The DOI matches its Crossref record; 143 of the 143 references it cites were found in a registry or an index.
Sniffing around oxytocin: review and meta-analyses of trials in healthy and clinical groups with implications for pharmacotherapy
Open accessAbstract
The popularity of oxytocin (OT) has grown exponentially during the past decade, and so has the number of OT trials in healthy and clinical groups. We take stock of the evidence from these studies to explore potentials and limitations of pharmacotherapeutic applications. In healthy participants, intranasally administered OT leads to better emotion recognition and more trust in conspecifics, but the effects appear to be moderated by context (perceived threat of the 'out-group'), personality and childhood experiences. In individuals with untoward childhood experiences, positive behavioral or neurobiological effects seem lowered or absent. In 19 clinical trials, covering autism, social anxiety, postnatal depression, obsessive-compulsive problems, schizophrenia, borderline personality disorder and post-traumatic stress, the effects of OT administration were tested, with doses ranging from 15 IU to more than 7000 IU. The combined effect size was d=0.32 (N=304; 95% confidence interval (CI): 0.18-0.47; P<0.01). However, of all disorders, only studies on autism spectrum disorder showed a significant combined effect size (d=0.57; N=68; 95% CI: 0.15-0.99; P<0.01). We hypothesize that for some of the other disorders, etiological factors rooted in negative childhood experiences may also have a role in the diminished effectiveness of treatment with OT.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source doesn’t support the claim as written.
In the citing paper
“These studies yielded summarized effect sizes ranging from d=0.21 to d=0.48.”
From Statistical and Methodological Considerations for the Interpretation of Intranasal Oxytocin Studies (2016) · cites this paper as [11]
Checked by a reasoning model — may be wrong.
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“The meta-analyses mentioned in this paper all tested for evidence of publication bias in the IN-OT literature, with mixed results (9–11).”
From Statistical and Methodological Considerations for the Interpretation of Intranasal Oxytocin Studies (2016) · cites this paper as [11]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Finally, in the meta-analysis by Bakermans-Kranenburg and Van IJzendoorn (11) IN-OT seems to have the largest effect size in individuals with autism. Only four studies of autism were included in the analysis and should therefore be interpreted cautiously. However, the larger effect size for autism (d=0.57) compared to all clinical studies (d=0.32)”
From Statistical and Methodological Considerations for the Interpretation of Intranasal Oxytocin Studies (2016) · cites this paper as [11]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“Bakermans-Kranenburg and Van IJzendoorn studied the effect of IN-OT in clinical trials (19 effect sizes, total N=304)(11).”
From Statistical and Methodological Considerations for the Interpretation of Intranasal Oxytocin Studies (2016) · cites this paper as [11]
The cited source says what the claim attributes to it.
In the citing paper
“To date three meta-analyses of the effects of IN-OT on human behavior have been published.”
From Statistical and Methodological Considerations for the Interpretation of Intranasal Oxytocin Studies (2016) · cites this paper as [11]
The cited source says what the claim attributes to it.
In the citing paper
“Only four studies of autism were included in the analysis and should therefore be interpreted cautiously.”
From Statistical and Methodological Considerations for the Interpretation of Intranasal Oxytocin Studies (2016) · cites this paper as [11]
In the citing paper
“Several clinical studies have also investigated the potential of intranasal oxytocin as a treatment for socio-cognitive, behavioral, and socio-affective symptoms of ASD. So far, these studies cannot provide a certain conclusion about oxytocin’s therapeutic potential43–47.”
From Randomized clinical trial shows no substantial modulation of empathy-related neural activation by intranasal oxytocin in autism (2021) · cites this paper as [46]
In the citing paper
“In typically developing individuals, OT has been linked to interpersonal bonding, parental care, and the ability to establish trust and form social attachments [2, 3].”
From Behavioral effects of multiple-dose oxytocin treatment in autism: a randomized, placebo-controlled trial with long-term follow-up (2020) · cites this paper as [2]
In the citing paper
“the genetic background of oxytocin system might influence efficacy of oxytocin administration.19, 20”
From Oxytocin efficacy is modulated by dosage and oxytocin receptor genotype in young adults with high-functioning autism: a 24-week randomized clinical trial (2016) · cites this paper as [19]
In the citing paper
“oxytocin is emerging as a pharmacological target for social dysfunction in clinical trials (29, 30).”
