Clinical Psychopharmacology · doi:10.1097/00004714-199606002-00011 · Cited by 122 · see citing works
Lanzenberger, R. R., Baldinger, P., Hahn, A., Ungersboeck, J., Mitterhauser, M., Winkler, D., Micskei, Z., Stein, P., Karanikas, G., Wadsak, W., et al. (2012) · Molecular Psychiatry · doi:10.1038/mp.2012.93 · Cited by 120 · see citing works
Herrera-Guzmán, I., Herrera-Abarca, J. E., Gudayol-Ferré, E., Herrera-Guzmán, D., Gómez-Carbajal, L., Peña-Olvira, M., Villuendas-González, E., & Joan, G.-O. (2010) · Psychiatry Research · doi:10.1016/j.psychres.2010.03.006 · Cited by 120 · see citing works
Vilgis, V., Silk, T. J., & Vance, A. L. A. (2015) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-015-0675-7 · Cited by 118 · see citing works
&NA; (1989) · Behavioural Pharmacology · doi:10.1097/00008877-198923000-00001 · Cited by 83 · see citing works
Topics in Integrative Neuroscience: From Cells To Cognition
Geda, Y. E. (2010) · Journal of Neuropsychiatry · doi:10.1176/jnp.2010.22.1.124 · Cited by 72 · see citing works
Beiko, J., Candusso, L., & Cain, D. P. (1997) · Behavioural Brain Research · doi:10.1016/s0166-4328(97)02298-5 · Cited by 65 · see citing works
de Oliveira, R. A., Cunha, G. M. A., Borges, K. D. M., de Bruin, G. S., Filho, E. A. S., Viana, G. S. D. B., & de Bruin, V. M. S. (2004) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2004.09.001 · Cited by 65 · see citing works
Fan, J., Dam, N. T. V., Gu, X., Liu, X., Wang, H., Tang, C. Y., & Hof, P. R. (2014) · Journal of Cognitive Neuroscience · doi:10.1162/jocn_a_00554 · Cited by 58 · see citing works
Self-citationNeuropsychological Deficits in Adolescent Unipolar Depression
Klimkeit, E., Tonge, B. J., Bradshaw, J. L., Melvin, G. A., & Gould, K. R. (2011) · Archives of Clinical Neuropsychology · doi:10.1093/arclin/acr051 · Cited by 57 · see citing works
Pardo, J. V., Pardo, P. J., Humes, S. W., & Posner, M. I. (2006) · Journal of Affective Disorders · doi:10.1016/j.jad.2005.12.037 · Cited by 53 · see citing works
Popovic, D., Vieta, E., Fornaro, M., & Perugi, G. (2015) · Journal of Affective Disorders · doi:10.1016/j.jad.2014.11.008 · Cited by 51 · see citing works
Attention Network Dysfunction and Treatment Response of Geriatric Depression
Murphy, C. F., & Alexopoulos, G. S. (2006) · Journal of Clinical and Experimental Neuropsychology · doi:10.1080/13803390490918101 · Cited by 44 · see citing works
Fujino, J., Yamasaki, N., Miyata, J., Sasaki, H., Matsukawa, N., Takemura, A., Tei, S., Sugihara, G., Aso, T., Fukuyama, H., et al. (2015) · Journal of Affective Disorders · doi:10.1016/j.jad.2014.12.009 · Cited by 43 · see citing works
Executive Function Impairments in Patients with Depression
Alves, M. R. P., Yamamoto, T., Arias-Carrión, Ó., Rocha, N., Nardi, A. E., Machado, S. E. D. C., & Cardoso, A. (2014) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527313666140612102321 · Cited by 40 · see citing works
Safety and efficacy of high dose of venlafaxine XL in treatment resistant major depression
Mbaya, P. Y. (2002) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.419 · Cited by 31 · see citing works
Clozapine improves the orienting of attention in schizophrenia
Spagna, A., Dong, Y., Mackie, M., Li, M., Harvey, P. D., Tian, Y., Wang, K., & Fan, J. (2015) · Schizophrenia Research · doi:10.1016/j.schres.2015.08.009 · Cited by 30 · see citing works
Self-citationAlertness and visuospatial attention in clinical depression
Schock, L., Schwenzer, M., Sturm, W., & Mathiak, K. (2011) · BMC Psychiatry · doi:10.1186/1471-244x-11-78 · Cited by 24 · see citing works
Venlafaxine enhances the effect of bupropion on extracellular dopamine in rat frontal cortex
Hudson, A. L., Lalies, M. D., & Silverstone, P. H. (2012) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y2012-045 · Cited by 20 · see citing works
Czubak, A., Nowakowska, E., Gołembiowska, K., Kus, K., Burda, K., & Metelska, J. (2010) · PubMed · Cited by 17 · see citing works
SYSTEMIC AND LOCAL MODULATION OF COVERT ORIENTING IN PRIMATES
Marrocco, R. T., & Davidson, M. C. (1998) · Behavioural Pharmacology · doi:10.1097/00008877-199808000-00124 · Cited by 1 · see citing works
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- Fan J.. Quantitative characterization of functional anatomical contributions to cognitive control under uncertainty. Journal of Cognitive Neuroscience 26, 1490– 1506, 10.1162/jocn_a_00554 (2014). 24392900 PMC5070967 · DOI
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Cognitive dysfunction in major depression: From assessment to novel therapies
Atique-Ur-Rehman, H., & Neill, J. C. (2019) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2019.05.013 · Cited by 72 · see citing works
Salagre, E., Solé, B., Tomioka, Y., Fernandes, B. S., Hidalgo-Mazzei, D., Garriga, M., Jimenez, E., Sanchez-Moreno, J., Vieta, E., & Grande, I. (2017) · Journal of Affective Disorders · doi:10.1016/j.jad.2017.06.034 · Cited by 71 · see citing works
Holczer, A., Németh, V. L., Vékony, T., Kocsis, K., Király, A., Kincses, Z. T., Vécsei, L., Klivényi, P., & Must, A. (2021) · Neuroscience · doi:10.1016/j.neuroscience.2021.03.001 · Cited by 15 · see citing works
- Authors
- Tian, Y., Du, J., Spagna, A., Mackie, M.-A., Gu, X., Dong, Y., Fan, J., & Wang, K.
- Affiliations
- Anhui Medical University (CN)
- Second Affiliated Hospital of Anhui Medical University (CN)
- Queens College, CUNY (US)
- The University of Texas at Dallas (US)
- Anhui Mental Health Center (CN)
- Corresponding author
- Wang, Kai
- Venue
- Scientific Reports
- Published
- 2016-06-16
- Volume
- 6
- Issue
- 1
- Pages
- 28028-28028
- ISSN
- 2045-2322 (ISSN-L)
- PMC
- PMC4910055
- OpenAlex
- W2427060740
- Cited by
- 36
- References
- 64
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 1 · 2023: 2 · 2022: 5 · 2021: 4 · 2020: 6 · 2019: 11 · 2018: 1 · 2017: 1 · 2016: 1
- FWCI
- 3.77
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Scientific Reports (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- CUNY Academic Works (City University of New York) (submittedVersion, cc-by)
- Funders
- National Natural Science Foundation of China (81471117, 91432301)
- Topics
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- venlafaxine, major depressive disorder, attention deficits, alerting, orienting, Attention Network Test, antidepressant treatment, cognitive function
- MeSH terms
- Venlafaxine Hydrochloride, Adult, Attention Deficit Disorder with Hyperactivity, Major Depressive Disorder, Female, Humans, Male, Neuropsychological Tests, Reaction Time, Antidepressive Agents, Second-Generation, Executive Function
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