From Placebo treatment facilitates social trust and approach behavior (2018) · cites this paper as [30]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Statistical Power Analysis for the Behavioral Sciences
Muller, K. E., & Cohen, J. (1989) · Technometrics · doi:10.2307/1270020 · Cited by 99,603
Statistical power analysis for the behavioral sciences
Cohen, J. (1990) · Computers Environment and Urban Systems · doi:10.1016/0198-9715(90)90050-4 · Cited by 65,417
(1969) · Cited by 18,340
Duval, S., & Tweedie, R. (2000) · Biometrics · doi:10.1111/j.0006-341x.2000.00455.x · Cited by 14,099
(2000) · Cited by 9,198
LeDoux, J. E. (2000) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.23.1.155 · Cited by 8,444
Baron-Cohen, S., Wheelwright, S., Skinner, R., Martin, J., & Clubley, E. (2001) · Journal of Autism and Developmental Disorders · doi:10.1023/a:1005653411471 · Cited by 6,450
Kirschbaum, C., Pirke, K.-M., & Hellhammer, D. H. (2008) · Neuropsychobiology · doi:10.1159/000119004 · Cited by 6,093
The precuneus: a review of its functional anatomy and behavioural correlates
Cavanna, A. E., & Trimble, M. R. (2006) · Brain · doi:10.1093/brain/awl004 · Cited by 5,128
Meta-Analytic Procedures for Social Research
Rosenthal, R. (1991) · doi:10.4135/9781412984997 · Cited by 4,635
Flagged first, then by citations
Research works printed but not linked: 1
- Borenstein M, Hedges LV, Higgins JPT, Rothstein HR . Comprehensive Meta-Analysis, Version 2. Biostat: Englewood, NJ, USA, 2005.
Cited by
Sorted by citations
Items 101–200 of 382
The Mimicry Among Us: Intra- and Inter-Personal Mechanisms of Spontaneous Mimicry
Arnold, A. J., & Winkielman, P. (2019) · Journal of Nonverbal Behavior · doi:10.1007/s10919-019-00324-z · Cited by 62
Daniëls, N., Moerkerke, M., Steyaert, J. G., Bamps, A., Debbaut, E., Prinsen, J., Tang, T., der Donck, S. V., Boets, B., & Alaerts, K. (2023) · Molecular Autism · doi:10.1186/s13229-023-00546-5 · Cited by 57
Neurobiological correlates of social anxiety disorder: an update
Marazziti, D., Abelli, M., Baroni, S., Carpita, B., Ramacciotti, C., & Dell’Osso, L. (2014) · CNS Spectrums · doi:10.1017/s109285291400008x · Cited by 59
Szymanska, M., Schneider, M., Chateau‐Smith, C., Nezelof, S., & Vulliez‐Coady, L. (2017) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.12544 · Cited by 54
Kim, Y., Kim, C., Park, S. J., Pyo, J., & Treasure, J. L. (2014) · PLoS ONE · doi:10.1371/journal.pone.0090721 · Cited by 54
“Additionally, the experience of childhood care, personality, and interpersonal context are known to influence the effects of oxytocin [70].”
BackgroundOxytocin and social cognition in affective and psychotic disorders
Pérez-Rodríguez, M. M., Mahon, K., Russo, M., Ungar, A. K., & Burdick, K. E. (2014) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2014.07.012 · Cited by 58
“Because of its anxiolytic, prosocial, and social cognitiveenhancing effects (Bakermans-Kranenburg and van, 2013; Bos et al., 2012; Gumley et al., 2014; Macdonald and Macdonald, 2010; Meyer-Lindenberg et al., 2011; Zink and Meyer-Lindenberg, 2012), oxytocin has been suggested as a promising novel treatment for patients…”
BackgroundInfluentialBakker-Huvenaars, M. J., Greven, C. U., Herpers, P., Wiegers, E., Jansen, A., van der Steen, R., van Herwaarden, A. E., Baanders, A. N., Nijhof, K. S., Scheepers, F., et al. (2020) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2018.07.097 · Cited by 51
Clarici, A., Pellizzoni, S., Guaschino, S., Alberico, S., Bembich, S., Giuliani, R., Short, A., Guarino, G., & Panksepp, J. (2015) · Frontiers in Psychology · doi:10.3389/fpsyg.2015.00426 · Cited by 54
“Oxytocin is well known to promote prosocial behaviors, especially in the short term following its administration (Bartz et al., 2011; Bakermans-Kranenburg and van I Jzendoorn, 2013) with a variety of reported effects, of which antidepressant effects are most relevant here (for an extensive recent…”
BackgroundInfluentialThe oxytocin receptor gene predicts brain activity during an emotion recognition task in autism
Uzefovsky, F., Bethlehem, R. A. I., Shamay-Tsoory, S., Ruigrok, A., Holt, R., Spencer, M., Chura, L., Warrier, V., Chakrabarti, B., Bullmore, E., et al. (2019) · Molecular Autism · doi:10.1186/s13229-019-0258-4 · Cited by 49
On the role of oxytocin in borderline personality disorder
Brüne, M. (2015) · British Journal of Clinical Psychology · doi:10.1111/bjc.12100 · Cited by 55
Krause, S., Boeck, C., Gumpp, A. M., Rottler, E., Schury, K., Karabatsiakis, A., Buchheim, A., Gündel, H., Kolassa, I., & Waller, C. (2018) · Frontiers in Psychology · doi:10.3389/fpsyg.2018.00173 · Cited by 49
Riem, M., Bakermans-Kranenburg, M., & van IJzendoorn, M. H. (2016) · Attachment & Human Development · doi:10.1080/14616734.2016.1149872 · Cited by 30
Quintana, D. S., & Woolley, J. D. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.06.021 · Cited by 46
Naderi, M., Puar, P., JavadiEsfahani, R., & Kwong, R. W. M. (2021) · NeuroToxicology · doi:10.1016/j.neuro.2021.11.009 · Cited by 49
Leppanen, J., Ng, K. W., Kim, Y.-R., Tchanturia, K., & Treasure, J. (2018) · Journal of Affective Disorders · doi:10.1016/j.jad.2017.08.041 · Cited by 45
Hofmann, S. G., Fang, A., & Brager, D. N. (2015) · Psychiatry Research · doi:10.1016/j.psychres.2015.05.039 · Cited by 44
RetractedThe two fold role of oxytocin in social developmental disorders: A cause and a remedy?
Lefèvre, A., & Sirigu, A. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.01.011 · Cited by 48
Kamp‐Becker, I., Poustka, L., Bachmann, C., Ehrlich, S., Hoffmann, F., Kanske, P., Kirsch, P., Krach, S., Paulus, F. M., Rietschel, M., et al. (2017) · BMC Psychiatry · doi:10.1186/s12888-017-1362-7 · Cited by 47
“A recently published review and a meta-analysis [63, 64] summarizing the potentials and limitations of pharmacotherapeutic applications of OXT, came to the conclusion that studies on ASD did show significant effect sizes and that more sophisticated and targeted clinical trials were required.”
BackgroundSeeley, S. H., Chou, Y., & O'Connor, M. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.09.011 · Cited by 43
McInnis, O. A., McQuaid, R. J., Matheson, K., & Anisman, H. (2015) · Frontiers in Psychology · doi:10.3389/fpsyg.2015.01133 · Cited by 44
“The involvement of oxytocin in these prosocial behaviors in humans has been demonstrated following its administration through a nasal spray (Bakermans-Kranenburg and van IJzendoorn, 2013).”
BackgroundOxytocin and Anxiety Disorders: Translational and Therapeutic Aspects
Naja, W., & Aoun, M. P. (2017) · Current Psychiatry Reports · doi:10.1007/s11920-017-0819-1 · Cited by 42
Bienboire‐Frosini, C., Chabaud, C., Cozzi, A., Codecasa, E., & Pageat, P. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00524 · Cited by 44
“…levels is noteworthy when considering the increasing number of reports stating the sex importance in relation to the OT system (Neumann, 2008; Bakermans-Kranenburg and van IJzendoorn, 2013; Crockford et al., 2014; Alves et al., 2015), notably through the influence of steroid hormones, such…”
BackgroundIntrinsic, dynamic and effective connectivity among large-scale brain networks modulated by oxytocin
Jiang, X., Ma, X., Geng, Y., Zhao, Z., Zhou, F., Zhao, W., Yao, S., Yang, S., Zhao, Z., Becker, B., et al. (2020) · NeuroImage · doi:10.1016/j.neuroimage.2020.117668 · Cited by 39
Do we need oxytocin to treat schizophrenia? A randomized clinical trial
Dagani, J., Sisti, D., Abelli, M., Paolo, L. D., Pini, S., Raimondi, S., Rocchi, M., Saviotti, F. M., Scocco, P., Totaro, S., et al. (2016) · Schizophrenia Research · doi:10.1016/j.schres.2016.02.011 · Cited by 43
Intranasal Oxytocin and Vasopressin Modulate Divergent Brainwide Functional Substrates
Galbusera, A., Felice, A. D., Girardi, S., Bassetto, G., Maschietto, M., Nishimori, K., Chini, B., Papaleo, F., Vassanelli, S., & Gozzi, A. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2016.283 · Cited by 38
Alaerts, K., Bernaerts, S., Vanaudenaerde, B. M., Daniëls, N., & Wenderoth, N. (2019) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2019.01.008 · Cited by 42
“Less is more”: A dose-response account of intranasal oxytocin pharmacodynamics in the human brain
Martins, D., Brodmann, K., Veronese, M., Dipasquale, O., Mazibuko, N., Schuschnig, U., Zelaya, F. O., Fotopoulou, A., & Paloyelis, Y. (2022) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2022.102239 · Cited by 43
Placebo treatment facilitates social trust and approach behavior
Yan, X., Yong, X., Huang, W., & Ma, Y. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1800779115 · Cited by 39
Yee, J. R., Kenkel, W. M., Frijling, J. L., Dodhia, S., Onishi, K. G., Tovar, S., Saber, M. J., Lewis, G. F., Liu, W., Porges, S. W., et al. (2016) · Hormones and Behavior · doi:10.1016/j.yhbeh.2016.01.010 · Cited by 40
“OXT treatments have been suggested as therapies for a wide variety of neuropsychiatric disorders; especially those associated with exaggerated reactivity in response to a challenge (Bakermans-Kranenburg and van I. Jzendoorn, 2013; Harris and Carter, 2013; Macdonald and Feifel, 2013).”
BackgroundOxytocin and emotion processing
Simplicio, M. C. D., & Harmer, C. J. (2016) · Journal of Psychopharmacology · doi:10.1177/0269881116641872 · Cited by 38
Tollenaar, M. S., Molendijk, M. L., Penninx, B. W. J. H., Milaneschi, Y., & Antypa, N. (2017) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-017-0784-z · Cited by 40
“Lastly, while in recent years clinical trials have been performed to examine the effects of oxytocin administration on anxiety and depressive disorders [53, 54], the role of individual differences in genetic makeup of the oxytocin system and the role of early life trauma in both the etiology of these disorders, and in…”
BackgroundGuoynes, C. D., Simmons, T. C., Downing, G., Jacob, S., Solomon, M., & Bales, K. L. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2017.11.037 · Cited by 38
Chen, X., Nishitani, S., Haroon, E., Smith, A. K., & Rilling, J. K. (2019) · Genes Brain & Behavior · doi:10.1111/gbb.12555 · Cited by 39
Effects of oxytocin on aggressive responding in healthy adult men
Alcorn, J. L., Green, C. E., Schmitz, J. M., & Lane, S. D. (2015) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000173 · Cited by 37
Effects of opioids on the parental brain in health and disease
Swain, J. E., Ho, S.-H. S., Fox, H. C., Garry, D. J., & Brummelte, S. (2019) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2019.100766 · Cited by 38
Oxytocin increases eye-gaze towards novel social and non-social stimuli
Eckstein, M., Bamert, V., Stephens, S. B. Z., Wallen, K., Young, L. J., Ehlert, U., & Ditzen, B. (2018) · Social Neuroscience · doi:10.1080/17470919.2018.1542341 · Cited by 36
“This is in line with other studies reporting only small to medium effects of intranasal OT (Bakermans-Kranenburg & Van Ijzendoorn, 2013; Walum, Waldman, & Young, 2016) and underlines the context-specific mechanisms of OT.”
ResultHorta de Macedo, L. R., Zuardi, A. W., Machado-de-Sousa, J. P., Chagas, M. H. N., & Hallak, J. E. C. (2014) · Psychiatry Research · doi:10.1016/j.psychres.2014.07.082 · Cited by 35
Brüne, M., Kolb, M., Ebert, A., Roser, P., & Edel, M.-A. (2015) · Journal of Nervous & Mental Disease · doi:10.1097/nmd.0000000000000240 · Cited by 35
Kim, S., & Strathearn, L. (2017) · The Psychoanalytic Study of the Child · doi:10.1080/00797308.2016.1277897 · Cited by 38
Intranasal Neuropeptide Administration To Target the Human Brain in Health and Disease
Spetter, M. S., & Hallschmid, M. (2015) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.5b00047 · Cited by 35
Bernaerts, S., Boets, B., Steyaert, J. G., Wenderoth, N., & Alaerts, K. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-01069-w · Cited by 36
“The interaction between treatment and emotion was not significant (F(1, 386)= 0.”
BackgroundMethodResultInfluentialEffects of Intranasal Oxytocin on Aggressive Responding in Antisocial Personality Disorder
Alcorn, J. L., Rathnayaka, N. S., Swann, A. C., Moeller, F. G., & Lane, S. D. (2015) · The Psychological Record · doi:10.1007/s40732-015-0139-y · Cited by 38
Ruissen, M. I., & de Bruijn, E. R. A. (2015) · Cortex · doi:10.1016/j.cortex.2015.04.017 · Cited by 35
Samuel, S., Hayton, B. C., Gold, I., Feeley, N., Carter, C. S., & Zelkowitz, P. (2015) · Attachment & Human Development · doi:10.1080/14616734.2015.1029951 · Cited by 37
van IJzendoorn, M. H., & Bakermans‐Kranenburg, M. J. (2015) · Journal of Neuroendocrinology · doi:10.1111/jne.12355 · Cited by 33
The Potential of Nasal Oxytocin Administration for Remediation of Autism Spectrum Disorders
Okamoto, Y., Ishitobi, M., Wada, Y., & Kosaka, H. (2016) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527315666160413120845 · Cited by 33
“In TD individuals, they suggested that the oxytocininduced effect was modulated by personal history; for instance, positive oxytocin effects on behavior and neurobiology is attenuated in individuals with negative childhood experiences [61].”
BackgroundOxytocin is implicated in social memory deficits induced by early sensory deprivation in mice
Zhang, J., Chen, L., Lv, Z.-M., Niu, X.-Y., Shao, C.-C., Zhang, C., Pruski, M., Huang, Y., Qi, C., Song, N., et al. (2016) · Molecular Brain · doi:10.1186/s13041-016-0278-3 · Cited by 33
Oxytocin and Facial Emotion Recognition
Ellenbogen, M. A. (2017) · Current topics in behavioral neurosciences · doi:10.1007/7854_2017_20 · Cited by 34
Schwaiger, M., Heinrichs, M., & Kumsta, R. (2018) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2018.08.025 · Cited by 36
Social-learning parenting intervention research in the era of translational neuroscience
Fisher, P. A., & Skowron, E. A. (2017) · Current Opinion in Psychology · doi:10.1016/j.copsyc.2017.02.017 · Cited by 38
“experiences, in that the least responsive individuals appear to be those parents most in need of support [43].”
Montag, C., Sauer, C., Reuter, M., & Kirsch, P. (2013) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-013-0452-x · Cited by 32
“A recent meta-analysis by Bakermans-Kranenburg and van IJzendoorn [10] on relevant studies investigating the effects of oxytocin as a suitable pharmaceutical to treat autism was able to underline these positive effects of oxytocin on autistic behavior.”
BackgroundOxytocin and Human Sensitive and Protective Parenting
Bakermans‐Kranenburg, M. J., & van IJzendoorn, M. H. (2017) · Current topics in behavioral neurosciences · doi:10.1007/7854_2017_23 · Cited by 36
Oxytocin plasma levels predict the outcome of psychotherapy: A pilot study in chronic depression
Jobst, A., Sabaß, L., Hall, D., Brücklmeier, B., Buchheim, A., Hall, J., Sarubin, N., Zill, P., Falkai, P., Brakemeier, E.-L., et al. (2017) · Journal of Affective Disorders · doi:10.1016/j.jad.2017.10.037 · Cited by 34
Pfundmair, M., Aydin, N., Frey, D., & Echterhoff, G. (2014) · Journal of Experimental Social Psychology · doi:10.1016/j.jesp.2014.07.016 · Cited by 31
Patin, A., & Hurlemann, R. (2015) · Handbook of experimental pharmacology · doi:10.1007/978-3-319-16522-6_10 · Cited by 37
Baron-Cohen, K. L., Feldman, R., Fearon, P. R. M., & Fonagy, P. (2021) · Journal of Affective Disorders · doi:10.1016/j.jad.2021.11.062 · Cited by 31
Endogenous Testosterone and Exogenous Oxytocin Modulate Attentional Processing of Infant Faces
Holtfrerich, S. K. C., Schwarz, K. A., Sprenger, C., Reimers, L., & Diekhof, E. K. (2016) · PLoS ONE · doi:10.1371/journal.pone.0166617 · Cited by 30
Oxytocin Fails to Recruit Serotonergic Neurotransmission in the Autistic Brain
Lefèvre, A., Mottolese, R., Redouté, J., Costes, N., Bars, D. L., Geoffray, M., Leboyer, M., & Sirigu, A. (2017) · Cerebral Cortex · doi:10.1093/cercor/bhx272 · Cited by 31
Choi, D., Tsuchiya, K. J., & Takei, N. (2019) · Scientific Reports · doi:10.1038/s41598-019-44175-6 · Cited by 30
Modi, M. E., Majchrzak, M. J., Fonseca, K. R., Doran, A., Osgood, S., Vanase-Frawley, M., Feyfant, E., McInnes, H., Darvari, R., Buhl, D. L., et al. (2016) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.116.232702 · Cited by 29
“164 mediated behavioral effects, we tested the effects of novel longacting OT receptor agonists on conditioned fear responses.”
BackgroundInfluentialWitteveen, A. B., Stramrood, C. A. I., Henrichs, J., Flanagan, J. C., van Pampus, M. G., & Olff, M. (2019) · Archives of Women s Mental Health · doi:10.1007/s00737-019-00994-0 · Cited by 33
Alaerts, K., Steyaert, J. G., Vanaudenaerde, B. M., Wenderoth, N., & Bernaerts, S. (2020) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2020.11.014 · Cited by 28
Oxytozin: Evidenz für ein therapeutisches Potenzial des sozialen Neuromodulators
Eckstein, M., & Hurlemann, R. (2013) · Der Nervenarzt · doi:10.1007/s00115-013-3832-6 · Cited by 28
Garay, R. P., Citrome, L., Samalin, L., Liu, C., Thomsen, M. S., Correll, C. U., Hameg, A., & Llorca, P. (2016) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.2016.1149164 · Cited by 30
“clinical trials in psychiatric disorders, including schizophrenia, showed negative results (with the exception of autism spectrum disorder).[103]”
ResultGrace, S., Labuschagne, I., Castle, D. J., & Rossell, S. L. (2019) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2019.05.022 · Cited by 31
Salivary oxytocin, cognitive anxiety and self-confidence in pre-competition athletes
Fratta, I. L., Franceschelli, S., Speranza, L., Patruno, A., Michetti, C., D’Ercole, P., Ballerini, P., Grilli, A., & Pesce, M. (2021) · Scientific Reports · doi:10.1038/s41598-021-96392-7 · Cited by 32
The Role of Oxytocin in Early-Life-Stress-Related Neuropsychiatric Disorders
Jin, Y., Song, D. F., Yan, Y., Quan, Z., & Qing, H. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241310430 · Cited by 30
Feeser, M., Fan, Y., Weigand, A., Hahn, A., Gärtner, M., Aust, S., Böker, H., Bajbouj, M., & Grimm, S. (2014) · Psychopharmacology · doi:10.1007/s00213-014-3631-1 · Cited by 29
The effects of oxytocin on social cognition in borderline personality disorder
Servan, A., Brunelin, J., & Poulet, E. (2017) · L Encéphale · doi:10.1016/j.encep.2017.11.001 · Cited by 29
Evenepoel, M., Moerkerke, M., Daniëls, N., Chubar, V., Claes, S. J., Turner, J. D., Vanaudenaerde, B. M., Willems, L., Verhaeghe, J., Prinsen, J., et al. (2023) · Translational Psychiatry · doi:10.1038/s41398-023-02524-0 · Cited by 27
Weinstein, T. A. R., Bales, K. L., Maninger, N., Hostetler, C. M., & Capitanio, J. P. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00295 · Cited by 27
Althaus, M., Groen, Y., Wijers, A. A., Noltes, H., Tucha, O. M., Sweep, F. C. G. J., Calcagnoli, F., & Hoekstra, P. J. (2016) · Psychopharmacology · doi:10.1007/s00213-016-4339-1 · Cited by 28
Voorthuis, A., Riem, M. M. E., van IJzendoorn, M. H., & Bakermans‐Kranenburg, M. J. (2013) · Brain Research · doi:10.1016/j.brainres.2013.10.051 · Cited by 28
“We found however no difference in basal oxytocin levels, no associations between basal oxytocin and emotion recognition, and in a meta-analysis differences in OXTR rs53576 and rs2254298 were not related to social-emotional behavior (Bakermans-Kranenburg and Van IJzendoorn, 2013).”
BackgroundResultOxytocin Normalizes Approach–Avoidance Behavior in Women With Borderline Personality Disorder
Schneider, I., Boll, S., Volman, I., Roelofs, K., Spohn, A., Herpertz, S. C., & Bertsch, K. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.00120 · Cited by 28
“The AAT was conducted ∼75min after substance application, which is still in the range of elevated peripheral and presumably also central oxytocin levels (40, 41) but might be past its peak levels (30–60min after application) in the cerebral spinal fluid (42).”
BackgroundPopow, C., Ohmann, S., & Plener, P. L. (2021) · Neuropsychiatrie · doi:10.1007/s40211-021-00395-9 · Cited by 37
Kovács, B., & Kéri, S. (2015) · European Psychiatry · doi:10.1016/j.eurpsy.2015.02.010 · Cited by 26
“The authors of these papers emphasized the limited understating of mechanism of action, lack of information on dose-response relationship, long-term safety, social contextual effects, ethical issues regarding behavioral modulation, and the controversial impact of oxytocin in real-life circumstances [2,5,13,20,29,52,54…”
BackgroundBos, P. A., Montoya, E. R., Terburg, D., & van Honk, J. (2014) · Human Brain Mapping · doi:10.1002/hbm.22537 · Cited by 26
Recent findings on the pathophysiology of social anxiety disorder
Marazziti, D., Abelli, M., Baroni, S., Carpita, B., Piccinni, A., & Dell’Osso, L. (2014) · Cited by 26
Oxytocin Reduces Cigarette Consumption in Daily Smokers
Hedger, K. V., Kushner, M. J., Lee, R., & de Wit, H. (2018) · Nicotine & Tobacco Research · doi:10.1093/ntr/nty080 · Cited by 26
Moy, S. S., Teng, B. L., Nikolova, V. D., Riddick, N. V., Simpson, C. D., Deusen, A. L. V., Janzen, W. P., Sassano, M. F., Pedersen, C. A., & Jarstfer, M. B. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.10.036 · Cited by 26
Neuroendocrine Regulation of Anxiety: Beyond the Hypothalamic‐Pituitary‐Adrenal Axis
Borrow, A. P., Stranahan, A. M., Suchecki, D., & Yunes, R. (2016) · Journal of Neuroendocrinology · doi:10.1111/jne.12403 · Cited by 27
Riem, M. M. E., Carli, P. D., van IJzendoorn, M. H., Linting, M., Grewen, K., & Bakermans‐Kranenburg, M. J. (2017) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2017.08.017 · Cited by 29
Riem, M. M. E., Kunst, L. E., Steenbakkers, F. D. F., Kir, M., Sluijtman, A., Karreman, A., & Bekker, M. H. J. (2019) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2019.06.012 · Cited by 25
Kujath, A. S., Quinn, L. T., Elliott, M. E., Varady, K. A., LeCaire, T. J., Carter, C. S., & Danielson, K. K. (2014) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.2577 · Cited by 24
“Oxytocin has been widely studied in the context of social behaviours, including oxytocin’s inverse association with stress and depression [22].”
BackgroundTobón, A. L., Newport, D. J., & Nemeroff, C. B. (2018) · Current Treatment Options in Psychiatry · doi:10.1007/s40501-018-0158-9 · Cited by 26
Childhood Maltreatment Alters the Neural Processing of Chemosensory Stress Signals
Maier, A., Heinen-Ludwig, L., Güntürkün, O., Hurlemann, R., & Scheele, D. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.00783 · Cited by 27
“However, previous studies also reported diminished stress-attenuating (92) or prosocial (93) effects of OXT in individuals who have experienced CM.”
ResultMorais, L. H., Golubeva, A. V., Casey, S., Scott, K. A., Costa, A. P., Moloney, G. M., Dinan, T. G., & Cryan, J. F. (2021) · Neuropsychopharmacology · doi:10.1038/s41386-021-01040-3 · Cited by 24
Moerkerke, M., Daniëls, N., der Donck, S. V., Tibermont, L., Tang, T., Debbaut, E., Bamps, A., Prinsen, J., Steyaert, J. G., Alaerts, K., et al. (2023) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.13850 · Cited by 23
Olofsdotter, S., Åslund, C., Furmark, T., Comasco, E., & Nilsson, K. W. (2017) · Development and Psychopathology · doi:10.1017/s0954579417000967 · Cited by 26
Effects of Three Lipidated Oxytocin Analogs on Behavioral Deficits in CD38 Knockout Mice
Михайлович, Ч. С., Akther, S., Nishimura, T., Shabalova, A. A., Mizuno, A., Ichinose, W., Shuto, S., Yamamoto, Y., Yokoyama, S., & Higashida, H. (2017) · Brain Sciences · doi:10.3390/brainsci7100132 · Cited by 23
“A single or repetitive intranasal administration of OT in randomized controlled trials has been demonstrated to elicit the recovery of some parameters of social behavior in ASD patients [25,26], while other trials failed to show positive effects [27–29].”
ResultStrauss, G. P., Granholm, E. L., Holden, J. L., Ruiz, I., Gold, J. M., Kelly, D. L., & Buchanan, R. W. (2018) · Psychological Medicine · doi:10.1017/s0033291718002465 · Cited by 25
“…tasks (e.g. dosing, pharmacodynamics, whether oxytocin reaches intended neural structures, and receptor distribution) (Guastella and MacLeod, 2012; Bakermans-Kranenburg and Van Ijzendoorn, 2013; Freeman and Young, 2016; Leng and Ludwig, 2016; Quintana and Woolley, 2016; Quintana et al., 2018).”
BackgroundMayer, A. V., Wermter, A.-K., Stroth, S., Alter, P., Haberhausen, M., Stehr, T., Paulus, F. M., Krach, S., & Kamp-Becker, I. (2021) · Scientific Reports · doi:10.1038/s41598-021-94407-x · Cited by 23
Hosseini, S. M. R., Farokhnia, M., Rezaei, F., Gougol, A., Yekehtaz, H., Iranpour, N., Salehi, B., Tabrizi, M. H., Tajdini, M., Ghaleiha, A., et al. (2014) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2014.02.001 · Cited by 23
Borderline Personality Disorder and Oxytocin: Review of Clinical Trials and Future Directions
Amad, A., Thomas, P., & Pérez-Rodríguez, M. M. (2015) · Current Pharmaceutical Design · doi:10.2174/1381612821666150619093019 · Cited by 22
Oxytocin treatment in pediatric populations
Taylor, A. E., Lee, H.-E., & Buisman‐Pijlman, F. T. A. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00360 · Cited by 23
“In the context of developmental trauma, positive effects (behaviorally or neurobiologically) were in fact lowered or absent (Bakermans-Kranenburg and Van IJzendoorn, 2013).”
BackgroundBhandari, R., van der Veen, R., Parsons, C. E., Young, K. S., Voorthuis, A., Bakermans‐Kranenburg, M. J., Stein, A. L., Kringelbach, M. L., & van IJzendoorn, M. H. (2014) · Social Neuroscience · doi:10.1080/17470919.2014.932307 · Cited by 23
Transcutaneous Vagus Nerve Stimulation (tVNS) does not increase prosocial behavior in Cyberball
Sellaro, R., Steenbergen, L., Verkuil, B., van IJzendoorn, M. H., & Colzato, L. S. (2015) · Frontiers in Psychology · doi:10.3389/fpsyg.2015.00499 · Cited by 26
L’ocytocine et la dépression du post-partum
Cardaillac, C., Rua, C., Simon, E. G., & El‐Hage, W. (2016) · Journal de gynécologie, obstétrique et biologie de la reproduction. Supplément/Journal de gynécologie obstétrique et biologie de la reproduction · doi:10.1016/j.jgyn.2016.05.002 · Cited by 23
Oxytocin improves the ability of dogs to follow informative pointing: a neuroemotional hypothesis
Macchitella, L., Stegagno, T., Giaconella, R., di Sorrentino, E. P., Schino, G., & Addessi, E. (2016) · RENDICONTI LINCEI · doi:10.1007/s12210-016-0579-6 · Cited by 22
Fragkaki, I., Cima, M., Verhagen, M., Maciejewski, D. F., Boks, M. P., van Lier, P. A. C., Koot, H. M., Branje, S., & Meeus, W. (2018) · Journal of Youth and Adolescence · doi:10.1007/s10964-018-0939-x · Cited by 24
Metadata
- Authors
- Bakermans-Kranenburg, M. J., & van IJzendoorn, M. H.
- Venue
- Translational Psychiatry
- Published
- 2013-05-21
- Volume
- 3
- Issue
- 5
- Pages
- e258-e258
- ISSN
- 2158-3188 (ISSN-L)
- PMC
- PMC3669921
- OpenAlex
- W1966317054
- Cited by
- 383
- References
- 142
- Citations by year
- 2026: 7 · 2025: 13 · 2024: 12 · 2023: 18 · 2022: 11 · 2021: 24 · 2020: 22 · 2019: 29 · 2018: 41 · 2017: 55 · 2016: 43 · 2015: 59 · 2014: 40 · 2013: 9
- FWCI
- 6.67
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by-nc-nd
- www.springer.com/tdm (unspecified)
- Locations
- Translational Psychiatry (publishedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- oxytocin, intranasal administration, pharmacotherapy, autism spectrum disorder, social anxiety, postpartum depression, obsessive-compulsive disorder, schizophrenia, borderline personality disorder, post-traumatic stress disorder, emotion recognition, trust, child abuse, personality moderators, treatment effect size
- MeSH terms
- Administration, Intranasal, Anxiety, Mental Disorders, Child, Child Development Disorders, Pervasive, Depression, Humans, Oxytocin, Personality Disorders, Phobic Disorders, Schizophrenia, Stress Disorders, Post-Traumatic, Anti-Anxiety Agents, Trust
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
